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Search results 1 to 100 out of 336 for Als2

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0.075s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chicken
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Gene
Type: gene
Organism: human
Publication
First Author: Erie EA
Year: 2007
Journal: J Neuroimmunol
Title: Mice deficient in the ALS2 gene exhibit lymphopenia and abnormal hematopietic function.
Volume: 182
Issue: 1-2
Pages: 226-31
Publication
First Author: Gros-Louis F
Year: 2008
Journal: Hum Mol Genet
Title: Als2 mRNA splicing variants detected in KO mice rescue severe motor dysfunction phenotype in Als2 knock-down zebrafish.
Volume: 17
Issue: 17
Pages: 2691-702
Publication
First Author: Cai H
Year: 2005
Journal: J Neurosci
Title: Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress.
Volume: 25
Issue: 33
Pages: 7567-74
Publication
First Author: Suzuki-Utsunomiya K
Year: 2007
Journal: Biochem Biophys Res Commun
Title: ALS2CL, a novel ALS2-interactor, modulates ALS2-mediated endosome dynamics.
Volume: 354
Issue: 2
Pages: 491-7
Publication
First Author: Lin X
Year: 2007
Journal: Neurobiol Aging
Title: Deficiency in the ALS2 gene does not affect the motor neuron degeneration in SOD1(G93A) transgenic mice.
Volume: 28
Issue: 10
Pages: 1628-30
Publication
First Author: Hadano S
Year: 2016
Journal: Hum Mol Genet
Title: Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice.
Volume: 25
Issue: 15
Pages: 3321-3340
Publication
First Author: Kanekura K
Year: 2005
Journal: J Biol Chem
Title: A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death.
Volume: 280
Issue: 6
Pages: 4532-43
Publication
First Author: Otomo A
Year: 2008
Journal: Biochem Biophys Res Commun
Title: ALS2/alsin deficiency in neurons leads to mild defects in macropinocytosis and axonal growth.
Volume: 370
Issue: 1
Pages: 87-92
Publication
First Author: Hadano S
Year: 2006
Journal: Hum Mol Genet
Title: Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking.
Volume: 15
Issue: 2
Pages: 233-50
Publication
First Author: Hadano S
Year: 2010
Journal: Neurosci Res
Title: Genetic background and gender effects on gross phenotypes in congenic lines of ALS2/alsin-deficient mice.
Volume: 68
Issue: 2
Pages: 131-6
Publication  
First Author: Sato K
Year: 2023
Journal: Biochem Biophys Res Commun
Title: Central nervous system specific high molecular weight ALS2/alsin homophilic complex is enriched in mouse brain synaptosomes.
Volume: 638
Pages: 168-175
Publication
First Author: Lai C
Year: 2006
Journal: J Neurosci
Title: Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking.
Volume: 26
Issue: 45
Pages: 11798-806
Publication
First Author: Hadano S
Year: 2010
Journal: PLoS One
Title: Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking.
Volume: 5
Issue: 3
Pages: e9805
Publication
First Author: Hadano S
Year: 2004
Journal: FEBS Lett
Title: ALS2CL, the novel protein highly homologous to the carboxy-terminal half of ALS2, binds to Rab5 and modulates endosome dynamics.
Volume: 575
Issue: 1-3
Pages: 64-70
Publication
First Author: Hadano S
Year: 2001
Journal: Nat Genet
Title: A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2.
Volume: 29
Issue: 2
Pages: 166-73
Publication
First Author: Deng HX
Year: 2007
Journal: Hum Mol Genet
Title: Distal axonopathy in an alsin-deficient mouse model.
Volume: 16
Issue: 23
Pages: 2911-20
Publication
First Author: Pan L
Year: 2012
Journal: PLoS One
Title: Different human copper-zinc superoxide dismutase mutants, SOD1G93A and SOD1H46R, exert distinct harmful effects on gross phenotype in mice.
Volume: 7
Issue: 3
Pages: e33409
Publication
First Author: Devon RS
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities.
Volume: 103
Issue: 25
Pages: 9595-600
Publication
First Author: Çobanoğlu G
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Are alsin and spartin novel interaction partners?
Volume: 427
Issue: 1
Pages: 1-4
Publication
First Author: Gautam M
Year: 2016
Journal: Hum Mol Genet
Title: Absence of alsin function leads to corticospinal motor neuron vulnerability via novel disease mechanisms.
Volume: 25
Issue: 6
Pages: 1074-87
Publication
First Author: Yamanaka K
Year: 2006
Journal: Ann Neurol
Title: Progressive spinal axonal degeneration and slowness in ALS2-deficient mice.
Volume: 60
Issue: 1
Pages: 95-104
Publication
First Author: Millecamps S
Year: 2005
Journal: Biochim Biophys Acta
Title: Alsin is partially associated with centrosome in human cells.
Volume: 1745
Issue: 1
Pages: 84-100
Publication
First Author: Topp JD
Year: 2004
Journal: J Biol Chem
Title: Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor.
Volume: 279
Issue: 23
Pages: 24612-23
Publication
First Author: Enunlu I
Year: 2011
Journal: Biochem Biophys Res Commun
Title: Alfa-class prefoldin protein UXT is a novel interacting partner of Amyotrophic Lateral Sclerosis 2 (Als2) protein.
Volume: 413
Issue: 3
Pages: 471-5
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: frog, African clawed
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Jacquier A
Year: 2009
Journal: Hum Mol Genet
Title: Astrocytic protection of spinal motor neurons but not cortical neurons against loss of Als2/alsin function.
Volume: 18
Issue: 12
Pages: 2127-39
GXD Expression      
Probe: MGI:6280996
Assay Type: Western blot
Annotation Date: 2019-03-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6281007
Age: postnatal
Specimen Label: ALS2+/+
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6280996
Assay Type: Western blot
Annotation Date: 2019-03-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6281007
Age: postnatal
Specimen Label: ALS2+/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6280996
Assay Type: Western blot
Annotation Date: 2019-03-01
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6281007
Age: postnatal
Specimen Label: ALS2-/-
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:6281000
Assay Type: Western blot
Annotation Date: 2019-03-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6281010
Age: postnatal
Specimen Label: ALS2+/+
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6281000
Assay Type: Western blot
Annotation Date: 2019-03-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6281010
Age: postnatal
Specimen Label: ALS2+/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6281000
Assay Type: Western blot
Annotation Date: 2019-03-01
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6281010
Age: postnatal
Specimen Label: ALS2-/-
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:6281000
Assay Type: Western blot
Annotation Date: 2019-03-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:6281016
Age: embryonic day 15.0
Specimen Label: E15 brain
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6281000
Assay Type: Western blot
Annotation Date: 2019-03-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691026
Stage: TS26
Assay Id: MGI:6281016
Age: embryonic day 18.5
Specimen Label: Cerebrum E18.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6281000
Assay Type: Western blot
Annotation Date: 2019-03-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691028
Stage: TS28
Assay Id: MGI:6281016
Age: postnatal day 5
Specimen Label: Cerebrum P5
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6281000
Assay Type: Western blot
Annotation Date: 2019-03-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691028
Stage: TS28
Assay Id: MGI:6281016
Age: postnatal month 2
Specimen Label: Cerebrum 2 mo
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6281000
Assay Type: Western blot
Annotation Date: 2019-03-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691028
Stage: TS28
Assay Id: MGI:6281016
Age: postnatal month 7
Specimen Label: Cerebrum 7 mo
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6414758
Assay Type: Western blot
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:6414841
Age: embryonic day 13.5
Specimen Label: E13.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6414758
Assay Type: Western blot
Annotation Date: 2020-05-05
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6414841
Age: postnatal month 7-22
Specimen Label: -/-
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:6414758
Assay Type: Western blot
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Stage: TS28
Assay Id: MGI:6414841
Age: postnatal month 7-22
Specimen Label: Brain Stem
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6414758
Assay Type: Western blot
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:6414841
Age: postnatal month 7-22
Specimen Label: Cerebellum
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6414758
Assay Type: Western blot
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Stage: TS28
Assay Id: MGI:6414841
Age: postnatal month 7-22
Specimen Label: Hippocampus
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6414758
Assay Type: Western blot
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:6414841
Age: postnatal month 7-22
Specimen Label: Spinal Cord
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:6414826
Assay Type: Northern blot
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6414827
Age: postnatal month 7-22
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6414826
Assay Type: Northern blot
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6414827
Age: postnatal month 7-22
Specimen Label: -/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6414820
Assay Type: RT-PCR
Annotation Date: 2020-05-05
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6414831
Age: postnatal month 7-22
Specimen Label: -/-
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:6414820
Assay Type: RT-PCR
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6414831
Age: postnatal month 7-22
Specimen Label: +/+
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6414819
Assay Type: RT-PCR
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6414835
Age: postnatal month 7-22
Specimen Label: -/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6414819
Assay Type: RT-PCR
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6414835
Age: postnatal month 7-22
Specimen Label: +/+
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6414821
Assay Type: RT-PCR
Annotation Date: 2020-05-05
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6414836
Age: postnatal month 7-22
Specimen Label: -/-
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:6414821
Assay Type: RT-PCR
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6414836
Age: postnatal month 7-22
Specimen Label: +/+
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6414822
Assay Type: RT-PCR
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6414838
Age: postnatal month 7-22
Specimen Label: -/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6414822
Assay Type: RT-PCR
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6414838
Age: postnatal month 7-22
Specimen Label: +/+
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6414823
Assay Type: RT-PCR
Annotation Date: 2020-05-05
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6414839
Age: postnatal month 7-22
Specimen Label: -/-
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:6414823
Assay Type: RT-PCR
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6414839
Age: postnatal month 7-22
Specimen Label: +/+
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6414824
Assay Type: RT-PCR
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6414840
Age: postnatal month 7-22
Specimen Label: -/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6414824
Assay Type: RT-PCR
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6414840
Age: postnatal month 7-22
Specimen Label: +/+
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6414824
Assay Type: RT-PCR
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:6414840
Age: postnatal month 7-22
Specimen Label: Ctx
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6414824
Assay Type: RT-PCR
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:6414840
Age: postnatal month 7-22
Specimen Label: CerB
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6414824
Assay Type: RT-PCR
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:6414840
Age: postnatal month 7-22
Specimen Label: Sc
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6414758
Assay Type: Western blot
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:6414844
Age: postnatal month 7-22
Specimen Label: Heart
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6414758
Assay Type: Western blot
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6414844
Age: postnatal month 7-22
Specimen Label: Kidney
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6414758
Assay Type: Western blot
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6414844
Age: postnatal month 7-22
Specimen Label: Liver
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6414758
Assay Type: Western blot
Annotation Date: 2020-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:6414844
Age: postnatal month 7-22
Specimen Label: Lung
Detected: true
Specimen Num: 4