Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry includes the CDP-archaeol synthase from archaea and a group of putative integral membrane proteins from bacteria. CDP-archaeol synthase functions in the archaeal lipid biosynthetic pathway. It catalyses the transfer of the nucleotide to its specific archaeal lipid substrate, leading to the formation of a CDP-activated precursor (CDP-archaeol) to which polar head groups are attached []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Jain S |
Year: |
2014 |
Journal: |
Chem Biol |
Title: |
Identification of CDP-archaeol synthase, a missing link of ether lipid biosynthesis in Archaea. |
Volume: |
21 |
Issue: |
10 |
Pages: |
1392-1401 |
|
•
•
•
•
•
|
Publication |
First Author: |
Whitworth DE |
Year: |
2001 |
Journal: |
Mol Microbiol |
Title: |
Light-induced carotenogenesis in Myxococcus xanthus: evidence that CarS acts as an anti-repressor of CarA. |
Volume: |
42 |
Issue: |
3 |
Pages: |
809-19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Navarro-Avilés G |
Year: |
2007 |
Journal: |
Mol Microbiol |
Title: |
Structural basis for operator and antirepressor recognition by Myxococcus xanthus CarA repressor. |
Volume: |
63 |
Issue: |
4 |
Pages: |
980-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
López-Rubio JJ |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
A repressor-antirepressor pair links two loci controlling light-induced carotenogenesis in Myxococcus xanthus. |
Volume: |
277 |
Issue: |
9 |
Pages: |
7262-70 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
CarS, an antirepressor present in Cystobacterineae, recognizes repressors to turn on the photo-inducible promoter P(B). In the dark, access to the P(B) promoter is blocked by the repressor CarA []. Blue light causes expression of CarS, leading the way to the CarA-CarS interaction which dismantles the CarA-operator complex, resulting in the derepression of the P(B) promoter [, ]. A parallel pathway for regulating P(B) involves the interaction of CarS with the repressor CarH, which shares the domain architecture of CarA. CarH and CarA contain an N-terminal, MerR-type winged-helix DNA-binding domain that recognizes CarS. CarS adopts an SH3-like fold with loop length variations and acts as an operator DNA mimic []. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
293
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
León E |
Year: |
2010 |
Journal: |
Nucleic Acids Res |
Title: |
A bacterial antirepressor with SH3 domain topology mimics operator DNA in sequestering the repressor DNA recognition helix. |
Volume: |
38 |
Issue: |
15 |
Pages: |
5226-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lim RS |
Year: |
2011 |
Journal: |
J Lipid Res |
Title: |
Identification of cholesterol crystals in plaques of atherosclerotic mice using hyperspectral CARS imaging. |
Volume: |
52 |
Issue: |
12 |
Pages: |
2177-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tolstik E |
Year: |
2022 |
Journal: |
Int J Mol Sci |
Title: |
CARS Imaging Advances Early Diagnosis of Cardiac Manifestation of Fabry Disease. |
Volume: |
23 |
Issue: |
10 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Harris DT |
Year: |
2018 |
Journal: |
J Immunol |
Title: |
Comparison of T Cell Activities Mediated by Human TCRs and CARs That Use the Same Recognition Domains. |
Volume: |
200 |
Issue: |
3 |
Pages: |
1088-1100 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lim RS |
Year: |
2010 |
Journal: |
J Lipid Res |
Title: |
Multimodal CARS microscopy determination of the impact of diet on macrophage infiltration and lipid accumulation on plaque formation in ApoE-deficient mice. |
Volume: |
51 |
Issue: |
7 |
Pages: |
1729-37 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
831
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
748
|
Fragment?: |
false |
|
•
•
•
•
•
|
Allele |
Name: |
cysteinyl-tRNA synthetase 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This is an SH3 domain found in antirepressor proteins such as CarS from Myxococcus xanthus. CarS antirepressor recognizes and neutralizes its cognate repressors to turn on a photo-inducible promoter. CarS physically interacts with the MerR-type winged-helix DNA-binding domain of these repressors leading to activation of carB operon. Structural studies of CarS from M. Xanthus reveals a β-barrel fold akin to that in SH3 domains. However, it diverges from the typical SH3 domain fold in the lengths and conformations of the connecting loops. Functional analysis reveal that SH3 domain-like fold in the antirepressor CasS, mimics operator DNA in sequestering the repressor DNA recognition helix to activate transcription []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Rodriguez L |
Year: |
2014 |
Journal: |
Plant Cell |
Title: |
C2-domain abscisic acid-related proteins mediate the interaction of PYR/PYL/RCAR abscisic acid receptors with the plasma membrane and regulate abscisic acid sensitivity in Arabidopsis. |
Volume: |
26 |
Issue: |
12 |
Pages: |
4802-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yung YL |
Year: |
2015 |
Journal: |
J Biol Chem |
Title: |
Site-directed Mutagenesis Shows the Significance of Interactions with Phospholipids and the G-protein OsYchF1 for the Physiological Functions of the Rice GTPase-activating Protein 1 (OsGAP1). |
Volume: |
290 |
Issue: |
39 |
Pages: |
23984-96 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
CarS (CDP-archaeol synthase) is a membrane protein that functions in the archaeal lipid biosynthetic pathway. It catalyses the transfer of the nucleotide to its specific archaeal lipid substrate, leading to the formation of a CDP-activated precursor (CDP-archaeol) to which polar head groups are attached []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry includes C2-domain abscisic acid-related protein CAR1-11 from Arabidopsis and GTPase activating protein 1 (OsGAP1) from rice. CARs interact with the PYR/PYL ABA receptors and recruit them to membranes in a Ca2+-dependent manner []. OsGAP1 is a soluble protein that can loosely associate with plasma membrane. It can also interact with an unconventional G-protein, OsYchF1, and stimulate its NTPase activities []. |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 1952, Andrea Riccio |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Publication |
First Author: |
Long AH |
Year: |
2015 |
Journal: |
Nat Med |
Title: |
4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors. |
Volume: |
21 |
Issue: |
6 |
Pages: |
581-90 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
Publication |
First Author: |
Kato R |
Year: |
1999 |
Journal: |
DNA Res |
Title: |
Sequence-ready 1-Mb YAC, BAC and cosmid contigs covering the distal imprinted region of mouse chromosome 7. |
Volume: |
6 |
Issue: |
6 |
Pages: |
401-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cerrato F |
Year: |
2005 |
Journal: |
Hum Mol Genet |
Title: |
The two-domain hypothesis in Beckwith-Wiedemann syndrome: autonomous imprinting of the telomeric domain of the distal chromosome 7 cluster. |
Volume: |
14 |
Issue: |
4 |
Pages: |
503-11 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(YACW408A5)1952Ricc/? |
Background: |
involves: 129/Sv * SD7 |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Chang W |
Year: |
1999 |
Journal: |
Endocrinology |
Title: |
Expression and signal transduction of calcium-sensing receptors in cartilage and bone. |
Volume: |
140 |
Issue: |
12 |
Pages: |
5883-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang H |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
In vivo coherent Raman imaging of the melanomagenesis-associated pigment pheomelanin. |
Volume: |
6 |
|
Pages: |
37986 |
|
•
•
•
•
•
|
Publication |
First Author: |
Suryadevara CM |
Year: |
2019 |
Journal: |
Clin Cancer Res |
Title: |
Preventing Lck Activation in CAR T Cells Confers Treg Resistance but Requires 4-1BB Signaling for Them to Persist and Treat Solid Tumors in Nonlymphodepleted Hosts. |
Volume: |
25 |
Issue: |
1 |
Pages: |
358-368 |
|
•
•
•
•
•
|
Publication |
First Author: |
Szade K |
Year: |
2020 |
Journal: |
EMBO Rep |
Title: |
Heme oxygenase-1 deficiency triggers exhaustion of hematopoietic stem cells. |
Volume: |
21 |
Issue: |
2 |
Pages: |
e47895 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oshima K |
Year: |
2019 |
Journal: |
Am J Physiol Lung Cell Mol Physiol |
Title: |
Loss of endothelial sulfatase-1 after experimental sepsis attenuates subsequent pulmonary inflammatory responses. |
Volume: |
317 |
Issue: |
5 |
Pages: |
L667-L677 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cheng Z |
Year: |
2007 |
Journal: |
Endocrinology |
Title: |
Type B gamma-aminobutyric acid receptors modulate the function of the extracellular Ca2+-sensing receptor and cell differentiation in murine growth plate chondrocytes. |
Volume: |
148 |
Issue: |
10 |
Pages: |
4984-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Riese MJ |
Year: |
2013 |
Journal: |
Cancer Res |
Title: |
Enhanced effector responses in activated CD8+ T cells deficient in diacylglycerol kinases. |
Volume: |
73 |
Issue: |
12 |
Pages: |
3566-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rodriguez L |
Year: |
2005 |
Journal: |
Endocrinology |
Title: |
Expression and functional assessment of an alternatively spliced extracellular Ca2+-sensing receptor in growth plate chondrocytes. |
Volume: |
146 |
Issue: |
12 |
Pages: |
5294-303 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee JC |
Year: |
2011 |
Journal: |
Cancer Res |
Title: |
In vivo inhibition of human CD19-targeted effector T cells by natural T regulatory cells in a xenotransplant murine model of B cell malignancy. |
Volume: |
71 |
Issue: |
8 |
Pages: |
2871-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ghosh A |
Year: |
2017 |
Journal: |
Nat Med |
Title: |
Donor CD19 CAR T cells exert potent graft-versus-lymphoma activity with diminished graft-versus-host activity. |
Volume: |
23 |
Issue: |
2 |
Pages: |
242-249 |
|
•
•
•
•
•
|
Publication |
First Author: |
González Coraspe JA |
Year: |
2018 |
Journal: |
Skelet Muscle |
Title: |
Biochemical and pathological changes result from mutated Caveolin-3 in muscle. |
Volume: |
8 |
Issue: |
1 |
Pages: |
28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee B |
Year: |
2009 |
Journal: |
Biochim Biophys Acta |
Title: |
Differential association of adipophilin and TIP47 proteins with cytoplasmic lipid droplets in mouse enterocytes during dietary fat absorption. |
Volume: |
1791 |
Issue: |
12 |
Pages: |
1173-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|