Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The only CX3C chemokine identified to date is CX3C chemokine ligand 1 (CX3CL1), also known as fractalkine or neurotactin. With its unique CX3CR1 receptor [], it is involved in adherence to the endothelium of the inflammatory monocyte population [].CX3CL1 and CXCL16 represent two exceptions among the members of the chemokine family. In addition to their chemokine domain, they possess three other domains: a mucin-like stalk, a transmembrane (TM) domain, and a cytosolic tail [, ]. When interacting with their cognate receptors (CX3CR1 and CXCR6, respectively), these chemokines induce cell-cell adhesion []. CX3CL1 and CXCL16 can also be cleaved by metalloproteinases to yield a soluble form that is chemotactic [, ]. CX3CL1 also binds and activates integrins through its chemokine domain in a CX3CR1-dependent and independent manner, binding to the classical ligand-binding site (RGD-binding site, site 1) or to a second site (site 2) in integrins, respectively [].Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions,and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1). |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Hundhausen C |
Year: |
2003 |
Journal: |
Blood |
Title: |
The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion. |
Volume: |
102 |
Issue: |
4 |
Pages: |
1186-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tardáguila M |
Year: |
2013 |
Journal: |
Cancer Res |
Title: |
CX3CL1 promotes breast cancer via transactivation of the EGF pathway. |
Volume: |
73 |
Issue: |
14 |
Pages: |
4461-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cipriani R |
Year: |
2011 |
Journal: |
J Neurosci |
Title: |
CX3CL1 is neuroprotective in permanent focal cerebral ischemia in rodents. |
Volume: |
31 |
Issue: |
45 |
Pages: |
16327-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gevrey JC |
Year: |
2005 |
Journal: |
J Immunol |
Title: |
Syk is required for monocyte/macrophage chemotaxis to CX3CL1 (Fractalkine). |
Volume: |
175 |
Issue: |
6 |
Pages: |
3737-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Winter AN |
Year: |
2020 |
Journal: |
J Neuroinflammation |
Title: |
Two forms of CX3CL1 display differential activity and rescue cognitive deficits in CX3CL1 knockout mice. |
Volume: |
17 |
Issue: |
1 |
Pages: |
157 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zieger M |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
CX3CL1 (fractalkine) protein expression in normal and degenerating mouse retina: in vivo studies. |
Volume: |
9 |
Issue: |
9 |
Pages: |
e106562 |
|
•
•
•
•
•
|
Publication |
First Author: |
Suzuki F |
Year: |
2005 |
Journal: |
J Immunol |
Title: |
Inhibition of CX3CL1 (fractalkine) improves experimental autoimmune myositis in SJL/J mice. |
Volume: |
175 |
Issue: |
10 |
Pages: |
6987-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fan Q |
Year: |
2019 |
Journal: |
J Exp Med |
Title: |
The intracellular domain of CX3CL1 regulates adult neurogenesis and Alzheimer's amyloid pathology. |
Volume: |
216 |
Issue: |
8 |
Pages: |
1891-1903 |
|
•
•
•
•
•
|
Publication |
First Author: |
Morganti JM |
Year: |
2012 |
Journal: |
J Neurosci |
Title: |
The soluble isoform of CX3CL1 is necessary for neuroprotection in a mouse model of Parkinson's disease. |
Volume: |
32 |
Issue: |
42 |
Pages: |
14592-601 |
|
•
•
•
•
•
|
Publication |
First Author: |
Johnson LA |
Year: |
2013 |
Journal: |
J Cell Sci |
Title: |
The chemokine CX3CL1 promotes trafficking of dendritic cells through inflamed lymphatics. |
Volume: |
126 |
Issue: |
Pt 22 |
Pages: |
5259-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gayen M |
Year: |
2022 |
Journal: |
J Biol Chem |
Title: |
The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/insulin-like growth factor receptor signaling. |
Volume: |
298 |
Issue: |
11 |
Pages: |
102532 |
|
•
•
•
•
•
|
Publication |
First Author: |
Morimura S |
Year: |
2013 |
Journal: |
Am J Pathol |
Title: |
Interaction between CX3CL1 and CX3CR1 regulates vasculitis induced by immune complex deposition. |
Volume: |
182 |
Issue: |
5 |
Pages: |
1640-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee S |
Year: |
2014 |
Journal: |
J Neurosci |
Title: |
Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathway. |
Volume: |
34 |
Issue: |
37 |
Pages: |
12538-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pallandre JR |
Year: |
2008 |
Journal: |
Blood |
Title: |
Dendritic cell and natural killer cell cross-talk: a pivotal role of CX3CL1 in NK cytoskeleton organization and activation. |
Volume: |
112 |
Issue: |
12 |
Pages: |
4420-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Goto Y |
Year: |
2016 |
Journal: |
Stem Cells |
Title: |
CXCR4+ CD45- Cells are Niche Forming for Osteoclastogenesis via the SDF-1, CXCL7, and CX3CL1 Signaling Pathways in Bone Marrow. |
Volume: |
34 |
Issue: |
11 |
Pages: |
2733-2743 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6170578 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:6190074 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Cx3cl1 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6170578 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6190074 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Cx3cl1 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6170578 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:6190074 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Cx3cl1 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6170578 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6190074 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Cx3cl1 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6170578 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190074 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Cx3cl1 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6170578 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190074 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Cx3cl1 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6170578 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190074 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Cx3cl1 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Corcione A |
Year: |
2009 |
Journal: |
PLoS One |
Title: |
CX3CR1 is expressed by human B lymphocytes and mediates [corrected] CX3CL1 driven chemotaxis of tonsil centrocytes. |
Volume: |
4 |
Issue: |
12 |
Pages: |
e8485 |
|
•
•
•
•
•
|
Publication |
First Author: |
McComb JG |
Year: |
2008 |
Journal: |
Am J Pathol |
Title: |
CX3CL1 up-regulation is associated with recruitment of CX3CR1+ mononuclear phagocytes and T lymphocytes in the lungs during cigarette smoke-induced emphysema. |
Volume: |
173 |
Issue: |
4 |
Pages: |
949-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ludwig A |
Year: |
2007 |
Journal: |
Thromb Haemost |
Title: |
Transmembrane chemokines: versatile 'special agents' in vascular inflammation. |
Volume: |
97 |
Issue: |
5 |
Pages: |
694-703 |
|
•
•
•
•
•
|
Publication |
First Author: |
Garton KJ |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1). |
Volume: |
276 |
Issue: |
41 |
Pages: |
37993-8001 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fujita M |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
The chemokine fractalkine can activate integrins without CX3CR1 through direct binding to a ligand-binding site distinct from the classical RGD-binding site. |
Volume: |
9 |
Issue: |
5 |
Pages: |
e96372 |
|
•
•
•
•
•
|
Publication |
First Author: |
Umehara H |
Year: |
2004 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Fractalkine in vascular biology: from basic research to clinical disease. |
Volume: |
24 |
Issue: |
1 |
Pages: |
34-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Imai T |
Year: |
1997 |
Journal: |
Cell |
Title: |
Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. |
Volume: |
91 |
Issue: |
4 |
Pages: |
521-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bazan JF |
Year: |
1997 |
Journal: |
Nature |
Title: |
A new class of membrane-bound chemokine with a CX3C motif. |
Volume: |
385 |
Issue: |
6617 |
Pages: |
640-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ancuta P |
Year: |
2003 |
Journal: |
J Exp Med |
Title: |
Fractalkine preferentially mediates arrest and migration of CD16+ monocytes. |
Volume: |
197 |
Issue: |
12 |
Pages: |
1701-7 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
395
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
395
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
64
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Ma Q |
Year: |
1998 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. |
Volume: |
95 |
Issue: |
16 |
Pages: |
9448-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Horuk R |
Year: |
2001 |
Journal: |
Cytokine Growth Factor Rev |
Title: |
Chemokine receptors. |
Volume: |
12 |
Issue: |
4 |
Pages: |
313-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Charbonnier AS |
Year: |
1999 |
Journal: |
J Exp Med |
Title: |
Macrophage inflammatory protein 3alpha is involved in the constitutive trafficking of epidermal langerhans cells. |
Volume: |
190 |
Issue: |
12 |
Pages: |
1755-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sallusto F |
Year: |
1998 |
Journal: |
J Exp Med |
Title: |
Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. |
Volume: |
187 |
Issue: |
6 |
Pages: |
875-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Strieter RM |
Year: |
1995 |
Journal: |
J Biol Chem |
Title: |
The functional role of the ELR motif in CXC chemokine-mediated angiogenesis. |
Volume: |
270 |
Issue: |
45 |
Pages: |
27348-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zlotnik A |
Year: |
2000 |
Journal: |
Immunity |
Title: |
Chemokines: a new classification system and their role in immunity. |
Volume: |
12 |
Issue: |
2 |
Pages: |
121-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bemiller SM |
Year: |
2018 |
Journal: |
J Neuroinflammation |
Title: |
Genetically enhancing the expression of chemokine domain of CX3CL1 fails to prevent tau pathology in mouse models of tauopathy. |
Volume: |
15 |
Issue: |
1 |
Pages: |
278 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jobling AI |
Year: |
2018 |
Journal: |
J Neurosci |
Title: |
The Role of the Microglial Cx3cr1 Pathway in the Postnatal Maturation of Retinal Photoreceptors. |
Volume: |
38 |
Issue: |
20 |
Pages: |
4708-4723 |
|
•
•
•
•
•
|
Publication |
First Author: |
Godwin MS |
Year: |
2020 |
Journal: |
Am J Physiol Lung Cell Mol Physiol |
Title: |
The chemokine CX3CL1/fractalkine regulates immunopathogenesis during fungal-associated allergic airway inflammation. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mizoguchi M |
Year: |
2018 |
Journal: |
PLoS One |
Title: |
Prevention of lipopolysaccharide-induced preterm labor by the lack of CX3CL1-CX3CR1 interaction in mice. |
Volume: |
13 |
Issue: |
11 |
Pages: |
e0207085 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cunha C |
Year: |
2018 |
Journal: |
Mol Neurobiol |
Title: |
Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage. |
Volume: |
55 |
Issue: |
5 |
Pages: |
4207-4224 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Y |
Year: |
2018 |
Journal: |
Sci Adv |
Title: |
Repopulating retinal microglia restore endogenous organization and function under CX3CL1-CX3CR1 regulation. |
Volume: |
4 |
Issue: |
3 |
Pages: |
eaap8492 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim KW |
Year: |
2011 |
Journal: |
Blood |
Title: |
In vivo structure/function and expression analysis of the CX3C chemokine fractalkine. |
Volume: |
118 |
Issue: |
22 |
Pages: |
e156-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gunner G |
Year: |
2019 |
Journal: |
Nat Neurosci |
Title: |
Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling. |
Volume: |
22 |
Issue: |
7 |
Pages: |
1075-1088 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hoshiko M |
Year: |
2012 |
Journal: |
J Neurosci |
Title: |
Deficiency of the microglial receptor CX3CR1 impairs postnatal functional development of thalamocortical synapses in the barrel cortex. |
Volume: |
32 |
Issue: |
43 |
Pages: |
15106-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Staumont-Sallé D |
Year: |
2014 |
Journal: |
J Exp Med |
Title: |
CX₃CL1 (fractalkine) and its receptor CX₃CR1 regulate atopic dermatitis by controlling effector T cell retention in inflamed skin. |
Volume: |
211 |
Issue: |
6 |
Pages: |
1185-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bian C |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
Involvement of CX3CL1/CX3CR1 signaling in spinal long term potentiation. |
Volume: |
10 |
Issue: |
3 |
Pages: |
e0118842 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu YR |
Year: |
2007 |
Journal: |
Int J Cancer |
Title: |
Defective antitumor responses in CX3CR1-deficient mice. |
Volume: |
121 |
Issue: |
2 |
Pages: |
316-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mikosz A |
Year: |
2023 |
Journal: |
Am J Physiol Lung Cell Mol Physiol |
Title: |
Alpha-1 antitrypsin inhibits fractalkine-mediated monocyte-lung endothelial cell interactions. |
Volume: |
325 |
Issue: |
6 |
Pages: |
L711-L725 |
|
•
•
•
•
•
|
Publication |
First Author: |
Grizenkova J |
Year: |
2014 |
Journal: |
BMC Neurosci |
Title: |
Microglial Cx3cr1 knockout reduces prion disease incubation time in mice. |
Volume: |
15 |
|
Pages: |
44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koizumi K |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
Role of CX3CL1/fractalkine in osteoclast differentiation and bone resorption. |
Volume: |
183 |
Issue: |
12 |
Pages: |
7825-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fan Q |
Year: |
2020 |
Journal: |
J Neurosci |
Title: |
Activated CX3CL1/Smad2 Signals Prevent Neuronal Loss and Alzheimer's Tau Pathology-Mediated Cognitive Dysfunction. |
Volume: |
40 |
Issue: |
5 |
Pages: |
1133-1144 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nagashimada M |
Year: |
2021 |
Journal: |
Endocrinology |
Title: |
CX3CL1-CX3CR1 Signaling Deficiency Exacerbates Obesity-induced Inflammation and Insulin Resistance in Male Mice. |
Volume: |
162 |
Issue: |
6 |
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Publication |
First Author: |
Huang D |
Year: |
2006 |
Journal: |
FASEB J |
Title: |
The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous system. |
Volume: |
20 |
Issue: |
7 |
Pages: |
896-905 |
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Publication |
First Author: |
Lu P |
Year: |
2008 |
Journal: |
J Immunol |
Title: |
Protective roles of the fractalkine/CX3CL1-CX3CR1 interactions in alkali-induced corneal neovascularization through enhanced antiangiogenic factor expression. |
Volume: |
180 |
Issue: |
6 |
Pages: |
4283-91 |
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Publication |
First Author: |
Seo Y |
Year: |
2016 |
Journal: |
Glia |
Title: |
Cathepsin S contributes to microglia-mediated olfactory dysfunction through the regulation of Cx3cl1-Cx3cr1 axis in a Niemann-Pick disease type C1 model. |
Volume: |
64 |
Issue: |
12 |
Pages: |
2291-2305 |
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Publication |
First Author: |
Zabel MK |
Year: |
2016 |
Journal: |
Glia |
Title: |
Microglial phagocytosis and activation underlying photoreceptor degeneration is regulated by CX3CL1-CX3CR1 signaling in a mouse model of retinitis pigmentosa. |
Volume: |
64 |
Issue: |
9 |
Pages: |
1479-91 |
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Publication |
First Author: |
Green SR |
Year: |
2006 |
Journal: |
J Immunol |
Title: |
The CC chemokine MCP-1 stimulates surface expression of CX3CR1 and enhances the adhesion of monocytes to fractalkine/CX3CL1 via p38 MAPK. |
Volume: |
176 |
Issue: |
12 |
Pages: |
7412-20 |
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Publication |
First Author: |
Ni Y |
Year: |
2022 |
Journal: |
Metabolism |
Title: |
CX3CL1/CX3CR1 interaction protects against lipotoxicity-induced nonalcoholic steatohepatitis by regulating macrophage migration and M1/M2 status. |
Volume: |
136 |
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Pages: |
155272 |
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Publication |
First Author: |
Thome AD |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
Fractalkine Signaling Regulates the Inflammatory Response in an α-Synuclein Model of Parkinson Disease. |
Volume: |
10 |
Issue: |
10 |
Pages: |
e0140566 |
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Publication |
First Author: |
Montagud-Romero S |
Year: |
2020 |
Journal: |
Prog Neuropsychopharmacol Biol Psychiatry |
Title: |
Social defeat-induced increase in the conditioned rewarding effects of cocaine: Role of CX3CL1. |
Volume: |
96 |
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Pages: |
109753 |
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Publication |
First Author: |
Saederup N |
Year: |
2008 |
Journal: |
Circulation |
Title: |
Fractalkine deficiency markedly reduces macrophage accumulation and atherosclerotic lesion formation in CCR2-/- mice: evidence for independent chemokine functions in atherogenesis. |
Volume: |
117 |
Issue: |
13 |
Pages: |
1642-8 |
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Publication |
First Author: |
Wang Y |
Year: |
2016 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Icariin inhibits atherosclerosis progress in Apoe null mice by downregulating CX3CR1 in macrophage. |
Volume: |
470 |
Issue: |
4 |
Pages: |
845-50 |
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Publication |
First Author: |
Amsellem V |
Year: |
2017 |
Journal: |
Am J Respir Cell Mol Biol |
Title: |
Roles for the CX3CL1/CX3CR1 and CCL2/CCR2 Chemokine Systems in Hypoxic Pulmonary Hypertension. |
Volume: |
56 |
Issue: |
5 |
Pages: |
597-608 |
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Publication |
First Author: |
Ishida Y |
Year: |
2008 |
Journal: |
J Immunol |
Title: |
Chemokine receptor CX3CR1 mediates skin wound healing by promoting macrophage and fibroblast accumulation and function. |
Volume: |
180 |
Issue: |
1 |
Pages: |
569-79 |
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Publication |
First Author: |
MartÃnez-Hervás S |
Year: |
2014 |
Journal: |
Cardiovasc Res |
Title: |
Insulin resistance aggravates atherosclerosis by reducing vascular smooth muscle cell survival and increasing CX3CL1/CX3CR1 axis. |
Volume: |
103 |
Issue: |
2 |
Pages: |
324-36 |
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Publication |
First Author: |
Zhang D |
Year: |
2006 |
Journal: |
J Neurochem |
Title: |
Identification of potential target genes for RFX4_v3, a transcription factor critical for brain development. |
Volume: |
98 |
Issue: |
3 |
Pages: |
860-75 |
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
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•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
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Publication |
First Author: |
Pan Y |
Year: |
1997 |
Journal: |
Nature |
Title: |
Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation. |
Volume: |
387 |
Issue: |
6633 |
Pages: |
611-7 |
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