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Search results 1 to 43 out of 43 for Cdc50b

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Type Details Score
Protein
Q8BHG3
Organism: Mus musculus/domesticus
Length: 353  
Fragment?: false
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Publication
15375526 | -
First Author: Katoh Y
Year: 2004
Journal: Oncol Rep
Title: Identification and characterization of CDC50A, CDC50B and CDC50C genes in silico.
Volume: 12
Issue: 4
Pages: 939-43
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Publication
12880872 | -
First Author: Harris MJ
Year: 2003
Journal: Biochim Biophys Acta
Title: FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body.
Volume: 1633
Issue: 2
Pages: 127-31
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Publication
17998437 | -
First Author: Li H
Year: 2008
Journal: Arch Neurol
Title: Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease.
Volume: 65
Issue: 1
Pages: 45-53
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Protein Domain
IPR030347 | ATP8B2
Type: Family
Description: Phospholipid-transporting ATPase ID (also known as ATP8B2 or ATPID) belongs to the IV subfamily of the P-type ATPases family, whose members transport phospholipids across the membrane. The function of ATP8B2 is not clear. It can bind either CDC50A or CDC50B as its accessory protein required for its function []. ATP8B2 is expressed throughout the body [].
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Protein Domain
IPR030348 | ATP8B4
Type: Family
Description: Probable phospholipid-transporting ATPase IM (also known as ATP8B4) belongs to subfamily IV of the P-type ATPases family, whose members transport phospholipids across the membrane. It appears to be a component of a P4-ATPase flippase complex and can bind either CDC50A or CDC50B as its accessory protein []. ATPase IM is expressed throughout the brain and may be involved in Alzheimer's disease [].
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Publication
17258408 | -
First Author: Osada N
Year: 2007
Journal: Gene
Title: Aberrant termination of reproduction-related TMEM30C transcripts in the hominoids.
Volume: 392
Issue: 1-2
Pages: 151-6
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Publication
17928922 | -
First Author: Xu P
Year: 2007
Journal: Acta Biochim Biophys Sin (Shanghai)
Title: Characterization and expression of mouse Cdc50c during spermatogenesis.
Volume: 39
Issue: 10
Pages: 739-44
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Protein Domain
IPR030353 | TMEM30C
Type: Family
Description: Cell cycle control protein 50C (CDC50C, also known as TMEM30C) is one of the CDC50 (CDC50A/B/C) proteins []. CDC50A and CDC50B are accessory components of the phospholipid-transporting ATPase (P4-ATPase) complex which catalyses the hydrolysis of ATP coupled to the transport of phospholipids across the membrane []. The function of CDC50C is not clear. Unlike the broad expression of CDC50A and CDC50B, CDC50C is expressed specifically in mouse testis [, ]. However, no full-length transcripts of CDC50C have been found in humans [].
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Publication
20961850 | -
First Author: Bryde S
Year: 2010
Journal: J Biol Chem
Title: CDC50 proteins are critical components of the human class-1 P4-ATPase transport machinery.
Volume: 285
Issue: 52
Pages: 40562-72
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Publication
14975727 | J:88796
First Author: Wang L
Year: 2004
Journal: Dev Biol
Title: A novel aminophospholipid transporter exclusively expressed in spermatozoa is required for membrane lipid asymmetry and normal fertilization.
Volume: 267
Issue: 1
Pages: 203-15
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Protein
F6WT01
Organism: Mus musculus/domesticus
Length: 145  
Fragment?: true
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Protein
E9Q491
Organism: Mus musculus/domesticus
Length: 72  
Fragment?: true
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Protein Domain
IPR030349 | ATP8B3
Type: Family
Description: Phospholipid-transporting ATPase IK (also known as ATP8B3 orATP1K) belongs to the subfamily IV of the P-type ATPases family, whose members transport phospholipids across the membrane. The function of ATP8B3 is not clear. Unlike other type IV members (ATP8B1,2,4), ATP8B3 does not seem to interact with either CDC50A or CDC50B []. It is exclusively expressed in the testis where it localises to the acrosomes of spermatids, the organelle which develops in the anterior half of the head of spermatozoa []. However, the disruption of ATP8B3 in mice does not affect sperm morphology or fertilisation rate [].
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Publication
21820390 | -
First Author: Groen A
Year: 2011
Journal: Gastroenterology
Title: Complementary functions of the flippase ATP8B1 and the floppase ABCB4 in maintaining canalicular membrane integrity.
Volume: 141
Issue: 5
Pages: 1927-37.e1-4
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Protein
Q923U1
Organism: Mus musculus/domesticus
Length: 103  
Fragment?: true
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Publication
9500542 | -
First Author: Bull LN
Year: 1998
Journal: Nat Genet
Title: A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis.
Volume: 18
Issue: 3
Pages: 219-24
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Publication
20512993 | -
First Author: Verhulst PM
Year: 2010
Journal: Hepatology
Title: A flippase-independent function of ATP8B1, the protein affected in familial intrahepatic cholestasis type 1, is required for apical protein expression and microvillus formation in polarized epithelial cells.
Volume: 51
Issue: 6
Pages: 2049-60
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Publication
17948906 | -
First Author: Paulusma CC
Year: 2008
Journal: Hepatology
Title: ATP8B1 requires an accessory protein for endoplasmic reticulum exit and plasma membrane lipid flippase activity.
Volume: 47
Issue: 1
Pages: 268-78
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Publication
27301931 | J:251366
First Author: van der Mark VA
Year: 2016
Journal: Biochim Biophys Acta
Title: The phospholipid flippase ATP8B1 mediates apical localization of the cystic fibrosis transmembrane regulator.
Volume: 1863
Issue: 9
Pages: 2280-8
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Protein Domain
IPR030346 | ATP8B1
Type: Family
Description: Phospholipid-transporting ATPase IC (also known as ATP8B1 or ATPIC) belongs to subfamily IV of the P-type ATPases family, whose members transport phospholipids across the membrane. ATP8B1 can bind either CDC50A or CDC50B as its accessory protein for endoplasmic reticulum exit and plasma membrane lipid flippase activity [, , ].In hepatocytes, ATP8B1 localises in the canalicular membrane, where it may maintain the membrane integrity and to the function of ABCB4, an ABC floppase that play a role in bile export []. In the epithelial Caco-2 cells, ATP8B1 is required for apical protein expression and microvillus formation in polarised epithelial cells []. Mutations in ATP8B1 cause two forms of intrahepatic cholestasis, progressive familial intrahepatic cholestasis (PFIC) and benign recurrent intrahepatic cholestasis (BFIC) []. It is involved in the correct apical membrane localization of CDC42, CFTR and SLC10A2 [].
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Publication
20947505 | -
First Author: van der Velden LM
Year: 2010
Journal: J Biol Chem
Title: Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases.
Volume: 285
Issue: 51
Pages: 40088-96
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Protein
Q9D4D7
Organism: Mus musculus/domesticus
Length: 342  
Fragment?: false
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Publication
23269685 | J:197107
First Author: Kato U
Year: 2013
Journal: J Biol Chem
Title: Role for phospholipid flippase complex of ATP8A1 and CDC50A proteins in cell migration.
Volume: 288
Issue: 7
Pages: 4922-34
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Publication
19017724 | J:150226
First Author: Gong EY
Year: 2009
Journal: Reproduction
Title: Expression of Atp8b3 in murine testis and its characterization as a testis specific P-type ATPase.
Volume: 137
Issue: 2
Pages: 345-51
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Protein
F6SPT4
Organism: Mus musculus/domesticus
Length: 86  
Fragment?: true
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Protein
A9C448
Organism: Mus musculus/domesticus
Length: 292  
Fragment?: false
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Protein
E9Q8R2
Organism: Mus musculus/domesticus
Length: 112  
Fragment?: true
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Protein
E9Q114
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: true
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Protein
F6QLG1
Organism: Mus musculus/domesticus
Length: 169  
Fragment?: true
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Protein
A0A494BB33
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: true
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Protein
A1L3S5
Organism: Mus musculus/domesticus
Length: 553  
Fragment?: false
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Protein
Q0VF52
Organism: Mus musculus/domesticus
Length: 857  
Fragment?: false
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Protein
F2Z411
Organism: Mus musculus/domesticus
Length: 435  
Fragment?: false
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Protein
A2ANX2
Organism: Mus musculus/domesticus
Length: 426  
Fragment?: true
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Protein
Q69ZR1
Organism: Mus musculus/domesticus
Length: 923  
Fragment?: true
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Protein
P98199
Organism: Mus musculus/domesticus
Length: 1209  
Fragment?: false
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Protein
Q148W0
Organism: Mus musculus/domesticus
Length: 1251  
Fragment?: false
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Protein
Q6UQ17
Organism: Mus musculus/domesticus
Length: 1335  
Fragment?: false
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Protein
D3YXQ5
Organism: Mus musculus/domesticus
Length: 1214  
Fragment?: false
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Protein
E9QAL4
Organism: Mus musculus/domesticus
Length: 1190  
Fragment?: false
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Protein
Q69Z59
Organism: Mus musculus/domesticus
Length: 798  
Fragment?: true
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Protein
A2ANX3
Organism: Mus musculus/domesticus
Length: 1194  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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