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Search results 1 to 100 out of 340 for Dgcr8

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Hits by Strain

Type Details Score
Gene
54487 | DGCR8
Type: gene
Organism: human
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Gene
100144670 | dgcr8
Type: gene
Organism: frog, western clawed
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Gene
119866241 | DGCR8
Type: gene
Organism: dog, domestic
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Gene
287954 | Dgcr8
Type: gene
Organism: rat
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Gene
540254 | DGCR8
Type: gene
Organism: cattle
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Gene
101059245 | DGCR8
Type: gene
Organism: chimpanzee
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Gene
563963 | dgcr8
Type: gene
Organism: zebrafish
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Gene
100425351 | DGCR8
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR040375 | DGCR8
Type: Family
Description: Primary microRNA transcripts (pri-miRs) are cleaved by Microprocessor, a complex containing RNase III DROSHA and its cofactor DGCR8 []. DGCR8 functions as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs [, ]. DGCR8 binds heme, and this binding activates DGCR8 to recognize pri-miRs by specifically binding the terminal loop near the 3' single-stranded segment [].
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Gene
416785 | DGCR8
Type: gene
Organism: chicken
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Protein Coding Gene
MGI:2151114 | Dgcr8
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
29170488 | -
First Author: Partin AC
Year: 2017
Journal: Nat Commun
Title: Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs.
Volume: 8
Issue: 1
Pages: 1737
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Protein
Q9EQM6
Organism: Mus musculus/domesticus
Length: 773  
Fragment?: false
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Protein
A0A338P691
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: true
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Publication
26027739 | -
First Author: Nguyen TA
Year: 2015
Journal: Cell
Title: Functional Anatomy of the Human Microprocessor.
Volume: 161
Issue: 6
Pages: 1374-87
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Publication
17259983 | J:141670
First Author: Wang Y
Year: 2007
Journal: Nat Genet
Title: DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal.
Volume: 39
Issue: 3
Pages: 380-5
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Publication
12705904 | J:83362
First Author: Shiohama A
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Molecular cloning and expression analysis of a novel gene DGCR8 located in the DiGeorge syndrome chromosomal region.
Volume: 304
Issue: 1
Pages: 184-90
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Publication
26748718 | -
First Author: Kwon SC
Year: 2016
Journal: Cell
Title: Structure of Human DROSHA.
Volume: 164
Issue: 1-2
Pages: 81-90
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Publication
22138056 | J:180151
First Author: Chapnik E
Year: 2012
Journal: Dev Biol
Title: Dgcr8 controls neural crest cells survival in cardiovascular development.
Volume: 362
Issue: 1
Pages: 50-6
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Publication
28739418 | J:255130
 
First Author: Choi YJ
Year: 2017
Journal: Bone
Title: Deficiency of DGCR8 increases bone formation through downregulation of miR-22 expression.
Volume: 103
Pages: 287-294
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Publication
36591274 | J:332443
 
First Author: Daum P
Year: 2022
Journal: Front Immunol
Title: The microRNA processing subunit DGCR8 is required for a T cell-dependent germinal center response.
Volume: 13
Pages: 991347
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Publication
26206718 | J:224835
First Author: Belair CD
Year: 2015
Journal: EMBO Rep
Title: DGCR8 is essential for tumor progression following PTEN loss in the prostate.
Volume: 16
Issue: 9
Pages: 1219-32
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Publication
28232627 | J:241293
First Author: Marinaro F
Year: 2017
Journal: EMBO Rep
Title: MicroRNA-independent functions of DGCR8 are essential for neocortical development and TBR1 expression.
Volume: 18
Issue: 4
Pages: 603-618
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Publication
33771876 | J:332377
 
First Author: Killy B
Year: 2021
Journal: Life Sci Alliance
Title: DGCR8 deficiency impairs macrophage growth and unleashes the interferon response to mycobacteria.
Volume: 4
Issue: 6
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Publication
25934699 | J:232835
First Author: Modzelewski AJ
Year: 2015
Journal: J Cell Sci
Title: Dgcr8 and Dicer are essential for sex chromosome integrity during meiosis in males.
Volume: 128
Issue: 12
Pages: 2314-27
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Publication
29362439 | J:259678
First Author: Zou Y
Year: 2018
Journal: Sci Rep
Title: Deletion of DGCR8 in VSMCs of adult mice results in loss of vascular reactivity, reduced blood pressure and neointima formation.
Volume: 8
Issue: 1
Pages: 1468
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Publication
29760646 | J:264394
 
First Author: Hoffmann N
Year: 2018
Journal: Front Neurosci
Title: DGCR8 Promotes Neural Progenitor Expansion and Represses Neurogenesis in the Mouse Embryonic Neocortex.
Volume: 12
Pages: 281
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Publication
30128894 | J:315974
First Author: Chen X
Year: 2019
Journal: Protein Cell
Title: Dgcr8 deletion in the primitive heart uncovered novel microRNA regulating the balance of cardiac-vascular gene program.
Volume: 10
Issue: 5
Pages: 327-346
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Publication
38110169 | J:344102
 
First Author: Racedo SE
Year: 2024
Journal: Dev Biol
Title: Dgcr8 functions in the secondary heart field for outflow tract and right ventricle development in mammals.
Volume: 506
Pages: 72-84
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Publication
26126715 | J:259443
First Author: Tu CC
Year: 2015
Journal: Sci Signal
Title: The kinase ABL phosphorylates the microprocessor subunit DGCR8 to stimulate primary microRNA processing in response to DNA damage.
Volume: 8
Issue: 383
Pages: ra64
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Publication
33496365 | J:307387
First Author: Kim YS
Year: 2021
Journal: Cell Prolif
Title: Different Cre systems induce differential microRNA landscapes and abnormalities in the female reproductive tracts of Dgcr8 conditional knockout mice.
Volume: 54
Issue: 3
Pages: e12996
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Publication
21466685 | J:171661
 
First Author: Schofield CM
Year: 2011
Journal: Neural Dev
Title: Monoallelic deletion of the microRNA biogenesis gene Dgcr8 produces deficits in the development of excitatory synaptic transmission in the prefrontal cortex.
Volume: 6
Pages: 11
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Publication
21712401 | J:267300
First Author: Babiarz JE
Year: 2011
Journal: RNA
Title: A role for noncanonical microRNAs in the mammalian brain revealed by phenotypic differences in Dgcr8 versus Dicer1 knockouts and small RNA sequencing.
Volume: 17
Issue: 8
Pages: 1489-501
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Publication
25244517 | J:220631
First Author: Zimmermann C
Year: 2014
Journal: PLoS One
Title: Germ cell-specific targeting of DICER or DGCR8 reveals a novel role for endo-siRNAs in the progression of mammalian spermatogenesis and male fertility.
Volume: 9
Issue: 9
Pages: e107023
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Publication
23719809 | J:198659
First Author: Ouchi Y
Year: 2013
Journal: J Neurosci
Title: Reduced adult hippocampal neurogenesis and working memory deficits in the Dgcr8-deficient mouse model of 22q11.2 deletion-associated schizophrenia can be rescued by IGF2.
Volume: 33
Issue: 22
Pages: 9408-19
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Publication
32060266 | J:285391
First Author: Eom TY
Year: 2020
Journal: Nat Commun
Title: Schizophrenia-related microdeletion causes defective ciliary motility and brain ventricle enlargement via microRNA-dependent mechanisms in mice.
Volume: 11
Issue: 1
Pages: 912
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Publication
25002228 | J:215642
First Author: Busskamp V
Year: 2014
Journal: Neuron
Title: miRNAs 182 and 183 are necessary to maintain adult cone photoreceptor outer segments and visual function.
Volume: 83
Issue: 3
Pages: 586-600
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Publication
28102192 | J:244240
 
First Author: Gambardella G
Year: 2017
Journal: Nat Commun
Title: The impact of microRNAs on transcriptional heterogeneity and gene co-expression across single embryonic stem cells.
Volume: 8
Pages: 14126
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Publication
18978791 | J:143230
First Author: Wang Y
Year: 2008
Journal: Nat Genet
Title: Embryonic stem cell-specific microRNAs regulate the G1-S transition and promote rapid proliferation.
Volume: 40
Issue: 12
Pages: 1478-83
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Publication
39226174 | J:354625
First Author: Trigg NA
Year: 2024
Journal: Cell Rep
Title: Epididymal acquired sperm microRNAs modify post-fertilization embryonic gene expression.
Volume: 43
Issue: 9
Pages: 114698
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Publication
24027283 | J:202335
First Author: Fénelon K
Year: 2013
Journal: J Neurosci
Title: The pattern of cortical dysfunction in a mouse model of a schizophrenia-related microdeletion.
Volume: 33
Issue: 37
Pages: 14825-39
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Publication
21368174 | J:170822
First Author: Fénelon K
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Deficiency of Dgcr8, a gene disrupted by the 22q11.2 microdeletion, results in altered short-term plasticity in the prefrontal cortex.
Volume: 108
Issue: 11
Pages: 4447-52
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Publication
20116247 | J:158511
First Author: Suh N
Year: 2010
Journal: Curr Biol
Title: MicroRNA function is globally suppressed in mouse oocytes and early embryos.
Volume: 20
Issue: 3
Pages: 271-7
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Publication
25008181 | J:230141
First Author: Kim HJ
Year: 2014
Journal: Diabetes
Title: MicroRNAs are required for the feature maintenance and differentiation of brown adipocytes.
Volume: 63
Issue: 12
Pages: 4045-56
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Publication
27892953 | J:250663
First Author: Chun S
Year: 2017
Journal: Nat Med
Title: Thalamic miR-338-3p mediates auditory thalamocortical disruption and its late onset in models of 22q11.2 microdeletion.
Volume: 23
Issue: 1
Pages: 39-48
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Publication
18469815 | J:136969
First Author: Stark KL
Year: 2008
Journal: Nat Genet
Title: Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model.
Volume: 40
Issue: 6
Pages: 751-60
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Publication
25881298 | J:233486
 
First Author: Bartram MP
Year: 2015
Journal: BMC Nephrol
Title: Loss of Dgcr8-mediated microRNA expression in the kidney results in hydronephrosis and renal malformation.
Volume: 16
Pages: 55
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Publication
27641147 | J:246331
First Author: Brandl A
Year: 2016
Journal: Eur J Immunol
Title: The microprocessor component, DGCR8, is essential for early B-cell development in mice.
Volume: 46
Issue: 12
Pages: 2710-2718
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Publication
20054295 | J:156757
First Author: Melton C
Year: 2010
Journal: Nature
Title: Opposing microRNA families regulate self-renewal in mouse embryonic stem cells.
Volume: 463
Issue: 7281
Pages: 621-6
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Publication
24904170 | J:211625
First Author: Chun S
Year: 2014
Journal: Science
Title: Specific disruption of thalamic inputs to the auditory cortex in schizophrenia models.
Volume: 344
Issue: 6188
Pages: 1178-82
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Publication
26748703 | J:277596
First Author: Swahari V
Year: 2016
Journal: Cell Rep
Title: Essential Function of Dicer in Resolving DNA Damage in the Rapidly Dividing Cells of the Developing and Malignant Cerebellum.
Volume: 14
Issue: 2
Pages: 216-24
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Publication
26833131 | J:251593
 
First Author: Kim YS
Year: 2016
Journal: Sci Rep
Title: Deficiency in DGCR8-dependent canonical microRNAs causes infertility due to multiple abnormalities during uterine development in mice.
Volume: 6
Pages: 20242
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Publication
22897173 | J:190566
First Author: Lugli G
Year: 2012
Journal: J Neurochem
Title: Primary microRNA precursor transcripts are localized at post-synaptic densities in adult mouse forebrain.
Volume: 123
Issue: 4
Pages: 459-66
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Publication
22728723 | J:203596
First Author: Hsu R
Year: 2012
Journal: Mol Cell Neurosci
Title: Loss of microRNAs in pyramidal neurons leads to specific changes in inhibitory synaptic transmission in the prefrontal cortex.
Volume: 50
Issue: 3-4
Pages: 283-92
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Publication
29146941 | J:257286
First Author: Amin H
Year: 2017
Journal: Sci Rep
Title: Developmental excitatory-to-inhibitory GABA-polarity switch is disrupted in 22q11.2 deletion syndrome: a potential target for clinical therapeutics.
Volume: 7
Issue: 1
Pages: 15752
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Publication
19759829 | J:223635
First Author: Shenoy A
Year: 2009
Journal: PLoS One
Title: Genomic analysis suggests that mRNA destabilization by the microprocessor is specialized for the auto-regulation of Dgcr8.
Volume: 4
Issue: 9
Pages: e6971
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Publication
27090781 | J:319576
 
First Author: Bartram MP
Year: 2016
Journal: BMC Mol Biol
Title: Mice lacking microRNAs in Pax8-expressing cells develop hypothyroidism and end-stage renal failure.
Volume: 17
Pages: 11
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Publication
20805417 | J:164317
First Author: Bezman NA
Year: 2010
Journal: J Immunol
Title: Distinct requirements of microRNAs in NK cell activation, survival, and function.
Volume: 185
Issue: 7
Pages: 3835-46
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Publication
30295958 | J:268793
First Author: Gökbuget D
Year: 2018
Journal: Glia
Title: The miRNA biogenesis pathway prevents inappropriate expression of injury response genes in developing and adult Schwann cells.
Volume: 66
Issue: 12
Pages: 2632-2644
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Publication
25707934 | J:317047
First Author: Kobayashi T
Year: 2015
Journal: Osteoarthritis Cartilage
Title: Early postnatal ablation of the microRNA-processing enzyme, Drosha, causes chondrocyte death and impairs the structural integrity of the articular cartilage.
Volume: 23
Issue: 7
Pages: 1214-20
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Publication
26272614 | J:225866
First Author: Lin HP
Year: 2015
Journal: J Biol Chem
Title: Microprocessor complex subunit DiGeorge syndrome critical region gene 8 (Dgcr8) is required for schwann cell myelination and myelin maintenance.
Volume: 290
Issue: 40
Pages: 24294-307
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Publication
22511778 | J:186203
First Author: Chen Z
Year: 2012
Journal: J Biol Chem
Title: DiGeorge syndrome critical region 8 (DGCR8) protein-mediated microRNA biogenesis is essential for vascular smooth muscle cell development in mice.
Volume: 287
Issue: 23
Pages: 19018-28
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Publication
24449888 | J:206433
First Author: Chakravarti D
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Induced multipotency in adult keratinocytes through down-regulation of ΔNp63 or DGCR8.
Volume: 111
Issue: 5
Pages: E572-81
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Publication
24101523 | J:201966
First Author: Toritsuka M
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model.
Volume: 110
Issue: 43
Pages: 17552-7
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Publication
26062936 | J:224079
First Author: Ohana R
Year: 2015
Journal: Development
Title: MicroRNAs are essential for differentiation of the retinal pigmented epithelium and maturation of adjacent photoreceptors.
Volume: 142
Issue: 14
Pages: 2487-98
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Publication
36197846 | J:329565
First Author: Kim J
Year: 2022
Journal: PLoS Genet
Title: The RNA helicase DDX6 controls early mouse embryogenesis by repressing aberrant inhibition of BMP signaling through miRNA-mediated gene silencing.
Volume: 18
Issue: 10
Pages: e1009967
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Protein Coding Gene
MGP_CAROLIEiJ_G0020542 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0022607 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0022568 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0022545 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0022573 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0022340 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2151114 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0023022 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0021867 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0022309 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0022441 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0022416 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0022508 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0022438 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0023033 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0021609 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0021913 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0016247 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0021437 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
34678162 | J:319882
First Author: Zick JL
Year: 2022
Journal: Curr Biol
Title: Disparate insults relevant to schizophrenia converge on impaired spike synchrony and weaker synaptic interactions in prefrontal local circuits.
Volume: 32
Issue: 1
Pages: 14-25.e4
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Publication
19679836 | J:161342
First Author: Rao PK
Year: 2009
Journal: Circ Res
Title: Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure.
Volume: 105
Issue: 6
Pages: 585-94
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Publication
21820330 | J:175847
First Author: Steiner DF
Year: 2011
Journal: Immunity
Title: MicroRNA-29 regulates T-box transcription factors and interferon-γ production in helper T cells.
Volume: 35
Issue: 2
Pages: 169-81
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Publication
25519956 | J:217873
First Author: Ma Y
Year: 2015
Journal: EMBO J
Title: Functional screen reveals essential roles of miR-27a/24 in differentiation of embryonic stem cells.
Volume: 34
Issue: 3
Pages: 361-78
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GXD Expression
GXD Expression
   
Probe: MGI:3028100
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689517
Stage: TS17
Assay Id: MGI:3028161
Age: embryonic day 10.5
Image: 1
Specimen Label: fnm/fb
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3028100
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611717
Stage: TS17
Assay Id: MGI:3028161
Age: embryonic day 10.5
Image: 1
Specimen Label: ba
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:3028100
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610417
Stage: TS17
Assay Id: MGI:3028161
Age: embryonic day 10.5
Image: 1
Specimen Label: aah
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:3028100
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640617
Stage: TS17
Assay Id: MGI:3028161
Age: embryonic day 10.5
Image: 1
Specimen Label: flb
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:3028100
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603916
Stage: TS16
Assay Id: MGI:3028201
Age: embryonic day 10.0
Image: 2
Specimen Label: E10 Whole
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3028100
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:3028201
Age: embryonic day 14.0
Image: 2
Specimen Label: E14 Whole
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:3028100
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689420
Stage: TS20
Assay Id: MGI:3028201
Age: embryonic day 12.0
Image: 2
Specimen Label: E12 Brain
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:3028100
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689422
Stage: TS22
Assay Id: MGI:3028201
Age: embryonic day 14.0
Image: 2
Specimen Label: E14 Brain
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3028100
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:3028201
Age: embryonic day 18.0
Image: 2
Specimen Label: E18 Brain
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3028100
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:3028201
Age: postnatal day 0
Image: 2
Specimen Label: P0 Brain
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3028100
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3028201
Age: postnatal day 7
Image: 2
Specimen Label: P7 Brain
Detected: true
Specimen Num: 7
•
•
•
•
•




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