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Search results 1 to 89 out of 89 for Catsper2

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
117155 | CATSPER2
Type: gene
Organism: human
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Gene
129135248 | CATSPER2
Type: gene
Organism: chimpanzee
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Gene
366174 | Catsper2
Type: gene
Organism: rat
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Gene
609008 | CATSPER2
Type: gene
Organism: dog, domestic
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Gene
517699 | CATSPER2
Type: gene
Organism: cattle
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Protein Coding Gene
MGI:2387404 | Catsper2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR028747 | CatSper2
Type: Family
Description: CATSPER (cationic channel of sperm) is a complex ion channel that mediates Ca2+ entry in sperm flagellum and is required for sperm hyperactivation and male fertility []. The CATSPER channel consists of four CatSper proteins (CatSper1-4) that form a tetramer surrounding a Ca(2+)-selective pore. In addition to the pore-forming proteins, the CATSPER channel contains auxiliary subunits [].All four CatSper proteins are predicted to contain a common coiled-coil protein-protein interaction domain in their C-terminal tail []and all four are required for male fertility and sperm cell hyperactivated motility []. The CatSper channel of human sperm is activated by progesterone [].This entry represents cation channel sperm-associated protein 2 (CatSper2) [].
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Publication
17227845 | J:116406
First Author: Qi H
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility.
Volume: 104
Issue: 4
Pages: 1219-23
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Publication
21224844 | J:182472
 
First Author: Chung JJ
Year: 2011
Journal: Nat Commun
Title: A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa.
Volume: 2
Pages: 153
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Gene
440278 | CATSPER2P1
Type: gene
Organism: human
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Gene
100127986 | CATSPER2P2
Type: gene
Organism: human
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Protein
A2ARP9
Organism: Mus musculus/domesticus
Length: 588  
Fragment?: false
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Publication
14657366 | J:86972
First Author: Quill TA
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Hyperactivated sperm motility driven by CatSper2 is required for fertilization.
Volume: 100
Issue: 25
Pages: 14869-74
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Publication
16036917 | J:128548
First Author: Carlson AE
Year: 2005
Journal: J Biol Chem
Title: Identical phenotypes of CatSper1 and CatSper2 null sperm.
Volume: 280
Issue: 37
Pages: 32238-44
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Publication
17174296 | J:118812
First Author: Marquez B
Year: 2007
Journal: Dev Biol
Title: Contributions of extracellular and intracellular Ca2+ to regulation of sperm motility: Release of intracellular stores can hyperactivate CatSper1 and CatSper2 null sperm.
Volume: 303
Issue: 1
Pages: 214-21
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Publication
12932298 | J:90355
 
First Author: Lobley A
Year: 2003
Journal: Reprod Biol Endocrinol
Title: Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis.
Volume: 1
Pages: 53
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Publication
11595941 | J:72046
First Author: Ren D
Year: 2001
Journal: Nature
Title: A sperm ion channel required for sperm motility and male fertility.
Volume: 413
Issue: 6856
Pages: 603-9
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Publication
21412339 | -
First Author: Lishko PV
Year: 2011
Journal: Nature
Title: Progesterone activates the principal Ca2+ channel of human sperm.
Volume: 471
Issue: 7338
Pages: 387-91
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Protein
A0A0A0MQ85
Organism: Mus musculus/domesticus
Length: 588  
Fragment?: false
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Protein
D6RCY8
Organism: Mus musculus/domesticus
Length: 134  
Fragment?: false
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Publication
12825070 | -
First Author: Avidan N
Year: 2003
Journal: Eur J Hum Genet
Title: CATSPER2, a human autosomal nonsyndromic male infertility gene.
Volume: 11
Issue: 7
Pages: 497-502
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Publication
11675491 | J:78669
First Author: Quill TA
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: A voltage-gated ion channel expressed specifically in spermatozoa.
Volume: 98
Issue: 22
Pages: 12527-31
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Protein Coding Gene
MGP_CAROLIEiJ_G0024191 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0026390 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0026351 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0026330 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0026364 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0026110 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2387404 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0026811 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0025572 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0026086 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0026225 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0026187 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0026326 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0026206 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0026866 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0025308 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0025641 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0025633 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0025107 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
19210926 | J:151121
First Author: Ho K
Year: 2009
Journal: Reprod Fertil Dev
Title: CatSper-null mutant spermatozoa are unable to ascend beyond the oviductal reservoir.
Volume: 21
Issue: 2
Pages: 345-50
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Publication
17554080 | J:128317
First Author: Xia J
Year: 2007
Journal: Biol Reprod
Title: CATSPER channel-mediated Ca2+ entry into mouse sperm triggers a tail-to-head propagation.
Volume: 77
Issue: 3
Pages: 551-9
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Publication
34225353 | J:314092
First Author: Lin S
Year: 2021
Journal: Nature
Title: Structure of a mammalian sperm cation channel complex.
Volume: 595
Issue: 7869
Pages: 746-750
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Publication
29617656 | J:263646
First Author: Horiuchi K
Year: 2018
Journal: Cell Rep
Title: Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice.
Volume: 23
Issue: 1
Pages: 143-155
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
17344468 | J:124054
First Author: Jin J
Year: 2007
Journal: Biol Reprod
Title: Catsper3 and Catsper4 are essential for sperm hyperactivated motility and male fertility in the mouse.
Volume: 77
Issue: 1
Pages: 37-44
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Publication
17317015 | -
First Author: Chen Y
Year: 2007
Journal: Neuroscience
Title: Site-directed antibodies to low-voltage-activated calcium channel CaV3.3 (alpha1I) subunit also target neural cell adhesion molecule-180.
Volume: 145
Issue: 3
Pages: 981-96
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Publication
21344408 | -
First Author: Liu XB
Year: 2011
Journal: J Comp Neurol
Title: Low-threshold calcium channel subunit Ca(v) 3.3 is specifically localized in GABAergic neurons of rodent thalamus and cerebral cortex.
Volume: 519
Issue: 6
Pages: 1181-95
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Protein Domain
IPR030162 | CACNA1I
Type: Family
Description: This entry represents the T-type voltage-dependent calcium channel alpha-1I subtype, also known as Cav3.3. Sperm-specific CatSper1 and CatSper2 proteins can associate with and modulate the function of this channel, which might be important in the regulation of sperm motility []. It may also play a role in regulating GABAergic neurons [].Voltage-dependent calcium channels (VDCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. T-type VDCC belongs to low-voltage-activated (LVA) Ca2+ channels, whereas others belong to high-voltage-activated (HVA) Ca2+ channels.VDCCs consist of subunits. The alpha-1 subunit constitute the pore region which determines the fundamental channel properties []. Three types of alpha-1 subunit have been identified in T-type VDCCs molecules: alpha-1G [], alpha-1H [], and alpha-1I []. T-currents generated by the alpha-1I subunit display slow kinetics that differ markedly from the alpha-1G and alpha-1H currents [, , ].
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Publication
16107607 | J:117731
First Author: Jin JL
Year: 2005
Journal: Biol Reprod
Title: Catsper3 and catsper4 encode two cation channel-like proteins exclusively expressed in the testis.
Volume: 73
Issue: 6
Pages: 1235-42
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Publication
32051257 | J:333286
First Author: Lv M
Year: 2020
Journal: J Med Genet
Title: Homozygous mutations in DZIP1 can induce asthenoteratospermia with severe MMAF.
Volume: 57
Issue: 7
Pages: 445-453
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Publication
9670923 | J:67141
First Author: Cribbs LL
Year: 1998
Journal: Circ Res
Title: Cloning and characterization of alpha1H from human heart, a member of the T-type Ca2+ channel gene family.
Volume: 83
Issue: 1
Pages: 103-9
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Publication
7516685 | -
First Author: Isom LL
Year: 1994
Journal: Neuron
Title: Auxiliary subunits of voltage-gated ion channels.
Volume: 12
Issue: 6
Pages: 1183-94
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Publication
10692398 | J:60930
First Author: Monteil A
Year: 2000
Journal: J Biol Chem
Title: Molecular and functional properties of the human alpha(1G) subunit that forms T-type calcium channels.
Volume: 275
Issue: 9
Pages: 6090-100
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Publication
10749850 | J:62588
First Author: Monteil A
Year: 2000
Journal: J Biol Chem
Title: Specific properties of T-type calcium channels generated by the human alpha 1I subunit.
Volume: 275
Issue: 22
Pages: 16530-5
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Publication
10594642 | -
First Author: Klöckner U
Year: 1999
Journal: Eur J Neurosci
Title: Comparison of the Ca2 + currents induced by expression of three cloned alpha1 subunits, alpha1G, alpha1H and alpha1I, of low-voltage-activated T-type Ca2 + channels.
Volume: 11
Issue: 12
Pages: 4171-8
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Publication
11073957 | -
First Author: McRory JE
Year: 2001
Journal: J Biol Chem
Title: Molecular and functional characterization of a family of rat brain T-type calcium channels.
Volume: 276
Issue: 6
Pages: 3999-4011
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Protein
Q99M83
Organism: Mus musculus/domesticus
Length: 174  
Fragment?: true
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Protein
F6V0N5
Organism: Mus musculus/domesticus
Length: 260  
Fragment?: true
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Protein
E9Q7P2
Organism: Mus musculus/domesticus
Length: 2199  
Fragment?: false
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Protein
E0CXK2
Organism: Mus musculus/domesticus
Length: 1835  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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