| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5002555 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2011-06-03 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1603911 |
|
| Stage: |
TS11 |
| Assay Id: |
MGI:5002871 |
| Age: |
embryonic day 7.5 |
|
|
| Specimen Label: |
E7.5 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hall NG |
| Year: |
2003 |
| Journal: |
Matrix Biol |
| Title: |
ADAMTSL-3/punctin-2, a novel glycoprotein in extracellular matrix related to the ADAMTS family of metalloproteases. |
| Volume: |
22 |
| Issue: |
6 |
| Pages: |
501-10 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Du J |
| Year: |
2010 |
| Journal: |
Dev Biol |
| Title: |
O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. |
| Volume: |
346 |
| Issue: |
1 |
| Pages: |
25-38 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Naba A |
| Year: |
2017 |
| Journal: |
Sci Rep |
| Title: |
Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. |
| Volume: |
7 |
|
| Pages: |
40495 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Naba A |
| Year: |
2012 |
| Journal: |
Mol Cell Proteomics |
| Title: |
The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. |
| Volume: |
11 |
| Issue: |
4 |
| Pages: |
M111.014647 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tang T |
| Year: |
2010 |
| Journal: |
Nat Biotechnol |
| Title: |
A mouse knockout library for secreted and transmembrane proteins. |
| Volume: |
28 |
| Issue: |
7 |
| Pages: |
749-55 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lexicon Genetics, Inc |
| Year: |
2011 |
| Journal: |
Database Download |
| Title: |
MGI download of Lexicon knockout data |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shanghai Model Organisms Center |
| Year: |
2017 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
FANTOM2 Data Curation in Mouse Genome Informatics |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ko MS |
| Year: |
2000 |
| Journal: |
Development |
| Title: |
Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. |
| Volume: |
127 |
| Issue: |
8 |
| Pages: |
1737-49 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lennon G |
| Year: |
1999 |
| Journal: |
Database Download |
| Title: |
WashU-HHMI Mouse EST Project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hansen GM |
| Year: |
2008 |
| Journal: |
Genome Res |
| Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
| Volume: |
18 |
| Issue: |
10 |
| Pages: |
1670-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carninci P |
| Year: |
2005 |
| Journal: |
Science |
| Title: |
The transcriptional landscape of the mammalian genome. |
| Volume: |
309 |
| Issue: |
5740 |
| Pages: |
1559-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kawai J |
| Year: |
2001 |
| Journal: |
Nature |
| Title: |
Functional annotation of a full-length mouse cDNA collection. |
| Volume: |
409 |
| Issue: |
6821 |
| Pages: |
685-90 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
| Year: |
2008 |
| Journal: |
Database Download |
| Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cyagen Biosciences Inc. |
| Year: |
2022 |
|
| Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2003 |
|
| Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
| Year: |
2004 |
| Journal: |
Database Release |
| Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Okazaki Y |
| Year: |
2002 |
| Journal: |
Nature |
| Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
| Volume: |
420 |
| Issue: |
6915 |
| Pages: |
563-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
GemPharmatech |
| Year: |
2020 |
|
| Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
| Year: |
2001 |
|
| Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI Genome Annotation Group and UniGene Staff |
| Year: |
2015 |
| Journal: |
Database Download |
| Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics and Ensembl Genome Database Project |
| Year: |
2026 |
| Journal: |
Database Release |
| Title: |
MGI Strain Genome Feature and Gene Model Load from Ensembl. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ADAMTS-like 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yim AKY |
| Year: |
2022 |
| Journal: |
Nat Neurosci |
| Title: |
Disentangling glial diversity in peripheral nerves at single-nuclei resolution. |
| Volume: |
25 |
| Issue: |
2 |
| Pages: |
238-251 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
429
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
429
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
170
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
209
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
168
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
429
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
164
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen CI |
| Year: |
2012 |
| Journal: |
EMBO J |
| Title: |
Structure of human POFUT2: insights into thrombospondin type 1 repeat fold and O-fucosylation. |
| Volume: |
31 |
| Issue: |
14 |
| Pages: |
3183-97 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Berardinelli SJ |
| Year: |
2020 |
| Journal: |
Methods Mol Biol |
| Title: |
Analyzing the Effects of O-Fucosylation on Secretion of ADAMTS Proteins Using Cell-Based Assays. |
| Volume: |
2043 |
|
| Pages: |
25-43 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ricketts LM |
| Year: |
2007 |
| Journal: |
J Biol Chem |
| Title: |
O-fucosylation is required for ADAMTS13 secretion. |
| Volume: |
282 |
| Issue: |
23 |
| Pages: |
17014-23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Voxeur A |
| Year: |
2012 |
| Journal: |
PLoS One |
| Title: |
Identification of putative rhamnogalacturonan-II specific glycosyltransferases in Arabidopsis using a combination of bioinformatics approaches. |
| Volume: |
7 |
| Issue: |
12 |
| Pages: |
e51129 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang LW |
| Year: |
2007 |
| Journal: |
J Biol Chem |
| Title: |
O-fucosylation of thrombospondin type 1 repeats in ADAMTS-like-1/punctin-1 regulates secretion: implications for the ADAMTS superfamily. |
| Volume: |
282 |
| Issue: |
23 |
| Pages: |
17024-31 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nofiani R |
| Year: |
2018 |
| Journal: |
Nat Commun |
| Title: |
Strobilurin biosynthesis in Basidiomycete fungi. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
3940 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry represents protein O-fucosyltransferase 2 (POFUT2), a GDP-fucose protein O-fucosyltransferase involved in one of the two pathways responsible for protein O-linked fucosylation, a post-translational modification that regulates various biological functions in cysteine-knotted proteins []. This pathway targets proteins bearing Thrombospondin type-1 (TSP1) repeats (TSRs) in the endoplasmic reticulum.POFUT2 catalyses the attachment of fucose through an O-glycosidic linkage to a conserved serine or threonine residue within the consensus sequence C1-X-X-S/T-C2 of TSRs, where C1 and C2 are the first and second cysteines of the repeat, respectively []. It O-fucosylates members of several protein families, including the ADAMTS, thrombospondin (TSP) and spondin families [].POFUT2 is required for the proper secretion of ADAMTS (a disintegrin and metalloproteinase with thrombospondin type 1 repeats) family members such as ADAMTSL1 and ADAMTS13 [, , ]. Additionally, O-fucosylation of TSRs is required for restricting epithelial to mesenchymal transition (EMT), maintaining correct patterning of mesoderm and localisation of the definitive endoderm.This entry also includes strobilurin A biosynthesis cluster protein Stl1, a component of the gene cluster mediating the biosynthesis of strobilurin A, an antifungal polyketide characterised by a beta-methoxyacrylate toxophore that targets complex III of the mitochondrial electron transport chain [].Strobilurin A biosynthesis is initiated by the construction of benzoyl CoA from phenylalanine through sequential reactions involving a phenylalanine ammonia-lyase (Str11), an oxygenase (Str8), and a retro-Claisen reaction to yield benzoic acid, which is then activated to benzoyl CoA by the CoA ligase Str10. Benzoyl CoA serves as the starter unit for the highly reducing polyketide synthase StPKS1, which produces the intermediate prestrobilutin A. The FAD-dependent oxygenase Str9 then catalyses the key oxidative rearrangement that generates the beta-methoxyacrylate toxophore, likely through epoxidation of the 2,3 olefin of prestrobilutin A followed by Meinwald rearrangement. Final methylations by Str2 and Str3 complete the synthesis of strobilurin A, while the dehydrogenases Stl2 and Str4 are involved in a shunt pathway leading to the production of bolineol [].This entry also includes some O-fucosyltransferase (5, 14, 36) from plants. These proteins are involved in glycan metabolism []. |
|
•
•
•
•
•
|