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Search results 1 to 100 out of 271 for Ehmt1

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Domain
Type: Family
Description: Histone-lysine N-methyltransferase EHMT1, () mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin []. H3K9me is a specific tag for repression of epigenetic transcription, recruiting HP1 proteins to methylated histones. EHMT1 also methylates 'Lys-27' of histone H3 (H3K27me), but weakly []. EHMT1 also dimethylates other proteins, including 'Lys-373' of p53 []. EHMT1 forms a heterodimer with EHMT2 [], and is a component of the E2F6.com-1 complex in G0 phase []. EHMT1 contains eight ankyrin repeats which bind the monomethylated RELA subunit of NF-kappa-B, a SET domain which interacts with WIZ [], and a pre-SET domain that binds three zinc ions via cysteine residues [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Ueda J
Year: 2006
Journal: J Biol Chem
Title: Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP.
Volume: 281
Issue: 29
Pages: 20120-8
Protein
Organism: Mus musculus
Length: 286  
Fragment?: true
Protein
Organism: Mus musculus
Length: 224  
Fragment?: true
Protein
Organism: Mus musculus
Length: 232  
Fragment?: true
Protein
Organism: Mus musculus
Length: 254  
Fragment?: true
Protein
Organism: Mus musculus
Length: 362  
Fragment?: true
Protein
Organism: Mus musculus
Length: 107  
Fragment?: true
Protein
Organism: Mus musculus
Length: 203  
Fragment?: true
Protein
Organism: Mus musculus
Length: 1296  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1289  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1288  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1248  
Fragment?: false
Protein
Organism: Mus musculus
Length: 263  
Fragment?: true
Protein
Organism: Mus musculus
Length: 278  
Fragment?: true
Protein
Organism: Mus musculus
Length: 287  
Fragment?: true
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Tachibana M
Year: 2001
Journal: J Biol Chem
Title: Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3.
Volume: 276
Issue: 27
Pages: 25309-17
Publication
First Author: Collins RE
Year: 2008
Journal: Nat Struct Mol Biol
Title: The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules.
Volume: 15
Issue: 3
Pages: 245-50
Publication
First Author: Huang J
Year: 2010
Journal: J Biol Chem
Title: G9a and Glp methylate lysine 373 in the tumor suppressor p53.
Volume: 285
Issue: 13
Pages: 9636-41
Publication
First Author: Benevento M
Year: 2016
Journal: Neuron
Title: Histone Methylation by the Kleefstra Syndrome Protein EHMT1 Mediates Homeostatic Synaptic Scaling.
Volume: 91
Issue: 2
Pages: 341-55
Publication  
First Author: Benevento M
Year: 2017
Journal: Sci Rep
Title: Haploinsufficiency of EHMT1 improves pattern separation and increases hippocampal cell proliferation.
Volume: 7
Pages: 40284
Publication
First Author: Meng TG
Year: 2020
Journal: Nat Commun
Title: PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome.
Volume: 11
Issue: 1
Pages: 6354
Publication
First Author: Ohno H
Year: 2013
Journal: Nature
Title: EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex.
Volume: 504
Issue: 7478
Pages: 163-7
Protein
Organism: Mus musculus
Length: 348  
Fragment?: true
Protein
Organism: Mus musculus
Length: 282  
Fragment?: true
Protein
Organism: Mus musculus
Length: 917  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1241  
Fragment?: false
Publication
First Author: Ogawa H
Year: 2002
Journal: Science
Title: A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells.
Volume: 296
Issue: 5570
Pages: 1132-6
GXD Expression
Probe: MGI:5811114
Assay Type: Immunohistochemistry
Annotation Date: 2016-12-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3669911
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:5811143
Age: embryonic day 8.0
Image: 4h Cbfa2t2<-/->
Note: Primordial germ cells in mutant embryos exhibited a specific Ehmt1 derepression.
Specimen Label: 4h Cbfa2t2<-/->
Detected: true
Specimen Num: 2
Publication
First Author: Tachibana M
Year: 2008
Journal: EMBO J
Title: G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription.
Volume: 27
Issue: 20
Pages: 2681-90
Publication
First Author: Yuan J
Year: 2020
Journal: Nature
Title: Two conserved epigenetic regulators prevent healthy ageing.
Volume: 579
Issue: 7797
Pages: 118-122
Publication
First Author: Tachibana M
Year: 2005
Journal: Genes Dev
Title: Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9.
Volume: 19
Issue: 7
Pages: 815-26
Publication
First Author: Levy D
Year: 2011
Journal: Nat Immunol
Title: Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling.
Volume: 12
Issue: 1
Pages: 29-36
Publication
First Author: Frega M
Year: 2019
Journal: Nat Commun
Title: Neuronal network dysfunction in a model for Kleefstra syndrome mediated by enhanced NMDAR signaling.
Volume: 10
Issue: 1
Pages: 4928
Publication  
First Author: Schut EHS
Year: 2020
Journal: Neurobiol Learn Mem
Title: The Object Space Task reveals increased expression of cumulative memory in a mouse model of Kleefstra syndrome.
Volume: 173
Pages: 107265
Publication
First Author: Balemans MC
Year: 2010
Journal: Behav Brain Res
Title: Reduced exploration, increased anxiety, and altered social behavior: Autistic-like features of euchromatin histone methyltransferase 1 heterozygous knockout mice.
Volume: 208
Issue: 1
Pages: 47-55
Publication
First Author: Balemans MC
Year: 2014
Journal: Dev Biol
Title: Reduced Euchromatin histone methyltransferase 1 causes developmental delay, hypotonia, and cranial abnormalities associated with increased bone gene expression in Kleefstra syndrome mice.
Volume: 386
Issue: 2
Pages: 395-407
Publication
First Author: Balemans MC
Year: 2013
Journal: Hum Mol Genet
Title: Hippocampal dysfunction in the Euchromatin histone methyltransferase 1 heterozygous knockout mouse model for Kleefstra syndrome.
Volume: 22
Issue: 5
Pages: 852-66
Publication
First Author: Hasegawa Y
Year: 2018
Journal: Cell Metab
Title: Repression of Adipose Tissue Fibrosis through a PRDM16-GTF2IRD1 Complex Improves Systemic Glucose Homeostasis.
Volume: 27
Issue: 1
Pages: 180-194.e6
Publication
First Author: Palmer N
Year: 2019
Journal: J Cell Biol
Title: CDK2 regulates the NRF1/Ehmt1 axis during meiotic prophase I.
Volume: 218
Issue: 9
Pages: 2896-2918
Publication
First Author: Chen L
Year: 2010
Journal: EMBO J
Title: MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output.
Volume: 29
Issue: 15
Pages: 2538-52
Publication
First Author: Iacono G
Year: 2018
Journal: Nucleic Acids Res
Title: Increased H3K9 methylation and impaired expression of Protocadherins are associated with the cognitive dysfunctions of the Kleefstra syndrome.
Volume: 46
Issue: 10
Pages: 4950-4965
Publication
First Author: Thienpont B
Year: 2017
Journal: J Clin Invest
Title: The H3K9 dimethyltransferases EHMT1/2 protect against pathological cardiac hypertrophy.
Volume: 127
Issue: 1
Pages: 335-348
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Frega M
Year: 2020
Journal: Cell Rep
Title: Distinct Pathogenic Genes Causing Intellectual Disability and Autism Exhibit a Common Neuronal Network Hyperactivity Phenotype.
Volume: 30
Issue: 1
Pages: 173-186.e6
GXD Expression    
Probe: MGI:6194849
Assay Type: RT-PCR
Annotation Date: 2018-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3535024
Stage: TS24
Assay Id: MGI:6194878
Age: embryonic day 16.5
Image: 4
Specimen Label: a
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6194849
Assay Type: RT-PCR
Annotation Date: 2018-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3535024
Stage: TS24
Assay Id: MGI:6194878
Age: embryonic day 16.5
Image: 4
Specimen Label: b
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6194849
Assay Type: RT-PCR
Annotation Date: 2018-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3535024
Stage: TS24
Assay Id: MGI:6194878
Age: embryonic day 16.5
Image: 4
Specimen Label: c
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6194849
Assay Type: RT-PCR
Annotation Date: 2018-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3535024
Stage: TS24
Assay Id: MGI:6194878
Age: embryonic day 16.5
Image: 4
Specimen Label: d
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:5811114
Assay Type: Western blot
Annotation Date: 2018-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3535024
Stage: TS24
Assay Id: MGI:6194893
Age: embryonic day 16.5
Image: 5
Specimen Label: a
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5811114
Assay Type: Western blot
Annotation Date: 2018-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3535024
Stage: TS24
Assay Id: MGI:6194893
Age: embryonic day 16.5
Image: 5
Specimen Label: b
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5811114
Assay Type: Western blot
Annotation Date: 2018-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3535024
Stage: TS24
Assay Id: MGI:6194893
Age: embryonic day 16.5
Image: 5
Specimen Label: c
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:5811114
Assay Type: Western blot
Annotation Date: 2018-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3535024
Stage: TS24
Assay Id: MGI:6194893
Age: embryonic day 16.5
Image: 5
Specimen Label: d
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5309547
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3516422
Stage: TS22
Assay Id: MGI:5422915
Age: embryonic day 14.5
Specimen Label: MH3353; Specimen C4445
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309547
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716122
Stage: TS22
Assay Id: MGI:5422915
Age: embryonic day 14.5
Specimen Label: MH3353; Specimen C4445
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:5309547
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1691622
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422915
Age: embryonic day 14.5
Image: MH3353; Specimen C4445
Specimen Label: MH3353; Specimen C4445
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:5811114
Assay Type: Immunohistochemistry
Annotation Date: 2018-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3262622
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:6194861
Age: embryonic day 14.5
Image: 2B
Note: Very weak expression was detected in proliferating chondrocytes. A relatively low expression was observed in the prehypertrophic and hypertrophic chondrocytes.
Specimen Label: 2B
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5309547
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1760622
Stage: TS22
Assay Id: MGI:5422915
Age: embryonic day 14.5
Specimen Label: MH3353; Specimen C4445
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5811114
Assay Type: Immunohistochemistry
Annotation Date: 2018-08-17
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3262520
Stage: TS20
Assay Id: MGI:6194861
Age: embryonic day 12.5
Image: 1B
Specimen Label: 1B
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:5309547
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1737322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422915
Age: embryonic day 14.5
Image: MH3353; Specimen C4445
Specimen Label: MH3353; Specimen C4445
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5309547
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3284222
Stage: TS22
Assay Id: MGI:5422915
Age: embryonic day 14.5
Specimen Label: MH3353; Specimen C4445
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309547
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1666522
Stage: TS22
Assay Id: MGI:5422915
Age: embryonic day 14.5
Specimen Label: MH3353; Specimen C4445
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309547
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619822
Stage: TS22
Assay Id: MGI:5422915
Age: embryonic day 14.5
Specimen Label: MH3353; Specimen C4445
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5309547
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754922
Stage: TS22
Assay Id: MGI:5422915
Age: embryonic day 14.5
Note: Expression was not detected in the corpus striatum (lateral ganglionic eminence).
Specimen Label: MH3353; Specimen C4445
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:5309547
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1697422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422915
Age: embryonic day 14.5
Image: MH3353; Specimen C4445
Specimen Label: MH3353; Specimen C4445
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5309547
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3276322
Stage: TS22
Assay Id: MGI:5422915
Age: embryonic day 14.5
Note: Expression was not detected in the face/soft tissues.
Specimen Label: MH3353; Specimen C4445
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309547
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1783822
Stage: TS22
Assay Id: MGI:5422915
Age: embryonic day 14.5
Specimen Label: MH3353; Specimen C4445
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309547
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1665922
Stage: TS22
Assay Id: MGI:5422915
Age: embryonic day 14.5
Specimen Label: MH3353; Specimen C4445
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309547
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1706822
Stage: TS22
Assay Id: MGI:5422915
Age: embryonic day 14.5
Specimen Label: MH3353; Specimen C4445
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309547
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1674822
Stage: TS22
Assay Id: MGI:5422915
Age: embryonic day 14.5
Specimen Label: MH3353; Specimen C4445
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309547
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1670622
Stage: TS22
Assay Id: MGI:5422915
Age: embryonic day 14.5
Specimen Label: MH3353; Specimen C4445
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309547
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738222
Stage: TS22
Assay Id: MGI:5422915
Age: embryonic day 14.5
Specimen Label: MH3353; Specimen C4445
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309547
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1654222
Stage: TS22
Assay Id: MGI:5422915
Age: embryonic day 14.5
Specimen Label: MH3353; Specimen C4445
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309547
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1777922
Stage: TS22
Assay Id: MGI:5422915
Age: embryonic day 14.5
Specimen Label: MH3353; Specimen C4445
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309547
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684922
Stage: TS22
Assay Id: MGI:5422915
Age: embryonic day 14.5
Specimen Label: MH3353; Specimen C4445
Detected: false
Specimen Num: 1
GXD Expression
Probe: MGI:5811114
Assay Type: Immunohistochemistry
Annotation Date: 2018-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3535024
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:6194861
Age: embryonic day 16.5
Image: 3B
Note: Expression was detected in the prehypertrophic and hypertrophic chondrocytes and the trabecular bones.
Specimen Label: 3B
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:5309547
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716822
Stage: TS22
Assay Id: MGI:5422915
Age: embryonic day 14.5
Specimen Label: MH3353; Specimen C4445
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309547
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619322
Stage: TS22
Assay Id: MGI:5422915
Age: embryonic day 14.5
Specimen Label: MH3353; Specimen C4445
Detected: false
Specimen Num: 1