Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Disks large-associated protein 1, also known as GKAP or DAP-1, is a member of the SAPAP family. It is a synaptic protein that may play several roles in the molecular organisation of synapses and neuronal cell signalling [, ]. It has been linked to obsessive-compulsive disorder (OCD) [].SAPAP family members are PSD-95/SAP90-associated proteins localised at postsynaptic density []. Postsynaptic density (PSD) is a specialised submembranous structure within which synaptic membrane proteins are linked to cytoskeletonand signalling proteins. PSD-95/SAP90 is one of the major components of PSD, and functions as a scaffold protein for various ion channels and associated signalling molecules. |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Publication |
First Author: |
Coba MP |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
Dlgap1 knockout mice exhibit alterations of the postsynaptic density and selective reductions in sociability. |
Volume: |
8 |
Issue: |
1 |
Pages: |
2281 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang J |
Year: |
2020 |
Journal: |
Lipids Health Dis |
Title: |
Dlgap1 negatively regulates browning of white fat cells through effects on cell proliferation and apoptosis. |
Volume: |
19 |
Issue: |
1 |
Pages: |
39 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
992
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
535
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
699
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
944
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
692
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
982
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
726
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
666
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
682
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
660
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
636
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim E |
Year: |
1997 |
Journal: |
J Cell Biol |
Title: |
GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules. |
Volume: |
136 |
Issue: |
3 |
Pages: |
669-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Satoh K |
Year: |
1997 |
Journal: |
Genes Cells |
Title: |
DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95. |
Volume: |
2 |
Issue: |
6 |
Pages: |
415-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mattheisen M |
Year: |
2015 |
Journal: |
Mol Psychiatry |
Title: |
Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS. |
Volume: |
20 |
Issue: |
3 |
Pages: |
337-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takeuchi M |
Year: |
1997 |
Journal: |
J Biol Chem |
Title: |
SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density. |
Volume: |
272 |
Issue: |
18 |
Pages: |
11943-51 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Ehlers MD |
Year: |
1999 |
Journal: |
Curr Biol |
Title: |
Synapse structure: glutamate receptors connected by the shanks. |
Volume: |
9 |
Issue: |
22 |
Pages: |
R848-50 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4428843 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-09-26 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271122 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:7530860 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
Supplementary table 2 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5287868 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2011-10-03 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3284526 |
Pattern: |
Punctate |
Stage: |
TS26 |
Assay Id: |
MGI:5287899 |
Age: |
embryonic day 18.0 |
Image: |
2i |
Note: |
Expression is concentrated at synapses. |
Specimen Label: |
2i |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5287868 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2011-10-03 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3284526 |
Pattern: |
Punctate |
Stage: |
TS26 |
Assay Id: |
MGI:5287899 |
Age: |
embryonic day 18.0 |
Image: |
2o |
Note: |
Expression is concentrated at synapses and is the same as in wild-type. |
Specimen Label: |
2o |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5287868 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2011-10-03 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3284528 |
Pattern: |
Punctate |
Stage: |
TS28 |
Assay Id: |
MGI:5287899 |
Age: |
postnatal adult |
Image: |
2c |
Note: |
Expression is concentrated at synapses. |
Specimen Label: |
2c |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Parker MJ |
Year: |
2004 |
Journal: |
J Neurosci |
Title: |
PSD93 regulates synaptic stability at neuronal cholinergic synapses. |
Volume: |
24 |
Issue: |
2 |
Pages: |
378-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Baud A |
Year: |
2021 |
Journal: |
Genome Biol |
Title: |
Dissecting indirect genetic effects from peers in laboratory mice. |
Volume: |
22 |
Issue: |
1 |
Pages: |
216 |
|
•
•
•
•
•
|
Publication |
First Author: |
Moutin E |
Year: |
2012 |
Journal: |
J Cell Sci |
Title: |
GKAP-DLC2 interaction organizes the postsynaptic scaffold complex to enhance synaptic NMDA receptor activity. |
Volume: |
125 |
Issue: |
Pt 8 |
Pages: |
2030-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Welch JM |
Year: |
2004 |
Journal: |
J Comp Neurol |
Title: |
Differential mRNA expression and protein localization of the SAP90/PSD-95-associated proteins (SAPAPs) in the nervous system of the mouse. |
Volume: |
472 |
Issue: |
1 |
Pages: |
24-39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Horner AE |
Year: |
2021 |
Journal: |
Genes Brain Behav |
Title: |
Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2. |
Volume: |
20 |
Issue: |
1 |
Pages: |
e12723 |
|
•
•
•
•
•
|
Publication |
First Author: |
Naim E |
Year: |
2005 |
Journal: |
Kidney Int |
Title: |
Mutagenesis of the epithelial polarity gene, discs large 1, perturbs nephrogenesis in the developing mouse kidney. |
Volume: |
68 |
Issue: |
3 |
Pages: |
955-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang X |
Year: |
2011 |
Journal: |
Hum Mol Genet |
Title: |
Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3. |
Volume: |
20 |
Issue: |
15 |
Pages: |
3093-108 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schütt J |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
Fragile X mental retardation protein regulates the levels of scaffold proteins and glutamate receptors in postsynaptic densities. |
Volume: |
284 |
Issue: |
38 |
Pages: |
25479-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Serpinskaya AS |
Year: |
1999 |
Journal: |
Dev Biol |
Title: |
Synapse formation by hippocampal neurons from agrin-deficient mice. |
Volume: |
205 |
Issue: |
1 |
Pages: |
65-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Boon AC |
Year: |
2009 |
Journal: |
J Virol |
Title: |
Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice. |
Volume: |
83 |
Issue: |
20 |
Pages: |
10417-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Verpelli C |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. |
Volume: |
286 |
Issue: |
40 |
Pages: |
34839-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lie E |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3-LAR adhesion. |
Volume: |
7 |
|
Pages: |
12328 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sawallisch C |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity. |
Volume: |
284 |
Issue: |
14 |
Pages: |
9225-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li J |
Year: |
2017 |
Journal: |
Nat Neurosci |
Title: |
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. |
Volume: |
20 |
Issue: |
8 |
Pages: |
1150-1161 |
|
•
•
•
•
•
|
Publication |
First Author: |
Munton RP |
Year: |
2007 |
Journal: |
Mol Cell Proteomics |
Title: |
Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. |
Volume: |
6 |
Issue: |
2 |
Pages: |
283-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bouwman J |
Year: |
2006 |
Journal: |
J Neurochem |
Title: |
Reduced expression of neuropeptide genes in a genome-wide screen of a secretion-deficient mouse. |
Volume: |
99 |
Issue: |
1 |
Pages: |
84-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brady KP |
Year: |
1997 |
Journal: |
Genome Res |
Title: |
Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. |
Volume: |
7 |
Issue: |
11 |
Pages: |
1085-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Backcross DNA Panel Mapping Resource |
Year: |
1999 |
Journal: |
Database Release |
Title: |
JAX BSS Panel Mapping Data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI and IMPC |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Mouse Synonym Curation |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Friedel RH |
Year: |
2007 |
Journal: |
Brief Funct Genomic Proteomic |
Title: |
EUCOMM--the European conditional mouse mutagenesis program. |
Volume: |
6 |
Issue: |
3 |
Pages: |
180-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bedogni F |
Year: |
2021 |
Journal: |
Front Mol Neurosci |
Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
Volume: |
14 |
|
Pages: |
686034 |
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•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
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Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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