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Search results 1 to 100 out of 991 for Enpp2

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0.046s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Protein Domain
Type: Family
Description: Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (ENPP2 or NPP2), also known as autotaxin (ATX), is a is a secreted lysophospholipase D that hydrolyses lysophospholipids to produce lysophosphatidic acid (LPA), a mitogen and chemoattractant for many cell types []. It is a tumor motility-stimulating protein and an angiogenic factor [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Nishimura S
Year: 2014
Journal: Diabetes
Title: ENPP2 contributes to adipose tissue expansion and insulin resistance in diet-induced obesity.
Volume: 63
Issue: 12
Pages: 4154-64
Publication      
First Author: Aidinis V
Year: 2008
Journal: MGI Direct Data Submission
Title: Generation of mice bearing a floxed mutation of Enpp2 (ATX)
GXD Expression      
Probe: MGI:4354258
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3270422
Stage: TS22
Assay Id: MGI:4354816
Age: embryonic day 14.5
Specimen Label: Table S5 - Enpp2
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:4354258
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:4354816
Age: embryonic day 14.5
Note: Expression is present in the upper, but not the lower, cortical plate.
Specimen Label: Table S5 - Enpp2
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4354258
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4354816
Age: embryonic day 14.5
Specimen Label: Table S5 - Enpp2
Detected: true
Specimen Num: 1
Protein
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 910  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 62  
Fragment?: true
Publication
First Author: Hausmann J
Year: 2011
Journal: Nat Struct Mol Biol
Title: Structural basis of substrate discrimination and integrin binding by autotaxin.
Volume: 18
Issue: 2
Pages: 198-204
Publication
First Author: Nam SW
Year: 2001
Journal: Cancer Res
Title: Autotaxin (NPP-2), a metastasis-enhancing motogen, is an angiogenic factor.
Volume: 61
Issue: 18
Pages: 6938-44
Publication
First Author: Pamuklar Z
Year: 2009
Journal: J Biol Chem
Title: Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis.
Volume: 284
Issue: 11
Pages: 7385-94
Publication
First Author: Ninou I
Year: 2020
Journal: PLoS One
Title: Genetic deletion of Autotaxin from CD11b+ cells decreases the severity of experimental autoimmune encephalomyelitis.
Volume: 15
Issue: 4
Pages: e0226050
Publication
First Author: Brandon JA
Year: 2019
Journal: PLoS One
Title: Adipose-derived autotaxin regulates inflammation and steatosis associated with diet-induced obesity.
Volume: 14
Issue: 2
Pages: e0208099
Publication
First Author: Lin S
Year: 2019
Journal: FASEB J
Title: Autotaxin determines colitis severity in mice and is secreted by B cells in the colon.
Volume: 33
Issue: 3
Pages: 3623-3635
Publication
First Author: Oikonomou N
Year: 2012
Journal: Am J Respir Cell Mol Biol
Title: Pulmonary autotaxin expression contributes to the pathogenesis of pulmonary fibrosis.
Volume: 47
Issue: 5
Pages: 566-74
Publication  
First Author: Koike S
Year: 2023
Journal: Biol Open
Title: The autotaxin-LPA axis promotes membrane trafficking and secretion in yolk sac visceral endoderm cells.
Volume: 12
Issue: 11
Publication
First Author: Ray R
Year: 2021
Journal: Cell Rep
Title: Atx regulates skeletal muscle regeneration via LPAR1 and promotes hypertrophy.
Volume: 34
Issue: 9
Pages: 108809
Publication
First Author: Nikitopoulou I
Year: 2012
Journal: J Exp Med
Title: Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis.
Volume: 209
Issue: 5
Pages: 925-33
Publication
First Author: Magkrioti C
Year: 2018
Journal: Cancer Res
Title: The Autotaxin-Lysophosphatidic Acid Axis Promotes Lung Carcinogenesis.
Volume: 78
Issue: 13
Pages: 3634-3644
Publication  
First Author: Sah JP
Year: 2020
Journal: Int J Biochem Cell Biol
Title: Ectonucleotide pyrophosphatase 2 (ENPP2) plays a crucial role in myogenic differentiation through the regulation by WNT/β-Catenin signaling.
Volume: 118
Pages: 105661
Publication
First Author: Grisanti L
Year: 2013
Journal: J Invest Dermatol
Title: Enpp2/Autotaxin in dermal papilla precursors is dispensable for hair follicle morphogenesis.
Volume: 133
Issue: 10
Pages: 2332-2339
Publication
First Author: Koike S
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Deficiency of autotaxin/lysophospholipase D results in head cavity formation in mouse embryos through the LPA receptor-Rho-ROCK pathway.
Volume: 400
Issue: 1
Pages: 66-71
Publication
First Author: Koike S
Year: 2009
Journal: J Biol Chem
Title: Autotaxin/lysophospholipase D-mediated lysophosphatidic acid signaling is required to form distinctive large lysosomes in the visceral endoderm cells of the mouse yolk sac.
Volume: 284
Issue: 48
Pages: 33561-70
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Piao JH
Year: 1999
Journal: Cytogenet Cell Genet
Title: Assignment of Pdnp2, the gene encoding phosphodiesterase I/nucleotide pyrophosphatase 2, to mouse chromosome 15D2.
Volume: 87
Issue: 3-4
Pages: 172-4
Publication
First Author: Giganti A
Year: 2008
Journal: J Biol Chem
Title: Murine and human autotaxin alpha, beta, and gamma isoforms: gene organization, tissue distribution, and biochemical characterization.
Volume: 283
Issue: 12
Pages: 7776-89
Publication
First Author: Pradère JP
Year: 2007
Journal: Biochim Biophys Acta
Title: Secretion and lysophospholipase D activity of autotaxin by adipocytes are controlled by N-glycosylation and signal peptidase.
Volume: 1771
Issue: 1
Pages: 93-102
Publication
First Author: Yukiura H
Year: 2015
Journal: PLoS One
Title: Autotaxin overexpression causes embryonic lethality and vascular defects.
Volume: 10
Issue: 5
Pages: e0126734
Publication
First Author: Ohkawa R
Year: 2018
Journal: Sci Rep
Title: Measurement of plasma choline in acute coronary syndrome: importance of suitable sampling conditions for this assay.
Volume: 8
Issue: 1
Pages: 4725
Publication
First Author: Dusaulcy R
Year: 2011
Journal: J Lipid Res
Title: Adipose-specific disruption of autotaxin enhances nutritional fattening and reduces plasma lysophosphatidic acid.
Volume: 52
Issue: 6
Pages: 1247-55
Publication
First Author: Katsifa A
Year: 2015
Journal: PLoS One
Title: The Bulk of Autotaxin Activity Is Dispensable for Adult Mouse Life.
Volume: 10
Issue: 11
Pages: e0143083
Publication
First Author: Nagai J
Year: 2011
Journal: J Neurochem
Title: Pre-emptive morphine treatment abolishes nerve injury-induced lysophospholipid synthesis in mass spectrometrical analysis.
Volume: 118
Issue: 2
Pages: 256-65
Publication  
First Author: Bhattarai S
Year: 2023
Journal: Cells
Title: Endothelial Specific Deletion of Autotaxin Improves Stroke Outcomes.
Volume: 12
Issue: 3
Publication
First Author: Ferry G
Year: 2007
Journal: FEBS Lett
Title: Functional invalidation of the autotaxin gene by a single amino acid mutation in mouse is lethal.
Volume: 581
Issue: 18
Pages: 3572-8
Publication
First Author: D'Souza K
Year: 2018
Journal: J Lipid Res
Title: Autotaxin-LPA signaling contributes to obesity-induced insulin resistance in muscle and impairs mitochondrial metabolism.
Volume: 59
Issue: 10
Pages: 1805-1817
Publication
First Author: Narita M
Year: 1994
Journal: J Biol Chem
Title: Molecular cloning, expression, and localization of a brain-specific phosphodiesterase I/nucleotide pyrophosphatase (PD-I alpha) from rat brain.
Volume: 269
Issue: 45
Pages: 28235-42
Publication
First Author: Koike S
Year: 2006
Journal: Genes Cells
Title: The N-terminal hydrophobic sequence of autotaxin (ENPP2) functions as a signal peptide.
Volume: 11
Issue: 2
Pages: 133-42
Publication
First Author: Kanda H
Year: 2008
Journal: Nat Immunol
Title: Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs.
Volume: 9
Issue: 4
Pages: 415-23
Publication
First Author: Ohuchi H
Year: 2010
Journal: Dev Dyn
Title: Autotaxin controls caudal diencephalon-mesencephalon development in the chick.
Volume: 239
Issue: 10
Pages: 2647-58
Publication
First Author: Hozumi H
Year: 2013
Journal: Lab Invest
Title: Involvement of autotaxin/lysophospholipase D expression in intestinal vessels in aggravation of intestinal damage through lymphocyte migration.
Volume: 93
Issue: 5
Pages: 508-19
Publication
First Author: Kaffe E
Year: 2017
Journal: Hepatology
Title: Hepatocyte autotaxin expression promotes liver fibrosis and cancer.
Volume: 65
Issue: 4
Pages: 1369-1383
GXD Expression    
Probe: MGI:3588070
Assay Type: RT-PCR
Annotation Date: 2005-09-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1741220
Stage: TS20
Assay Id: MGI:3588141
Age: embryonic day 12.5
Image: 3
Specimen Label: LB
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3588070
Assay Type: RT-PCR
Annotation Date: 2005-09-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2992728
Stage: TS28
Assay Id: MGI:3588141
Age: postnatal week 10
Image: 3
Specimen Label: C/V
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3588070
Assay Type: RT-PCR
Annotation Date: 2005-09-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1898628
Stage: TS28
Assay Id: MGI:3588141
Age: postnatal week 10
Image: 3
Specimen Label: C/V
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3588070
Assay Type: RT-PCR
Annotation Date: 2005-09-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1741220
Stage: TS20
Assay Id: MGI:3588158
Age: embryonic day 12.5
Specimen Label: Hoxa13+/+
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3588070
Assay Type: RT-PCR
Annotation Date: 2005-09-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1741220
Stage: TS20
Assay Id: MGI:3588158
Age: embryonic day 12.5
Specimen Label: Hoxa13-/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5545760
Assay Type: RT-PCR
Annotation Date: 2014-02-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Stage: TS28
Assay Id: MGI:5545877
Age: postnatal adult
Image: 6
Specimen Label: +/+
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5545760
Assay Type: RT-PCR
Annotation Date: 2014-02-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Stage: TS28
Assay Id: MGI:5545877
Age: postnatal adult
Image: 6
Specimen Label: -/-
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:7382999
Assay Type: RT-PCR
Annotation Date: 2022-11-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:7384379
Age: embryonic day 8.5
Image: 6
Specimen Label: E8.5 embryo
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7382999
Assay Type: RT-PCR
Annotation Date: 2022-11-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:7384379
Age: embryonic day 9.5
Image: 6
Specimen Label: E9.5 embryo
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:7382999
Assay Type: RT-PCR
Annotation Date: 2022-11-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:7384379
Age: embryonic day 10.5
Image: 6
Specimen Label: E10.5 embryo
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:7382999
Assay Type: RT-PCR
Annotation Date: 2022-11-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608513
Stage: TS13
Assay Id: MGI:7384379
Age: embryonic day 8.5
Image: 6
Specimen Label: E8.5 yolk sac
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7382999
Assay Type: RT-PCR
Annotation Date: 2022-11-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608515
Stage: TS15
Assay Id: MGI:7384379
Age: embryonic day 9.5
Image: 6
Specimen Label: E9.5 yolk sac
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:7382999
Assay Type: RT-PCR
Annotation Date: 2022-11-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608517
Stage: TS17
Assay Id: MGI:7384379
Age: embryonic day 10.5
Image: 6
Specimen Label: E10.5 yolk sac
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:7382999
Assay Type: RT-PCR
Annotation Date: 2022-11-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:7384361
Age: embryonic day 8.5
Image: 1
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7382999
Assay Type: RT-PCR
Annotation Date: 2022-11-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:7384361
Age: embryonic day 8.5
Image: 1
Specimen Label: +/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7382999
Assay Type: RT-PCR
Annotation Date: 2022-11-15
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:7384361
Age: embryonic day 8.5
Image: 1
Specimen Label: -/-
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:7384405
Assay Type: Western blot
Annotation Date: 2022-11-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3569028
Stage: TS28
Assay Id: MGI:7384409
Age: postnatal adult
Image: 2
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7384405
Assay Type: Western blot
Annotation Date: 2022-11-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3569028
Stage: TS28
Assay Id: MGI:7384409
Age: postnatal adult
Image: 2
Specimen Label: +/+
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7384405
Assay Type: Western blot
Annotation Date: 2022-11-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3569028
Stage: TS28
Assay Id: MGI:7384409
Age: postnatal adult
Image: 2
Specimen Label: +/+
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:7384405
Assay Type: Western blot
Annotation Date: 2022-11-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3569028
Stage: TS28
Assay Id: MGI:7384409
Age: postnatal adult
Image: 2
Specimen Label: +/+
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:7384405
Assay Type: Western blot
Annotation Date: 2022-11-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3569028
Stage: TS28
Assay Id: MGI:7384409
Age: postnatal adult
Image: 2
Specimen Label: +/-
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:7384405
Assay Type: Western blot
Annotation Date: 2022-11-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3569028
Stage: TS28
Assay Id: MGI:7384409
Age: postnatal adult
Image: 2
Specimen Label: +/-
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:7384405
Assay Type: Western blot
Annotation Date: 2022-11-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3569028
Stage: TS28
Assay Id: MGI:7384409
Age: postnatal adult
Image: 2
Specimen Label: +/-
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:7384405
Assay Type: Western blot
Annotation Date: 2022-11-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3569028
Stage: TS28
Assay Id: MGI:7384409
Age: postnatal adult
Image: 2
Specimen Label: +/-
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:7384405
Assay Type: Western blot
Annotation Date: 2022-11-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3677115
Stage: TS15
Assay Id: MGI:7384450
Age: embryonic day 9.5
Image: 2
Specimen Label: amniotic fluid
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7384405
Assay Type: Western blot
Annotation Date: 2022-11-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3677115
Stage: TS15
Assay Id: MGI:7384450
Age: embryonic day 9.5
Image: 2
Specimen Label: amniotic fluid
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7384405
Assay Type: Western blot
Annotation Date: 2022-11-15
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:7384450
Age: embryonic day 9.5
Image: 2
Specimen Label: embryo proper
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:7384405
Assay Type: Western blot
Annotation Date: 2022-11-15
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1608515
Stage: TS15
Assay Id: MGI:7384450
Age: embryonic day 9.5
Image: 2
Specimen Label: yolk sac
Detected: false
Specimen Num: 6
GXD Expression    
Probe: MGI:7384405
Assay Type: Western blot
Annotation Date: 2022-11-15
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:7384450
Age: embryonic day 9.5
Image: 2
Specimen Label: embryo proper
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:7384405
Assay Type: Western blot
Annotation Date: 2022-11-15
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1608515
Stage: TS15
Assay Id: MGI:7384450
Age: embryonic day 9.5
Image: 2
Specimen Label: yolk sac
Detected: false
Specimen Num: 5