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Search results 1 to 100 out of 492 for Cx3cl1

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Protein Domain
Type: Family
Description: The only CX3C chemokine identified to date is CX3C chemokine ligand 1 (CX3CL1), also known as fractalkine or neurotactin. With its unique CX3CR1 receptor [], it is involved in adherence to the endothelium of the inflammatory monocyte population [].CX3CL1 and CXCL16 represent two exceptions among the members of the chemokine family. In addition to their chemokine domain, they possess three other domains: a mucin-like stalk, a transmembrane (TM) domain, and a cytosolic tail [, ]. When interacting with their cognate receptors (CX3CR1 and CXCR6, respectively), these chemokines induce cell-cell adhesion []. CX3CL1 and CXCL16 can also be cleaved by metalloproteinases to yield a soluble form that is chemotactic [, ]. CX3CL1 also binds and activates integrins through its chemokine domain in a CX3CR1-dependent and independent manner, binding to the classical ligand-binding site (RGD-binding site, site 1) or to a second site (site 2) in integrins, respectively [].Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions,and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Hundhausen C
Year: 2003
Journal: Blood
Title: The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion.
Volume: 102
Issue: 4
Pages: 1186-95
Publication
First Author: Tardáguila M
Year: 2013
Journal: Cancer Res
Title: CX3CL1 promotes breast cancer via transactivation of the EGF pathway.
Volume: 73
Issue: 14
Pages: 4461-73
Publication
First Author: Cipriani R
Year: 2011
Journal: J Neurosci
Title: CX3CL1 is neuroprotective in permanent focal cerebral ischemia in rodents.
Volume: 31
Issue: 45
Pages: 16327-35
Publication
First Author: Gevrey JC
Year: 2005
Journal: J Immunol
Title: Syk is required for monocyte/macrophage chemotaxis to CX3CL1 (Fractalkine).
Volume: 175
Issue: 6
Pages: 3737-45
Publication
First Author: Winter AN
Year: 2020
Journal: J Neuroinflammation
Title: Two forms of CX3CL1 display differential activity and rescue cognitive deficits in CX3CL1 knockout mice.
Volume: 17
Issue: 1
Pages: 157
Publication
First Author: Zieger M
Year: 2014
Journal: PLoS One
Title: CX3CL1 (fractalkine) protein expression in normal and degenerating mouse retina: in vivo studies.
Volume: 9
Issue: 9
Pages: e106562
Publication
First Author: Suzuki F
Year: 2005
Journal: J Immunol
Title: Inhibition of CX3CL1 (fractalkine) improves experimental autoimmune myositis in SJL/J mice.
Volume: 175
Issue: 10
Pages: 6987-96
Publication
First Author: Fan Q
Year: 2019
Journal: J Exp Med
Title: The intracellular domain of CX3CL1 regulates adult neurogenesis and Alzheimer's amyloid pathology.
Volume: 216
Issue: 8
Pages: 1891-1903
Publication
First Author: Morganti JM
Year: 2012
Journal: J Neurosci
Title: The soluble isoform of CX3CL1 is necessary for neuroprotection in a mouse model of Parkinson's disease.
Volume: 32
Issue: 42
Pages: 14592-601
Publication
First Author: Johnson LA
Year: 2013
Journal: J Cell Sci
Title: The chemokine CX3CL1 promotes trafficking of dendritic cells through inflamed lymphatics.
Volume: 126
Issue: Pt 22
Pages: 5259-70
Publication
First Author: Gayen M
Year: 2022
Journal: J Biol Chem
Title: The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/insulin-like growth factor receptor signaling.
Volume: 298
Issue: 11
Pages: 102532
Publication
First Author: Morimura S
Year: 2013
Journal: Am J Pathol
Title: Interaction between CX3CL1 and CX3CR1 regulates vasculitis induced by immune complex deposition.
Volume: 182
Issue: 5
Pages: 1640-7
Publication
First Author: Lee S
Year: 2014
Journal: J Neurosci
Title: Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathway.
Volume: 34
Issue: 37
Pages: 12538-46
Publication
First Author: Pallandre JR
Year: 2008
Journal: Blood
Title: Dendritic cell and natural killer cell cross-talk: a pivotal role of CX3CL1 in NK cytoskeleton organization and activation.
Volume: 112
Issue: 12
Pages: 4420-4
Publication
First Author: Goto Y
Year: 2016
Journal: Stem Cells
Title: CXCR4+ CD45- Cells are Niche Forming for Osteoclastogenesis via the SDF-1, CXCL7, and CX3CL1 Signaling Pathways in Bone Marrow.
Volume: 34
Issue: 11
Pages: 2733-2743
GXD Expression    
Probe: MGI:6170578
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190074
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Cx3cl1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6170578
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190074
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Cx3cl1
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6170578
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190074
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Cx3cl1
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6170578
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190074
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Cx3cl1
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6170578
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190074
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Cx3cl1
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6170578
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190074
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Cx3cl1
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6170578
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190074
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Cx3cl1
Detected: true
Specimen Num: 7
Publication
First Author: Corcione A
Year: 2009
Journal: PLoS One
Title: CX3CR1 is expressed by human B lymphocytes and mediates [corrected] CX3CL1 driven chemotaxis of tonsil centrocytes.
Volume: 4
Issue: 12
Pages: e8485
Publication
First Author: McComb JG
Year: 2008
Journal: Am J Pathol
Title: CX3CL1 up-regulation is associated with recruitment of CX3CR1+ mononuclear phagocytes and T lymphocytes in the lungs during cigarette smoke-induced emphysema.
Volume: 173
Issue: 4
Pages: 949-61
Publication
First Author: Ludwig A
Year: 2007
Journal: Thromb Haemost
Title: Transmembrane chemokines: versatile 'special agents' in vascular inflammation.
Volume: 97
Issue: 5
Pages: 694-703
Publication
First Author: Garton KJ
Year: 2001
Journal: J Biol Chem
Title: Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1).
Volume: 276
Issue: 41
Pages: 37993-8001
Publication
First Author: Fujita M
Year: 2014
Journal: PLoS One
Title: The chemokine fractalkine can activate integrins without CX3CR1 through direct binding to a ligand-binding site distinct from the classical RGD-binding site.
Volume: 9
Issue: 5
Pages: e96372
Publication
First Author: Umehara H
Year: 2004
Journal: Arterioscler Thromb Vasc Biol
Title: Fractalkine in vascular biology: from basic research to clinical disease.
Volume: 24
Issue: 1
Pages: 34-40
Publication
First Author: Imai T
Year: 1997
Journal: Cell
Title: Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion.
Volume: 91
Issue: 4
Pages: 521-30
Publication
First Author: Bazan JF
Year: 1997
Journal: Nature
Title: A new class of membrane-bound chemokine with a CX3C motif.
Volume: 385
Issue: 6617
Pages: 640-4
Publication
First Author: Ancuta P
Year: 2003
Journal: J Exp Med
Title: Fractalkine preferentially mediates arrest and migration of CD16+ monocytes.
Volume: 197
Issue: 12
Pages: 1701-7
Protein
Organism: Mus musculus/domesticus
Length: 395  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 395  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 64  
Fragment?: false
Publication
First Author: Ma Q
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice.
Volume: 95
Issue: 16
Pages: 9448-53
Publication
First Author: Horuk R
Year: 2001
Journal: Cytokine Growth Factor Rev
Title: Chemokine receptors.
Volume: 12
Issue: 4
Pages: 313-35
Publication
First Author: Charbonnier AS
Year: 1999
Journal: J Exp Med
Title: Macrophage inflammatory protein 3alpha is involved in the constitutive trafficking of epidermal langerhans cells.
Volume: 190
Issue: 12
Pages: 1755-68
Publication
First Author: Sallusto F
Year: 1998
Journal: J Exp Med
Title: Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes.
Volume: 187
Issue: 6
Pages: 875-83
Publication
First Author: Strieter RM
Year: 1995
Journal: J Biol Chem
Title: The functional role of the ELR motif in CXC chemokine-mediated angiogenesis.
Volume: 270
Issue: 45
Pages: 27348-57
Publication
First Author: Zlotnik A
Year: 2000
Journal: Immunity
Title: Chemokines: a new classification system and their role in immunity.
Volume: 12
Issue: 2
Pages: 121-7
Publication
First Author: Bemiller SM
Year: 2018
Journal: J Neuroinflammation
Title: Genetically enhancing the expression of chemokine domain of CX3CL1 fails to prevent tau pathology in mouse models of tauopathy.
Volume: 15
Issue: 1
Pages: 278
Publication
First Author: Jobling AI
Year: 2018
Journal: J Neurosci
Title: The Role of the Microglial Cx3cr1 Pathway in the Postnatal Maturation of Retinal Photoreceptors.
Volume: 38
Issue: 20
Pages: 4708-4723
Publication      
First Author: Godwin MS
Year: 2020
Journal: Am J Physiol Lung Cell Mol Physiol
Title: The chemokine CX3CL1/fractalkine regulates immunopathogenesis during fungal-associated allergic airway inflammation.
Publication
First Author: Mizoguchi M
Year: 2018
Journal: PLoS One
Title: Prevention of lipopolysaccharide-induced preterm labor by the lack of CX3CL1-CX3CR1 interaction in mice.
Volume: 13
Issue: 11
Pages: e0207085
Publication
First Author: Cunha C
Year: 2018
Journal: Mol Neurobiol
Title: Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage.
Volume: 55
Issue: 5
Pages: 4207-4224
Publication
First Author: Zhang Y
Year: 2018
Journal: Sci Adv
Title: Repopulating retinal microglia restore endogenous organization and function under CX3CL1-CX3CR1 regulation.
Volume: 4
Issue: 3
Pages: eaap8492
Publication
First Author: Kim KW
Year: 2011
Journal: Blood
Title: In vivo structure/function and expression analysis of the CX3C chemokine fractalkine.
Volume: 118
Issue: 22
Pages: e156-67
Publication
First Author: Gunner G
Year: 2019
Journal: Nat Neurosci
Title: Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling.
Volume: 22
Issue: 7
Pages: 1075-1088
Publication
First Author: Hoshiko M
Year: 2012
Journal: J Neurosci
Title: Deficiency of the microglial receptor CX3CR1 impairs postnatal functional development of thalamocortical synapses in the barrel cortex.
Volume: 32
Issue: 43
Pages: 15106-11
Publication
First Author: Staumont-Sallé D
Year: 2014
Journal: J Exp Med
Title: CX₃CL1 (fractalkine) and its receptor CX₃CR1 regulate atopic dermatitis by controlling effector T cell retention in inflamed skin.
Volume: 211
Issue: 6
Pages: 1185-96
Publication
First Author: Bian C
Year: 2015
Journal: PLoS One
Title: Involvement of CX3CL1/CX3CR1 signaling in spinal long term potentiation.
Volume: 10
Issue: 3
Pages: e0118842
Publication
First Author: Yu YR
Year: 2007
Journal: Int J Cancer
Title: Defective antitumor responses in CX3CR1-deficient mice.
Volume: 121
Issue: 2
Pages: 316-22
Publication
First Author: Mikosz A
Year: 2023
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Alpha-1 antitrypsin inhibits fractalkine-mediated monocyte-lung endothelial cell interactions.
Volume: 325
Issue: 6
Pages: L711-L725
Publication  
First Author: Grizenkova J
Year: 2014
Journal: BMC Neurosci
Title: Microglial Cx3cr1 knockout reduces prion disease incubation time in mice.
Volume: 15
Pages: 44
Publication
First Author: Koizumi K
Year: 2009
Journal: J Immunol
Title: Role of CX3CL1/fractalkine in osteoclast differentiation and bone resorption.
Volume: 183
Issue: 12
Pages: 7825-31
Publication
First Author: Fan Q
Year: 2020
Journal: J Neurosci
Title: Activated CX3CL1/Smad2 Signals Prevent Neuronal Loss and Alzheimer's Tau Pathology-Mediated Cognitive Dysfunction.
Volume: 40
Issue: 5
Pages: 1133-1144
Publication  
First Author: Nagashimada M
Year: 2021
Journal: Endocrinology
Title: CX3CL1-CX3CR1 Signaling Deficiency Exacerbates Obesity-induced Inflammation and Insulin Resistance in Male Mice.
Volume: 162
Issue: 6
Publication
First Author: Huang D
Year: 2006
Journal: FASEB J
Title: The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous system.
Volume: 20
Issue: 7
Pages: 896-905
Publication
First Author: Lu P
Year: 2008
Journal: J Immunol
Title: Protective roles of the fractalkine/CX3CL1-CX3CR1 interactions in alkali-induced corneal neovascularization through enhanced antiangiogenic factor expression.
Volume: 180
Issue: 6
Pages: 4283-91
Publication
First Author: Seo Y
Year: 2016
Journal: Glia
Title: Cathepsin S contributes to microglia-mediated olfactory dysfunction through the regulation of Cx3cl1-Cx3cr1 axis in a Niemann-Pick disease type C1 model.
Volume: 64
Issue: 12
Pages: 2291-2305
Publication
First Author: Zabel MK
Year: 2016
Journal: Glia
Title: Microglial phagocytosis and activation underlying photoreceptor degeneration is regulated by CX3CL1-CX3CR1 signaling in a mouse model of retinitis pigmentosa.
Volume: 64
Issue: 9
Pages: 1479-91
Publication
First Author: Green SR
Year: 2006
Journal: J Immunol
Title: The CC chemokine MCP-1 stimulates surface expression of CX3CR1 and enhances the adhesion of monocytes to fractalkine/CX3CL1 via p38 MAPK.
Volume: 176
Issue: 12
Pages: 7412-20
Publication  
First Author: Ni Y
Year: 2022
Journal: Metabolism
Title: CX3CL1/CX3CR1 interaction protects against lipotoxicity-induced nonalcoholic steatohepatitis by regulating macrophage migration and M1/M2 status.
Volume: 136
Pages: 155272
Publication
First Author: Thome AD
Year: 2015
Journal: PLoS One
Title: Fractalkine Signaling Regulates the Inflammatory Response in an α-Synuclein Model of Parkinson Disease.
Volume: 10
Issue: 10
Pages: e0140566
Publication  
First Author: Montagud-Romero S
Year: 2020
Journal: Prog Neuropsychopharmacol Biol Psychiatry
Title: Social defeat-induced increase in the conditioned rewarding effects of cocaine: Role of CX3CL1.
Volume: 96
Pages: 109753
Publication
First Author: Saederup N
Year: 2008
Journal: Circulation
Title: Fractalkine deficiency markedly reduces macrophage accumulation and atherosclerotic lesion formation in CCR2-/- mice: evidence for independent chemokine functions in atherogenesis.
Volume: 117
Issue: 13
Pages: 1642-8
Publication
First Author: Wang Y
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Icariin inhibits atherosclerosis progress in Apoe null mice by downregulating CX3CR1 in macrophage.
Volume: 470
Issue: 4
Pages: 845-50
Publication
First Author: Amsellem V
Year: 2017
Journal: Am J Respir Cell Mol Biol
Title: Roles for the CX3CL1/CX3CR1 and CCL2/CCR2 Chemokine Systems in Hypoxic Pulmonary Hypertension.
Volume: 56
Issue: 5
Pages: 597-608
Publication
First Author: Ishida Y
Year: 2008
Journal: J Immunol
Title: Chemokine receptor CX3CR1 mediates skin wound healing by promoting macrophage and fibroblast accumulation and function.
Volume: 180
Issue: 1
Pages: 569-79
Publication
First Author: Martínez-Hervás S
Year: 2014
Journal: Cardiovasc Res
Title: Insulin resistance aggravates atherosclerosis by reducing vascular smooth muscle cell survival and increasing CX3CL1/CX3CR1 axis.
Volume: 103
Issue: 2
Pages: 324-36
Publication
First Author: Zhang D
Year: 2006
Journal: J Neurochem
Title: Identification of potential target genes for RFX4_v3, a transcription factor critical for brain development.
Volume: 98
Issue: 3
Pages: 860-75
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Pan Y
Year: 1997
Journal: Nature
Title: Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation.
Volume: 387
Issue: 6633
Pages: 611-7