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Search results 1 to 67 out of 67 for Alpk1

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Danio rerio
Protein
Organism: Mus musculus
Length: 1224  
Fragment?: false
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Family
Description: This entry includes the alpha-protein kinase 1, a serine/threonine-protein kinase that has no homology to conventional protein kinases and phosphorylate amino acids located within α-helices []. The N-terminal region had several conserved secondary α-helix structures with amphipathic properties []. The structure contains 18 helices (α1 to α18), forming seven antiparallel pairs. The one-by-one-packed seven helix pairs form a right-hand solenoid, similar to the tetratricopeptide repeat (TPR) domain structure [].This kinase detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity. Specifically recognises and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria. ADP-Heptose binds to a narrow pocket of the concave side of the alpha-protein kinase 1 N-terminal which stimulates its kinase activity to phosphorylate and activate TIFA, triggering proinflammatory NF-kappa-B signalling [, ]. In addition, alpha-protein kinase 1 may play a role in regulating intracellular trafficking processes through the phosphorylation of myosin MYO1A []. It has been shown that this kinase is also involved in monosodium urate monohydrate (MSU)-induced inflammation and gout by phosphorylation of myosin motor protein which enable the vesicle transport of of certain cytokines (like TNF-alpha) to the plasma membrane [].
Publication
First Author: Zhou P
Year: 2018
Journal: Nature
Title: Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose.
Volume: 561
Issue: 7721
Pages: 122-126
Publication  
First Author: Kuo TM
Year: 2015
Journal: J Steroid Biochem Mol Biol
Title: ALPK1 affects testosterone mediated regulation of proinflammatory cytokines production.
Volume: 154
Pages: 150-8
Publication      
First Author: Birling M-C
Year: 2021
Journal: Direct Data Submission
Title: Direct Data Submission for Alpk1 and Iscu alleles.
Publication
First Author: Williams LB
Year: 2019
Journal: Genet Med
Title: ALPK1 missense pathogenic variant in five families leads to ROSAH syndrome, an ocular multisystem autosomal dominant disorder.
Volume: 21
Issue: 9
Pages: 2103-2115
Publication  
First Author: Lee CP
Year: 2016
Journal: Sci Rep
Title: ALPK1 phosphorylates myosin IIA modulating TNF-α trafficking in gout flares.
Volume: 6
Pages: 25740
Publication
First Author: Milivojevic M
Year: 2017
Journal: PLoS Pathog
Title: ALPK1 controls TIFA/TRAF6-dependent innate immunity against heptose-1,7-bisphosphate of gram-negative bacteria.
Volume: 13
Issue: 2
Pages: e1006224
Protein
Organism: Mus musculus
Length: 1231  
Fragment?: false
Protein
Organism: Mus musculus
Length: 183  
Fragment?: true
Protein
Organism: Mus musculus
Length: 1231  
Fragment?: false
Publication
First Author: Heine M
Year: 2005
Journal: J Biol Chem
Title: Alpha-kinase 1, a new component in apical protein transport.
Volume: 280
Issue: 27
Pages: 25637-43
Publication
First Author: Ryzhakov G
Year: 2018
Journal: Nat Commun
Title: Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis.
Volume: 9
Issue: 1
Pages: 3797
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Archambaud C
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Impact of lactobacilli on orally acquired listeriosis.
Volume: 109
Issue: 41
Pages: 16684-9
Publication      
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication      
First Author: GemPharmatech
Year: 2020
Journal: website
Title: GemPharmatech website
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication
First Author: Lee CP
Year: 2019
Journal: J Cell Mol Med
Title: ALPK1 regulates streptozotocin-induced nephropathy through CCL2 and CCL5 expressions.
Volume: 23
Issue: 11
Pages: 7699-7708
Publication  
First Author: Chen M
Year: 2011
Journal: BMC Neurosci
Title: Motor coordination deficits in Alpk1 mutant mice with the inserted piggyBac transposon.
Volume: 12
Pages: 1
Publication
First Author: Boulard O
Year: 2012
Journal: J Exp Med
Title: Identification of a genetic locus controlling bacteria-driven colitis and associated cancer through effects on innate inflammation.
Volume: 209
Issue: 7
Pages: 1309-24
Publication
First Author: Bleich A
Year: 2010
Journal: Inflamm Bowel Dis
Title: Cdcs1 a major colitis susceptibility locus in mice; subcongenic analysis reveals genetic complexity.
Volume: 16
Issue: 5
Pages: 765-75
Publication
First Author: Kuo TM
Year: 2016
Journal: Biochim Biophys Acta
Title: Enhanced alpha-kinase 1 accelerates multiple early nephropathies in streptozotocin-induced hyperglycemic mice.
Volume: 1862
Issue: 11
Pages: 2034-2042