| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
rabbit, European |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Acyloxyacyl hydrolase (AOAH) is a a host enzyme that removes the secondary (acyloxyacyl-linked) fatty acids from LPS (a potent bacterial endotoxin), rendering it immunologically inert [, , ]. This activity is important for the recovery from immune tolerance that follows Gram-negative infection []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gorelik A |
| Year: |
2018 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Crystal structure of the mammalian lipopolysaccharide detoxifier. |
| Volume: |
115 |
| Issue: |
5 |
| Pages: |
E896-E905 |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
574
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
145
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yang W |
| Year: |
2020 |
| Journal: |
PLoS One |
| Title: |
AOAH remodels arachidonic acid-containing phospholipid pools in a model of interstitial cystitis pain: A MAPP Network study. |
| Volume: |
15 |
| Issue: |
9 |
| Pages: |
e0235384 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
574
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
574
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
574
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
574
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
508
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hagen FS |
| Year: |
1991 |
| Journal: |
Biochemistry |
| Title: |
Expression and characterization of recombinant human acyloxyacyl hydrolase, a leukocyte enzyme that deacylates bacterial lipopolysaccharides. |
| Volume: |
30 |
| Issue: |
34 |
| Pages: |
8415-23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Staab JF |
| Year: |
1994 |
| Journal: |
J Biol Chem |
| Title: |
A saposin-like domain influences the intracellular localization, stability, and catalytic activity of human acyloxyacyl hydrolase. |
| Volume: |
269 |
| Issue: |
38 |
| Pages: |
23736-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Feulner JA |
| Year: |
2004 |
| Journal: |
Infect Immun |
| Title: |
Identification of acyloxyacyl hydrolase, a lipopolysaccharide-detoxifying enzyme, in the murine urinary tract. |
| Volume: |
72 |
| Issue: |
6 |
| Pages: |
3171-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Qian G |
| Year: |
2018 |
| Journal: |
J Exp Med |
| Title: |
LPS inactivation by a host lipase allows lung epithelial cell sensitization for allergic asthma. |
| Volume: |
215 |
| Issue: |
9 |
| Pages: |
2397-2412 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yang W |
| Year: |
2018 |
| Journal: |
Am J Physiol Regul Integr Comp Physiol |
| Title: |
Acyloxyacyl hydrolase modulates pelvic pain severity. |
| Volume: |
314 |
| Issue: |
3 |
| Pages: |
R353-R365 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rahman-Enyart A |
| Year: |
2021 |
| Journal: |
Am J Physiol Regul Integr Comp Physiol |
| Title: |
Acyloxyacyl hydrolase is a host determinant of gut microbiome-mediated pelvic pain. |
| Volume: |
321 |
| Issue: |
3 |
| Pages: |
R396-R412 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cheng X |
| Year: |
2022 |
| Journal: |
J Mol Med (Berl) |
| Title: |
Acyloxyacyl hydrolase deficiency induces chronic inflammation and bone loss in male mice. |
| Volume: |
100 |
| Issue: |
11 |
| Pages: |
1599-1616 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shao B |
| Year: |
2007 |
| Journal: |
J Biol Chem |
| Title: |
A host lipase detoxifies bacterial lipopolysaccharides in the liver and spleen. |
| Volume: |
282 |
| Issue: |
18 |
| Pages: |
13726-35 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zou B |
| Year: |
2017 |
| Journal: |
PLoS Pathog |
| Title: |
Acyloxyacyl hydrolase promotes the resolution of lipopolysaccharide-induced acute lung injury. |
| Volume: |
13 |
| Issue: |
6 |
| Pages: |
e1006436 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Janelsins BM |
| Year: |
2014 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Altered inactivation of commensal LPS due to acyloxyacyl hydrolase deficiency in colonic dendritic cells impairs mucosal Th17 immunity. |
| Volume: |
111 |
| Issue: |
1 |
| Pages: |
373-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Aguiniga LM |
| Year: |
2019 |
| Journal: |
Am J Physiol Regul Integr Comp Physiol |
| Title: |
Acyloxyacyl hydrolase modulates depressive-like behaviors through aryl hydrocarbon receptor. |
| Volume: |
317 |
| Issue: |
2 |
| Pages: |
R289-R300 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Aguiniga LM |
| Year: |
2020 |
| Journal: |
Am J Physiol Renal Physiol |
| Title: |
Acyloxyacyl hydrolase regulates voiding activity. |
| Volume: |
318 |
| Issue: |
4 |
| Pages: |
F1006-F1016 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu J |
| Year: |
2020 |
| Journal: |
Cell Death Differ |
| Title: |
HSPA12A attenuates lipopolysaccharide-induced liver injury through inhibiting caspase-11-mediated hepatocyte pyroptosis via PGC-1α-dependent acyloxyacyl hydrolase expression. |
| Volume: |
27 |
| Issue: |
9 |
| Pages: |
2651-2667 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lu M |
| Year: |
2003 |
| Journal: |
J Exp Med |
| Title: |
Stimulus-dependent deacylation of bacterial lipopolysaccharide by dendritic cells. |
| Volume: |
197 |
| Issue: |
12 |
| Pages: |
1745-54 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lu M |
| Year: |
2005 |
| Journal: |
Nat Immunol |
| Title: |
Lipopolysaccharide deacylation by an endogenous lipase controls innate antibody responses to Gram-negative bacteria. |
| Volume: |
6 |
| Issue: |
10 |
| Pages: |
989-94 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5000766 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2014-02-07 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1797224 |
| Pattern: |
Not Specified |
| Stage: |
TS24 |
| Assay Id: |
MGI:5541326 |
| Age: |
embryonic day 16.0 |
| Image: |
GUDMAP:8394 |
| Note: |
ubiquitous testis expression |
| Specimen Label: |
GUDMAP:8394 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Munford RS |
| Year: |
1997 |
| Journal: |
GenBank Submission |
| Title: |
Mus musculus acyloxyacyl hydrolase (Aoah) mRNA, complete cds |
|
|
| Pages: |
AF018172 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lu M |
| Year: |
2011 |
| Journal: |
J Immunol |
| Title: |
The transport and inactivation kinetics of bacterial lipopolysaccharide influence its immunological potency in vivo. |
| Volume: |
187 |
| Issue: |
6 |
| Pages: |
3314-20 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lu M |
| Year: |
2013 |
| Journal: |
PLoS Pathog |
| Title: |
Persistently active microbial molecules prolong innate immune tolerance in vivo. |
| Volume: |
9 |
| Issue: |
5 |
| Pages: |
e1003339 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Song Z |
| Year: |
2020 |
| Journal: |
Front Genet |
| Title: |
Comprehensive Proteomic Profiling of Urinary Exosomes and Identification of Potential Non-invasive Early Biomarkers of Alzheimer's Disease in 5XFAD Mouse Model. |
| Volume: |
11 |
|
| Pages: |
565479 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Foronda M |
| Year: |
2014 |
| Journal: |
Cell Rep |
| Title: |
Sox4 links tumor suppression to accelerated aging in mice by modulating stem cell activation. |
| Volume: |
8 |
| Issue: |
2 |
| Pages: |
487-500 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kawai J |
| Year: |
2001 |
| Journal: |
Nature |
| Title: |
Functional annotation of a full-length mouse cDNA collection. |
| Volume: |
409 |
| Issue: |
6821 |
| Pages: |
685-90 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Okazaki Y |
| Year: |
2002 |
| Journal: |
Nature |
| Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
| Volume: |
420 |
| Issue: |
6915 |
| Pages: |
563-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mammalian Functional Genomics Centre |
| Year: |
2010 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the NorCOMM project by the Mammalian Functional Genomics Centre (Mfgc), University of Manitoba |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI and IMPC |
| Year: |
2017 |
| Journal: |
MGI Direct Data Submission |
| Title: |
MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hansen J |
| Year: |
2003 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
| Volume: |
100 |
| Issue: |
17 |
| Pages: |
9918-22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Friedel RH |
| Year: |
2007 |
| Journal: |
Brief Funct Genomic Proteomic |
| Title: |
EUCOMM--the European conditional mouse mutagenesis program. |
| Volume: |
6 |
| Issue: |
3 |
| Pages: |
180-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
GUDMAP Consortium |
| Year: |
2004 |
| Journal: |
www.gudmap.org |
| Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shanghai Model Organisms Center |
| Year: |
2017 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hansen GM |
| Year: |
2008 |
| Journal: |
Genome Res |
| Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
| Volume: |
18 |
| Issue: |
10 |
| Pages: |
1670-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2003 |
|
| Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carninci P |
| Year: |
2005 |
| Journal: |
Science |
| Title: |
The transcriptional landscape of the mammalian genome. |
| Volume: |
309 |
| Issue: |
5740 |
| Pages: |
1559-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Adams DJ |
| Year: |
2024 |
| Journal: |
Nature |
| Title: |
Genetic determinants of micronucleus formation in vivo. |
| Volume: |
627 |
| Issue: |
8002 |
| Pages: |
130-136 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zambrowicz BP |
| Year: |
2003 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
| Volume: |
100 |
| Issue: |
24 |
| Pages: |
14109-14 |
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•
•
•
•
•
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| Publication |
| First Author: |
GemPharmatech |
| Year: |
2020 |
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| Title: |
GemPharmatech Website. |
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
| Year: |
2008 |
| Journal: |
Database Download |
| Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
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| Publication |
| First Author: |
Cyagen Biosciences Inc. |
| Year: |
2022 |
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| Title: |
Cyagen Biosciences Website. |
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•
•
•
•
•
|
| Publication |
| First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
| Year: |
2011 |
|
| Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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|
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•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
| Year: |
2004 |
| Journal: |
Database Release |
| Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2010 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Diez-Roux G |
| Year: |
2011 |
| Journal: |
PLoS Biol |
| Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
e1000582 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI Genome Annotation Group and UniGene Staff |
| Year: |
2015 |
| Journal: |
Database Download |
| Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
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•
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| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
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| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
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| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
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| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
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| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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| Publication |
| First Author: |
Carninci P |
| Year: |
2000 |
| Journal: |
Genome Res |
| Title: |
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. |
| Volume: |
10 |
| Issue: |
10 |
| Pages: |
1617-30 |
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| Publication |
| First Author: |
Carninci P |
| Year: |
1999 |
| Journal: |
Methods Enzymol |
| Title: |
High-efficiency full-length cDNA cloning. |
| Volume: |
303 |
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| Pages: |
19-44 |
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| Publication |
| First Author: |
Shibata K |
| Year: |
2000 |
| Journal: |
Genome Res |
| Title: |
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. |
| Volume: |
10 |
| Issue: |
11 |
| Pages: |
1757-71 |
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