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Search results 1 to 100 out of 313 for Aspm

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Type Details Score
Gene
Type: gene
Organism: human
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Gene
Type: gene
Organism: frog, western clawed
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Gene
Type: gene
Organism: gorilla, western
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Gene
Type: gene
Organism: orangutan, Bornean
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Gene
Type: gene
Organism: cat, domestic
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Gene
Type: gene
Organism: rat
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Gene
Type: gene
Organism: cattle
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Gene
Type: gene
Organism: chimpanzee
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Gene
Type: gene
Organism: dog, domestic
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Gene
Type: gene
Organism: chicken
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Gene
Type: gene
Organism: zebrafish
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Gene
Type: gene
Organism: macaque, rhesus
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Protein Domain
Type: Family
Description: The Abnormal Spindle-like Microcephaly-associated (ASPM) protein family is involved in the regulation and coordination of mitotic spindle dynamics during cell division. Members of this family play a crucial role in maintaining the structure of the centrosomal microtubule organizing center (MTOC) and are essential for proper neurogenesis, germ cell mitosis, and oocyte differentiation. They interact with the katanin complex, enhancing microtubule severing activity and influencing microtubule dynamics at spindle poles, including spindle orientation, astral microtubule density, and poleward microtubule flux. The family's ability to block microtubule minus-end growth is also modulated by its association with the katanin complex.
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
First Author: Williams SE
Year: 2015
Journal: Development
Title: Aspm sustains postnatal cerebellar neurogenesis and medulloblastoma growth in mice.
Volume: 142
Issue: 22
Pages: 3921-32
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Publication
First Author: Marinaro C
Year: 2011
Journal: PLoS One
Title: In vivo fate analysis reveals the multipotent and self-renewal features of embryonic AspM expressing cells.
Volume: 6
Issue: 4
Pages: e19419
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Publication
First Author: Bond J
Year: 2002
Journal: Nat Genet
Title: ASPM is a major determinant of cerebral cortical size.
Volume: 32
Issue: 2
Pages: 316-20
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Publication
First Author: Buchman JJ
Year: 2011
Journal: Genes Dev
Title: ASPM regulates Wnt signaling pathway activity in the developing brain.
Volume: 25
Issue: 18
Pages: 1909-14
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Publication
First Author: Fujimori A
Year: 2014
Journal: Brain Dev
Title: Disruption of Aspm causes microcephaly with abnormal neuronal differentiation.
Volume: 36
Issue: 8
Pages: 661-9
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Publication
First Author: Fish JL
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells.
Volume: 103
Issue: 27
Pages: 10438-10443
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Protein
Organism: Mus musculus/domesticus
Length: 3122  
Fragment?: false
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Publication  
First Author: Capecchi MR
Year: 2015
Journal: Nat Commun
Title: ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination.
Volume: 6
Pages: 8763
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Protein
Organism: Mus musculus/domesticus
Length: 379  
Fragment?: false
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Publication
First Author: Garrett L
Year: 2020
Journal: Transl Psychiatry
Title: A truncating Aspm allele leads to a complex cognitive phenotype and region-specific reductions in parvalbuminergic neurons.
Volume: 10
Issue: 1
Pages: 66
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Publication  
First Author: Ogi H
Year: 2018
Journal: Neuroscience
Title: Longitudinal Diffusion Tensor Imaging Revealed Nerve Fiber Alterations in Aspm Mutated Microcephaly Model Mice.
Volume: 371
Pages: 325-336
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Publication
First Author: Xu XL
Year: 2012
Journal: PLoS One
Title: The microtubule-associated protein ASPM regulates spindle assembly and meiotic progression in mouse oocytes.
Volume: 7
Issue: 11
Pages: e49303
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Publication
First Author: Kouprina N
Year: 2005
Journal: Hum Mol Genet
Title: The microcephaly ASPM gene is expressed in proliferating tissues and encodes for a mitotic spindle protein.
Volume: 14
Issue: 15
Pages: 2155-65
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Publication
First Author: Gai M
Year: 2016
Journal: EMBO Rep
Title: ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules.
Volume: 17
Issue: 10
Pages: 1396-1409
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Publication
First Author: Tonosaki M
Year: 2023
Journal: PLoS One
Title: Loss of Aspm causes increased apoptosis of developing neural cells during mouse cerebral corticogenesis.
Volume: 18
Issue: 11
Pages: e0294893
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Publication
First Author: Vange P
Year: 2015
Journal: J Pathol
Title: Genome-wide analysis of the oxyntic proliferative isthmus zone reveals ASPM as a possible gastric stem/progenitor cell marker over-expressed in cancer.
Volume: 237
Issue: 4
Pages: 447-59
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Publication
First Author: Jayaraman D
Year: 2016
Journal: Neuron
Title: Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate.
Volume: 92
Issue: 4
Pages: 813-828
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Publication
First Author: Pulvers JN
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline.
Volume: 107
Issue: 38
Pages: 16595-600
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Publication
First Author: Mori M
Year: 2022
Journal: Reprod Biol
Title: Loss of abnormal spindle-like, microcephaly-associated (Aspm) disrupts female folliculogenesis in mice during maturation and aging.
Volume: 22
Issue: 3
Pages: 100673
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Publication
First Author: Evans PD
Year: 2004
Journal: Hum Mol Genet
Title: Adaptive evolution of ASPM, a major determinant of cerebral cortical size in humans.
Volume: 13
Issue: 5
Pages: 489-94
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Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
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Publication  
First Author: Craig R
Year: 1998
Journal: J Cell Sci
Title: The novel murine calmodulin-binding protein Sha1 disrupts mitotic spindle and replication checkpoint functions in fission yeast.
Volume: 111 ( Pt 24)
Pages: 3609-19
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GXD Expression    
Probe: MGI:3757591
Assay Type: Northern blot
Annotation Date: 2007-10-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:3757598
Age: embryonic day 7.0
Image: 4
Specimen Label: E7
Detected: true
Specimen Num: 1
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GXD Expression    
Probe: MGI:3757591
Assay Type: Northern blot
Annotation Date: 2007-10-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:3757598
Age: embryonic day 11.0
Image: 4
Specimen Label: E11
Detected: true
Specimen Num: 2
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GXD Expression    
Probe: MGI:3757591
Assay Type: Northern blot
Annotation Date: 2007-10-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:3757598
Age: embryonic day 15.0
Image: 4
Specimen Label: E15
Detected: true
Specimen Num: 3
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GXD Expression    
Probe: MGI:3757591
Assay Type: Northern blot
Annotation Date: 2007-10-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:3757598
Age: embryonic day 17.0
Image: 4
Specimen Label: E17
Detected: true
Specimen Num: 4
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GXD Expression    
Probe: MGI:5812802
Assay Type: Northern blot
Annotation Date: 2016-12-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185820
Stage: TS20
Assay Id: MGI:5812803
Age: embryonic day 12.0
Image: 1
Specimen Label: E12 fog
Detected: true
Specimen Num: 1
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GXD Expression    
Probe: MGI:5812802
Assay Type: Northern blot
Annotation Date: 2016-12-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185820
Stage: TS20
Assay Id: MGI:5812803
Age: embryonic day 12.0
Image: 1
Specimen Label: E12 wt
Detected: true
Specimen Num: 2
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GXD Expression    
Probe: MGI:5812802
Assay Type: Northern blot
Annotation Date: 2016-12-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185822
Stage: TS22
Assay Id: MGI:5812803
Age: embryonic day 14.0
Image: 1
Specimen Label: E14 fog
Detected: true
Specimen Num: 3
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GXD Expression    
Probe: MGI:5812802
Assay Type: Northern blot
Annotation Date: 2016-12-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185822
Stage: TS22
Assay Id: MGI:5812803
Age: embryonic day 14.0
Image: 1
Specimen Label: E14 wt
Detected: true
Specimen Num: 4
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GXD Expression    
Probe: MGI:5812802
Assay Type: Northern blot
Annotation Date: 2016-12-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185824
Stage: TS24
Assay Id: MGI:5812803
Age: embryonic day 16.0
Image: 1
Specimen Label: E16 fog
Detected: true
Specimen Num: 5
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GXD Expression    
Probe: MGI:5812802
Assay Type: Northern blot
Annotation Date: 2016-12-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185824
Stage: TS24
Assay Id: MGI:5812803
Age: embryonic day 16.0
Image: 1
Specimen Label: E16 wt
Detected: true
Specimen Num: 6
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GXD Expression    
Probe: MGI:5812802
Assay Type: Northern blot
Annotation Date: 2016-12-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5812804
Age: postnatal adult
Image: 1
Specimen Label: spleen
Detected: true
Specimen Num: 1
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GXD Expression    
Probe: MGI:5812802
Assay Type: Northern blot
Annotation Date: 2016-12-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:5812804
Age: postnatal adult
Image: 1
Specimen Label: liver
Detected: false
Specimen Num: 2
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GXD Expression    
Probe: MGI:5812802
Assay Type: Northern blot
Annotation Date: 2016-12-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5812804
Age: postnatal adult
Image: 1
Specimen Label: heart
Detected: false
Specimen Num: 3
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GXD Expression    
Probe: MGI:5812802
Assay Type: Northern blot
Annotation Date: 2016-12-22
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5812804
Age: postnatal adult
Image: 1
Specimen Label: testis
Detected: true
Specimen Num: 4
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GXD Expression    
Probe: MGI:5812802
Assay Type: Northern blot
Annotation Date: 2016-12-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5812804
Age: postnatal adult
Image: 1
Specimen Label: kidney
Detected: false
Specimen Num: 5
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GXD Expression    
Probe: MGI:5812802
Assay Type: Northern blot
Annotation Date: 2016-12-22
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:5812804
Age: postnatal adult
Image: 1
Specimen Label: ovary
Detected: true
Specimen Num: 6
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GXD Expression    
Probe: MGI:5812802
Assay Type: Northern blot
Annotation Date: 2016-12-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:5812804
Age: postnatal adult
Image: 1
Specimen Label: brain
Detected: false
Specimen Num: 7
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GXD Expression    
Probe: MGI:5812802
Assay Type: Northern blot
Annotation Date: 2016-12-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:5812804
Age: postnatal adult
Image: 1
Specimen Label: not shown
Detected: false
Specimen Num: 8
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GXD Expression      
Probe: MGI:6752591
Assay Type: RT-PCR
Annotation Date: 2021-08-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691020
Stage: TS20
Assay Id: MGI:6753125
Age: embryonic day 12.5
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression      
Probe: MGI:6752591
Assay Type: RT-PCR
Annotation Date: 2021-08-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691020
Stage: TS20
Assay Id: MGI:6753125
Age: embryonic day 12.5
Specimen Label: PA1
Detected: true
Specimen Num: 2
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GXD Expression      
Probe: MGI:6752591
Assay Type: RT-PCR
Annotation Date: 2021-08-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691022
Stage: TS22
Assay Id: MGI:6753125
Age: embryonic day 14.5
Specimen Label: WT
Detected: true
Specimen Num: 3
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GXD Expression      
Probe: MGI:6752591
Assay Type: RT-PCR
Annotation Date: 2021-08-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691022
Stage: TS22
Assay Id: MGI:6753125
Age: embryonic day 14.5
Specimen Label: PA1
Detected: true
Specimen Num: 4
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GXD Expression      
Probe: MGI:6752591
Assay Type: RT-PCR
Annotation Date: 2021-08-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691026
Stage: TS26
Assay Id: MGI:6753125
Age: embryonic day 18.5
Specimen Label: WT
Detected: true
Specimen Num: 5
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GXD Expression      
Probe: MGI:6752591
Assay Type: RT-PCR
Annotation Date: 2021-08-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691026
Stage: TS26
Assay Id: MGI:6753125
Age: embryonic day 18.5
Specimen Label: PA1
Detected: true
Specimen Num: 6
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GXD Expression      
Probe: MGI:7530756
Assay Type: RT-PCR
Annotation Date: 2023-09-26
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:7530899
Age: postnatal adult
Specimen Label: +/+
Detected: true
Specimen Num: 1
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GXD Expression      
Probe: MGI:7530756
Assay Type: RT-PCR
Annotation Date: 2023-09-26
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:7530899
Age: postnatal adult
Specimen Label: Gt/Gt
Detected: true
Specimen Num: 2
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GXD Expression
Probe: MGI:5812802
Assay Type: RNA in situ
Annotation Date: 2016-12-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270424
Pattern: Scattered
Stage: TS24
Assay Id: MGI:5812806
Age: embryonic day 16.5
Image: 2f
Note: Expression in scattered cells in the cortical plate and subventricular zone.
Specimen Label: 2f
Detected: true
Specimen Num: 5
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GXD Expression  
Probe: MGI:4886598
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691619
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945952
Age: embryonic day 11.5
Image: g02336 E11.5
Specimen Label: g02336 E11.5
Detected: true
Specimen Num: 1
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GXD Expression  
Probe: MGI:4886598
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691623
Pattern: Scattered
Stage: TS23
Assay Id: MGI:4945952
Age: embryonic day 15.5
Image: g02336 E15.5
Specimen Label: g02336 E15.5
Detected: true
Specimen Num: 2
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GXD Expression    
Probe: MGI:5298956
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2813028
Stage: TS28
Assay Id: MGI:5542943
Age: postnatal day 84
Image: GUDMAP:14426
Specimen Label: GUDMAP:14426
Detected: false
Specimen Num: 1
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GXD Expression
Probe: MGI:5812802
Assay Type: RNA in situ
Annotation Date: 2016-12-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876724
Pattern: Clusters
Stage: TS24
Assay Id: MGI:5812806
Age: embryonic day 16.5
Image: 2k
Note: Expression in clusters of cells in the fetal spleen.
Specimen Label: 2k
Detected: true
Specimen Num: 8
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GXD Expression    
Probe: MGI:5298956
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5542943
Age: postnatal day 84
Image: GUDMAP:14426
Specimen Label: GUDMAP:14426
Detected: false
Specimen Num: 1
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GXD Expression
Probe: MGI:4886598
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3284223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945952
Age: embryonic day 15.5
Image: g02336 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g02336 E15.5
Detected: true
Specimen Num: 2
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GXD Expression  
Probe: MGI:4886598
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Pattern: Scattered
Stage: TS28
Assay Id: MGI:4945952
Age: postnatal day 7
Image: g02336 P7
Specimen Label: g02336 P7
Detected: true
Specimen Num: 3
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GXD Expression  
Probe: MGI:4886598
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945952
Age: postnatal day 42
Image: g02336 Adult
Specimen Label: g02336 Adult
Detected: true
Specimen Num: 4
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GXD Expression  
Probe: MGI:4886598
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1697419
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945952
Age: embryonic day 11.5
Image: g02336 E11.5
Specimen Label: g02336 E11.5
Detected: true
Specimen Num: 1
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GXD Expression
Probe: MGI:4886598
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1697423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945952
Age: embryonic day 15.5
Image: g02336 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g02336 E15.5
Detected: true
Specimen Num: 2
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GXD Expression  
Probe: MGI:4886598
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697428
Pattern: Scattered
Stage: TS28
Assay Id: MGI:4945952
Age: postnatal day 7
Image: g02336 P7
Specimen Label: g02336 P7
Detected: true
Specimen Num: 3
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GXD Expression  
Probe: MGI:4886598
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697428
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945952
Age: postnatal day 42
Image: g02336 Adult
Specimen Label: g02336 Adult
Detected: true
Specimen Num: 4
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GXD Expression    
Probe: MGI:5298956
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:3131228
Stage: TS28
Assay Id: MGI:5542943
Age: postnatal day 84
Image: GUDMAP:14426
Specimen Label: GUDMAP:14426
Detected: false
Specimen Num: 1
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GXD Expression    
Probe: MGI:5812802
Assay Type: RNA in situ
Annotation Date: 2016-12-22
Strength: Present
Sex: Male
Emaps: EMAPS:3148228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5812806
Age: postnatal day 8
Specimen Label: P8 not shown
Detected: true
Specimen Num: 21
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GXD Expression    
Probe: MGI:5812802
Assay Type: RNA in situ
Annotation Date: 2016-12-22
Strength: Present
Sex: Male
Emaps: EMAPS:3148228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5812806
Age: postnatal adult
Specimen Label: adult testis not shown
Detected: true
Specimen Num: 22
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GXD Expression  
Probe: MGI:5812802
Assay Type: RNA in situ
Annotation Date: 2016-12-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3295224
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:5812806
Age: embryonic day 16.5
Note: Expression in distal tips of branching pancreatic ducts.
Specimen Label: E16.5 not shown
Detected: true
Specimen Num: 15
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GXD Expression  
Probe: MGI:3757592
Assay Type: RNA in situ
Annotation Date: 2007-10-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1903728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3757599
Age: postnatal day 9
Image: 5g
Specimen Label: 5g
Detected: true
Specimen Num: 7
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GXD Expression
Probe: MGI:5812802
Assay Type: RNA in situ
Annotation Date: 2016-12-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3577824
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:5812806
Age: embryonic day 16.5
Image: 2o
Note: Expression confined to epithelial cells lining the crypts. No expression in epithelial cells lining the villi.
Specimen Label: 2o
Detected: true
Specimen Num: 13
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