|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 1714 for Dnmt3a

<< First    < Previous  |  Next >    Last >>
0.057s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
1788 | DNMT3A
Type: gene
Organism: human
•
•
•
•
•
Gene
100496503 | dnmt3a
Type: gene
Organism: frog, western clawed
•
•
•
•
•
Gene
444984 | Dnmt3a
Type: gene
Organism: rat
•
•
•
•
•
Gene
482996 | DNMT3A
Type: gene
Organism: dog, domestic
•
•
•
•
•
Gene
739139 | DNMT3A
Type: gene
Organism: chimpanzee
•
•
•
•
•
Gene
359716 | DNMT3A
Type: gene
Organism: cattle
•
•
•
•
•
Gene
421991 | DNMT3A
Type: gene
Organism: chicken
•
•
•
•
•
Gene
694822 | DNMT3A
Type: gene
Organism: macaque, rhesus
•
•
•
•
•
Protein Domain
IPR030487 | DNMT3A
Type: Family
Description: In mammals, DNA methylation patterns are thought to be established during embryonic development by de novo DNA methyltransferases 3A and 3B (DNMT3A/3B) []. DNMT3A/3B work synergistically to propagate methylation patterns with DNMT3B stimulating DNMT3A activity by promoting its association with nucleosomes []. DNMT3A exists in an autoinhibitory form that can be activated by the histone H3 tail in a DNMT3L-independent manner []. DNMT3A has been linked to cancers [, , ].
•
•
•
•
•
Protein Coding Gene
MGI:1261827 | Dnmt3a
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Publication
25416277 | J:221203
First Author: Mayle A
Year: 2015
Journal: Blood
Title: Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation.
Volume: 125
Issue: 4
Pages: 629-38
•
•
•
•
•
Publication
10555141 | J:58298
First Author: Okano M
Year: 1999
Journal: Cell
Title: DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.
Volume: 99
Issue: 3
Pages: 247-57
•
•
•
•
•
Publication
25416276 | J:221204
First Author: Celik H
Year: 2015
Journal: Blood
Title: Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation.
Volume: 125
Issue: 4
Pages: 619-28
•
•
•
•
•
Protein
O88508
Organism: Mus musculus/domesticus
Length: 908  
Fragment?: false
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:7470897
Assay Type: RT-PCR
Annotation Date: 2023-05-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360355
Stage: TS05
Assay Id: MGI:7470906
Age: embryonic day 3.5
Image: 3
Specimen Label: E3.5 Dnmt3a
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:7470897
Assay Type: RT-PCR
Annotation Date: 2023-05-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:7470906
Age: embryonic day 7.5
Image: 3
Specimen Label: E7.5 Dnmt3a
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:7470897
Assay Type: RT-PCR
Annotation Date: 2023-05-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:7470906
Age: embryonic day 10.5
Image: 3
Specimen Label: E10.5 Dnmt3a
Detected: true
Specimen Num: 12
•
•
•
•
•
Protein
G3UX07
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: true
•
•
•
•
•
Protein
Q3TYD7
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: false
•
•
•
•
•
Protein
G3UX63
Organism: Mus musculus/domesticus
Length: 94  
Fragment?: true
•
•
•
•
•
Publication
25383530 | -
First Author: Guo X
Year: 2015
Journal: Nature
Title: Structural insight into autoinhibition and histone H3-induced activation of DNMT3A.
Volume: 517
Issue: 7536
Pages: 640-4
•
•
•
•
•
Publication
25358520 | -
First Author: Santos GC Jr
Year: 2015
Journal: J Cell Biochem
Title: Epigenetic modifications, chromatin distribution and TP53 transcription in a model of breast cancer progression.
Volume: 116
Issue: 4
Pages: 533-41
•
•
•
•
•
Publication
21304883 | -
First Author: Sharma S
Year: 2011
Journal: PLoS Genet
Title: Nucleosomes containing methylated DNA stabilize DNA methyltransferases 3A/3B and ensure faithful epigenetic inheritance.
Volume: 7
Issue: 2
Pages: e1001286
•
•
•
•
•
Protein
G3UXY2
Organism: Mus musculus/domesticus
Length: 332  
Fragment?: true
•
•
•
•
•
Protein
Q3UWR0
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: true
•
•
•
•
•
Protein
G3UZN5
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: true
•
•
•
•
•
Protein
G3UZF8
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: true
•
•
•
•
•
Protein
G3UZK0
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: true
•
•
•
•
•
Protein
G3UZG8
Organism: Mus musculus/domesticus
Length: 107  
Fragment?: true
•
•
•
•
•
Publication
35245608 | J:323396
 
First Author: Higo T
Year: 2022
Journal: Exp Hematol
Title: Heterozygous Dnmt3a R878C induces expansion of quiescent hematopoietic stem cell pool.
Volume: 109
Pages: 45-54
•
•
•
•
•
Publication
22138693 | J:179661
First Author: Challen GA
Year: 2011
Journal: Nat Genet
Title: Dnmt3a is essential for hematopoietic stem cell differentiation.
Volume: 44
Issue: 1
Pages: 23-31
•
•
•
•
•
Publication
15671018 | J:98706
First Author: Gowher H
Year: 2005
Journal: J Biol Chem
Title: Mechanism of stimulation of catalytic activity of Dnmt3A and Dnmt3B DNA-(cytosine-C5)-methyltransferases by Dnmt3L.
Volume: 280
Issue: 14
Pages: 13341-8
•
•
•
•
•
Publication
38838669 | J:350994
First Author: Wang H
Year: 2024
Journal: Cell
Title: Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss.
Volume: 187
Issue: 14
Pages: 3690-3711.e19
•
•
•
•
•
Publication
29091029 | J:254998
   
First Author: You D
Year: 2017
Journal: Elife
Title: Dnmt3a is an epigenetic mediator of adipose insulin resistance.
Volume: 6
•
•
•
•
•
Publication
27300438 | J:232326
First Author: Yang L
Year: 2016
Journal: Cancer Cell
Title: DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias.
Volume: 29
Issue: 6
Pages: 922-934
•
•
•
•
•
Publication
38522809 | J:348991
 
First Author: Bell-Hensley A
Year: 2024
Journal: Bone
Title: Skeletal abnormalities in mice with Dnmt3a missense mutations.
Volume: 183
Pages: 117085
•
•
•
•
•
Publication
23284304 | J:194932
First Author: Raddatz G
Year: 2012
Journal: PLoS Genet
Title: Dnmt3a protects active chromosome domains against cancer-associated hypomethylation.
Volume: 8
Issue: 12
Pages: e1003146
•
•
•
•
•
Publication
29617651 | J:270694
First Author: Jeong M
Year: 2018
Journal: Cell Rep
Title: Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo.
Volume: 23
Issue: 1
Pages: 1-10
•
•
•
•
•
Publication
37615936 | J:339310
 
First Author: Feng Y
Year: 2023
Journal: J Exp Med
Title: Hematopoietic-specific heterozygous loss of Dnmt3a exacerbates colitis-associated colon cancer.
Volume: 220
Issue: 11
•
•
•
•
•
Publication
28321121 | J:249414
First Author: Kramer AC
Year: 2017
Journal: Leukemia
Title: Dnmt3a regulates T-cell development and suppresses T-ALL transformation.
Volume: 31
Issue: 11
Pages: 2479-2490
•
•
•
•
•
Publication
12351185 | J:79524
First Author: Watanabe D
Year: 2002
Journal: Mech Dev
Title: Stage- and cell-specific expression of Dnmt3a and Dnmt3b during embryogenesis.
Volume: 118
Issue: 1-2
Pages: 187-90
•
•
•
•
•
Publication
25392496 | J:217402
First Author: Kohno D
Year: 2014
Journal: J Neurosci
Title: Dnmt3a in Sim1 neurons is necessary for normal energy homeostasis.
Volume: 34
Issue: 46
Pages: 15288-96
•
•
•
•
•
Publication
23772023 | J:204817
First Author: Pham D
Year: 2013
Journal: J Immunol
Title: Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation.
Volume: 191
Issue: 2
Pages: 902-11
•
•
•
•
•
Publication
31932841 | J:289551
First Author: Zhang X
Year: 2020
Journal: Blood
Title: Dnmt3a loss and Idh2 neomorphic mutations mutually potentiate malignant hematopoiesis.
Volume: 135
Issue: 11
Pages: 845-856
•
•
•
•
•
Publication
32096741 | J:309158
First Author: Li N
Year: 2020
Journal: Curr Mol Med
Title: Uterine Dnmt3a is not Required for Mouse Embryo Implantation.
Volume: 20
Issue: 8
Pages: 633-642
•
•
•
•
•
Publication
30102379 | J:266270
First Author: Rajavelu A
Year: 2018
Journal: Nucleic Acids Res
Title: Chromatin-dependent allosteric regulation of DNMT3A activity by MeCP2.
Volume: 46
Issue: 17
Pages: 9044-9056
•
•
•
•
•
Publication
32876528 | J:310981
First Author: González-Rodríguez P
Year: 2021
Journal: Autophagy
Title: The DNA methyltransferase DNMT3A contributes to autophagy long-term memory.
Volume: 17
Issue: 5
Pages: 1259-1277
•
•
•
•
•
Publication
27415617 | J:234177
First Author: Naito M
Year: 2016
Journal: PLoS Genet
Title: Dnmt3a Regulates Proliferation of Muscle Satellite Cells via p57Kip2.
Volume: 12
Issue: 7
Pages: e1006167
•
•
•
•
•
Publication
34315901 | J:321204
First Author: Smith AM
Year: 2021
Journal: Nat Commun
Title: Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome.
Volume: 12
Issue: 1
Pages: 4549
•
•
•
•
•
Publication
20729844 | J:356914
First Author: LaPlant Q
Year: 2010
Journal: Nat Neurosci
Title: Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens.
Volume: 13
Issue: 9
Pages: 1137-43
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6171381
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190136
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Dnmt3a
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6171381
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190136
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Dnmt3a
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6171381
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190136
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Dnmt3a
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6171381
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190136
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Dnmt3a
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6171381
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190136
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Dnmt3a
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6171381
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190136
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Dnmt3a
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6171381
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190136
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Dnmt3a
Detected: true
Specimen Num: 7
•
•
•
•
•
Publication
25123312 | J:217776
First Author: Colquitt BM
Year: 2014
Journal: Neuron
Title: Dnmt3a regulates global gene expression in olfactory sensory neurons and enables odorant-induced transcription.
Volume: 83
Issue: 4
Pages: 823-38
•
•
•
•
•
Publication
35635747 | J:325050
   
First Author: Tovy A
Year: 2022
Journal: Elife
Title: Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis.
Volume: 11
•
•
•
•
•
Publication
26710888 | J:231479
First Author: Guryanova OA
Year: 2016
Journal: Leukemia
Title: Dnmt3a regulates myeloproliferation and liver-specific expansion of hematopoietic stem and progenitor cells.
Volume: 30
Issue: 5
Pages: 1133-42
•
•
•
•
•
Publication
22913541 | J:202731
First Author: Minero AS
Year: 2012
Journal: FEBS J
Title: Probing murine methyltransfease Dnmt3a interactions with benzo[a]pyrene-modified DNA by fluorescence methods.
Volume: 279
Issue: 20
Pages: 3965-80
•
•
•
•
•
Publication
30366920 | J:269934
First Author: Jacquelin S
Year: 2018
Journal: Blood
Title: Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation.
Volume: 132
Issue: 26
Pages: 2707-2721
•
•
•
•
•
Publication
25822089 | J:231791
First Author: Liao J
Year: 2015
Journal: Nat Genet
Title: Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells.
Volume: 47
Issue: 5
Pages: 469-78
•
•
•
•
•
Publication
27690235 | J:235643
First Author: Haney SL
Year: 2016
Journal: PLoS Genet
Title: Dnmt3a Is a Haploinsufficient Tumor Suppressor in CD8+ Peripheral T Cell Lymphoma.
Volume: 12
Issue: 9
Pages: e1006334
•
•
•
•
•
Publication
26791204 | J:229452
First Author: Elliott E
Year: 2016
Journal: J Neurosci
Title: Dnmt3a in the Medial Prefrontal Cortex Regulates Anxiety-Like Behavior in Adult Mice.
Volume: 36
Issue: 3
Pages: 730-40
•
•
•
•
•
Publication
36931244 | J:353083
First Author: Khazaei S
Year: 2023
Journal: Cell
Title: Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration.
Volume: 186
Issue: 6
Pages: 1162-1178.e20
•
•
•
•
•
Publication
38834136 | J:349887
 
First Author: Rogers JH
Year: 2024
Journal: Exp Hematol
Title: Dose-dependent effects of Dnmt3a in an inducible murine model of Kras(G12D)-driven leukemia.
Volume: 135
Pages: 104248
•
•
•
•
•
Publication
35534561 | J:331942
First Author: Gu T
Year: 2022
Journal: Nat Genet
Title: The disordered N-terminal domain of DNMT3A recognizes H2AK119ub and is required for postnatal development.
Volume: 54
Issue: 5
Pages: 625-636
•
•
•
•
•
Publication
28270689 | J:243864
 
First Author: Zhao JY
Year: 2017
Journal: Nat Commun
Title: DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons.
Volume: 8
Pages: 14712
•
•
•
•
•
Publication
37952155 | J:348795
First Author: Beard DC
Year: 2023
Journal: Cell Rep
Title: Distinct disease mutations in DNMT3A result in a spectrum of behavioral, epigenetic, and transcriptional deficits.
Volume: 42
Issue: 11
Pages: 113411
•
•
•
•
•
Publication
28461508 | J:242205
First Author: Dai YJ
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Conditional knockin of Dnmt3a R878H initiates acute myeloid leukemia with mTOR pathway involvement.
Volume: 114
Issue: 20
Pages: 5237-5242
•
•
•
•
•
Publication
31015495 | J:275556
First Author: Sendžikaitė G
Year: 2019
Journal: Nat Commun
Title: A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice.
Volume: 10
Issue: 1
Pages: 1884
•
•
•
•
•
Publication
32052888 | J:304935
First Author: Li X
Year: 2020
Journal: FASEB J
Title: LncRNA Dnmt3aos regulates Dnmt3a expression leading to aberrant DNA methylation in macrophage polarization.
Volume: 34
Issue: 4
Pages: 5077-5091
•
•
•
•
•
Publication
33238114 | J:300107
First Author: Christian DL
Year: 2020
Journal: Cell Rep
Title: DNMT3A Haploinsufficiency Results in Behavioral Deficits and Global Epigenomic Dysregulation Shared across Neurodevelopmental Disorders.
Volume: 33
Issue: 8
Pages: 108416
•
•
•
•
•
Publication
27428748 | J:274091
First Author: Zhang X
Year: 2016
Journal: Nat Genet
Title: DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells.
Volume: 48
Issue: 9
Pages: 1014-23
•
•
•
•
•
Publication
36073548 | J:329450
 
First Author: Ramdas B
Year: 2022
Journal: JCI Insight
Title: Combined heterozygosity of FLT3 ITD, TET2, and DNMT3A results in aggressive leukemia.
Volume: 7
Issue: 17
•
•
•
•
•
Publication
35604009 | J:337783
   
First Author: Li J
Year: 2022
Journal: Elife
Title: Dnmt3a knockout in excitatory neurons impairs postnatal synapse maturation and increases the repressive histone modification H3K27me3.
Volume: 11
•
•
•
•
•
Publication
21481189 | J:193011
First Author: Siddique AN
Year: 2011
Journal: FEBS J
Title: Auto-methylation of the mouse DNA-(cytosine C5)-methyltransferase Dnmt3a at its active site cysteine residue.
Volume: 278
Issue: 12
Pages: 2055-63
•
•
•
•
•
Publication
27677595 | J:259573
 
First Author: Haney SL
Year: 2016
Journal: Sci Rep
Title: Loss of Dnmt3a induces CLL and PTCL with distinct methylomes and transcriptomes in mice.
Volume: 6
Pages: 34222
•
•
•
•
•
Publication
27841873 | J:241153
First Author: Guryanova OA
Year: 2016
Journal: Nat Med
Title: DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling.
Volume: 22
Issue: 12
Pages: 1488-1495
•
•
•
•
•
Publication
15215868 | J:91108
First Author: Kaneda M
Year: 2004
Journal: Nature
Title: Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting.
Volume: 429
Issue: 6994
Pages: 900-3
•
•
•
•
•
Publication
22011581 | J:180053
First Author: Gao Q
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression.
Volume: 108
Issue: 44
Pages: 18061-6
•
•
•
•
•
Publication
25130491 | J:233370
First Author: Challen GA
Year: 2014
Journal: Cell Stem Cell
Title: Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells.
Volume: 15
Issue: 3
Pages: 350-364
•
•
•
•
•
Publication
18945701 | J:173049
First Author: Jurkowska RZ
Year: 2008
Journal: Nucleic Acids Res
Title: Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L.
Volume: 36
Issue: 21
Pages: 6656-63
•
•
•
•
•
Publication
27010239 | J:236834
 
First Author: Koya J
Year: 2016
Journal: Nat Commun
Title: DNMT3A R882 mutants interact with polycomb proteins to block haematopoietic stem and leukaemic cell differentiation.
Volume: 7
Pages: 10924
•
•
•
•
•
Publication
32159514 | J:288771
   
First Author: Lavery LA
Year: 2020
Journal: Elife
Title: Losing Dnmt3a dependent methylation in inhibitory neurons impairs neural function by a mechanism impacting Rett syndrome.
Volume: 9
•
•
•
•
•
Publication
32581223 | J:294879
First Author: Yagi M
Year: 2020
Journal: Nat Commun
Title: Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development.
Volume: 11
Issue: 1
Pages: 3199
•
•
•
•
•
Publication
30258352 | J:310664
 
First Author: Saunders J
Year: 2018
Journal: Front Mol Neurosci
Title: Negative Evidence for a Functional Role of Neuronal DNMT3a in Persistent Pain.
Volume: 11
Pages: 332
•
•
•
•
•
Publication
35122024 | J:334992
First Author: Scheller M
Year: 2021
Journal: Nat Cancer
Title: Hotspot DNMT3A mutations in clonal hematopoiesis and acute myeloid leukemia sensitize cells to azacytidine via viral mimicry response.
Volume: 2
Issue: 5
Pages: 527-544
•
•
•
•
•
Publication
27240213 | J:260234
First Author: Li X
Year: 2016
Journal: Nat Immunol
Title: Methyltransferase Dnmt3a upregulates HDAC9 to deacetylate the kinase TBK1 for activation of antiviral innate immunity.
Volume: 17
Issue: 7
Pages: 806-15
•
•
•
•
•
Publication
38295174 | J:349297
First Author: Li Y
Year: 2024
Journal: Sci Adv
Title: Rapid and accurate remethylation of DNA in Dnmt3a-deficient hematopoietic cells with restoration of DNMT3A activity.
Volume: 10
Issue: 5
Pages: eadk8598
•
•
•
•
•
Publication
20228804 | J:159689
First Author: Feng J
Year: 2010
Journal: Nat Neurosci
Title: Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons.
Volume: 13
Issue: 4
Pages: 423-30
•
•
•
•
•
Publication
16472822 | J:110326
First Author: Gowher H
Year: 2006
Journal: J Mol Biol
Title: Mutational analysis of the catalytic domain of the murine Dnmt3a DNA-(cytosine C5)-methyltransferase.
Volume: 357
Issue: 3
Pages: 928-41
•
•
•
•
•
Publication
17175537 | J:120275
First Author: Li YQ
Year: 2007
Journal: Nucleic Acids Res
Title: Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair.
Volume: 35
Issue: 2
Pages: 390-400
•
•
•
•
•
Publication
39196062 | J:359891
First Author: Rauch PJ
Year: 2023
Journal: Nat Cardiovasc Res
Title: Loss-of-function mutations in Dnmt3a and Tet2 lead to accelerated atherosclerosis and concordant macrophage phenotypes.
Volume: 2
Issue: 9
Pages: 805-818
•
•
•
•
•
Publication
22898819 | J:191579
First Author: Chen CC
Year: 2012
Journal: J Biol Chem
Title: The mammalian de novo DNA methyltransferases DNMT3A and DNMT3B are also DNA 5-hydroxymethylcytosine dehydroxymethylases.
Volume: 287
Issue: 40
Pages: 33116-21
•
•
•
•
•
Publication
18823905 | J:168955
First Author: Takeshima H
Year: 2008
Journal: J Mol Biol
Title: Mouse Dnmt3a preferentially methylates linker DNA and is inhibited by histone H1.
Volume: 383
Issue: 4
Pages: 810-21
•
•
•
•
•
Publication
27636998 | J:309648
First Author: Poitras JL
Year: 2016
Journal: Oncotarget
Title: Dnmt3a deletion cooperates with the Flt3/ITD mutation to drive leukemogenesis in a murine model.
Volume: 7
Issue: 43
Pages: 69124-69135
•
•
•
•
•
Publication
35608905 | J:326870
 
First Author: Ktena YP
Year: 2022
Journal: J Clin Invest
Title: Donor T cell DNMT3a regulates alloreactivity in mouse models of hematopoietic stem cell transplantation.
Volume: 132
Issue: 13
•
•
•
•
•
Publication
25639876 | J:260757
First Author: Haney SL
Year: 2015
Journal: Oncogene
Title: Methylation-independent repression of Dnmt3b contributes to oncogenic activity of Dnmt3a in mouse MYC-induced T-cell lymphomagenesis.
Volume: 34
Issue: 43
Pages: 5436-5446
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom