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Search results 1 to 100 out of 4398 for Apc

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Protein Domain
Type: Family
Description: Adenomatous polyposis coli (APC) is a tumor suppressor protein that induces thedegradation of oncogenic beta-catenin and negatively regulates Wnt signalling []. It has roles in regulating cell migration, DNA replication/repair, mitosis and apoptosis [, ]. APC regulates cell-cell adhesion and cell migration through activating the APC-stimulated guanine nucleotide-exchange factor (GEF; Asef) [, ]. It acts as a mediator of ERBB2-dependent stabilisation of microtubules at the cell cortex []. It is required for the localisation of MACF1/ACF7 to the cell membrane and this localisation of MACF1/ACF7 is critical for its function in microtubule stabilisation []. APC mutations are particularly prevalent in colorectal cancer [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
GXD Expression
Probe: MGI:6502587
Assay Type: RNA in situ
Annotation Date: 2021-01-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1859021
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:6502635
Age: embryonic day 13.5
Image: 4A Apc Vax2-/-
Note: Expression lost specifically in the ventral retina.
Specimen Label: 4A Apc Vax2-/-
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:6502587
Assay Type: RNA in situ
Annotation Date: 2021-01-28
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1859021
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:6502635
Age: embryonic day 13.5
Image: 4A Apc WT
Note: Strongest expression in retinal ganglion cell layer.
Specimen Label: 4A Apc WT
Detected: true
Specimen Num: 1
Protein
Organism: Mus musculus/domesticus
Length: 2845  
Fragment?: false
Publication
First Author: Powell SM
Year: 1992
Journal: Nature
Title: APC mutations occur early during colorectal tumorigenesis.
Volume: 359
Issue: 6392
Pages: 235-7
Gene
Type: gene
Organism: human
Publication
First Author: Lui C
Year: 2012
Journal: IUBMB Life
Title: APC as a mobile scaffold: regulation and function at the nucleus, centrosomes, and mitochondria.
Volume: 64
Issue: 3
Pages: 209-14
Publication
First Author: Kawasaki Y
Year: 2000
Journal: Science
Title: Asef, a link between the tumor suppressor APC and G-protein signaling.
Volume: 289
Issue: 5482
Pages: 1194-7
Gene
Type: gene
Organism: human
Publication
First Author: Aoki K
Year: 2007
Journal: J Cell Sci
Title: Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene.
Volume: 120
Issue: Pt 19
Pages: 3327-35
Publication
First Author: MacDonald BT
Year: 2009
Journal: Dev Cell
Title: Wnt/beta-catenin signaling: components, mechanisms, and diseases.
Volume: 17
Issue: 1
Pages: 9-26
Publication
First Author: Zhang Z
Year: 2012
Journal: Cell Res
Title: Structural basis for the recognition of Asef by adenomatous polyposis coli.
Volume: 22
Issue: 2
Pages: 372-86
Publication
First Author: Zaoui K
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells.
Volume: 107
Issue: 43
Pages: 18517-22
Publication
First Author: Daly CS
Year: 2017
Journal: Oncogene
Title: Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium.
Volume: 36
Issue: 13
Pages: 1793-1803
Protein
Organism: Mus musculus/domesticus
Length: 344  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 146  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 324  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 51  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 2842  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2808  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1056  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1133  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: false
CL Term
Protein
Organism: Mus musculus/domesticus
Length: 1132  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 780  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 672  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 635  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 254  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 96  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 146  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 391  
Fragment?: false
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Protein
Organism: Mus musculus/domesticus
Length: 25  
Fragment?: true
Publication
First Author: McCart AE
Year: 2008
Journal: Pathol Res Pract
Title: Apc mice: models, modifiers and mutants.
Volume: 204
Issue: 7
Pages: 479-90
Publication
First Author: Zeineldin M
Year: 2013
Journal: Cancer Res
Title: Understanding phenotypic variation in rodent models with germline Apc mutations.
Volume: 73
Issue: 8
Pages: 2389-99
Publication      
First Author: Jung YS
Year: 2020
Journal: Hepatology
Title: TMEM9-v-ATPase Activates Wnt/β-Catenin Signaling via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis.
Publication      
First Author: Jacks T
Year: 2010
Journal: MGI Direct Data Submission
Title: Generation of a conditional Apc allele
Publication
First Author: Sansom OJ
Year: 2005
Journal: Oncogene
Title: Apc deficiency predisposes to renal carcinoma in the mouse.
Volume: 24
Issue: 55
Pages: 8205-10
GXD Expression    
Probe: MGI:6167542
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6189790
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Apc
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6167542
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6189790
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Apc
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6167542
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189790
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Apc
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6167542
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6189790
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Apc
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6167542
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6189790
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Apc
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6167542
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189790
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Apc
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6167542
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189790
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Apc
Detected: true
Specimen Num: 7
Publication
First Author: Wasan HS
Year: 1998
Journal: J Pathol
Title: APC in the regulation of intestinal crypt fission.
Volume: 185
Issue: 3
Pages: 246-55
Publication
First Author: Fischer JM
Year: 2012
Journal: Oncogene
Title: Different phenotypic consequences of simultaneous versus stepwise Apc loss.
Volume: 31
Issue: 16
Pages: 2028-38
Publication
First Author: Sansom OJ
Year: 2007
Journal: Nature
Title: Myc deletion rescues Apc deficiency in the small intestine.
Volume: 446
Issue: 7136
Pages: 676-9
Publication
First Author: Roose J
Year: 1999
Journal: Science
Title: Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1.
Volume: 285
Issue: 5435
Pages: 1923-6
Publication
First Author: Saito-Diaz K
Year: 2018
Journal: Dev Cell
Title: APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway.
Volume: 44
Issue: 5
Pages: 566-581.e8
Publication
First Author: Levy DB
Year: 1994
Journal: Cancer Res
Title: Inactivation of both APC alleles in human and mouse tumors.
Volume: 54
Issue: 22
Pages: 5953-8
Publication
First Author: Benhamouche S
Year: 2006
Journal: Dev Cell
Title: Apc tumor suppressor gene is the "zonation-keeper" of mouse liver.
Volume: 10
Issue: 6
Pages: 759-70
Publication
First Author: Bruxvoort KJ
Year: 2007
Journal: Cancer Res
Title: Inactivation of Apc in the mouse prostate causes prostate carcinoma.
Volume: 67
Issue: 6
Pages: 2490-6
Publication
First Author: Schatoff EM
Year: 2019
Journal: Cancer Discov
Title: Distinct Colorectal Cancer-Associated APC Mutations Dictate Response to Tankyrase Inhibition.
Volume: 9
Issue: 10
Pages: 1358-1371
Publication
First Author: Méniel V
Year: 2005
Journal: Cancer Res
Title: Mutations in Apc and p53 synergize to promote mammary neoplasia.
Volume: 65
Issue: 2
Pages: 410-6
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Publication
First Author: Cheung AF
Year: 2010
Journal: Oncogene
Title: Complete deletion of Apc results in severe polyposis in mice.
Volume: 29
Issue: 12
Pages: 1857-64
Publication
First Author: Crist RC
Year: 2010
Journal: Mamm Genome
Title: The armadillo repeat domain of Apc suppresses intestinal tumorigenesis.
Volume: 21
Issue: 9-10
Pages: 450-7
Publication
First Author: Liu S
Year: 2017
Journal: Oncogene
Title: Disruption of the RP-MDM2-p53 pathway accelerates APC loss-induced colorectal tumorigenesis.
Volume: 36
Issue: 10
Pages: 1374-1383
Publication
First Author: He Z
Year: 2017
Journal: Sci Rep
Title: Epithelial-derived IL-33 promotes intestinal tumorigenesis in Apc Min/+ mice.
Volume: 7
Issue: 1
Pages: 5520
Publication
First Author: Lapierre M
Year: 2014
Journal: J Clin Invest
Title: RIP140 increases APC expression and controls intestinal homeostasis and tumorigenesis.
Volume: 124
Issue: 5
Pages: 1899-913
Publication  
First Author: Pirone A
Year: 2017
Journal: Neurobiol Dis
Title: APC conditional knock-out mouse is a model of infantile spasms with elevated neuronal β-catenin levels, neonatal spasms, and chronic seizures.
Volume: 98
Pages: 149-157
Publication
First Author: Prescott SM
Year: 1996
Journal: Cell
Title: Self-promotion? Intimate connections between APC and prostaglandin H synthase-2.
Volume: 87
Issue: 5
Pages: 783-6
Publication
First Author: Hart MJ
Year: 1998
Journal: Curr Biol
Title: Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta.
Volume: 8
Issue: 10
Pages: 573-81
Publication
First Author: Eom TY
Year: 2014
Journal: Dev Cell
Title: Differential regulation of microtubule severing by APC underlies distinct patterns of projection neuron and interneuron migration.
Volume: 31
Issue: 6
Pages: 677-89
Publication
First Author: Gaspar C
Year: 2009
Journal: PLoS Genet
Title: A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis.
Volume: 5
Issue: 7
Pages: e1000547
Publication
First Author: Sansom OJ
Year: 2004
Journal: Genes Dev
Title: Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration.
Volume: 18
Issue: 12
Pages: 1385-90
Publication
First Author: Shibata H
Year: 1997
Journal: Science
Title: Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene.
Volume: 278
Issue: 5335
Pages: 120-3
Publication
First Author: Cen B
Year: 2021
Journal: Oncogene
Title: Mutant APC promotes tumor immune evasion via PD-L1 in colorectal cancer.
Volume: 40
Issue: 41
Pages: 5984-5992
Publication
First Author: Song JH
Year: 2014
Journal: Cell Rep
Title: The APC network regulates the removal of mutated cells from colonic crypts.
Volume: 7
Issue: 1
Pages: 94-103
Publication
First Author: Li W
Year: 2013
Journal: Blood
Title: Apc regulates the function of hematopoietic stem cells largely through β-catenin-dependent mechanisms.
Volume: 121
Issue: 20
Pages: 4063-72
Publication
First Author: Athineos D
Year: 2010
Journal: Oncogene
Title: Myc heterozygosity attenuates the phenotypes of APC deficiency in the small intestine.
Volume: 29
Issue: 17
Pages: 2585-90
Publication
First Author: Bjerknes M
Year: 1997
Journal: Am J Pathol
Title: APC mutation and the crypt cycle in murine and human intestine.
Volume: 150
Issue: 3
Pages: 833-9
Publication
First Author: Lewis A
Year: 2012
Journal: J Pathol
Title: The C-terminus of Apc does not influence intestinal adenoma development or progression.
Volume: 226
Issue: 1
Pages: 73-83
Publication
First Author: Abal M
Year: 2007
Journal: Gastroenterology
Title: APC inactivation associates with abnormal mitosis completion and concomitant BUB1B/MAD2L1 up-regulation.
Volume: 132
Issue: 7
Pages: 2448-58
Publication
First Author: Tao Y
Year: 2016
Journal: Carcinogenesis
Title: Hsp70 exerts oncogenic activity in the Apc mutant Min mouse model.
Volume: 37
Issue: 7
Pages: 731-739
Publication
First Author: Pollard P
Year: 2009
Journal: Gastroenterology
Title: The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression.
Volume: 136
Issue: 7
Pages: 2204-2213.e1-13
Publication
First Author: Radulescu S
Year: 2012
Journal: Cell Rep
Title: Luminal iron levels govern intestinal tumorigenesis after Apc loss in vivo.
Volume: 2
Issue: 2
Pages: 270-82
Publication
First Author: Foley TM
Year: 2017
Journal: Mol Cancer Res
Title: Dual PI3K/mTOR Inhibition in Colorectal Cancers with APC and PIK3CA Mutations.
Volume: 15
Issue: 3
Pages: 317-327
Publication
First Author: Moser AR
Year: 1995
Journal: Dev Dyn
Title: Homozygosity for the Min allele of Apc results in disruption of mouse development prior to gastrulation.
Volume: 203
Issue: 4
Pages: 422-33
Publication
First Author: Dow LE
Year: 2015
Journal: Cell
Title: Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer.
Volume: 161
Issue: 7
Pages: 1539-1552