Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
DCC (deleted in colorectal cancer) is a receptor for netrin required for axon guidance [, ]. It also binds a second axon guidance protein, Draxin []. The interactions between these guidance cues and DCC play a key role in the development of the nervous system.DCC belongs to the immunoglobulin superfamily. The protein consists of four N-terminal Ig-like domains []followed by six fibronectin type III domains (FN), a transmembrane segment and the cytosolic portion []. The deletion of DCC has been linked to the propensity of cancerous cells to metastasise [, ]. DCC indeed functions as a tumour suppressor through its ability to trigger tumour cell apoptosis []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Castets M |
Year: |
2011 |
Journal: |
Nature |
Title: |
DCC constrains tumour progression via its dependence receptor activity. |
Volume: |
482 |
Issue: |
7386 |
Pages: |
534-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ahmed G |
Year: |
2011 |
Journal: |
J Neurosci |
Title: |
Draxin inhibits axonal outgrowth through the netrin receptor DCC. |
Volume: |
31 |
Issue: |
39 |
Pages: |
14018-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Krimpenfort P |
Year: |
2012 |
Journal: |
Nature |
Title: |
Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours. |
Volume: |
482 |
Issue: |
7386 |
Pages: |
538-41 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1447
|
Fragment?: |
false |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2670856 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-05-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271122 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:7481908 |
Age: |
embryonic day 14.5 |
Image: |
2B DCC |
Note: |
Expression overlapping with CTIP2 (Bcl11b) expression. |
Specimen Label: |
2B DCC |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2670856 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-05-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271222 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:7481908 |
Age: |
embryonic day 14.5 |
Image: |
2B DCC |
Note: |
Expression overlapping with CTIP2 (Bcl11b) expression. |
Specimen Label: |
2B DCC |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stein E |
Year: |
2001 |
Journal: |
Science |
Title: |
Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation. |
Volume: |
291 |
Issue: |
5510 |
Pages: |
1976-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen Q |
Year: |
2013 |
Journal: |
J Cell Sci |
Title: |
N-terminal horseshoe conformation of DCC is functionally required for axon guidance and might be shared by other neural receptors. |
Volume: |
126 |
Issue: |
Pt 1 |
Pages: |
186-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miyake S |
Year: |
1994 |
Journal: |
Cancer Res |
Title: |
Point mutations and allelic deletion of tumor suppressor gene DCC in human esophageal squamous cell carcinomas and their relation to metastasis. |
Volume: |
54 |
Issue: |
11 |
Pages: |
3007-10 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3821385 |
Assay Type: |
RNA in situ |
Annotation Date: |
2009-01-15 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1750322 |
|
Stage: |
TS22 |
Assay Id: |
MGI:3825941 |
Age: |
embryonic day 14.5 |
Image: |
Additional file 4 Dcc |
|
Specimen Label: |
Additional file 4 Dcc |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6170971 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-05-30 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
Pattern: |
Regionally restricted |
Stage: |
TS19 |
Assay Id: |
MGI:6158893 |
Age: |
embryonic day 11.5 |
Image: |
Dcc - E11.5 |
Note: |
There is particularly highly expression at early stages in developing neurons of the cortical plate and brainstem nuclei; expression subsequently tapers off with age. |
Specimen Label: |
Dcc - E11.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6170971 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-05-30 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
Pattern: |
Regionally restricted |
Stage: |
TS21 |
Assay Id: |
MGI:6158893 |
Age: |
embryonic day 13.5 |
Image: |
Dcc - E13.5 |
Note: |
There is particularly highly expression at early stages in developing neurons of the cortical plate and brainstem nuclei; expression subsequently tapers off with age. |
Specimen Label: |
Dcc - E13.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6170971 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-05-30 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689423 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:6158893 |
Age: |
embryonic day 15.5 |
Image: |
Dcc - E15.5 |
Note: |
There is particularly highly expression at early stages in developing neurons of the cortical plate and brainstem nuclei; expression subsequently tapers off with age. |
Specimen Label: |
Dcc - E15.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6170971 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-05-30 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689426 |
Pattern: |
Regionally restricted |
Stage: |
TS26 |
Assay Id: |
MGI:6158893 |
Age: |
embryonic day 18.5 |
Image: |
Dcc - E18.5 |
Note: |
There is particularly highly expression at early stages in developing neurons of the cortical plate and brainstem nuclei; expression subsequently tapers off with age. |
Specimen Label: |
Dcc - E18.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Keino-Masu K |
Year: |
1996 |
Journal: |
Cell |
Title: |
Deleted in Colorectal Cancer (DCC) encodes a netrin receptor. |
Volume: |
87 |
Issue: |
2 |
Pages: |
175-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Manitt C |
Year: |
2011 |
Journal: |
J Neurosci |
Title: |
The netrin receptor DCC is required in the pubertal organization of mesocortical dopamine circuitry. |
Volume: |
31 |
Issue: |
23 |
Pages: |
8381-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Reynolds LM |
Year: |
2016 |
Journal: |
Behav Brain Res |
Title: |
dcc Haploinsufficiency results in blunted sensitivity to cocaine enhancement of reward seeking. |
Volume: |
298 |
Issue: |
Pt A |
Pages: |
27-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jamuar SS |
Year: |
2017 |
Journal: |
Nat Genet |
Title: |
Biallelic mutations in human DCC cause developmental split-brain syndrome. |
Volume: |
49 |
Issue: |
4 |
Pages: |
606-612 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pokinko M |
Year: |
2017 |
Journal: |
Neuroscience |
Title: |
Dcc haploinsufficiency regulates dopamine receptor expression across postnatal lifespan. |
Volume: |
346 |
|
Pages: |
182-189 |
|
•
•
•
•
•
|
Publication |
First Author: |
Horn KE |
Year: |
2013 |
Journal: |
Cell Rep |
Title: |
DCC expression by neurons regulates synaptic plasticity in the adult brain. |
Volume: |
3 |
Issue: |
1 |
Pages: |
173-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liang DY |
Year: |
2014 |
Journal: |
BMC Genomics |
Title: |
The Netrin-1 receptor DCC is a regulator of maladaptive responses to chronic morphine administration. |
Volume: |
15 |
|
Pages: |
345 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ly A |
Year: |
2008 |
Journal: |
Cell |
Title: |
DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1. |
Volume: |
133 |
Issue: |
7 |
Pages: |
1241-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Reynolds LM |
Year: |
2018 |
Journal: |
Biol Psychiatry |
Title: |
DCC Receptors Drive Prefrontal Cortex Maturation by Determining Dopamine Axon Targeting in Adolescence. |
Volume: |
83 |
Issue: |
2 |
Pages: |
181-192 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim YJ |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
Dcc Mediates Functional Assembly of Peripheral Auditory Circuits. |
Volume: |
6 |
|
Pages: |
23799 |
|
•
•
•
•
•
|
Publication |
First Author: |
Glasgow SD |
Year: |
2020 |
Journal: |
Mol Brain |
Title: |
Pre- and post-synaptic roles for DCC in memory consolidation in the adult mouse hippocampus. |
Volume: |
13 |
Issue: |
1 |
Pages: |
56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bull SJ |
Year: |
2014 |
Journal: |
J Neurosci |
Title: |
Progressive disorganization of paranodal junctions and compact myelin due to loss of DCC expression by oligodendrocytes. |
Volume: |
34 |
Issue: |
29 |
Pages: |
9768-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Manitt C |
Year: |
2013 |
Journal: |
Transl Psychiatry |
Title: |
dcc orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients. |
Volume: |
3 |
|
Pages: |
e338 |
|
•
•
•
•
•
|
Publication |
First Author: |
Grant A |
Year: |
2009 |
Journal: |
Eur J Neurosci |
Title: |
Post-pubertal emergence of a dopamine phenotype in netrin-1 receptor-deficient mice. |
Volume: |
30 |
Issue: |
7 |
Pages: |
1318-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yetnikoff L |
Year: |
2010 |
Journal: |
Eur J Neurosci |
Title: |
Netrin-1 receptor in the ventral tegmental area is required for sensitization to amphetamine. |
Volume: |
31 |
Issue: |
7 |
Pages: |
1292-302 |
|
•
•
•
•
•
|
Publication |
First Author: |
Castillo-Paterna M |
Year: |
2015 |
Journal: |
EMBO Rep |
Title: |
DCC functions as an accelerator of thalamocortical axonal growth downstream of spontaneous thalamic activity. |
Volume: |
16 |
Issue: |
7 |
Pages: |
851-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rabe Bernhardt N |
Year: |
2012 |
Journal: |
Dev Biol |
Title: |
DCC mediated axon guidance of spinal interneurons is essential for normal locomotor central pattern generator function. |
Volume: |
366 |
Issue: |
2 |
Pages: |
279-89 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1140
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Boussouar A |
Year: |
2020 |
Journal: |
Cancer Res |
Title: |
Netrin-1 and Its Receptor DCC Are Causally Implicated in Melanoma Progression. |
Volume: |
80 |
Issue: |
4 |
Pages: |
747-756 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thiry L |
Year: |
2022 |
Journal: |
eNeuro |
Title: |
Heterozygous Dcc Mutant Mice Have a Subtle Locomotor Phenotype. |
Volume: |
9 |
Issue: |
2 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Finger JH |
Year: |
2002 |
Journal: |
J Neurosci |
Title: |
The netrin 1 receptors Unc5h3 and Dcc are necessary at multiple choice points for the guidance of corticospinal tract axons. |
Volume: |
22 |
Issue: |
23 |
Pages: |
10346-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shi M |
Year: |
2010 |
Journal: |
Dev Biol |
Title: |
DCC is specifically required for the survival of retinal ganglion and displaced amacrine cells in the developing mouse retina. |
Volume: |
348 |
Issue: |
1 |
Pages: |
87-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang JH |
Year: |
2018 |
Journal: |
Cell Rep |
Title: |
DCC-Mediated Dab1 Phosphorylation Participates in the Multipolar-to-Bipolar Transition of Migrating Neurons. |
Volume: |
22 |
Issue: |
13 |
Pages: |
3598-3611 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang Y |
Year: |
2003 |
Journal: |
Dev Biol |
Title: |
Netrins and DCC in the guidance of migrating neural crest-derived cells in the developing bowel and pancreas. |
Volume: |
258 |
Issue: |
2 |
Pages: |
364-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shi M |
Year: |
2008 |
Journal: |
Mol Cell Neurosci |
Title: |
DCC is required for the tangential migration of noradrenergic neurons in locus coeruleus of mouse brain. |
Volume: |
39 |
Issue: |
4 |
Pages: |
529-38 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vosberg DE |
Year: |
2018 |
Journal: |
J Neurosci |
Title: |
Mesocorticolimbic Connectivity and Volumetric Alterations in DCC Mutation Carriers. |
Volume: |
38 |
Issue: |
20 |
Pages: |
4655-4665 |
|
•
•
•
•
•
|
Publication |
First Author: |
Welniarz Q |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Non cell-autonomous role of DCC in the guidance of the corticospinal tract at the midline. |
Volume: |
7 |
Issue: |
1 |
Pages: |
410 |
|
•
•
•
•
•
|
Publication |
First Author: |
Morcom L |
Year: |
2021 |
Journal: |
Elife |
Title: |
DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation. |
Volume: |
10 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marcos S |
Year: |
2009 |
Journal: |
Mol Cell Neurosci |
Title: |
Differential roles of Netrin-1 and its receptor DCC in inferior olivary neuron migration. |
Volume: |
41 |
Issue: |
4 |
Pages: |
429-39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Deiner MS |
Year: |
1997 |
Journal: |
Neuron |
Title: |
Netrin-1 and DCC mediate axon guidance locally at the optic disc: loss of function leads to optic nerve hypoplasia. |
Volume: |
19 |
Issue: |
3 |
Pages: |
575-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rajasekharan S |
Year: |
2009 |
Journal: |
Development |
Title: |
Netrin 1 and Dcc regulate oligodendrocyte process branching and membrane extension via Fyn and RhoA. |
Volume: |
136 |
Issue: |
3 |
Pages: |
415-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jarjour AA |
Year: |
2008 |
Journal: |
J Neurosci |
Title: |
Maintenance of axo-oligodendroglial paranodal junctions requires DCC and netrin-1. |
Volume: |
28 |
Issue: |
43 |
Pages: |
11003-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vigouroux RJ |
Year: |
2020 |
Journal: |
Elife |
Title: |
Revisiting the role of Dcc in visual system development with a novel eye clearing method. |
Volume: |
9 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Auger ML |
Year: |
2013 |
Journal: |
Eur J Neurosci |
Title: |
unc5c haploinsufficient phenotype: striking similarities with the dcc haploinsufficiency model. |
Volume: |
38 |
Issue: |
6 |
Pages: |
2853-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bouchard JF |
Year: |
2008 |
Journal: |
J Neurochem |
Title: |
Depolarization recruits DCC to the plasma membrane of embryonic cortical neurons and enhances axon extension in response to netrin-1. |
Volume: |
107 |
Issue: |
2 |
Pages: |
398-417 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6170971 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:6190099 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Dcc |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6170971 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6190099 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Dcc |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6170971 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:6190099 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Dcc |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6170971 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6190099 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Dcc |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6170971 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190099 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Dcc |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6170971 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190099 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Dcc |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6170971 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190099 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Dcc |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Peng J |
Year: |
2018 |
Journal: |
Dev Dyn |
Title: |
Loss of Dcc in the spinal cord is sufficient to cause a deficit in lateralized motor control and the switch to a hopping gait. |
Volume: |
247 |
Issue: |
4 |
Pages: |
620-629 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lo PS |
Year: |
2022 |
Journal: |
J Neurochem |
Title: |
The netrin-1 receptor DCC promotes the survival of a subpopulation of midbrain dopaminergic neurons: Relevance for ageing and Parkinson's disease. |
Volume: |
161 |
Issue: |
3 |
Pages: |
254-265 |
|
•
•
•
•
•
|
Publication |
First Author: |
Plooster M |
Year: |
2017 |
Journal: |
Mol Biol Cell |
Title: |
TRIM9-dependent ubiquitination of DCC constrains kinase signaling, exocytosis, and axon branching. |
Volume: |
28 |
Issue: |
18 |
Pages: |
2374-2385 |
|
•
•
•
•
•
|
Publication |
First Author: |
da Silva RV |
Year: |
2018 |
Journal: |
Cell Rep |
Title: |
DCC Is Required for the Development of Nociceptive Topognosis in Mice and Humans. |
Volume: |
22 |
Issue: |
5 |
Pages: |
1105-1114 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ding YQ |
Year: |
2005 |
Journal: |
Development |
Title: |
Ventral migration of early-born neurons requires Dcc and is essential for the projections of primary afferents in the spinal cord. |
Volume: |
132 |
Issue: |
9 |
Pages: |
2047-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cooper HM |
Year: |
1995 |
Journal: |
Oncogene |
Title: |
Cloning of the mouse homologue of the deleted in colorectal cancer gene (mDCC) and its expression in the developing mouse embryo. |
Volume: |
11 |
Issue: |
11 |
Pages: |
2243-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu Y |
Year: |
2012 |
Journal: |
J Cell Sci |
Title: |
Differential regulation of myosin X movements by its cargos, DCC and neogenin. |
Volume: |
125 |
Issue: |
Pt 3 |
Pages: |
751-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Laumonnerie C |
Year: |
2014 |
Journal: |
Development |
Title: |
Netrin 1 and Dcc signalling are required for confinement of central axons within the central nervous system. |
Volume: |
141 |
Issue: |
3 |
Pages: |
594-603 |
|
•
•
•
•
•
|
Publication |
First Author: |
Leggere JC |
Year: |
2016 |
Journal: |
Elife |
Title: |
NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord. |
Volume: |
5 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bourojeni FB |
Year: |
2021 |
Journal: |
Pain |
Title: |
Netrin-1 receptor DCC is required for the contralateral topography of lamina I anterolateral system neurons. |
Volume: |
162 |
Issue: |
1 |
Pages: |
161-175 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dalvin S |
Year: |
2003 |
Journal: |
Gene Expr Patterns |
Title: |
Expression of Netrin-1 and its two receptors DCC and UNC5H2 in the developing mouse lung. |
Volume: |
3 |
Issue: |
3 |
Pages: |
279-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tcherkezian J |
Year: |
2010 |
Journal: |
Cell |
Title: |
Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. |
Volume: |
141 |
Issue: |
4 |
Pages: |
632-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gad JM |
Year: |
2000 |
Journal: |
Exp Eye Res |
Title: |
The spatial and temporal expression patterns of netrin receptors, DCC and neogenin, in the developing mouse retina. |
Volume: |
70 |
Issue: |
6 |
Pages: |
711-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Grant A |
Year: |
2007 |
Journal: |
Eur J Neurosci |
Title: |
Netrin-1 receptor-deficient mice show enhanced mesocortical dopamine transmission and blunted behavioural responses to amphetamine. |
Volume: |
26 |
Issue: |
11 |
Pages: |
3215-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim JH |
Year: |
2013 |
Journal: |
Psychopharmacology (Berl) |
Title: |
Netrin-1 receptor-deficient mice show age-specific impairment in drug-induced locomotor hyperactivity but still self-administer methamphetamine. |
Volume: |
230 |
Issue: |
4 |
Pages: |
607-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Flores C |
Year: |
2005 |
Journal: |
Mol Psychiatry |
Title: |
Netrin receptor deficient mice exhibit functional reorganization of dopaminergic systems and do not sensitize to amphetamine. |
Volume: |
10 |
Issue: |
6 |
Pages: |
606-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xie Y |
Year: |
2005 |
Journal: |
Nat Cell Biol |
Title: |
Phosphatidylinositol transfer protein-alpha in netrin-1-induced PLC signalling and neurite outgrowth. |
Volume: |
7 |
Issue: |
11 |
Pages: |
1124-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dailey-Krempel B |
Year: |
2023 |
Journal: |
Cell Rep |
Title: |
A tug of war between DCC and ROBO1 signaling during commissural axon guidance. |
Volume: |
42 |
Issue: |
5 |
Pages: |
112455 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gad JM |
Year: |
1997 |
Journal: |
Dev Biol |
Title: |
The expression patterns of guidance receptors, DCC and Neogenin, are spatially and temporally distinct throughout mouse embryogenesis. |
Volume: |
192 |
Issue: |
2 |
Pages: |
258-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Srivatsa S |
Year: |
2014 |
Journal: |
Nat Commun |
Title: |
Unc5C and DCC act downstream of Ctip2 and Satb2 and contribute to corpus callosum formation. |
Volume: |
5 |
|
Pages: |
3708 |
|
•
•
•
•
•
|
Publication |
First Author: |
Salehi P |
Year: |
2016 |
Journal: |
J Assoc Res Otolaryngol |
Title: |
Genome-Wide Association Analysis Identifies Dcc as an Essential Factor in the Innervation of the Peripheral Vestibular System in Inbred Mice. |
Volume: |
17 |
Issue: |
5 |
Pages: |
417-31 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:27063 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-06-14 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1915724 |
Pattern: |
Regionally restricted |
Stage: |
TS24 |
Assay Id: |
MGI:7647248 |
Age: |
embryonic day 16.5 |
|
Note: |
Two distinct layers of DCC mRNA expressing E16.5 cells were observed in the central retina. The second in the outer region of the outer nuclear layer. |
Specimen Label: |
3C/D |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:27063 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-06-14 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3573924 |
Pattern: |
Regionally restricted |
Stage: |
TS24 |
Assay Id: |
MGI:7647248 |
Age: |
embryonic day 16.5 |
|
Note: |
Two distinct layers of DCC mRNA expressing E16.5 cells were observed in the central retina. The first in the retinal ganglion cell layer and presumptive amacrine cell layer. |
Specimen Label: |
3C/D |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:27063 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-06-14 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1915524 |
Pattern: |
Regionally restricted |
Stage: |
TS24 |
Assay Id: |
MGI:7647248 |
Age: |
embryonic day 16.5 |
|
Note: |
Two distinct layers of DCC mRNA expressing E16.5 cells were observed in the central retina. The first in the retinal ganglion cell layer and presumptive amacrine cell layer. |
Specimen Label: |
3C/D |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Howell DM |
Year: |
2007 |
Journal: |
J Comp Neurol |
Title: |
Molecular guidance cues necessary for axon pathfinding from the ventral cochlear nucleus. |
Volume: |
504 |
Issue: |
5 |
Pages: |
533-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bouhidel JO |
Year: |
2015 |
Journal: |
Biochim Biophys Acta |
Title: |
Netrin-1 improves post-injury cardiac function in vivo via DCC/NO-dependent preservation of mitochondrial integrity, while attenuating autophagy. |
Volume: |
1852 |
Issue: |
2 |
Pages: |
277-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shide K |
Year: |
2008 |
Journal: |
Leukemia |
Title: |
Development of ET, primary myelofibrosis and PV in mice expressing JAK2 V617F. |
Volume: |
22 |
Issue: |
1 |
Pages: |
87-95 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7647247 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2024-06-14 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1859223 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:7647258 |
Age: |
embryonic day 15.5 |
|
Note: |
At the outer edge of the outer nuclear layer, cell bodies expressing significant levels of DCC protein were distributed sparsely. Overall, the level of DCC protein detected in the E15.5 outer nuclear layer was low. |
Specimen Label: |
5A |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Furne C |
Year: |
2008 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Netrin-1 is a survival factor during commissural neuron navigation. |
Volume: |
105 |
Issue: |
38 |
Pages: |
14465-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu L |
Year: |
2021 |
Journal: |
Int J Mol Sci |
Title: |
A Novel Netrin-1-Derived Peptide Enhances Protection against Neuronal Death and Mitigates of Intracerebral Hemorrhage in Mice. |
Volume: |
22 |
Issue: |
9 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ren XR |
Year: |
2004 |
Journal: |
Nat Neurosci |
Title: |
Focal adhesion kinase in netrin-1 signaling. |
Volume: |
7 |
Issue: |
11 |
Pages: |
1204-12 |
|
•
•
•
•
•
|