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Search results 1 to 88 out of 88 for Catsper2

0.032s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Domain
Type: Family
Description: CATSPER (cationic channel of sperm) is a complex ion channel that mediates Ca2+ entry in sperm flagellum and is required for sperm hyperactivation and male fertility []. The CATSPER channel consists of four CatSper proteins (CatSper1-4) that form a tetramer surrounding a Ca(2+)-selective pore. In addition to the pore-forming proteins, the CATSPER channel contains auxiliary subunits [].All four CatSper proteins are predicted to contain a common coiled-coil protein-protein interaction domain in their C-terminal tail []and all four are required for male fertility and sperm cell hyperactivated motility []. The CatSper channel of human sperm is activated by progesterone [].This entry represents cation channel sperm-associated protein 2 (CatSper2) [].
Publication
First Author: Qi H
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility.
Volume: 104
Issue: 4
Pages: 1219-23
Publication  
First Author: Chung JJ
Year: 2011
Journal: Nat Commun
Title: A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa.
Volume: 2
Pages: 153
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Protein
Organism: Mus musculus/domesticus
Length: 588  
Fragment?: false
Publication
First Author: Quill TA
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Hyperactivated sperm motility driven by CatSper2 is required for fertilization.
Volume: 100
Issue: 25
Pages: 14869-74
Publication
First Author: Carlson AE
Year: 2005
Journal: J Biol Chem
Title: Identical phenotypes of CatSper1 and CatSper2 null sperm.
Volume: 280
Issue: 37
Pages: 32238-44
Publication
First Author: Marquez B
Year: 2007
Journal: Dev Biol
Title: Contributions of extracellular and intracellular Ca2+ to regulation of sperm motility: Release of intracellular stores can hyperactivate CatSper1 and CatSper2 null sperm.
Volume: 303
Issue: 1
Pages: 214-21
Publication  
First Author: Lobley A
Year: 2003
Journal: Reprod Biol Endocrinol
Title: Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis.
Volume: 1
Pages: 53
Publication
First Author: Ren D
Year: 2001
Journal: Nature
Title: A sperm ion channel required for sperm motility and male fertility.
Volume: 413
Issue: 6856
Pages: 603-9
Publication
First Author: Lishko PV
Year: 2011
Journal: Nature
Title: Progesterone activates the principal Ca2+ channel of human sperm.
Volume: 471
Issue: 7338
Pages: 387-91
Protein
Organism: Mus musculus/domesticus
Length: 588  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 134  
Fragment?: false
Publication
First Author: Avidan N
Year: 2003
Journal: Eur J Hum Genet
Title: CATSPER2, a human autosomal nonsyndromic male infertility gene.
Volume: 11
Issue: 7
Pages: 497-502
Publication
First Author: Quill TA
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: A voltage-gated ion channel expressed specifically in spermatozoa.
Volume: 98
Issue: 22
Pages: 12527-31
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Ho K
Year: 2009
Journal: Reprod Fertil Dev
Title: CatSper-null mutant spermatozoa are unable to ascend beyond the oviductal reservoir.
Volume: 21
Issue: 2
Pages: 345-50
Publication
First Author: Xia J
Year: 2007
Journal: Biol Reprod
Title: CATSPER channel-mediated Ca2+ entry into mouse sperm triggers a tail-to-head propagation.
Volume: 77
Issue: 3
Pages: 551-9
Publication
First Author: Lin S
Year: 2021
Journal: Nature
Title: Structure of a mammalian sperm cation channel complex.
Volume: 595
Issue: 7869
Pages: 746-750
Publication
First Author: Horiuchi K
Year: 2018
Journal: Cell Rep
Title: Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice.
Volume: 23
Issue: 1
Pages: 143-155
Publication
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
Publication      
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication
First Author: Jin J
Year: 2007
Journal: Biol Reprod
Title: Catsper3 and Catsper4 are essential for sperm hyperactivated motility and male fertility in the mouse.
Volume: 77
Issue: 1
Pages: 37-44
Publication
First Author: Chen Y
Year: 2007
Journal: Neuroscience
Title: Site-directed antibodies to low-voltage-activated calcium channel CaV3.3 (alpha1I) subunit also target neural cell adhesion molecule-180.
Volume: 145
Issue: 3
Pages: 981-96
Publication
First Author: Liu XB
Year: 2011
Journal: J Comp Neurol
Title: Low-threshold calcium channel subunit Ca(v) 3.3 is specifically localized in GABAergic neurons of rodent thalamus and cerebral cortex.
Volume: 519
Issue: 6
Pages: 1181-95
Protein Domain
Type: Family
Description: This entry represents the T-type voltage-dependent calcium channel alpha-1I subtype, also known as Cav3.3. Sperm-specific CatSper1 and CatSper2 proteins can associate with and modulate the function of this channel, which might be important in the regulation of sperm motility []. It may also play a role in regulating GABAergic neurons [].Voltage-dependent calcium channels (VDCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. T-type VDCC belongs to low-voltage-activated (LVA) Ca2+ channels, whereas others belong to high-voltage-activated (HVA) Ca2+ channels.VDCCs consist of subunits. The alpha-1 subunit constitute the pore region which determines the fundamental channel properties []. Three types of alpha-1 subunit have been identified in T-type VDCCs molecules: alpha-1G [], alpha-1H [], and alpha-1I []. T-currents generated by the alpha-1I subunit display slow kinetics that differ markedly from the alpha-1G and alpha-1H currents [, , ].
Publication
First Author: Jin JL
Year: 2005
Journal: Biol Reprod
Title: Catsper3 and catsper4 encode two cation channel-like proteins exclusively expressed in the testis.
Volume: 73
Issue: 6
Pages: 1235-42
Publication
First Author: Lv M
Year: 2020
Journal: J Med Genet
Title: Homozygous mutations in DZIP1 can induce asthenoteratospermia with severe MMAF.
Volume: 57
Issue: 7
Pages: 445-453
Publication
First Author: Cribbs LL
Year: 1998
Journal: Circ Res
Title: Cloning and characterization of alpha1H from human heart, a member of the T-type Ca2+ channel gene family.
Volume: 83
Issue: 1
Pages: 103-9
Publication
First Author: Isom LL
Year: 1994
Journal: Neuron
Title: Auxiliary subunits of voltage-gated ion channels.
Volume: 12
Issue: 6
Pages: 1183-94
Publication
First Author: Monteil A
Year: 2000
Journal: J Biol Chem
Title: Molecular and functional properties of the human alpha(1G) subunit that forms T-type calcium channels.
Volume: 275
Issue: 9
Pages: 6090-100
Publication
First Author: Monteil A
Year: 2000
Journal: J Biol Chem
Title: Specific properties of T-type calcium channels generated by the human alpha 1I subunit.
Volume: 275
Issue: 22
Pages: 16530-5
Publication
First Author: Klöckner U
Year: 1999
Journal: Eur J Neurosci
Title: Comparison of the Ca2 + currents induced by expression of three cloned alpha1 subunits, alpha1G, alpha1H and alpha1I, of low-voltage-activated T-type Ca2 + channels.
Volume: 11
Issue: 12
Pages: 4171-8
Publication
First Author: McRory JE
Year: 2001
Journal: J Biol Chem
Title: Molecular and functional characterization of a family of rat brain T-type calcium channels.
Volume: 276
Issue: 6
Pages: 3999-4011
Protein
Organism: Mus musculus/domesticus
Length: 174  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 260  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 2199  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1835  
Fragment?: false