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Search results 1 to 62 out of 62 for Casc1

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Type Details Score
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Liu P
Year: 2006
Journal: Nat Genet
Title: Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice.
Volume: 38
Issue: 8
Pages: 888-95
Publication
First Author: Zhang Y
Year: 2019
Journal: J Mol Cell Biol
Title: Vertebrate Dynein-f depends on Wdr78 for axonemal localization and is essential for ciliary beat.
Volume: 11
Issue: 5
Pages: 383-394
Publication
First Author: Zhang Z
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice.
Volume: 100
Issue: 22
Pages: 12642-7
Publication
First Author: Galbiati F
Year: 2006
Journal: Cancer Lett
Title: Allelic effects of mouse Pas1 candidate genes in human lung cancer cell lines.
Volume: 244
Issue: 2
Pages: 176-81
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Manenti G
Year: 2004
Journal: Oncogene
Title: Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice.
Volume: 23
Issue: 25
Pages: 4495-504
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication
First Author: Liu Y
Year: 2007
Journal: Cancer Res
Title: Degradation of lung adenoma susceptibility 1, a major candidate mouse lung tumor modifier, is required for cell cycle progression.
Volume: 67
Issue: 21
Pages: 10207-13
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication      
First Author: GemPharmatech
Year: 2020
Journal: website
Title: GemPharmatech website
Publication
First Author: Nathan BM
Year: 2006
Journal: Endocrinology
Title: A quantitative trait locus on chromosome 6 regulates the onset of puberty in mice.
Volume: 147
Issue: 11
Pages: 5132-8
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication
First Author: Wirschell M
Year: 2009
Journal: Mol Biol Cell
Title: IC97 is a novel intermediate chain of I1 dynein that interacts with tubulin and regulates interdoublet sliding.
Volume: 20
Issue: 13
Pages: 3044-54
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Protein
Organism: Mus musculus
Length: 730  
Fragment?: false
Protein
Organism: Mus musculus
Length: 153  
Fragment?: false
Protein
Organism: Mus musculus
Length: 679  
Fragment?: false
Allele
Name: cancer susceptibility candidate 1; gene trap 709, Lexicon Genetics
Allele Type: Gene trapped
Attribute String: Null/knockout
Protein Domain
Type: Family
Description: Dynein-f, also known as dynein I1, is an inner-arm dynein complex comprising two different heavy chains together with a number of intermediate and light chains. In Chlamydomonas, IC97 is the intermediate chain of the Dynein-f complex. This entry includes IC97 () and its homologues, including CASC1 (also known as Dnai7) from humans []. The CAncer Susceptibility Candidate 1 (CASC1) gene is expressed in lung tissues, and is a strong candidate for the pulmonary adenoma susceptibility 1 (Pas1) locus, the major determinant of strain variation in lung tumour susceptibility []. There appears to be a strong correlation between functional polymorphism of CASC1 and lung tumour suspectibility in mice [].Different mouse strains fall into two genotype groups (susceptible and intermediate) according to differences in the 60th codon of the CASC1 gene []. The mouse CASC1 gene shares 81% similarity with the human equivalent; the role of CASC1 in human lung-cancer risk may nevertheless differ from that in mice [, ].
Protein Domain
Type: Domain
Description: This domain can be found at the C terminus of CASC1.The CAncer Susceptibility Candidate 1 (CASC1) gene is expressed in lung tissues, and is a strong candidate for the pulmonary adenoma susceptibility 1 (Pas1) locus, the major determinant of strain variation in lung tumour susceptibility []. There appears to be a strong correlation between functional polymorphism of CASC1 and lung tumour suspectibility in mice [].Different mouse strains fall into two genotype groups (susceptible and intermediate) according to differences in the 60th codon of the CASC1 gene []. The mouse CASC1 gene shares 81% similarity with the human equivalent; the role of CASC1 in human lung-cancer risk may nevertheless differ from that in mice [, ].
Protein
Organism: Mus musculus
Length: 644  
Fragment?: false
Protein
Organism: Mus musculus
Length: 679  
Fragment?: false
Protein
Organism: Mus musculus
Length: 730  
Fragment?: false
Protein Domain
Type: Domain
Description: This domain is found in CASC1 (cancer susceptibility candidate gene 1 protein) from humans and IC97 from Chlamydomonas []. There are two completely conserved residues (N and W) that may be functionally important.Dynein-f, also known as dynein I1, is an inner-arm dynein complex comprising two different heavy chains together with a number of intermediate and light chains. In Chlamydomonas, IC97 is the intermediate chain of the Dynein-f complex. This entry includes IC97 () and its homologues, including CASC1 (also known as Dnai7) from humans []. The CAncer Susceptibility Candidate 1 (CASC1) gene is expressed in lung tissues, and is a strong candidate for the pulmonary adenoma susceptibility 1 (Pas1) locus, the major determinant of strain variation in lung tumour susceptibility []. There appears to be a strong correlation between functional polymorphism of CASC1 and lung tumour suspectibility in mice [].Different mouse strains fall into two genotype groups (susceptible and intermediate) according to differences in the 60th codon of the CASC1 gene []. The mouse CASC1 gene shares 81% similarity with the human equivalent; the role of CASC1 in human lung-cancer risk may nevertheless differ from that in mice [, ].
Publication
First Author: Manenti G
Year: 2006
Journal: Carcinogenesis
Title: A V141L polymorphism of the human LRMP gene is associated with survival of lung cancer patients.
Volume: 27
Issue: 7
Pages: 1386-90
Genotype
Symbol: Casc1/Casc1
Background: involves: 129S5/SvEvBrd
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Casc1/Casc1<+>
Background: involves: 129S5/SvEvBrd
Zygosity: ht
Has Mutant Allele: true