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Search results 1 to 100 out of 500 for Ehmt2

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
10919 | EHMT2
Type: gene
Organism: human
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Gene
569250 | ehmt2
Type: gene
Organism: zebrafish
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Gene
715824 | EHMT2
Type: gene
Organism: macaque, rhesus
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Gene
100484992 | ehmt2
Type: gene
Organism: frog, western clawed
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Gene
361798 | Ehmt2
Type: gene
Organism: rat
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Gene
474851 | EHMT2
Type: gene
Organism: dog, domestic
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Gene
462572 | EHMT2
Type: gene
Organism: chimpanzee
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Gene
514062 | EHMT2
Type: gene
Organism: cattle
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Protein Domain
IPR038034 | EHMT2
Type: Family
Description: Histone-lysine N-methyltransferase EHMT2 () mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin []. H3K9me is a specific tag for repression of epigenetic transcription, recruiting HP1 proteins to methylated histones. EHMT2 also monomethylates 'Lys-56' of histone H3 (H3K56me1) during the G1 phase of the cell cycle [], and methylates 'Lys-27' of histone H3 (H3K27me) []. EHMT2 also dimethylates other proteins [], including 'Lys-373' of p53 []. EHMT2 forms a heterdimer with EHMT1 [], and is a component of the E2F6.com-1 complex in G0 phase []. EHMT2 contains seven ankyrin repeats which bind the monomethylated RELA subunit of NF-kappa-B, a SET domain which interacts with WIZ [], and a pre-SET domain that binds three zinc ions via cysteine residues [].
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Protein Coding Gene
MGI:2148922 | Ehmt2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
22387026 | J:184478
First Author: Yu Y
Year: 2012
Journal: Mol Cell
Title: Histone H3 lysine 56 methylation regulates DNA replication through its interaction with PCNA.
Volume: 46
Issue: 1
Pages: 7-17
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Publication
16702210 | J:114884
First Author: Ueda J
Year: 2006
Journal: J Biol Chem
Title: Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP.
Volume: 281
Issue: 29
Pages: 20120-8
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Protein
G3UYH7
Organism: Mus musculus/domesticus
Length: 194  
Fragment?: true
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Protein
A2CG77
Organism: Mus musculus/domesticus
Length: 441  
Fragment?: true
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Protein
H3BIW5
Organism: Mus musculus/domesticus
Length: 155  
Fragment?: true
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Protein
Q9Z148
Organism: Mus musculus/domesticus
Length: 1263  
Fragment?: false
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Protein
A2CG76
Organism: Mus musculus/domesticus
Length: 1229  
Fragment?: false
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Publication
11316813 | -
First Author: Tachibana M
Year: 2001
Journal: J Biol Chem
Title: Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3.
Volume: 276
Issue: 27
Pages: 25309-17
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Publication
18438403 | -
First Author: Rathert P
Year: 2008
Journal: Nat Chem Biol
Title: Protein lysine methyltransferase G9a acts on non-histone targets.
Volume: 4
Issue: 6
Pages: 344-6
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Publication
18264113 | -
First Author: Collins RE
Year: 2008
Journal: Nat Struct Mol Biol
Title: The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules.
Volume: 15
Issue: 3
Pages: 245-50
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Publication
20118233 | -
First Author: Huang J
Year: 2010
Journal: J Biol Chem
Title: G9a and Glp methylate lysine 373 in the tumor suppressor p53.
Volume: 285
Issue: 13
Pages: 9636-41
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Protein
Q8BP38
Organism: Mus musculus/domesticus
Length: 615  
Fragment?: true
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Protein
Q3U4G9
Organism: Mus musculus/domesticus
Length: 1229  
Fragment?: false
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Gene
107986588 | EHMT2-AS1
Type: gene
Organism: human
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Publication
31088968 | J:276738
First Author: Zeng TB
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: EHMT2 and SETDB1 protect the maternal pronucleus from 5mC oxidation.
Volume: 116
Issue: 22
Pages: 10834-10841
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Publication
12004135 | -
First Author: Ogawa H
Year: 2002
Journal: Science
Title: A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells.
Volume: 296
Issue: 5570
Pages: 1132-6
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Publication
34793451 | J:315053
First Author: Zeng TB
Year: 2021
Journal: PLoS Genet
Title: EHMT2 suppresses the variation of transcriptional switches in the mouse embryo.
Volume: 17
Issue: 11
Pages: e1009908
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Publication
26576615 | J:271018
First Author: Auclair G
Year: 2016
Journal: Genome Res
Title: EHMT2 directs DNA methylation for efficient gene silencing in mouse embryos.
Volume: 26
Issue: 2
Pages: 192-202
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Publication
35864958 | J:333912
First Author: Meng TG
Year: 2022
Journal: Int J Biol Sci
Title: Maternal EHMT2 is essential for homologous chromosome segregation by regulating Cyclin B3 transcription in oocyte meiosis.
Volume: 18
Issue: 11
Pages: 4513-4531
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Publication
35983994 | J:327876
   
First Author: Pribluda A
Year: 2022
Journal: Elife
Title: EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation.
Volume: 11
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Publication
38948355 | J:350944
 
First Author: Pollin G
Year: 2024
Journal: Front Genet
Title: Ehmt2 inactivation in pancreatic epithelial cells shapes the transcriptional landscape and inflammation response of the whole pancreas.
Volume: 15
Pages: 1412767
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Publication
18480470 | J:139777
First Author: Monk D
Year: 2008
Journal: Genome Res
Title: Comparative analysis of human chromosome 7q21 and mouse proximal chromosome 6 reveals a placental-specific imprinted gene, TFPI2/Tfpi2, which requires EHMT2 and EED for allelic-silencing.
Volume: 18
Issue: 8
Pages: 1270-81
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Publication
12130538 | J:77998
First Author: Tachibana M
Year: 2002
Journal: Genes Dev
Title: G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis.
Volume: 16
Issue: 14
Pages: 1779-91
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Publication
28250819 | J:306882
 
First Author: Kidder BL
Year: 2017
Journal: Epigenetics Chromatin
Title: SMYD5 regulates H4K20me3-marked heterochromatin to safeguard ES cell self-renewal and prevent spurious differentiation.
Volume: 10
Pages: 8
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Publication
18818694 | J:143343
First Author: Tachibana M
Year: 2008
Journal: EMBO J
Title: G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription.
Volume: 27
Issue: 20
Pages: 2681-90
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Publication
15774718 | J:97244
First Author: Tachibana M
Year: 2005
Journal: Genes Dev
Title: Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9.
Volume: 19
Issue: 7
Pages: 815-26
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Publication
27932493 | J:277855
First Author: Parvanov ED
Year: 2017
Journal: Mol Biol Cell
Title: PRDM9 interactions with other proteins provide a link between recombination hotspots and the chromosomal axis in meiosis.
Volume: 28
Issue: 3
Pages: 488-499
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Publication
34519223 | J:356830
First Author: Zeng TB
Year: 2021
Journal: Epigenomics
Title: H3K9 methyltransferase EHMT2/G9a controls ERVK-driven noncanonical imprinted genes.
Volume: 13
Issue: 16
Pages: 1299-1314
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Publication
32994276 | J:300589
First Author: Zhang W
Year: 2020
Journal: Diabetes
Title: Muscular G9a Regulates Muscle-Liver-Fat Axis by Musclin Under Overnutrition in Female Mice.
Volume: 69
Issue: 12
Pages: 2642-2654
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Publication
32024693 | J:286562
First Author: Luo Y
Year: 2020
Journal: J Biol Chem
Title: Histone methyltransferase G9a diminishes expression of cannabinoid CB1 receptors in primary sensory neurons in neuropathic pain.
Volume: 295
Issue: 11
Pages: 3553-3562
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Publication
29554304 | J:263725
First Author: Iacono G
Year: 2018
Journal: Nucleic Acids Res
Title: Increased H3K9 methylation and impaired expression of Protocadherins are associated with the cognitive dysfunctions of the Kleefstra syndrome.
Volume: 46
Issue: 10
Pages: 4950-4965
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Publication
28698219 | J:274502
 
First Author: Li Z
Year: 2017
Journal: Sci Signal
Title: The transcription factor C/EBPβ in the dorsal root ganglion contributes to peripheral nerve trauma-induced nociceptive hypersensitivity.
Volume: 10
Issue: 487
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Publication
34249932 | J:308024
 
First Author: Urrutia G
Year: 2021
Journal: Front Cell Dev Biol
Title: Inactivation of the Euchromatic Histone-Lysine N-Methyltransferase 2 Pathway in Pancreatic Epithelial Cells Antagonizes Cancer Initiation and Pancreatitis-Associated Promotion by Altering Growth and Immune Gene Expression Networks.
Volume: 9
Pages: 681153
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Publication
27893464 | J:239852
First Author: Thienpont B
Year: 2017
Journal: J Clin Invest
Title: The H3K9 dimethyltransferases EHMT1/2 protect against pathological cardiac hypertrophy.
Volume: 127
Issue: 1
Pages: 335-348
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Publication
28128212 | J:244859
 
First Author: Liu W
Year: 2017
Journal: Nat Commun
Title: BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis.
Volume: 8
Pages: 14182
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Publication
26917724 | J:233714
First Author: Zhang Y
Year: 2016
Journal: J Biol Chem
Title: Nerve Injury Diminishes Opioid Analgesia through Lysine Methyltransferase-mediated Transcriptional Repression of μ-Opioid Receptors in Primary Sensory Neurons.
Volume: 291
Issue: 16
Pages: 8475-85
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Publication
23748610 | J:201469
First Author: Sridharan R
Year: 2013
Journal: Nat Cell Biol
Title: Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1γ in reprogramming to pluripotency.
Volume: 15
Issue: 7
Pages: 872-82
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Protein Coding Gene
MGP_CAROLIEiJ_G0021483 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0023597 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0023559 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0023525 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0023564 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0023324 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2148922 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0024004 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0022822 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0023302 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0023430 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0023397 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0023507 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0023420 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0024046 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0022571 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0022884 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0020478 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0022388 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
20421388 | J:160938
First Author: Lehnertz B
Year: 2010
Journal: J Exp Med
Title: Activating and inhibitory functions for the histone lysine methyltransferase G9a in T helper cell differentiation and function.
Volume: 207
Issue: 5
Pages: 915-22
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Publication
29720423 | J:263331
First Author: Verbaro DJ
Year: 2018
Journal: J Immunol
Title: Cutting Edge: The Histone Methyltransferase G9a Is Required for Silencing of Helper T Lineage-Associated Genes in Proliferating CD8 T Cells.
Volume: 200
Issue: 12
Pages: 3891-3896
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Publication
24584053 | J:212015
First Author: Maze I
Year: 2014
Journal: Nat Neurosci
Title: G9a influences neuronal subtype specification in striatum.
Volume: 17
Issue: 4
Pages: 533-9
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Publication
20056891 | J:155861
First Author: Maze I
Year: 2010
Journal: Science
Title: Essential role of the histone methyltransferase G9a in cocaine-induced plasticity.
Volume: 327
Issue: 5962
Pages: 213-6
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Publication
15493016 | J:94206
First Author: Ohhata T
Year: 2004
Journal: Genesis
Title: X-inactivation is stably maintained in mouse embryos deficient for histone methyl transferase G9a.
Volume: 40
Issue: 3
Pages: 151-6
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Publication
17707231 | J:155931
First Author: Sampath SC
Year: 2007
Journal: Mol Cell
Title: Methylation of a histone mimic within the histone methyltransferase G9a regulates protein complex assembly.
Volume: 27
Issue: 4
Pages: 596-608
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Publication
30943408 | J:290638
First Author: Au Yeung WK
Year: 2019
Journal: Cell Rep
Title: Histone H3K9 Methyltransferase G9a in Oocytes Is Essential for Preimplantation Development but Dispensable for CG Methylation Protection.
Volume: 27
Issue: 1
Pages: 282-293.e4
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Publication
33468997 | J:313992
First Author: Nakatsuka T
Year: 2021
Journal: Cell Death Dis
Title: Inhibition of histone methyltransferase G9a attenuates liver cancer initiation by sensitizing DNA-damaged hepatocytes to p53-induced apoptosis.
Volume: 12
Issue: 1
Pages: 99
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Publication
27298444 | J:236255
First Author: Antignano F
Year: 2016
Journal: J Exp Med
Title: G9a regulates group 2 innate lymphoid cell development by repressing the group 3 innate lymphoid cell program.
Volume: 213
Issue: 7
Pages: 1153-62
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Publication
33147463 | J:306551
First Author: Mabe NW
Year: 2020
Journal: Cell Rep
Title: G9a Promotes Breast Cancer Recurrence through Repression of a Pro-inflammatory Program.
Volume: 33
Issue: 5
Pages: 108341
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Publication
17212651 | J:123364
First Author: Ikegami K
Year: 2007
Journal: Genes Cells
Title: Genome-wide and locus-specific DNA hypomethylation in G9a deficient mouse embryonic stem cells.
Volume: 12
Issue: 1
Pages: 1-11
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Publication
17962312 | J:172173
First Author: Chin HG
Year: 2007
Journal: Nucleic Acids Res
Title: Automethylation of G9a and its implication in wider substrate specificity and HP1 binding.
Volume: 35
Issue: 21
Pages: 7313-23
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Publication
21825155 | J:175985
First Author: Lee JS
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Hypoxia-induced methylation of a pontin chromatin remodeling factor.
Volume: 108
Issue: 33
Pages: 13510-5
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Publication
22406531 | J:184560
First Author: Dong C
Year: 2012
Journal: J Clin Invest
Title: G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer.
Volume: 122
Issue: 4
Pages: 1469-86
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Publication
23151507 | J:192347
First Author: Bittencourt D
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: G9a functions as a molecular scaffold for assembly of transcriptional coactivators on a subset of glucocorticoid receptor target genes.
Volume: 109
Issue: 48
Pages: 19673-8
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Publication
23396011 | J:197841
 
First Author: Subbanna S
Year: 2013
Journal: Neurobiol Dis
Title: G9a-mediated histone methylation regulates ethanol-induced neurodegeneration in the neonatal mouse brain.
Volume: 54
Pages: 475-85
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Publication
24300108 | J:207922
 
First Author: Subbanna S
Year: 2014
Journal: Neuroscience
Title: Ethanol induced acetylation of histone at G9a exon1 and G9a-mediated histone H3 dimethylation leads to neurodegeneration in neonatal mice.
Volume: 258
Pages: 422-32
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Publication
28278257 | J:246123
First Author: Maeda K
Year: 2017
Journal: PLoS One
Title: Inhibition of H3K9 methyltransferase G9a ameliorates methylglyoxal-induced peritoneal fibrosis.
Volume: 12
Issue: 3
Pages: e0173706
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Publication
27229136 | J:246357
First Author: Rao VK
Year: 2016
Journal: Nucleic Acids Res
Title: G9a promotes proliferation and inhibits cell cycle exit during myogenic differentiation.
Volume: 44
Issue: 17
Pages: 8129-43
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GXD Expression
GXD Expression
     
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289647
Age: embryonic day 1.5
Specimen Label: 2-cell-A1-1
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289647
Age: embryonic day 1.5
Specimen Label: 2-cell-A1-2
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289647
Age: embryonic day 1.5
Specimen Label: 2-cell-A2-1
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289647
Age: embryonic day 1.5
Specimen Label: 2-cell-A2-2
Detected: false
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289647
Age: embryonic day 1.5
Specimen Label: 2-cell-B1-1
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289647
Age: embryonic day 1.5
Specimen Label: 2-cell-B1-2
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289647
Age: embryonic day 1.5
Specimen Label: 2-cell-B2-1
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289647
Age: embryonic day 1.5
Specimen Label: 2-cell-B2-2
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
       
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289647
Age: embryonic day 1.5
Specimen Label: 2-cell-C1-1
Specimen Num: 9
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GXD Expression
GXD Expression
       
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289647
Age: embryonic day 1.5
Specimen Label: 2-cell-C1-2
Specimen Num: 10
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289647
Age: embryonic day 1.5
Specimen Label: 2-cell-C2-1
Detected: true
Specimen Num: 11
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289647
Age: embryonic day 1.5
Specimen Label: 2-cell-C2-2
Detected: true
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289647
Age: embryonic day 2.0
Specimen Label: 4-cell-A1-1
Detected: true
Specimen Num: 13
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289647
Age: embryonic day 2.0
Specimen Label: 4-cell-A1-2
Detected: true
Specimen Num: 14
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289647
Age: embryonic day 2.0
Specimen Label: 4-cell-A2-1
Detected: true
Specimen Num: 15
•
•
•
•
•




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