Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
In mammals, DNA methylation patterns are thought to be established during embryonic development by de novo DNA methyltransferases 3A and 3B (DNMT3A/3B) []. DNMT3A/3B work synergistically to propagate methylation patterns with DNMT3B stimulating DNMT3A activity by promoting its association with nucleosomes []. DNMT3A exists in an autoinhibitory form that can be activated by the histone H3 tail in a DNMT3L-independent manner []. DNMT3A has been linked to cancers [, , ]. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Mayle A |
Year: |
2015 |
Journal: |
Blood |
Title: |
Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation. |
Volume: |
125 |
Issue: |
4 |
Pages: |
629-38 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okano M |
Year: |
1999 |
Journal: |
Cell |
Title: |
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. |
Volume: |
99 |
Issue: |
3 |
Pages: |
247-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Celik H |
Year: |
2015 |
Journal: |
Blood |
Title: |
Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation. |
Volume: |
125 |
Issue: |
4 |
Pages: |
619-28 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
908
|
Fragment?: |
false |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7470897 |
Assay Type: |
RT-PCR |
Annotation Date: |
2023-05-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360355 |
|
Stage: |
TS05 |
Assay Id: |
MGI:7470906 |
Age: |
embryonic day 3.5 |
Image: |
3 |
|
Specimen Label: |
E3.5 Dnmt3a |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7470897 |
Assay Type: |
RT-PCR |
Annotation Date: |
2023-05-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603917 |
|
Stage: |
TS17 |
Assay Id: |
MGI:7470906 |
Age: |
embryonic day 10.5 |
Image: |
3 |
|
Specimen Label: |
E10.5 Dnmt3a |
Detected: |
true |
Specimen Num: |
12 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7470897 |
Assay Type: |
RT-PCR |
Annotation Date: |
2023-05-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603911 |
|
Stage: |
TS11 |
Assay Id: |
MGI:7470906 |
Age: |
embryonic day 7.5 |
Image: |
3 |
|
Specimen Label: |
E7.5 Dnmt3a |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
193
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
198
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
94
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Guo X |
Year: |
2015 |
Journal: |
Nature |
Title: |
Structural insight into autoinhibition and histone H3-induced activation of DNMT3A. |
Volume: |
517 |
Issue: |
7536 |
Pages: |
640-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Santos GC Jr |
Year: |
2015 |
Journal: |
J Cell Biochem |
Title: |
Epigenetic modifications, chromatin distribution and TP53 transcription in a model of breast cancer progression. |
Volume: |
116 |
Issue: |
4 |
Pages: |
533-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sharma S |
Year: |
2011 |
Journal: |
PLoS Genet |
Title: |
Nucleosomes containing methylated DNA stabilize DNA methyltransferases 3A/3B and ensure faithful epigenetic inheritance. |
Volume: |
7 |
Issue: |
2 |
Pages: |
e1001286 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
332
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
202
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
184
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
140
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
181
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
107
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Higo T |
Year: |
2022 |
Journal: |
Exp Hematol |
Title: |
Heterozygous Dnmt3a R878C induces expansion of quiescent hematopoietic stem cell pool. |
Volume: |
109 |
|
Pages: |
45-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Challen GA |
Year: |
2011 |
Journal: |
Nat Genet |
Title: |
Dnmt3a is essential for hematopoietic stem cell differentiation. |
Volume: |
44 |
Issue: |
1 |
Pages: |
23-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gowher H |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
Mechanism of stimulation of catalytic activity of Dnmt3A and Dnmt3B DNA-(cytosine-C5)-methyltransferases by Dnmt3L. |
Volume: |
280 |
Issue: |
14 |
Pages: |
13341-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang H |
Year: |
2024 |
Journal: |
Cell |
Title: |
Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss. |
Volume: |
187 |
Issue: |
14 |
Pages: |
3690-3711.e19 |
|
•
•
•
•
•
|
Publication |
First Author: |
You D |
Year: |
2017 |
Journal: |
Elife |
Title: |
Dnmt3a is an epigenetic mediator of adipose insulin resistance. |
Volume: |
6 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Yang L |
Year: |
2016 |
Journal: |
Cancer Cell |
Title: |
DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias. |
Volume: |
29 |
Issue: |
6 |
Pages: |
922-934 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bell-Hensley A |
Year: |
2024 |
Journal: |
Bone |
Title: |
Skeletal abnormalities in mice with Dnmt3a missense mutations. |
Volume: |
183 |
|
Pages: |
117085 |
|
•
•
•
•
•
|
Publication |
First Author: |
Raddatz G |
Year: |
2012 |
Journal: |
PLoS Genet |
Title: |
Dnmt3a protects active chromosome domains against cancer-associated hypomethylation. |
Volume: |
8 |
Issue: |
12 |
Pages: |
e1003146 |
|
•
•
•
•
•
|
Publication |
First Author: |
Feng Y |
Year: |
2023 |
Journal: |
J Exp Med |
Title: |
Hematopoietic-specific heterozygous loss of Dnmt3a exacerbates colitis-associated colon cancer. |
Volume: |
220 |
Issue: |
11 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Jeong M |
Year: |
2018 |
Journal: |
Cell Rep |
Title: |
Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo. |
Volume: |
23 |
Issue: |
1 |
Pages: |
1-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kramer AC |
Year: |
2017 |
Journal: |
Leukemia |
Title: |
Dnmt3a regulates T-cell development and suppresses T-ALL transformation. |
Volume: |
31 |
Issue: |
11 |
Pages: |
2479-2490 |
|
•
•
•
•
•
|
Publication |
First Author: |
Watanabe D |
Year: |
2002 |
Journal: |
Mech Dev |
Title: |
Stage- and cell-specific expression of Dnmt3a and Dnmt3b during embryogenesis. |
Volume: |
118 |
Issue: |
1-2 |
Pages: |
187-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kohno D |
Year: |
2014 |
Journal: |
J Neurosci |
Title: |
Dnmt3a in Sim1 neurons is necessary for normal energy homeostasis. |
Volume: |
34 |
Issue: |
46 |
Pages: |
15288-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang X |
Year: |
2020 |
Journal: |
Blood |
Title: |
Dnmt3a loss and Idh2 neomorphic mutations mutually potentiate malignant hematopoiesis. |
Volume: |
135 |
Issue: |
11 |
Pages: |
845-856 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li N |
Year: |
2020 |
Journal: |
Curr Mol Med |
Title: |
Uterine Dnmt3a is not Required for Mouse Embryo Implantation. |
Volume: |
20 |
Issue: |
8 |
Pages: |
633-642 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rajavelu A |
Year: |
2018 |
Journal: |
Nucleic Acids Res |
Title: |
Chromatin-dependent allosteric regulation of DNMT3A activity by MeCP2. |
Volume: |
46 |
Issue: |
17 |
Pages: |
9044-9056 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pham D |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation. |
Volume: |
191 |
Issue: |
2 |
Pages: |
902-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
González-RodrÃguez P |
Year: |
2021 |
Journal: |
Autophagy |
Title: |
The DNA methyltransferase DNMT3A contributes to autophagy long-term memory. |
Volume: |
17 |
Issue: |
5 |
Pages: |
1259-1277 |
|
•
•
•
•
•
|
Publication |
First Author: |
Naito M |
Year: |
2016 |
Journal: |
PLoS Genet |
Title: |
Dnmt3a Regulates Proliferation of Muscle Satellite Cells via p57Kip2. |
Volume: |
12 |
Issue: |
7 |
Pages: |
e1006167 |
|
•
•
•
•
•
|
Publication |
First Author: |
Smith AM |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome. |
Volume: |
12 |
Issue: |
1 |
Pages: |
4549 |
|
•
•
•
•
•
|
Publication |
First Author: |
Colquitt BM |
Year: |
2014 |
Journal: |
Neuron |
Title: |
Dnmt3a regulates global gene expression in olfactory sensory neurons and enables odorant-induced transcription. |
Volume: |
83 |
Issue: |
4 |
Pages: |
823-38 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6171381 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:6190136 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Dnmt3a |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6171381 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:6190136 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Dnmt3a |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6171381 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190136 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Dnmt3a |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6171381 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190136 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Dnmt3a |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6171381 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6190136 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Dnmt3a |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6171381 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6190136 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Dnmt3a |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6171381 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190136 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Dnmt3a |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guryanova OA |
Year: |
2016 |
Journal: |
Leukemia |
Title: |
Dnmt3a regulates myeloproliferation and liver-specific expansion of hematopoietic stem and progenitor cells. |
Volume: |
30 |
Issue: |
5 |
Pages: |
1133-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tovy A |
Year: |
2022 |
Journal: |
Elife |
Title: |
Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis. |
Volume: |
11 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Minero AS |
Year: |
2012 |
Journal: |
FEBS J |
Title: |
Probing murine methyltransfease Dnmt3a interactions with benzo[a]pyrene-modified DNA by fluorescence methods. |
Volume: |
279 |
Issue: |
20 |
Pages: |
3965-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liao J |
Year: |
2015 |
Journal: |
Nat Genet |
Title: |
Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells. |
Volume: |
47 |
Issue: |
5 |
Pages: |
469-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jacquelin S |
Year: |
2018 |
Journal: |
Blood |
Title: |
Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation. |
Volume: |
132 |
Issue: |
26 |
Pages: |
2707-2721 |
|
•
•
•
•
•
|
Publication |
First Author: |
Haney SL |
Year: |
2016 |
Journal: |
PLoS Genet |
Title: |
Dnmt3a Is a Haploinsufficient Tumor Suppressor in CD8+ Peripheral T Cell Lymphoma. |
Volume: |
12 |
Issue: |
9 |
Pages: |
e1006334 |
|
•
•
•
•
•
|
Publication |
First Author: |
Elliott E |
Year: |
2016 |
Journal: |
J Neurosci |
Title: |
Dnmt3a in the Medial Prefrontal Cortex Regulates Anxiety-Like Behavior in Adult Mice. |
Volume: |
36 |
Issue: |
3 |
Pages: |
730-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Khazaei S |
Year: |
2023 |
Journal: |
Cell |
Title: |
Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration. |
Volume: |
186 |
Issue: |
6 |
Pages: |
1162-1178.e20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rogers JH |
Year: |
2024 |
Journal: |
Exp Hematol |
Title: |
Dose-dependent effects of Dnmt3a in an inducible murine model of Kras(G12D)-driven leukemia. |
Volume: |
135 |
|
Pages: |
104248 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhao JY |
Year: |
2017 |
Journal: |
Nat Commun |
Title: |
DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons. |
Volume: |
8 |
|
Pages: |
14712 |
|
•
•
•
•
•
|
Publication |
First Author: |
Beard DC |
Year: |
2023 |
Journal: |
Cell Rep |
Title: |
Distinct disease mutations in DNMT3A result in a spectrum of behavioral, epigenetic, and transcriptional deficits. |
Volume: |
42 |
Issue: |
11 |
Pages: |
113411 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gu T |
Year: |
2022 |
Journal: |
Nat Genet |
Title: |
The disordered N-terminal domain of DNMT3A recognizes H2AK119ub and is required for postnatal development. |
Volume: |
54 |
Issue: |
5 |
Pages: |
625-636 |
|
•
•
•
•
•
|
Publication |
First Author: |
Christian DL |
Year: |
2020 |
Journal: |
Cell Rep |
Title: |
DNMT3A Haploinsufficiency Results in Behavioral Deficits and Global Epigenomic Dysregulation Shared across Neurodevelopmental Disorders. |
Volume: |
33 |
Issue: |
8 |
Pages: |
108416 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dai YJ |
Year: |
2017 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Conditional knockin of Dnmt3a R878H initiates acute myeloid leukemia with mTOR pathway involvement. |
Volume: |
114 |
Issue: |
20 |
Pages: |
5237-5242 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sendžikaitė G |
Year: |
2019 |
Journal: |
Nat Commun |
Title: |
A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice. |
Volume: |
10 |
Issue: |
1 |
Pages: |
1884 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li X |
Year: |
2020 |
Journal: |
FASEB J |
Title: |
LncRNA Dnmt3aos regulates Dnmt3a expression leading to aberrant DNA methylation in macrophage polarization. |
Volume: |
34 |
Issue: |
4 |
Pages: |
5077-5091 |
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Publication |
First Author: |
Zhang X |
Year: |
2016 |
Journal: |
Nat Genet |
Title: |
DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells. |
Volume: |
48 |
Issue: |
9 |
Pages: |
1014-23 |
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Publication |
First Author: |
Ramdas B |
Year: |
2022 |
Journal: |
JCI Insight |
Title: |
Combined heterozygosity of FLT3 ITD, TET2, and DNMT3A results in aggressive leukemia. |
Volume: |
7 |
Issue: |
17 |
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Publication |
First Author: |
Li J |
Year: |
2022 |
Journal: |
Elife |
Title: |
Dnmt3a knockout in excitatory neurons impairs postnatal synapse maturation and increases the repressive histone modification H3K27me3. |
Volume: |
11 |
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Publication |
First Author: |
Haney SL |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
Loss of Dnmt3a induces CLL and PTCL with distinct methylomes and transcriptomes in mice. |
Volume: |
6 |
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Pages: |
34222 |
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Publication |
First Author: |
Guryanova OA |
Year: |
2016 |
Journal: |
Nat Med |
Title: |
DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling. |
Volume: |
22 |
Issue: |
12 |
Pages: |
1488-1495 |
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Publication |
First Author: |
Siddique AN |
Year: |
2011 |
Journal: |
FEBS J |
Title: |
Auto-methylation of the mouse DNA-(cytosine C5)-methyltransferase Dnmt3a at its active site cysteine residue. |
Volume: |
278 |
Issue: |
12 |
Pages: |
2055-63 |
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Publication |
First Author: |
Kaneda M |
Year: |
2004 |
Journal: |
Nature |
Title: |
Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting. |
Volume: |
429 |
Issue: |
6994 |
Pages: |
900-3 |
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Publication |
First Author: |
Saunders J |
Year: |
2018 |
Journal: |
Front Mol Neurosci |
Title: |
Negative Evidence for a Functional Role of Neuronal DNMT3a in Persistent Pain. |
Volume: |
11 |
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Pages: |
332 |
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Publication |
First Author: |
Jurkowska RZ |
Year: |
2008 |
Journal: |
Nucleic Acids Res |
Title: |
Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L. |
Volume: |
36 |
Issue: |
21 |
Pages: |
6656-63 |
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Publication |
First Author: |
Gao Q |
Year: |
2011 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression. |
Volume: |
108 |
Issue: |
44 |
Pages: |
18061-6 |
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Publication |
First Author: |
Yagi M |
Year: |
2020 |
Journal: |
Nat Commun |
Title: |
Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development. |
Volume: |
11 |
Issue: |
1 |
Pages: |
3199 |
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Publication |
First Author: |
Challen GA |
Year: |
2014 |
Journal: |
Cell Stem Cell |
Title: |
Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells. |
Volume: |
15 |
Issue: |
3 |
Pages: |
350-364 |
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Publication |
First Author: |
Lavery LA |
Year: |
2020 |
Journal: |
Elife |
Title: |
Losing Dnmt3a dependent methylation in inhibitory neurons impairs neural function by a mechanism impacting Rett syndrome. |
Volume: |
9 |
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Publication |
First Author: |
Koya J |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
DNMT3A R882 mutants interact with polycomb proteins to block haematopoietic stem and leukaemic cell differentiation. |
Volume: |
7 |
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Pages: |
10924 |
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Publication |
First Author: |
Scheller M |
Year: |
2021 |
Journal: |
Nat Cancer |
Title: |
Hotspot DNMT3A mutations in clonal hematopoiesis and acute myeloid leukemia sensitize cells to azacytidine via viral mimicry response. |
Volume: |
2 |
Issue: |
5 |
Pages: |
527-544 |
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Publication |
First Author: |
Li X |
Year: |
2016 |
Journal: |
Nat Immunol |
Title: |
Methyltransferase Dnmt3a upregulates HDAC9 to deacetylate the kinase TBK1 for activation of antiviral innate immunity. |
Volume: |
17 |
Issue: |
7 |
Pages: |
806-15 |
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Publication |
First Author: |
Li Y |
Year: |
2024 |
Journal: |
Sci Adv |
Title: |
Rapid and accurate remethylation of DNA in Dnmt3a-deficient hematopoietic cells with restoration of DNMT3A activity. |
Volume: |
10 |
Issue: |
5 |
Pages: |
eadk8598 |
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Publication |
First Author: |
Feng J |
Year: |
2010 |
Journal: |
Nat Neurosci |
Title: |
Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons. |
Volume: |
13 |
Issue: |
4 |
Pages: |
423-30 |
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Publication |
First Author: |
Gowher H |
Year: |
2006 |
Journal: |
J Mol Biol |
Title: |
Mutational analysis of the catalytic domain of the murine Dnmt3a DNA-(cytosine C5)-methyltransferase. |
Volume: |
357 |
Issue: |
3 |
Pages: |
928-41 |
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Publication |
First Author: |
Li YQ |
Year: |
2007 |
Journal: |
Nucleic Acids Res |
Title: |
Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair. |
Volume: |
35 |
Issue: |
2 |
Pages: |
390-400 |
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Publication |
First Author: |
Chen CC |
Year: |
2012 |
Journal: |
J Biol Chem |
Title: |
The mammalian de novo DNA methyltransferases DNMT3A and DNMT3B are also DNA 5-hydroxymethylcytosine dehydroxymethylases. |
Volume: |
287 |
Issue: |
40 |
Pages: |
33116-21 |
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Publication |
First Author: |
Sportoletti P |
Year: |
2021 |
Journal: |
Leukemia |
Title: |
Bcor deficiency perturbs erythro-megakaryopoiesis and cooperates with Dnmt3a loss in acute erythroid leukemia onset in mice. |
Volume: |
35 |
Issue: |
7 |
Pages: |
1949-1963 |
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Publication |
First Author: |
Gowher H |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Molecular enzymology of the catalytic domains of the Dnmt3a and Dnmt3b DNA methyltransferases. |
Volume: |
277 |
Issue: |
23 |
Pages: |
20409-14 |
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Publication |
First Author: |
Haney SL |
Year: |
2015 |
Journal: |
Oncogene |
Title: |
Methylation-independent repression of Dnmt3b contributes to oncogenic activity of Dnmt3a in mouse MYC-induced T-cell lymphomagenesis. |
Volume: |
34 |
Issue: |
43 |
Pages: |
5436-5446 |
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Publication |
First Author: |
Ktena YP |
Year: |
2022 |
Journal: |
J Clin Invest |
Title: |
Donor T cell DNMT3a regulates alloreactivity in mouse models of hematopoietic stem cell transplantation. |
Volume: |
132 |
Issue: |
13 |
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Publication |
First Author: |
Shi X |
Year: |
2019 |
Journal: |
BMC Cancer |
Title: |
Cooperation of Dnmt3a R878H with Nras G12D promotes leukemogenesis in knock-in mice: a pilot study. |
Volume: |
19 |
Issue: |
1 |
Pages: |
1072 |
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Publication |
First Author: |
Poitras JL |
Year: |
2016 |
Journal: |
Oncotarget |
Title: |
Dnmt3a deletion cooperates with the Flt3/ITD mutation to drive leukemogenesis in a murine model. |
Volume: |
7 |
Issue: |
43 |
Pages: |
69124-69135 |
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