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Search results 1 to 100 out of 1152 for Cd34

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0.088s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: The CD34 group of monoclonal antibodies recognises CD34 (also termed CD34antigen), a 105-120kDa cell surface glycoprotein, which is selectively expressed by human myeloid and lymphoid progenitor cells, including the haemopoietic stem cell. The protein is also expressed on vascularendothelial cells. Here, it is concentrated on the surface of the inter-digitating processes, suggesting a possible involvement in cell interactionsor adhesion, by mediating the attachment of stem cells to the bone marrow extracellular matrix, or directly to stromal cells. The restricted patternof expression of CD34 in haemopoiesis suggests that it may have a significant function in the earliest stages of blood cell differentiation in the bone marrow [, ].CD34 is a phosphoprotein shown to be activated by protein kinase C (PKC) ina developmental stage-specific manner. Analysis of the human CD34 sequencereveals that the protein appears to be a type I transmembrane (TM) molecule.The predicted internal portion of the protein appears to retain basic amino acid residues adjacent to Ser residues, presenting at least two potentialtarget sites for PKC phosphorylation. In addition, there are two other consensus motifs that correspond to potential target sites for Ca+/calmodulin-dependent kinase and/or protease activated kinase I [].The protein is not strongly similar to other known proteins, but some weaksimilarities do exist: e.g., to the S+T region (a region rich in potentialO-linked carbohydrate attachment sites), the TM domain and cytoplasmic domain of cell surface proteins such as leukosialin, a major sialoglyco-protein of rat and human leukocytes; to the N-terminal glycosylated regionof CD45 (the leukocyte common antigen); and to groups of interrelatedproteins involved in cell adhesion or the regulation of complement.A homologue of human CD34 is expressed in mouse. The amino acid sequencesonly diverge significantly at their N-termini, which are predicted to be highly glycosylated and whose functions are probably modulated by carbohydrate. The observed pattern of expression of the murine CD34 geneis consistent with that of the human antigen. That CD34 is also highlyexpressed outside haematopoiesis, by vascular endothelial cells and by fibroblasts in differentiated tissue, suggests a role common to a varietyof cell types. Concentration of CD34 on the interdigitating membraneprojections of adjacent capillary endothelial cells has strengthened theidea that it functions in the control of events leading to cell-cell orcell-matrix adhesion, which role could be modulated by variation in itslevels of glycosylation. The conservation between the human and mousecysteine-rich domain in the extracellular part of the protein, and theexceptionally high conservation of the cytoplasmic domain, imply that theprotein is more than a carrier for either carbohydrate or negatively chargedterminal sialic acid residues (a role postulated for leukosialin/sialophorin).The highly conserved domain may serve to provide an internal signal of external contact with a ligand.
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Brown J
Year: 1991
Journal: Int Immunol
Title: The gene encoding the stem cell antigen, CD34, is conserved in mouse and expressed in haemopoietic progenitor cell lines, brain, and embryonic fibroblasts.
Volume: 3
Issue: 2
Pages: 175-84
GXD Expression
Probe: MGI:3723030
Assay Type: Immunohistochemistry
Annotation Date: 2021-03-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3787628
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6512408
Age: postnatal
Image: 6H CD34
Note: Expression in stem cells of bulge region.
Specimen Label: 6H CD34
Detected: true
Specimen Num: 1
Protein
Organism: Mus musculus
Length: 382  
Fragment?: false
GXD Expression
Probe: MGI:2177286
Assay Type: Immunohistochemistry
Annotation Date: 2007-05-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3517627
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3708084
Age: postnatal newborn
Image: 5A CD34 -/-
Note: Expression was detected as in wild type.
Specimen Label: 5A CD34 -/-
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:1059300
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:2622022
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3826005
Age: embryonic day 14.5
Image: Additional file 4 Cd34
Specimen Label: Additional file 4 Cd34
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:2177286
Assay Type: Immunohistochemistry
Annotation Date: 2007-05-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3517627
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3708084
Age: postnatal newborn
Image: 5A CD34 +/+
Specimen Label: 5A CD34 +/+
Detected: true
Specimen Num: 1
Publication
First Author: Fackler MJ
Year: 1990
Journal: J Biol Chem
Title: Activated protein kinase C directly phosphorylates the CD34 antigen on hematopoietic cells.
Volume: 265
Issue: 19
Pages: 11056-61
Publication
First Author: Blanchet MR
Year: 2007
Journal: Blood
Title: CD34 facilitates the development of allergic asthma.
Volume: 110
Issue: 6
Pages: 2005-12
Protein
Organism: Mus musculus
Length: 382  
Fragment?: false
Protein
Organism: Mus musculus
Length: 382  
Fragment?: false
Protein
Organism: Mus musculus
Length: 325  
Fragment?: false
Protein
Organism: Mus musculus
Length: 325  
Fragment?: false
Publication
First Author: Lortie K
Year: 2018
Journal: Am J Respir Cell Mol Biol
Title: CD34 Differentially Regulates Contractile and Noncontractile Elements of Airway Reactivity.
Volume: 58
Issue: 1
Pages: 79-88
Publication
First Author: Suda J
Year: 1992
Journal: Blood
Title: Two types of murine CD34 mRNA generated by alternative splicing.
Volume: 79
Issue: 9
Pages: 2288-95
Publication
First Author: Siemerink MJ
Year: 2016
Journal: PLoS One
Title: CD34 Promotes Pathological Epi-Retinal Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy.
Volume: 11
Issue: 6
Pages: e0157902
Publication
First Author: Drew E
Year: 2005
Journal: Immunity
Title: CD34 and CD43 inhibit mast cell adhesion and are required for optimal mast cell reconstitution.
Volume: 22
Issue: 1
Pages: 43-57
Publication
First Author: Trempus CS
Year: 2007
Journal: Cancer Res
Title: CD34 expression by hair follicle stem cells is required for skin tumor development in mice.
Volume: 67
Issue: 9
Pages: 4173-81
Publication
First Author: Maltby S
Year: 2011
Journal: PLoS One
Title: Opposing roles for CD34 in B16 melanoma tumor growth alter early stage vasculature and late stage immune cell infiltration.
Volume: 6
Issue: 4
Pages: e18160
Strain
Attribute String: targeted mutation, mutant strain, congenic
Publication
First Author: Maltby S
Year: 2010
Journal: Am J Pathol
Title: CD34 is required for infiltration of eosinophils into the colon and pathology associated with DSS-induced ulcerative colitis.
Volume: 177
Issue: 3
Pages: 1244-54
GXD Expression  
Probe: MGI:1059300
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4823727
Age: embryonic day 14.5
Note: Expression is present in single cells in which the intercellular distance between stained cells is larger than or equal to the cell diameter of an individual cell. A thumbnail photo of the staining is contained in the table.
Specimen Label: Table S9 - Cd34
Detected: true
Specimen Num: 1
Publication
First Author: Alfaro LA
Year: 2011
Journal: Stem Cells
Title: CD34 promotes satellite cell motility and entry into proliferation to facilitate efficient skeletal muscle regeneration.
Volume: 29
Issue: 12
Pages: 2030-41
Publication
First Author: Blanchet MR
Year: 2010
Journal: J Immunol
Title: Loss of CD34 leads to exacerbated autoimmune arthritis through increased vascular permeability.
Volume: 184
Issue: 3
Pages: 1292-9
Publication
First Author: Okuno Y
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Differential regulation of the human and murine CD34 genes in hematopoietic stem cells.
Volume: 99
Issue: 9
Pages: 6246-51
Publication
First Author: Ito A
Year: 1995
Journal: Lab Invest
Title: Enhanced expression of CD34 messenger RNA by developing endothelial cells of mice.
Volume: 72
Issue: 5
Pages: 532-8
Publication
First Author: Morel F
Year: 1996
Journal: Blood
Title: Primitive hematopoietic cells in murine bone marrow express the CD34 antigen.
Volume: 88
Issue: 10
Pages: 3774-84
Publication
First Author: Young PE
Year: 1995
Journal: Blood
Title: The sialomucin CD34 is expressed on hematopoietic cells and blood vessels during murine development.
Volume: 85
Issue: 1
Pages: 96-105
Publication
First Author: Lin G
Year: 1995
Journal: Eur J Immunol
Title: Expression of CD34 in endothelial cells, hematopoietic progenitors and nervous cells in fetal and adult mouse tissues.
Volume: 25
Issue: 6
Pages: 1508-16
Publication
First Author: Suzuki A
Year: 1996
Journal: Blood
Title: CD34-deficient mice have reduced eosinophil accumulation after allergen exposure and show a novel crossreactive 90-kD protein.
Volume: 87
Issue: 9
Pages: 3550-62
Publication
First Author: Howell SM
Year: 1991
Journal: Hum Genet
Title: Localisation of the gene coding for the haemopoietic stem cell antigen CD34 to chromosome 1q32.
Volume: 87
Issue: 5
Pages: 625-7
Publication
First Author: Krause DS
Year: 1998
Journal: Exp Hematol
Title: CD34 expression by embryonic hematopoietic and endothelial cells does not require c-Myb.
Volume: 26
Issue: 11
Pages: 1086-92
Publication
First Author: Wood HB
Year: 1997
Journal: Blood
Title: CD34 expression patterns during early mouse development are related to modes of blood vessel formation and reveal additional sites of hematopoiesis.
Volume: 90
Issue: 6
Pages: 2300-11
MGI Directed Relationship Property
Name: Non-mouse_Gene_Symbol
Value: CD34
MGI Directed Relationship Property
Name: Non-mouse_Gene_Symbol
Value: CD34
Publication      
First Author: The RIKEN BioResource Center
Year: 2006
Journal: Unpublished
Title: Information obtained from The RIKEN BioResource Center
Allele
Name: transgene insertion 1, Yoichiro Iwakura
Allele Type: Transgenic
Attribute String: Recombinase
Strain
Attribute String: transgenic, mutant strain
Publication
First Author: Cheng J
Year: 1996
Journal: Blood
Title: Hematopoietic defects in mice lacking the sialomucin CD34.
Volume: 87
Issue: 2
Pages: 479-90
Publication
First Author: Beauchamp JR
Year: 2000
Journal: J Cell Biol
Title: Expression of CD34 and Myf5 defines the majority of quiescent adult skeletal muscle satellite cells.
Volume: 151
Issue: 6
Pages: 1221-34
Publication
First Author: Levantini E
Year: 2011
Journal: EMBO J
Title: RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element.
Volume: 30
Issue: 19
Pages: 4059-70
Publication
First Author: Lo BC
Year: 2017
Journal: Am J Respir Cell Mol Biol
Title: Loss of Vascular CD34 Results in Increased Sensitivity to Lung Injury.
Volume: 57
Issue: 6
Pages: 651-661
Publication
First Author: Sassetti C
Year: 2000
Journal: J Biol Chem
Title: Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins.
Volume: 275
Issue: 12
Pages: 9001-10
Publication
First Author: Yang Z
Year: 2016
Journal: Dev Biol
Title: Role of CD34 family members in lumen formation in the developing kidney.
Volume: 418
Issue: 1
Pages: 66-74
Publication
First Author: Ema M
Year: 2006
Journal: Blood
Title: Primitive erythropoiesis from mesodermal precursors expressing VE-cadherin, PECAM-1, Tie2, endoglin, and CD34 in the mouse embryo.
Volume: 108
Issue: 13
Pages: 4018-24
Publication
First Author: Doyonnas R
Year: 2005
Journal: Blood
Title: Podocalyxin is a CD34-related marker of murine hematopoietic stem cells and embryonic erythroid cells.
Volume: 105
Issue: 11
Pages: 4170-8
Publication
First Author: McSweeney PA
Year: 1996
Journal: Blood
Title: Canine CD34: cloning of the cDNA and evaluation of an antiserum to recombinant protein.
Volume: 88
Issue: 6
Pages: 1992-2003
Publication
First Author: Krause DS
Year: 1994
Journal: Blood
Title: Characterization of murine CD34, a marker for hematopoietic progenitor and stem cells.
Volume: 84
Issue: 3
Pages: 691-701
Publication
First Author: Krause DS
Year: 1997
Journal: Exp Hematol
Title: Regulation of CD34 expression in differentiating M1 cells.
Volume: 25
Issue: 10
Pages: 1051-61
Publication
First Author: Bennett JL
Year: 2009
Journal: J Immunol
Title: Bone marrow-derived mast cells accumulate in the central nervous system during inflammation but are dispensable for experimental autoimmune encephalomyelitis pathogenesis.
Volume: 182
Issue: 9
Pages: 5507-14
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Chamoto K
Year: 2012
Journal: Am J Respir Cell Mol Biol
Title: CD34+ progenitor to endothelial cell transition in post-pneumonectomy angiogenesis.
Volume: 46
Issue: 3
Pages: 283-9
GXD Expression    
Probe: MGI:1329052
Assay Type: RT-PCR
Annotation Date: 1999-02-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:1329062
Age: embryonic day 8.5
Image: 1
Specimen Label: +/-
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:1329052
Assay Type: RT-PCR
Annotation Date: 1999-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:1329797
Age: embryonic day 10.5
Image: 4
Specimen Label: Control
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:2179416
Assay Type: RT-PCR
Annotation Date: 2002-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:2179413
Age: embryonic day 9.5
Image: 5
Specimen Label: +
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:1329052
Assay Type: RT-PCR
Annotation Date: 2003-08-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1624715
Stage: TS15
Assay Id: MGI:2670383
Age: embryonic day 9.5
Specimen Label: 9
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:1329052
Assay Type: RT-PCR
Annotation Date: 2003-08-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1641115
Stage: TS15
Assay Id: MGI:2670383
Age: embryonic day 9.5
Specimen Label: 9
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:1329052
Assay Type: RT-PCR
Annotation Date: 2003-08-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1624716
Stage: TS16
Assay Id: MGI:2670383
Age: embryonic day 10.0
Specimen Label: 9.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:1329052
Assay Type: RT-PCR
Annotation Date: 2003-08-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1641116
Stage: TS16
Assay Id: MGI:2670383
Age: embryonic day 10.0
Specimen Label: 9.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:1329052
Assay Type: RT-PCR
Annotation Date: 2003-08-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1624719
Stage: TS19
Assay Id: MGI:2670383
Age: embryonic day 11.5
Specimen Label: 11
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:1329052
Assay Type: RT-PCR
Annotation Date: 2003-08-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608515
Stage: TS15
Assay Id: MGI:2670391
Age: embryonic day 9.5
Specimen Label: 9
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:1329052
Assay Type: RT-PCR
Annotation Date: 2003-08-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608518
Stage: TS18
Assay Id: MGI:2670391
Age: embryonic day 11.0
Specimen Label: 10.5
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:1329052
Assay Type: RT-PCR
Annotation Date: 2003-08-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608520
Stage: TS20
Assay Id: MGI:2670391
Age: embryonic day 12.5
Specimen Label: 12
Detected: true
Specimen Num: 6
GXD Expression        
Probe: MGI:1329052
Assay Type: RT-PCR
Annotation Date: 2003-08-26
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2670400
Age: postnatal adult
Specimen Label: Li
Specimen Num: 1
GXD Expression      
Probe: MGI:1329052
Assay Type: RT-PCR
Annotation Date: 2003-08-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684618
Stage: TS18
Assay Id: MGI:2670407
Age: embryonic day 11.0
Specimen Label: 10.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:1329052
Assay Type: RT-PCR
Annotation Date: 2003-08-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684620
Stage: TS20
Assay Id: MGI:2670407
Age: embryonic day 12.5
Specimen Label: 12
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:1329052
Assay Type: RT-PCR
Annotation Date: 2003-08-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:2670407
Age: embryonic day 14.5
Specimen Label: 14
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:1329052
Assay Type: RT-PCR
Annotation Date: 2003-08-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1789021
Stage: TS21
Assay Id: MGI:2670410
Age: embryonic day 13.5
Specimen Label: None
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:1329052
Assay Type: RT-PCR
Annotation Date: 2003-08-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684620
Stage: TS20
Assay Id: MGI:2670410
Age: embryonic day 12.5
Specimen Label: None
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:1329052
Assay Type: RT-PCR
Annotation Date: 2003-08-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:2670410
Age: embryonic day 14.5
Specimen Label: None
Detected: true
Specimen Num: 8
GXD Expression        
Probe: MGI:2179416
Assay Type: RT-PCR
Annotation Date: 2004-10-13
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:3054455
Age: embryonic day 9.5
Specimen Label: E9.5
Specimen Num: 4
GXD Expression    
Probe: MGI:5576014
Assay Type: RT-PCR
Annotation Date: 2014-08-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1786622
Stage: TS22
Assay Id: MGI:5576057
Age: embryonic day 14.5
Image: 4
Specimen Label: ko
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6163837
Assay Type: Northern blot
Annotation Date: 2018-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:6163839
Age: embryonic day 10.0
Specimen Label: 10 days p.c. Placenta
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6163837
Assay Type: Northern blot
Annotation Date: 2018-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:6163839
Age: embryonic day 18.0
Specimen Label: 18 days p.c. Placenta
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6163837
Assay Type: Northern blot
Annotation Date: 2018-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:6163839
Age: embryonic day 14.0
Specimen Label: 14 days p.c. Embryo
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6163837
Assay Type: Northern blot
Annotation Date: 2018-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:6163839
Age: embryonic day 14.0
Specimen Label: 14 days p.c. Liver
Detected: true
Specimen Num: 7
GXD Expression        
Probe: MGI:6163837
Assay Type: Northern blot
Annotation Date: 2018-07-02
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6163839
Age: postnatal day 14
Specimen Label: 14 days p.p. Liver
Specimen Num: 9
GXD Expression      
Probe: MGI:6163837
Assay Type: Northern blot
Annotation Date: 2018-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6163839
Age: postnatal day 14
Specimen Label: 14 days p.p. Kidney
Detected: true
Specimen Num: 11