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Search results 1 to 100 out of 428 for Ca4

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Hits by Strain

Type Details Score
Gene
762 | CA4
Type: gene
Organism: human
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Gene
280741 | CA4
Type: gene
Organism: cattle
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Gene
key_33872 | CA4
Type: gene
Organism: rabbit, European
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Gene
480591 | CA4
Type: gene
Organism: dog, domestic
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Gene
454807 | CA4
Type: gene
Organism: chimpanzee
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Gene
417647 | CA4
Type: gene
Organism: chicken
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Gene
716919 | CA4
Type: gene
Organism: macaque, rhesus
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MP Term
MP:0008270 | absent hippocampus CA4 region
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CL Term
CL:4023061 | hippocampal CA4 neuron
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GXD Expression
GXD Expression
 
Probe: MGI:3574060
Assay Type: RNA in situ
Annotation Date: 2005-04-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3574075
Age: postnatal day 7
Note: There is more expression in CA1 and CA3 pyramidal cells than in CA2 and CA4
Specimen Label: 2A
Detected: true
Specimen Num: 1
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MP Term
MP:0008269 | abnormal hippocampus CA4 region morphology
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Publication
15090652 | -
First Author: Rebello G
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Apoptosis-inducing signal sequence mutation in carbonic anhydrase IV identified in patients with the RP17 form of retinitis pigmentosa.
Volume: 101
Issue: 17
Pages: 6617-22
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Publication
17652713 | -
First Author: Alvarez BV
Year: 2007
Journal: Invest Ophthalmol Vis Sci
Title: Identification and characterization of a novel mutation in the carbonic anhydrase IV gene that causes retinitis pigmentosa.
Volume: 48
Issue: 8
Pages: 3459-68
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Protein Domain
IPR018343 | Carbonic_anhydrase_CA4
Type: Family
Description: Carbonic anhydrases (CA: ) are zinc metalloenzymes which catalyse the reversible hydration of carbon dioxide to bicarbonate [, ]. CAs have essential roles in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space; they are also involved in many other processes, from respiration and photosynthesis in eukaryotes to cyanate degradation in prokaryotes. There are five known evolutionarily distinct CA families (alpha, beta, gamma, delta and epsilon) that have no significant sequence identity and have structurally distinct overall folds. Some CAs are membrane-bound, while others act in the cytosol; there are several related proteins that lack enzymatic activity. The active site of alpha-CAs is well described, consisting of a zinc ion coordinated through 3 histidine residues and a water molecule/hydroxide ion that acts as a potent nucleophile. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site []. Beta- and gamma-CAs also employ a zinc hydroxide mechanism, although at least some beta-class enzymes do not have water directly coordinated to the metal ion. The alpha-CAs are found predominantly in animals but also in bacteria and green algae. There are at least 15 isoforms found in mammals, which can be subdivided into cytosolic CAs (CA-I, CA-II, CA-III, CA-VII and CA XIII), mitochondrial CAs (CA-VA and CA-VB), secreted CAs (CA-VI), membrane-associated (CA-IV, CA-IX, CA-XII and CA-XIV) and those without CA activity, the CA-related proteins (CA-RP VIII, X and XI).The beta-CAs are highly abundant in plants, diatoms, eubacteria and archaea [, ]. The beta-CAs are far more diverse in sequence than other classes, and can be divided into different clades based on sequence identity, with the plant enzymes forming two clades representing dicotyledonous and monocotyledonous plants. Characterisation of these enzymes reveals sharp differences between the beta class, which forms dimers, tetramers, hexamers and octomers, and the alpha and gamma classes, which form strictly monomers and trimers. The gamma-CAs may be the most ancient form of carbonic anhydrases, having evolved long before the alpha class, to which it is more closely related than to the beta-class [, ]. The reaction mechanism of the gamma-class is similar to that of the alpha-class, even though the overall folds are dissimilar and the active site residues differ. The delta-CAs are found in marine algae and dinoflagellates []. The epsilon-CAs are found in prokaryotes such as Thiobacillus neapolitanus (Halothiobacillus neapolitanus) in which it is a component of the carboxysome shell, where it could supply the active sites of RuBisCO in the carboxysome with the high concentrations of carbon dioxide necessary for optimal RuBisCO activity and efficient carbon fixation [].This entry represents plasma membrane-anchored mammalian CA4 carbonic anhydrases. Defects in CA4 are the cause of (autosomal dominant) retinitis pigmentosa type 17 (RP17), which leads to degeneration of retinal photoreceptor cells, night vision blindness and loss of midperipheral visual field [, ].
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Allele
Tg(KRT14-Notch*/ESR1)CA4Fmw | MGI:5824128
Name: transgene insertion CA4, Fiona M Watt
Allele Type: Transgenic
Attribute String: Constitutively active, Inserted expressed sequence
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EMAPA Term
hippocampus CA4 | EMAPA:32771
Starts At: 26
Ends At: 28
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GXD Expression
GXD Expression
   
Probe: MGI:3574062
Assay Type: RNA in situ
Annotation Date: 2005-04-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Uniform
Stage: TS28
Assay Id: MGI:3574081
Age: postnatal day 7
Specimen Label: 2B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3574060
Assay Type: RNA in situ
Annotation Date: 2005-04-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3574075
Age: postnatal week 3
Note: Expression is present in the pyramidal cells.
Specimen Label: 2C
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3655491
Assay Type: Immunohistochemistry
Annotation Date: 2006-09-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3655495
Age: postnatal day 14
Image: S5m,o
Specimen Label: S5m,o
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
Probe: MGI:3655493
Assay Type: Immunohistochemistry
Annotation Date: 2006-09-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3655497
Age: postnatal day 14
Image: S5n,p
Note: Expression is uniform in pyramidal neurons of hippocampal regions.
Specimen Label: S5n,p
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:3712911
Assay Type: RNA in situ
Annotation Date: 2007-06-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3712924
Age: postnatal adult
Specimen Label: 3a
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3795238
Assay Type: RNA in situ
Annotation Date: 2008-06-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3795239
Age: postnatal month 2
Image: 3O
Specimen Label: 3O
Detected: true
Specimen Num: 19
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GXD Expression
GXD Expression
   
Probe: MGI:20762
Assay Type: RNA in situ
Annotation Date: 2008-07-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3797129
Age: postnatal day 31
Specimen Label: 4B
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3805741
Assay Type: Immunohistochemistry
Annotation Date: 2008-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3805757
Age: postnatal adult
Note: Strong nuclear and moderate cytoplasmic labeling.
Specimen Label: Table 3
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:3805739
Assay Type: Immunohistochemistry
Annotation Date: 2008-09-16
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3805949
Age: postnatal adult
Note: Strong nuclear and moderate cytoplasmic labeling.
Specimen Label: Not shown
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:3805737
Assay Type: Immunohistochemistry
Annotation Date: 2008-09-16
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3805953
Age: postnatal adult
Note: Strong nuclear and moderate cytoplasmic labeling.
Specimen Label: Not shown
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:3812058
Assay Type: RNA in situ
Annotation Date: 2008-10-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3277127
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3812405
Age: postnatal day 3
Note: Expression is most abundant in cell dense regions.
Specimen Label: 3A,B
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3694463
Assay Type: Immunohistochemistry
Annotation Date: 2007-01-23
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Single cells
Stage: TS28
Assay Id: MGI:3694469
Age: postnatal adult
Note: Expression is present in scattered polymorphic neurons.
Specimen Label: 3I
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:3694465
Assay Type: Immunohistochemistry
Annotation Date: 2007-01-24
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Single cells
Stage: TS28
Assay Id: MGI:3694552
Age: postnatal adult
Note: Expression is present in scattered polymorphic neurons.
Specimen Label: 3J
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:4850061
Assay Type: RNA in situ
Annotation Date: 2011-01-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:4867006
Age: postnatal day 7
Specimen Label: 5Ac
Detected: true
Specimen Num: 14
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GXD Expression
GXD Expression
   
Probe: MGI:5285602
Assay Type: RNA in situ
Annotation Date: 2011-09-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5285611
Age: postnatal adult
Specimen Label: 5F
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:5285603
Assay Type: RNA in situ
Annotation Date: 2011-09-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:5285612
Age: postnatal adult
Note: Expression is in the pyramidal cells.
Specimen Label: 5G
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:5285604
Assay Type: RNA in situ
Annotation Date: 2011-09-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:5285613
Age: postnatal adult
Note: Expression is in the pyramidal cells.
Specimen Label: 5H
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:1194942
Assay Type: RNA in situ
Annotation Date: 2011-11-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5295279
Age: postnatal
Image: 4A
Specimen Label: 4A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:1194943
Assay Type: RNA in situ
Annotation Date: 2011-11-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5295280
Age: postnatal
Image: 4B
Specimen Label: 4B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5469480
Assay Type: RNA in situ
Annotation Date: 2013-03-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5469485
Age: postnatal day 7
Image: 2K
Specimen Label: 2K
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:5499018
Assay Type: RNA in situ
Annotation Date: 2013-08-01
Strength: Very strong
Sex: Not Specified
Emaps: EMAPS:3277127
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:5499096
Age: postnatal day 1
Image: 3B
Specimen Label: 3B
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:5511030
Assay Type: Immunohistochemistry
Annotation Date: 2013-10-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5512634
Age: postnatal week 8-10
Image: 3A1
Specimen Label: 3A1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5511025
Assay Type: Immunohistochemistry
Annotation Date: 2013-10-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5512666
Age: postnatal week 8-10
Image: 3A2
Specimen Label: 3A2
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3028127
Assay Type: Immunohistochemistry
Annotation Date: 2014-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5588018
Age: postnatal adult
Image: 4 hippocampus
Specimen Label: 4 hippocampus
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:3028129
Assay Type: Immunohistochemistry
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3028319
Age: postnatal adult
Image: 4 hippocampus
Specimen Label: 4 hippocampus
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:5636714
Assay Type: RNA in situ
Annotation Date: 2015-05-21
Strength: Very strong
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5636716
Age: postnatal week 6
Image: 5f
Specimen Label: 5f
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
 
Probe: MGI:5752635
Assay Type: RNA in situ
Annotation Date: 2016-03-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3277126
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5752749
Age: embryonic day 18.5
Image: 2K
Specimen Label: 2K
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:5752635
Assay Type: RNA in situ
Annotation Date: 2016-03-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Diffuse
Stage: TS28
Assay Id: MGI:5752749
Age: postnatal day 21
Image: 3E
Specimen Label: 3E
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:5752635
Assay Type: RNA in situ
Annotation Date: 2016-03-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Diffuse
Stage: TS28
Assay Id: MGI:5752749
Age: postnatal day 21
Image: 3H
Specimen Label: 3H
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:5752635
Assay Type: RNA in situ
Annotation Date: 2016-03-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5752749
Age: postnatal adult
Image: 4B
Specimen Label: 4B
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:5752636
Assay Type: RNA in situ
Annotation Date: 2016-03-22
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5752798
Age: postnatal day 21
Image: 3F
Specimen Label: 3F
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:5752636
Assay Type: RNA in situ
Annotation Date: 2016-03-22
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5752798
Age: postnatal adult
Image: 4C
Specimen Label: 4C
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:5752636
Assay Type: RNA in situ
Annotation Date: 2016-03-22
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5752798
Age: postnatal day 21
Image: 3I
Specimen Label: 3I
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:5795891
Assay Type: RNA in situ
Annotation Date: 2016-09-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5795899
Age: postnatal adult
Note: Expression was detected in the pyramidal cell layer.
Specimen Label: 5K
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
   
Probe: MGI:5904982
Assay Type: Immunohistochemistry
Annotation Date: 2017-07-19
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3277126
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5905004
Age: embryonic day 18.0
Specimen Label: Table 1 E18
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
   
Probe: MGI:5904982
Assay Type: Immunohistochemistry
Annotation Date: 2017-07-19
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5905004
Age: postnatal day 8
Specimen Label: Table 1 P8
Detected: true
Specimen Num: 16
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GXD Expression
GXD Expression
   
Probe: MGI:5904982
Assay Type: Immunohistochemistry
Annotation Date: 2017-07-19
Strength: Very strong
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5905004
Age: postnatal day 10
Specimen Label: Table 1 P10
Detected: true
Specimen Num: 18
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GXD Expression
GXD Expression
   
Probe: MGI:5904982
Assay Type: Immunohistochemistry
Annotation Date: 2017-07-19
Strength: Very strong
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5905004
Age: postnatal day 30
Specimen Label: Table 1 >/=30
Detected: true
Specimen Num: 20
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GXD Expression
GXD Expression
   
Probe: MGI:5904982
Assay Type: Immunohistochemistry
Annotation Date: 2017-07-19
Strength: Very strong
Sex: Not Specified
Emaps: EMAPS:3277127
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:5905004
Age: postnatal day 0
Specimen Label: Table 1 P0
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
   
Probe: MGI:5904982
Assay Type: Immunohistochemistry
Annotation Date: 2017-07-19
Strength: Very strong
Sex: Not Specified
Emaps: EMAPS:3277127
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:5905004
Age: postnatal day 1
Specimen Label: Table 1 P1
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
   
Probe: MGI:5904982
Assay Type: Immunohistochemistry
Annotation Date: 2017-07-19
Strength: Very strong
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5905004
Age: postnatal day 6
Specimen Label: Table 1 P6
Detected: true
Specimen Num: 14
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GXD Expression
GXD Expression
   
Probe: MGI:5904982
Assay Type: Immunohistochemistry
Annotation Date: 2017-07-19
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5905004
Age: postnatal day 7
Specimen Label: Table 1 P7
Detected: true
Specimen Num: 15
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GXD Expression
GXD Expression
   
Probe: MGI:5904982
Assay Type: Immunohistochemistry
Annotation Date: 2017-07-19
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5905004
Age: postnatal day 9
Specimen Label: Table 1 P9
Detected: true
Specimen Num: 17
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GXD Expression
GXD Expression
   
Probe: MGI:5904982
Assay Type: Immunohistochemistry
Annotation Date: 2017-07-19
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5905004
Age: postnatal day 15
Specimen Label: Table 1 P15
Detected: true
Specimen Num: 19
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GXD Expression
GXD Expression
   
Probe: MGI:5902729
Assay Type: RNA in situ
Annotation Date: 2017-08-22
Strength: Present
Sex: Male
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5907207
Age: postnatal week 6
Specimen Label: 6H
Detected: true
Specimen Num: 15
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GXD Expression
GXD Expression
Probe: MGI:6360230
Assay Type: RNA in situ
Annotation Date: 2019-09-18
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6360231
Age: postnatal adult
Image: 3D
Note: Expression is in pyramidal cells.
Specimen Label: 3D
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6383995
Assay Type: Immunohistochemistry
Annotation Date: 2020-01-10
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6384257
Age: postnatal adult
Specimen Label: 8 Hippocampus
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6383995
Assay Type: Immunohistochemistry
Annotation Date: 2020-01-10
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6384257
Age: postnatal adult
Specimen Label: Table 1
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:6400937
Assay Type: RNA in situ
Annotation Date: 2020-03-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6400951
Age: postnatal adult
Image: 8C
Specimen Label: 8C
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:6400937
Assay Type: RNA in situ
Annotation Date: 2020-03-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6400951
Age: postnatal adult
Image: 8A
Specimen Label: 8A
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:6403226
Assay Type: RNA in situ
Annotation Date: 2020-04-07
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6403229
Age: postnatal adult
Specimen Label: Table 1
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:6403261
Assay Type: RNA in situ
Annotation Date: 2020-04-08
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6403263
Age: postnatal adult
Specimen Label: Not shown
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6403262
Assay Type: RNA in situ
Annotation Date: 2020-04-08
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6403265
Age: postnatal adult
Specimen Label: Not shown
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:7280663
Assay Type: Immunohistochemistry
Annotation Date: 2022-05-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7280694
Age: postnatal adult
Note: Expression is in the soma and dendrites of all neurons.
Specimen Label: 2D
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:7611984
Assay Type: Immunohistochemistry
Annotation Date: 2024-03-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3277126
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:7612005
Age: embryonic day 18.0
Specimen Label: Table 1 E18
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7611984
Assay Type: Immunohistochemistry
Annotation Date: 2024-03-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7612005
Age: postnatal day 6
Specimen Label: Table 1 P6
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:7611984
Assay Type: Immunohistochemistry
Annotation Date: 2024-03-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3277128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7612005
Age: postnatal day 16
Specimen Label: Table 1 P16
Detected: true
Specimen Num: 5
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Allele
Prox1<tm1.1Fuma> | MGI:5438824
Name: prospero homeobox 1; targeted mutation 1.1, Fumio Matsuzaki
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Protein
F6ST32
Organism: Mus musculus/domesticus
Length: 164  
Fragment?: true
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GXD Expression
GXD Expression
 
Probe: MGI:3574060
Assay Type: RNA in situ
Annotation Date: 2005-04-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3276828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3574075
Age: postnatal day 7
Note: There is more expression in CA1 and CA3 pyramidal cells than in CA2 and CA4
Specimen Label: 2A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:27063
Assay Type: RNA in situ
Annotation Date: 2005-07-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3284526
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:3582395
Age: embryonic day 18.5
Image: 5K
Note: There is strong expression in the CA1, CA2, CA3, and CA4 regions of the hippocampus.
Specimen Label: 5K
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:3574060
Assay Type: RNA in situ
Annotation Date: 2005-04-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3276928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3574075
Age: postnatal day 7
Note: There is more expression in CA1 and CA3 pyramidal cells than in CA2 and CA4
Specimen Label: 2A
Detected: true
Specimen Num: 1
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•
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•
GXD Expression
GXD Expression
 
Probe: MGI:3574060
Assay Type: RNA in situ
Annotation Date: 2005-04-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3277028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3574075
Age: postnatal day 7
Note: There is more expression in CA1 and CA3 pyramidal cells than in CA2 and CA4
Specimen Label: 2A
Detected: true
Specimen Num: 1
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Protein
Q3U3I1
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: false
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Allele
Car1<tm1.1Nju> | MGI:7718420
Name: carbonic anhydrase 1; targeted mutation 1.1, Model Animal Research Center of Nanjing University
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Genotype
Genotype
Symbol: Prox1/Prox1 Tg(Camk2a-cre/ERT2)2Gsc/?
Background: involves: C57BL/6NCrlj * CBA/JNCrlj * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Prox1/Prox1 Tg(Camk2a-cre)20Kmik/?
Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Zygosity: cn
Has Mutant Allele: true
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•
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•
GXD Expression
GXD Expression
Probe: MGI:1196472
Assay Type: RNA in situ
Annotation Date: 2005-07-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3284526
Pattern: Non-Uniform
Stage: TS26
Assay Id: MGI:3582396
Age: embryonic day 18.5
Image: 5L
Note: There is stronger expression in the CA2 and CA3 regions compared to the CA1 and CA4 areas.
Specimen Label: 5L
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
 
Probe: MGI:5904982
Assay Type: Immunohistochemistry
Annotation Date: 2017-07-19
Strength: Very strong
Sex: Not Specified
Emaps: EMAPS:3284522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5905004
Age: embryonic day 14.0
Note: Expression is in the CA4 region, weak in the CA1 region, and is absent in the dentate gyrus.
Specimen Label: Table 1 E14
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:5904982
Assay Type: Immunohistochemistry
Annotation Date: 2017-07-19
Strength: Very strong
Sex: Not Specified
Emaps: EMAPS:3284524
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:5905004
Age: embryonic day 16.0
Note: Expression is in the CA4 region, weak in the CA1 region, and is absent in the dentate gyrus.
Specimen Label: Table 1 E16
Detected: true
Specimen Num: 10
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Protein
Q64444
Organism: Mus musculus/domesticus
Length: 305  
Fragment?: false
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Protein Coding Gene
MGI:88268 | Car1
Type: protein_coding_gene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Car1/Car1
Background: involves: C57BL/6J * C57BL/6NTac
Zygosity: hm
Has Mutant Allele: true
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Allele
Arx<tm1.1Jno> | MGI:4353222
 
Name: aristaless related homeobox; targeted mutation 1.1, Jeffrey L Noebels
Allele Type: Targeted
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•
•
•
•
Genotype
Genotype
Symbol: Slc9a6/Slc9a6<+>
Background: B6.129P2-Slc9a6/J
Zygosity: ht
Has Mutant Allele: true
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Publication
9336012 | -
First Author: Lindskog S
Year: 1997
Journal: Pharmacol Ther
Title: Structure and mechanism of carbonic anhydrase.
Volume: 74
Issue: 1
Pages: 1-20
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•
•
•
Publication
18336305 | -
First Author: Supuran CT
Year: 2008
Journal: Curr Pharm Des
Title: Carbonic anhydrases--an overview.
Volume: 14
Issue: 7
Pages: 603-14
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•
•
•
•
Publication
10978542 | -
First Author: Smith KS
Year: 2000
Journal: FEMS Microbiol Rev
Title: Prokaryotic carbonic anhydrases.
Volume: 24
Issue: 4
Pages: 335-66
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Publication
16407248 | -
First Author: Sawaya MR
Year: 2006
Journal: J Biol Chem
Title: The structure of beta-carbonic anhydrase from the carboxysomal shell reveals a distinct subclass with one active site for the price of two.
Volume: 281
Issue: 11
Pages: 7546-55
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Publication
12107142 | -
First Author: Smith KS
Year: 2002
Journal: J Bacteriol
Title: Roles of the conserved aspartate and arginine in the catalytic mechanism of an archaeal beta-class carbonic anhydrase.
Volume: 184
Issue: 15
Pages: 4240-5
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•
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Publication
18289884 | -
First Author: Fu X
Year: 2008
Journal: Mol Phylogenet Evol
Title: Evolution of structure in gamma-class carbonic anhydrase and structurally related proteins.
Volume: 47
Issue: 1
Pages: 211-20
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•
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Publication
18336318 | -
First Author: Zimmerman SA
Year: 2008
Journal: Curr Pharm Des
Title: The beta and gamma classes of carbonic anhydrase.
Volume: 14
Issue: 7
Pages: 716-21
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•
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Publication
18467453 | -
First Author: Lapointe M
Year: 2008
Journal: Plant Physiol
Title: An external delta-carbonic anhydrase in a free-living marine dinoflagellate may circumvent diffusion-limited carbon acquisition.
Volume: 147
Issue: 3
Pages: 1427-36
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Publication
14729686 | -
First Author: So AK
Year: 2004
Journal: J Bacteriol
Title: A novel evolutionary lineage of carbonic anhydrase (epsilon class) is a component of the carboxysome shell.
Volume: 186
Issue: 3
Pages: 623-30
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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