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Search results 1 to 100 out of 507 for Cdh23

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chicken
Protein Domain
Type: Family
Description: Cadherin-23 (CDH23) is an adhesion protein that contains several calcium dependent extracellular (EC) domains. It is required for establishing and/or maintaining the proper organisation of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development []. CDH23 is part of the tip-links, oblique filaments that interconnect the stereocilia of the hair bundle []. CDH23 is associated with Usher syndrome type 1 (USH1D), isolated deafness (DFNB12) in humans, and deafness and circling behavior in waltzer mice [, ].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Lagziel A
Year: 2005
Journal: Dev Biol
Title: Spatiotemporal pattern and isoforms of cadherin 23 in wild type and waltzer mice during inner ear hair cell development.
Volume: 280
Issue: 2
Pages: 295-306
Publication
First Author: Bolz H
Year: 2001
Journal: Nat Genet
Title: Mutation of CDH23, encoding a new member of the cadherin gene family, causes Usher syndrome type 1D.
Volume: 27
Issue: 1
Pages: 108-12
Publication
First Author: Caberlotto E
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia.
Volume: 108
Issue: 14
Pages: 5825-30
Gene
Type: gene
Organism: human
Publication      
First Author: Balan S
Year: 2021
Journal: Schizophr Bull
Title: Role of an Atypical Cadherin Gene, Cdh23 in Prepulse Inhibition, and Implication of CDH23 in Schizophrenia.
Publication
First Author: Sengupta S
Year: 2009
Journal: J Biol Chem
Title: EHD4 and CDH23 are interacting partners in cochlear hair cells.
Volume: 284
Issue: 30
Pages: 20121-9
Publication
First Author: Wilson SM
Year: 2001
Journal: Genomics
Title: Mutations in Cdh23 cause nonsyndromic hearing loss in waltzer mice.
Volume: 74
Issue: 2
Pages: 228-33
Publication
First Author: Kane KL
Year: 2012
Journal: Hear Res
Title: Genetic background effects on age-related hearing loss associated with Cdh23 variants in mice.
Volume: 283
Issue: 1-2
Pages: 80-8
Publication      
First Author: Harris BS
Year: 2005
Journal: MGI Direct Data Submission
Title: Waltzer 7 Jackson, a remutation of the Cdh23 gene
Publication  
First Author: Watson CJ
Year: 2013
Journal: Hear Res
Title: A new Atp2b2 deafwaddler allele, dfw(i5), interacts strongly with Cdh23 and other auditory modifiers.
Volume: 304
Pages: 41-8
Publication
First Author: Liu S
Year: 2012
Journal: Gene
Title: A mutation in the cdh23 gene causes age-related hearing loss in Cdh23(nmf308/nmf308) mice.
Volume: 499
Issue: 2
Pages: 309-17
Publication
First Author: Johnson KR
Year: 2010
Journal: Hear Res
Title: Separate and combined effects of Sod1 and Cdh23 mutations on age-related hearing loss and cochlear pathology in C57BL/6J mice.
Volume: 268
Issue: 1-2
Pages: 85-92
Publication
First Author: Manji SS
Year: 2011
Journal: Am J Pathol
Title: An ENU-induced mutation of Cdh23 causes congenital hearing loss, but no vestibular dysfunction, in mice.
Volume: 179
Issue: 2
Pages: 903-14
Publication
First Author: Libby RT
Year: 2003
Journal: Exp Eye Res
Title: Cdh23 mutations in the mouse are associated with retinal dysfunction but not retinal degeneration.
Volume: 77
Issue: 6
Pages: 731-9
Publication      
First Author: Kane K
Year: 2008
Journal: MGI Direct Data Submission
Title: Jackson waltzer 11J, a new spontaneous mutation in the Cdh23 gene
Publication
First Author: Han F
Year: 2012
Journal: Pharmacogenomics J
Title: A new mouse mutant of the Cdh23 gene with early-onset hearing loss facilitates evaluation of otoprotection drugs.
Volume: 12
Issue: 1
Pages: 30-44
Publication
First Author: Johnson KR
Year: 2008
Journal: Genomics
Title: A locus on distal chromosome 11 (ahl8) and its interaction with Cdh23 ahl underlie the early onset, age-related hearing loss of DBA/2J mice.
Volume: 92
Issue: 4
Pages: 219-25
Publication
First Author: Rzadzinska AK
Year: 2009
Journal: Neuroscience
Title: Presence of interstereocilial links in waltzer mutants suggests Cdh23 is not essential for tip link formation.
Volume: 158
Issue: 2
Pages: 365-8
Publication  
First Author: Johnson KR
Year: 2017
Journal: Sci Rep
Title: Effects of Cdh23 single nucleotide substitutions on age-related hearing loss in C57BL/6 and 129S1/Sv mice and comparisons with congenic strains.
Volume: 7
Pages: 44450
GXD Expression    
Probe: MGI:6169486
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6189941
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Cdh23
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6169486
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6189941
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Cdh23
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6169486
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6189941
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Cdh23
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6169486
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189941
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Cdh23
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6169486
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189941
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Cdh23
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:6169486
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6189941
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Cdh23
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6169486
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189941
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Cdh23
Detected: true
Specimen Num: 5
Publication
First Author: Holme RH
Year: 2004
Journal: J Assoc Res Otolaryngol
Title: Progressive hearing loss and increased susceptibility to noise-induced hearing loss in mice carrying a Cdh23 but not a Myo7a mutation.
Volume: 5
Issue: 1
Pages: 66-79
Protein
Organism: Mus musculus/domesticus
Length: 3354  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 347  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 3321  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 3352  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 3352  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 283  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 3283  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 3353  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 3267  
Fragment?: false
Publication
First Author: Zhao T
Year: 2021
Journal: J Neurosci Res
Title: Phenotypic differences in the inner ears of CBA/CaJ and C57BL/6J mice carrying missense and single base pair deletion mutations in the Cdh23 gene.
Volume: 99
Issue: 10
Pages: 2743-2758
Publication  
First Author: Li N
Year: 2020
Journal: Neural Plast
Title: Alternative Splicing of Cdh23 Exon 68 Is Regulated by RBM24, RBM38, and PTBP1.
Volume: 2020
Pages: 8898811
Publication  
First Author: Zhang L
Year: 2020
Journal: Front Genet
Title: Targeted Next-Generation Sequencing Identified Novel Compound Heterozygous Variants in the CDH23 Gene Causing Usher Syndrome Type ID in a Chinese Patient.
Volume: 11
Pages: 422
Publication
First Author: Noben-Trauth K
Year: 2003
Journal: Nat Genet
Title: Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss.
Volume: 35
Issue: 1
Pages: 21-3
Publication
First Author: Miyasaka Y
Year: 2013
Journal: Exp Anim
Title: Compound heterozygosity of the functionally null Cdh23(v-ngt) and hypomorphic Cdh23(ahl) alleles leads to early-onset progressive hearing loss in mice.
Volume: 62
Issue: 4
Pages: 333-46
Publication      
First Author: Prince L
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for hersey.
Publication  
First Author: Burghard AL
Year: 2019
Journal: Neurobiol Aging
Title: Mice heterozygous for the Cdh23/Ahl1 mutation show age-related deficits in auditory temporal processing.
Volume: 81
Pages: 47-57
Publication
First Author: Johnson KR
Year: 2005
Journal: Genomics
Title: The Mass1frings mutation underlies early onset hearing impairment in BUB/BnJ mice, a model for the auditory pathology of Usher syndrome IIC.
Volume: 85
Issue: 5
Pages: 582-90
Publication
First Author: Di Palma F
Year: 2001
Journal: Gene
Title: Genomic structure, alternative splice forms and normal and mutant alleles of cadherin 23 (Cdh23).
Volume: 281
Issue: 1-2
Pages: 31-41
Publication
First Author: Bork JM
Year: 2001
Journal: Am J Hum Genet
Title: Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of the novel cadherin-like gene CDH23.
Volume: 68
Issue: 1
Pages: 26-37
Publication
First Author: Zheng QY
Year: 2012
Journal: Hum Mol Genet
Title: Digenic inheritance of deafness caused by 8J allele of myosin-VIIA and mutations in other Usher I genes.
Volume: 21
Issue: 11
Pages: 2588-98
Publication  
First Author: Rogalla MM
Year: 2020
Journal: eNeuro
Title: Aging But Not Age-Related Hearing Loss Dominates the Decrease of Parvalbumin Immunoreactivity in the Primary Auditory Cortex of Mice.
Volume: 7
Issue: 3
Publication
First Author: Keithley EM
Year: 2004
Journal: Hear Res
Title: Age-related hearing loss and the ahl locus in mice.
Volume: 188
Issue: 1-2
Pages: 21-8
Publication
First Author: Mathews CE
Year: 1999
Journal: Diabetes
Title: Resistance of ALR/Lt islets to free radical-mediated diabetogenic stress is inherited as a dominant trait.
Volume: 48
Issue: 11
Pages: 2189-96
Publication
First Author: Davis RR
Year: 2001
Journal: Hear Res
Title: Genetic basis for susceptibility to noise-induced hearing loss in mice.
Volume: 155
Issue: 1-2
Pages: 82-90
Publication
First Author: Vázquez AE
Year: 2004
Journal: Hear Res
Title: Evaluating cochlear function and the effects of noise exposure in the B6.CAST+Ahl mouse with distortion product otoacoustic emissions.
Volume: 194
Issue: 1-2
Pages: 87-96
Publication  
First Author: Murillo-Cuesta S
Year: 2015
Journal: Front Aging Neurosci
Title: Transforming growth factor β1 inhibition protects from noise-induced hearing loss.
Volume: 7
Pages: 32
Publication
First Author: Di Palma F
Year: 2001
Journal: Nat Genet
Title: Mutations in Cdh23, encoding a new type of cadherin, cause stereocilia disorganization in waltzer, the mouse model for Usher syndrome type 1D.
Volume: 27
Issue: 1
Pages: 103-7
Publication
First Author: Yonezawa S
Year: 2006
Journal: Hum Mutat
Title: Fates of Cdh23/CDH23 with mutations affecting the cytoplasmic region.
Volume: 27
Issue: 1
Pages: 88-97
Publication
First Author: Mianné J
Year: 2016
Journal: Genome Med
Title: Correction of the auditory phenotype in C57BL/6N mice via CRISPR/Cas9-mediated homology directed repair.
Volume: 8
Issue: 1
Pages: 16
Publication  
First Author: Mock BE
Year: 2016
Journal: Neurobiol Aging
Title: Differential effects of Cdh23(753A) on auditory and vestibular functional aging in C57BL/6J mice.
Volume: 43
Pages: 13-22
Publication  
First Author: Si Y
Year: 2022
Journal: eNeuro
Title: High-Frequency Hearing Is Required to Compute a Topographic Map of Auditory Space in the Mouse Superior Colliculus.
Volume: 9
Issue: 3
Publication
First Author: Elledge HM
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Structure of the N terminus of cadherin 23 reveals a new adhesion mechanism for a subset of cadherin superfamily members.
Volume: 107
Issue: 23
Pages: 10708-12
Publication
First Author: Johnson KR
Year: 2006
Journal: Brain Res
Title: Strain background effects and genetic modifiers of hearing in mice.
Volume: 1091
Issue: 1
Pages: 79-88
Publication
First Author: Noben-Trauth K
Year: 2010
Journal: PLoS One
Title: Phenotype and genetics of progressive sensorineural hearing loss (Snhl1) in the LXS set of recombinant inbred strains of mice.
Volume: 5
Issue: 7
Pages: e11459
Publication
First Author: Atsuta Y
Year: 2024
Journal: Dev Cell
Title: Direct reprogramming of non-limb fibroblasts to cells with properties of limb progenitors.
Volume: 59
Issue: 3
Pages: 415-430.e8
Publication
First Author: Bermúdez-Muñoz JM
Year: 2020
Journal: Aging Cell
Title: G6PD overexpression protects from oxidative stress and age-related hearing loss.
Volume: 19
Issue: 12
Pages: e13275
Publication      
First Author: Lewis MA
Year: 2020
Journal: Dis Model Mech
Title: Hearing impairment due to Mir183/96/182 mutations suggests both loss and gain of function effects.
Publication
First Author: Johnson KR
Year: 2001
Journal: Nat Genet
Title: A nuclear-mitochondrial DNA interaction affecting hearing impairment in mice.
Volume: 27
Issue: 2
Pages: 191-4
Publication
First Author: Zheng QY
Year: 2009
Journal: Neurobiol Aging
Title: A locus on distal chromosome 10 (ahl4) affecting age-related hearing loss in A/J mice.
Volume: 30
Issue: 10
Pages: 1693-705
Publication
First Author: Xu Z
Year: 2008
Journal: J Neurosci
Title: MAGI-1, a candidate stereociliary scaffolding protein, associates with the tip-link component cadherin 23.
Volume: 28
Issue: 44
Pages: 11269-76
Publication
First Author: Zilberstein Y
Year: 2012
Journal: J Neurosci
Title: Inner hair cells are not required for survival of spiral ganglion neurons in the adult cochlea.
Volume: 32
Issue: 2
Pages: 405-10
Publication  
First Author: Zhang C
Year: 2017
Journal: Neuroscience
Title: Loss of sestrin 2 potentiates the early onset of age-related sensory cell degeneration in the cochlea.
Volume: 361
Pages: 179-191
Publication
First Author: Liu O
Year: 2021
Journal: iScience
Title: Adipose-mesenchymal stromal cells suppress experimental Sjögren syndrome by IL-33-driven expansion of ST2+ regulatory T cells.
Volume: 24
Issue: 5
Pages: 102446
Publication
First Author: Zheng QY
Year: 2005
Journal: Hum Mol Genet
Title: Digenic inheritance of deafness caused by mutations in genes encoding cadherin 23 and protocadherin 15 in mice and humans.
Volume: 14
Issue: 1
Pages: 103-11
Publication
First Author: Schwander M
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: A mouse model for nonsyndromic deafness (DFNB12) links hearing loss to defects in tip links of mechanosensory hair cells.
Volume: 106
Issue: 13
Pages: 5252-7
Publication
First Author: Miyasaka Y
Year: 2016
Journal: Hum Mol Genet
Title: Heterozygous mutation of Ush1g/Sans in mice causes early-onset progressive hearing loss, which is recovered by reconstituting the strain-specific mutation in Cdh23.
Volume: 25
Issue: 10
Pages: 2045-2059
Publication
First Author: Wang Q
Year: 2017
Journal: J Neurosci Res
Title: Otoprotective effects of mouse nerve growth factor in DBA/2J mice with early-onset progressive hearing loss.
Volume: 95
Issue: 10
Pages: 1937-1950
Publication
First Author: Kazmierczak P
Year: 2007
Journal: Nature
Title: Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells.
Volume: 449
Issue: 7158
Pages: 87-91
Publication
First Author: Drayton M
Year: 2006
Journal: Hear Res
Title: Mapping quantitative trait loci for hearing loss in Black Swiss mice.
Volume: 212
Issue: 1-2
Pages: 128-39
Publication
First Author: Phillips KR
Year: 2006
Journal: J Neurosci
Title: Stereociliary myosin-1c receptors are sensitive to calcium chelation and absent from cadherin 23 mutant mice.
Volume: 26
Issue: 42
Pages: 10777-88
Publication
First Author: Holme RH
Year: 2002
Journal: Hear Res
Title: Stereocilia defects in waltzer (Cdh23), shaker1 (Myo7a) and double waltzer/shaker1 mutant mice.
Volume: 169
Issue: 1-2
Pages: 13-23
Publication
First Author: Alagramam KN
Year: 2011
Journal: PLoS One
Title: Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells.
Volume: 6
Issue: 4
Pages: e19183
Publication
First Author: Liu X
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Usherin is required for maintenance of retinal photoreceptors and normal development of cochlear hair cells.
Volume: 104
Issue: 11
Pages: 4413-8
Publication
First Author: Zheng QY
Year: 2001
Journal: Hear Res
Title: Hearing loss associated with the modifier of deaf waddler (mdfw) locus corresponds with age-related hearing loss in 12 inbred strains of mice.
Volume: 154
Issue: 1-2
Pages: 45-53
Publication
First Author: Hurd EA
Year: 2011
Journal: Hear Res
Title: Mature middle and inner ears express Chd7 and exhibit distinctive pathologies in a mouse model of CHARGE syndrome.
Volume: 282
Issue: 1-2
Pages: 184-95
Publication
First Author: Manji SS
Year: 2011
Journal: PLoS One
Title: A mutation in synaptojanin 2 causes progressive hearing loss in the ENU-mutagenised mouse strain Mozart.
Volume: 6
Issue: 3
Pages: e17607
Publication
First Author: Noben-Trauth K
Year: 1997
Journal: Genomics
Title: mdfw: a deafness susceptibility locus that interacts with deaf waddler (dfw).
Volume: 44
Issue: 3
Pages: 266-72
Publication    
First Author: LeClair KB
Year: 2021
Journal: Elife
Title: Individual history of winning and hierarchy landscape influence stress susceptibility in mice.
Volume: 10
Publication  
First Author: Longaretti A
Year: 2020
Journal: Neurobiol Stress
Title: LSD1 is an environmental stress-sensitive negative modulator of the glutamatergic synapse.
Volume: 13
Pages: 100280
Publication
First Author: Perrin BJ
Year: 2013
Journal: J Neurosci
Title: β-Actin and fascin-2 cooperate to maintain stereocilia length.
Volume: 33
Issue: 19
Pages: 8114-21
Publication
First Author: Tanimoto N
Year: 2014
Journal: Doc Ophthalmol
Title: Auditory event-related signals in mouse ERG recordings.
Volume: 128
Issue: 1
Pages: 25-32
Publication
First Author: Nagtegaal AP
Year: 2015
Journal: J Neurosci
Title: Cockayne syndrome group B (Csb) and group a (Csa) deficiencies predispose to hearing loss and cochlear hair cell degeneration in mice.
Volume: 35
Issue: 10
Pages: 4280-6