Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Gressot LV |
Year: |
2017 |
Journal: |
Oncotarget |
Title: |
Analysis of the inhibitors of apoptosis identifies BIRC3 as a facilitator of malignant progression in glioma. |
Volume: |
8 |
Issue: |
8 |
Pages: |
12695-12704 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ma O |
Year: |
2009 |
Journal: |
Cancer Res |
Title: |
MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), amplified on chromosome 9, collaborate with p53 deficiency in mouse osteosarcoma progression. |
Volume: |
69 |
Issue: |
6 |
Pages: |
2559-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tan BM |
Year: |
2013 |
Journal: |
Diabetologia |
Title: |
Baculoviral inhibitors of apoptosis repeat containing (BIRC) proteins fine-tune TNF-induced nuclear factor κB and c-Jun N-terminal kinase signalling in mouse pancreatic beta cells. |
Volume: |
56 |
Issue: |
3 |
Pages: |
520-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schorn F |
Year: |
2023 |
Journal: |
EMBO J |
Title: |
cIAPs control RIPK1 kinase activity-dependent and -independent cell death and tissue inflammation. |
Volume: |
42 |
Issue: |
22 |
Pages: |
e113614 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
376
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Conte D |
Year: |
2006 |
Journal: |
Mol Cell Biol |
Title: |
Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survival. |
Volume: |
26 |
Issue: |
2 |
Pages: |
699-708 |
|
•
•
•
•
•
|
Publication |
First Author: |
Biswas DD |
Year: |
2022 |
Journal: |
J Neuroinflammation |
Title: |
Cellular inhibitor of apoptosis 2 (cIAP2) restricts neuroinflammation during experimental autoimmune encephalomyelitis. |
Volume: |
19 |
Issue: |
1 |
Pages: |
158 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chua CC |
Year: |
2007 |
Journal: |
Biochim Biophys Acta |
Title: |
Overexpression of IAP-2 attenuates apoptosis and protects against myocardial ischemia/reperfusion injury in transgenic mice. |
Volume: |
1773 |
Issue: |
4 |
Pages: |
577-83 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506858 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:2769723 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5539827 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:6210 |
|
Specimen Label: |
GUDMAP:6210 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506858 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:2845723 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5539827 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:6210 |
|
Specimen Label: |
GUDMAP:6210 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506858 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:1795023 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5539827 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:6210 |
|
Specimen Label: |
GUDMAP:6210 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506858 |
Assay Type: |
RNA in situ |
Annotation Date: |
2004-12-03 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1647017 |
Pattern: |
Not Specified |
Stage: |
TS17 |
Assay Id: |
MGI:3509537 |
Age: |
embryonic day 10.5 |
Image: |
1 - left embryo |
Note: |
Authors stated that in some instances they could not determine expression levels with certainty. |
Specimen Label: |
1 - left embryo |
|
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506858 |
Assay Type: |
RNA in situ |
Annotation Date: |
2004-12-03 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1647018 |
Pattern: |
Not Specified |
Stage: |
TS18 |
Assay Id: |
MGI:3509537 |
Age: |
embryonic day 10.5 |
Image: |
2 - right embryo |
Note: |
Authors stated that in some instances they could not determine expression levels with certainty. |
Specimen Label: |
2 - right embryo |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506858 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:2854023 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5539827 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:6210 |
|
Specimen Label: |
GUDMAP:6210 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506858 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:2762123 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5539827 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:6210 |
|
Specimen Label: |
GUDMAP:6210 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506858 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1832123 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5539827 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:6210 |
|
Specimen Label: |
GUDMAP:6210 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506858 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:2851823 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5539827 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:6210 |
|
Specimen Label: |
GUDMAP:6210 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506858 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:2760523 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5539827 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:6210 |
|
Specimen Label: |
GUDMAP:6210 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506858 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:2852723 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5539827 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:6210 |
|
Specimen Label: |
GUDMAP:6210 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506858 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:2874723 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5539827 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:6210 |
|
Specimen Label: |
GUDMAP:6210 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506858 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:2850023 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5539827 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:6210 |
|
Specimen Label: |
GUDMAP:6210 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506858 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1796223 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5539827 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:6210 |
|
Specimen Label: |
GUDMAP:6210 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liston P |
Year: |
1997 |
Journal: |
Genomics |
Title: |
Genomic characterization of the mouse inhibitor of apoptosis protein 1 and 2 genes. |
Volume: |
46 |
Issue: |
3 |
Pages: |
495-503 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lala-Tabbert N |
Year: |
2019 |
Journal: |
Skelet Muscle |
Title: |
Targeted ablation of the cellular inhibitor of apoptosis 1 (cIAP1) attenuates denervation-induced skeletal muscle atrophy. |
Volume: |
9 |
Issue: |
1 |
Pages: |
13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Annibaldi A |
Year: |
2018 |
Journal: |
Mol Cell |
Title: |
Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2. |
Volume: |
69 |
Issue: |
4 |
Pages: |
566-580.e5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Giardino Torchia ML |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
c-IAP1 and c-IAP2 redundancy differs between T and B cells. |
Volume: |
8 |
Issue: |
6 |
Pages: |
e66161 |
|
•
•
•
•
•
|
Publication |
First Author: |
Giardino Torchia ML |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
Balance between NF-κB p100 and p52 regulates T cell costimulation dependence. |
Volume: |
190 |
Issue: |
2 |
Pages: |
549-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Giardino Torchia ML |
Year: |
2015 |
Journal: |
Eur J Immunol |
Title: |
c-IAP ubiquitin protein ligase activity is required for 4-1BB signaling and CD8(+) memory T-cell survival. |
Volume: |
45 |
Issue: |
9 |
Pages: |
2672-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mace PD |
Year: |
2008 |
Journal: |
J Biol Chem |
Title: |
Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment. |
Volume: |
283 |
Issue: |
46 |
Pages: |
31633-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Darding M |
Year: |
2011 |
Journal: |
Cell Death Differ |
Title: |
Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2. |
Volume: |
18 |
Issue: |
8 |
Pages: |
1376-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kenneth NS |
Year: |
2012 |
Journal: |
Biochem J |
Title: |
An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1. |
Volume: |
443 |
Issue: |
2 |
Pages: |
355-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dagenais M |
Year: |
2016 |
Journal: |
Mucosal Immunol |
Title: |
A critical role for cellular inhibitor of protein 2 (cIAP2) in colitis-associated colorectal cancer and intestinal homeostasis mediated by the inflammasome and survival pathways. |
Volume: |
9 |
Issue: |
1 |
Pages: |
146-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guicciardi ME |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Cellular inhibitor of apoptosis (cIAP)-mediated ubiquitination of phosphofurin acidic cluster sorting protein 2 (PACS-2) negatively regulates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity. |
Volume: |
9 |
Issue: |
3 |
Pages: |
e92124 |
|
•
•
•
•
•
|
Publication |
First Author: |
Labbé K |
Year: |
2011 |
Journal: |
Immunity |
Title: |
Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasome. |
Volume: |
35 |
Issue: |
6 |
Pages: |
897-907 |
|
•
•
•
•
•
|
Publication |
First Author: |
Conze DB |
Year: |
2010 |
Journal: |
PLoS Biol |
Title: |
Non-canonical NF-κB activation and abnormal B cell accumulation in mice expressing ubiquitin protein ligase-inactive c-IAP2. |
Volume: |
8 |
Issue: |
10 |
Pages: |
e1000518 |
|
•
•
•
•
•
|
Publication |
First Author: |
Conze DB |
Year: |
2005 |
Journal: |
Mol Cell Biol |
Title: |
Posttranscriptional downregulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo. |
Volume: |
25 |
Issue: |
8 |
Pages: |
3348-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bertrand MJ |
Year: |
2009 |
Journal: |
Immunity |
Title: |
Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2. |
Volume: |
30 |
Issue: |
6 |
Pages: |
789-801 |
|
•
•
•
•
•
|
Publication |
First Author: |
Enwere EK |
Year: |
2012 |
Journal: |
Sci Signal |
Title: |
TWEAK and cIAP1 regulate myoblast fusion through the noncanonical NF-κB signaling pathway. |
Volume: |
5 |
Issue: |
246 |
Pages: |
ra75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rumble JM |
Year: |
2008 |
Journal: |
Biochem J |
Title: |
Apoptotic sensitivity of murine IAP-deficient cells. |
Volume: |
415 |
Issue: |
1 |
Pages: |
21-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Enwere EK |
Year: |
2013 |
Journal: |
Hum Mol Genet |
Title: |
Loss of cIAP1 attenuates soleus muscle pathology and improves diaphragm function in mdx mice. |
Volume: |
22 |
Issue: |
5 |
Pages: |
867-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Anderton H |
Year: |
2017 |
Journal: |
J Invest Dermatol |
Title: |
Inhibitor of Apoptosis Proteins (IAPs) Limit RIPK1-Mediated Skin Inflammation. |
Volume: |
137 |
Issue: |
11 |
Pages: |
2371-2379 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guicciardi ME |
Year: |
2017 |
Journal: |
Cell Death Dis |
Title: |
Biliary tract instillation of a SMAC mimetic induces TRAIL-dependent acute sclerosing cholangitis-like injury in mice. |
Volume: |
8 |
Issue: |
1 |
Pages: |
e2535 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ishigaki S |
Year: |
2002 |
Journal: |
J Neurochem |
Title: |
X-Linked inhibitor of apoptosis protein is involved in mutant SOD1-mediated neuronal degeneration. |
Volume: |
82 |
Issue: |
3 |
Pages: |
576-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawamura K |
Year: |
2003 |
Journal: |
Dev Biol |
Title: |
Survivin acts as an antiapoptotic factor during the development of mouse preimplantation embryos. |
Volume: |
256 |
Issue: |
2 |
Pages: |
331-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lang G |
Year: |
2005 |
Journal: |
Oncogene |
Title: |
Myb proteins regulate the expression of diverse target genes. |
Volume: |
24 |
Issue: |
8 |
Pages: |
1375-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tigno-Aranjuez JT |
Year: |
2013 |
Journal: |
Mol Cell Biol |
Title: |
A discrete ubiquitin-mediated network regulates the strength of NOD2 signaling. |
Volume: |
33 |
Issue: |
1 |
Pages: |
146-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamaguchi N |
Year: |
2012 |
Journal: |
Genes Cells |
Title: |
cIAP1/2 negatively regulate RANKL-induced osteoclastogenesis through the inhibition of NFATc1 expression. |
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