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Search results 1 to 100 out of 599 for Ext1

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Hits by Strain

Type Details Score
Gene
2131 | EXT1
Type: gene
Organism: human
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Gene
448393 | ext1
Type: gene
Organism: frog, western clawed
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Gene
107976420 | EXT1
Type: gene
Organism: chimpanzee
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Gene
299907 | Ext1
Type: gene
Organism: rat
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Gene
482024 | EXT1
Type: gene
Organism: dog, domestic
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Gene
538602 | EXT1
Type: gene
Organism: cattle
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Gene
100858205 | EXT1
Type: gene
Organism: chicken
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Gene
701488 | EXT1
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:894663 | Ext1
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
108491824 | LOC108491824
Type: gene
Organism: human
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Publication
9620772 | J:113833
First Author: McCormick C
Year: 1998
Journal: Nat Genet
Title: The putative tumour suppressor EXT1 alters the expression of cell-surface heparan sulfate.
Volume: 19
Issue: 2
Pages: 158-61
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Publication
15161920 | J:91757
First Author: Yamada S
Year: 2004
Journal: J Biol Chem
Title: Embryonic fibroblasts with a gene trap mutation in Ext1 produce short heparan sulfate chains.
Volume: 279
Issue: 31
Pages: 32134-41
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Publication
15777636 | J:104933
First Author: Hilton MJ
Year: 2005
Journal: Bone
Title: EXT1 regulates chondrocyte proliferation and differentiation during endochondral bone development.
Volume: 36
Issue: 3
Pages: 379-86
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Publication
19850926 | J:286758
First Author: Osterholm C
Year: 2009
Journal: J Biol Chem
Title: Mutation in the heparan sulfate biosynthesis enzyme EXT1 influences growth factor signaling and fibroblast interactions with the extracellular matrix.
Volume: 284
Issue: 50
Pages: 34935-43
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Publication
10864928 | J:64512
First Author: Wei G
Year: 2000
Journal: J Biol Chem
Title: Location of the glucuronosyltransferase domain in the heparan sulfate copolymerase EXT1 by analysis of Chinese hamster ovary cell mutants.
Volume: 275
Issue: 36
Pages: 27733-40
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Publication
12644256 | J:82657
First Author: Inatani M
Year: 2003
Journal: Brain Res Dev Brain Res
Title: Gene expression of EXT1 and EXT2 during mouse brain development.
Volume: 141
Issue: 1-2
Pages: 129-36
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Publication
20080592 | J:157599
First Author: Jones KB
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes.
Volume: 107
Issue: 5
Pages: 2054-9
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Publication
9254013 | J:42532
First Author: Lin X
Year: 1997
Journal: DNA Seq
Title: Isolation of the mouse cDNA homologous to the human EXT1 gene responsible for Hereditary Multiple Exostoses.
Volume: 7
Issue: 3-4
Pages: 199-202
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Publication
25741008 | J:297355
First Author: O'Hearn A
Year: 2015
Journal: J Virol
Title: Role of EXT1 and Glycosaminoglycans in the Early Stage of Filovirus Entry.
Volume: 89
Issue: 10
Pages: 5441-9
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Publication
10639137 | J:113870
First Author: McCormick C
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate.
Volume: 97
Issue: 2
Pages: 668-73
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Publication
- | J:145524
     
First Author: Sheffield VC
Year: 2009
Journal: MGI Direct Data Submission
Title: Generation of a floxed allele of Ext1
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Publication
8981950 | J:48119
First Author: Hecht JT
Year: 1997
Journal: Am J Hum Genet
Title: Hereditary multiple exostoses (EXT): mutational studies of familial EXT1 cases and EXT-associated malignancies.
Volume: 60
Issue: 1
Pages: 80-6
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Publication
25568062 | J:220029
First Author: Mooij HL
Year: 2015
Journal: J Lipid Res
Title: Ext1 heterozygosity causes a modest effect on postprandial lipid clearance in humans.
Volume: 56
Issue: 3
Pages: 665-73
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Publication
18337501 | J:133353
First Author: Presto J
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation.
Volume: 105
Issue: 12
Pages: 4751-6
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Publication
25644707 | J:221064
First Author: de Andrea CE
Year: 2015
Journal: J Pathol
Title: Cell cycle deregulation and mosaic loss of Ext1 drive peripheral chondrosarcomagenesis in the mouse and reveal an intrinsic cilia deficiency.
Volume: 236
Issue: 2
Pages: 210-8
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Publication
21310272 | J:286741
First Author: Zak BM
Year: 2011
Journal: Bone
Title: Compound heterozygous loss of Ext1 and Ext2 is sufficient for formation of multiple exostoses in mouse ribs and long bones.
Volume: 48
Issue: 5
Pages: 979-87
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Publication
9186511 | J:41009
First Author: Lohmann DR
Year: 1997
Journal: Cytogenet Cell Genet
Title: The murine Ext1 gene shows a high level of sequence similarity with its human homologue and is part of a conserved linkage group on chromosome 15.
Volume: 76
Issue: 3-4
Pages: 164-6
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Publication
21185280 | J:170582
First Author: Mundy C
Year: 2011
Journal: Dev Biol
Title: Synovial joint formation requires local Ext1 expression and heparan sulfate production in developing mouse embryo limbs and spine.
Volume: 351
Issue: 1
Pages: 70-81
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Publication
20534475 | J:161395
First Author: Matsumoto K
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: A mouse model of chondrocyte-specific somatic mutation reveals a role for Ext1 loss of heterozygosity in multiple hereditary exostoses.
Volume: 107
Issue: 24
Pages: 10932-7
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Publication
20404326 | J:164551
First Author: Matsumoto Y
Year: 2010
Journal: J Biol Chem
Title: Conditional ablation of the heparan sulfate-synthesizing enzyme Ext1 leads to dysregulation of bone morphogenic protein signaling and severe skeletal defects.
Volume: 285
Issue: 25
Pages: 19227-34
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Publication
25468659 | J:293600
First Author: Mooij HL
Year: 2014
Journal: J Am Heart Assoc
Title: Loss of function in heparan sulfate elongation genes EXT1 and EXT 2 results in improved nitric oxide bioavailability and endothelial function.
Volume: 3
Issue: 6
Pages: e001274
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Publication
23458899 | J:196289
First Author: Huegel J
Year: 2013
Journal: Dev Biol
Title: Perichondrium phenotype and border function are regulated by Ext1 and heparan sulfate in developing long bones: a mechanism likely deranged in Hereditary Multiple Exostoses.
Volume: 377
Issue: 1
Pages: 100-12
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Publication
33028660 | J:303971
First Author: Ohkawa Y
Year: 2021
Journal: Mol Cancer Res
Title: Heparan Sulfate Synthesized by Ext1 Regulates Receptor Tyrosine Kinase Signaling and Promotes Resistance to EGFR Inhibitors in GBM.
Volume: 19
Issue: 1
Pages: 150-161
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Publication
23192691 | J:237157
First Author: Jones KB
Year: 2013
Journal: J Orthop Res
Title: Toward an understanding of the short bone phenotype associated with multiple osteochondromas.
Volume: 31
Issue: 4
Pages: 651-7
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Publication
15177029 | J:92212
First Author: Koziel L
Year: 2004
Journal: Dev Cell
Title: Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification.
Volume: 6
Issue: 6
Pages: 801-13
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Publication
27030596 | J:269142
First Author: Liu CC
Year: 2016
Journal: Sci Transl Med
Title: Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-β clearance and aggregation in Alzheimer's disease.
Volume: 8
Issue: 332
Pages: 332ra44
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Publication
33278339 | J:306988
First Author: Brestoff JR
Year: 2021
Journal: Cell Metab
Title: Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity.
Volume: 33
Issue: 2
Pages: 270-282.e8
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Publication
28445472 | J:242977
First Author: Sinha S
Year: 2017
Journal: PLoS Genet
Title: Unsuspected osteochondroma-like outgrowths in the cranial base of Hereditary Multiple Exostoses patients and modeling and treatment with a BMP antagonist in mice.
Volume: 13
Issue: 4
Pages: e1006742
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Publication
9703997 | J:49122
First Author: Lin X
Year: 1998
Journal: Biochem Biophys Res Commun
Title: Expression and functional analysis of mouse EXT1, a homolog of the human multiple exostoses type 1 gene.
Volume: 248
Issue: 3
Pages: 738-43
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Publication
25202142 | J:297354
First Author: Saez B
Year: 2014
Journal: Blood
Title: Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning.
Volume: 124
Issue: 19
Pages: 2937-47
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Publication
17130131 | J:120294
First Author: Mahalingam Y
Year: 2007
Journal: J Biol Chem
Title: Cellular adhesion responses to the heparin-binding (HepII) domain of fibronectin require heparan sulfate with specific properties.
Volume: 282
Issue: 5
Pages: 3221-30
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Publication
29545125 | J:267570
 
First Author: Piombo V
Year: 2018
Journal: Bone
Title: Signaling systems affecting the severity of multiple osteochondromas.
Volume: 111
Pages: 71-81
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Publication
28768899 | J:286959
 
First Author: Inubushi T
Year: 2017
Journal: JCI Insight
Title: Aberrant perichondrial BMP signaling mediates multiple osteochondromagenesis in mice.
Volume: 2
Issue: 15
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Publication
34310946 | J:338711
First Author: Matsuzawa T
Year: 2021
Journal: J Biol Chem
Title: Heparan sulfate promotes differentiation of white adipocytes to maintain insulin sensitivity and glucose homeostasis.
Volume: 297
Issue: 3
Pages: 101006
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Publication
18480751 | J:152871
First Author: Chen S
Year: 2008
Journal: Kidney Int
Title: Loss of heparan sulfate glycosaminoglycan assembly in podocytes does not lead to proteinuria.
Volume: 74
Issue: 3
Pages: 289-99
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Publication
29605295 | J:270542
First Author: Matsuzawa T
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Heparan sulfate in pancreatic β-cells contributes to normal glucose homeostasis by regulating insulin secretion.
Volume: 499
Issue: 3
Pages: 688-695
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Publication
33600795 | J:304812
   
First Author: Hsu HP
Year: 2021
Journal: J Biol Chem
Title: Heparan sulfate is essential for thymus growth.
Pages: 100419
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Publication
14605369 | J:86465
First Author: Inatani M
Year: 2003
Journal: Science
Title: Mammalian brain morphogenesis and midline axon guidance require heparan sulfate.
Volume: 302
Issue: 5647
Pages: 1044-6
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Publication
32818603 | J:333143
First Author: Kawashima K
Year: 2020
Journal: Osteoarthritis Cartilage
Title: Heparan sulfate deficiency leads to hypertrophic chondrocytes by increasing bone morphogenetic protein signaling.
Volume: 28
Issue: 11
Pages: 1459-1470
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Publication
23958822 | J:203836
First Author: Sgariglia F
Year: 2013
Journal: Bone
Title: Epiphyseal abnormalities, trabecular bone loss and articular chondrocyte hypertrophy develop in the long bones of postnatal Ext1-deficient mice.
Volume: 57
Issue: 1
Pages: 220-31
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Publication
20377530 | J:163045
First Author: Okada M
Year: 2010
Journal: Biochem J
Title: Biosynthesis of heparan sulfate in EXT1-deficient cells.
Volume: 428
Issue: 3
Pages: 463-71
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Publication
39062860 | J:352526
 
First Author: Garcia SA
Year: 2024
Journal: Int J Mol Sci
Title: Analysis of the Actions of RARγ Agonists on Growing Osteochondromas in a Mouse Model.
Volume: 25
Issue: 14
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Publication
26491162 | J:227920
First Author: Zaiss AK
Year: 2015
Journal: J Virol
Title: Hepatocyte Heparan Sulfate Is Required for Adeno-Associated Virus 2 but Dispensable for Adenovirus 5 Liver Transduction In Vivo.
Volume: 90
Issue: 1
Pages: 412-20
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Publication
10878610 | J:63309
First Author: Stickens D
Year: 2000
Journal: Dev Dyn
Title: EXT genes are differentially expressed in bone and cartilage during mouse embryogenesis.
Volume: 218
Issue: 3
Pages: 452-64
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Publication
10926768 | J:64021
First Author: Lin X
Year: 2000
Journal: Dev Biol
Title: Disruption of gastrulation and heparan sulfate biosynthesis in EXT1-deficient mice.
Volume: 224
Issue: 2
Pages: 299-311
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Publication
26024086 | J:230966
First Author: Coulson-Thomas VJ
Year: 2015
Journal: Invest Ophthalmol Vis Sci
Title: Loss of corneal epithelial heparan sulfate leads to corneal degeneration and impaired wound healing.
Volume: 56
Issue: 5
Pages: 3004-14
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Publication
18667431 | J:142318
First Author: Nadanaka S
Year: 2008
Journal: J Biol Chem
Title: Chondroitin 4-O-sulfotransferase-1 modulates Wnt-3a signaling through control of E disaccharide expression of chondroitin sulfate.
Volume: 283
Issue: 40
Pages: 27333-43
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Publication
17761672 | J:126958
First Author: Busse M
Year: 2007
Journal: J Biol Chem
Title: Contribution of EXT1, EXT2, and EXTL3 to heparan sulfate chain elongation.
Volume: 282
Issue: 45
Pages: 32802-10
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Publication
22556407 | J:286754
First Author: Kraushaar DC
Year: 2012
Journal: J Biol Chem
Title: Heparan sulfate facilitates FGF and BMP signaling to drive mesoderm differentiation of mouse embryonic stem cells.
Volume: 287
Issue: 27
Pages: 22691-700
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Publication
21586278 | J:173613
First Author: Garner OB
Year: 2011
Journal: Dev Biol
Title: Stage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signaling.
Volume: 355
Issue: 2
Pages: 394-403
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Publication
32201365 | J:297362
 
First Author: Bachvarova V
Year: 2020
Journal: Matrix Biol
Title: Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate.
Volume: 93
Pages: 43-59
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Publication
17442818 | J:121105
First Author: Matsumoto Y
Year: 2007
Journal: J Neurosci
Title: Netrin-1/DCC signaling in commissural axon guidance requires cell-autonomous expression of heparan sulfate.
Volume: 27
Issue: 16
Pages: 4342-50
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Publication
19782070 | J:158330
First Author: Iwao K
Year: 2010
Journal: Exp Eye Res
Title: Heparan sulfate deficiency in periocular mesenchyme causes microphthalmia and ciliary body dysgenesis.
Volume: 90
Issue: 1
Pages: 81-8
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Publication
26295701 | J:243036
First Author: Zhang R
Year: 2015
Journal: PLoS One
Title: Heparan Sulfate Biosynthesis Enzyme, Ext1, Contributes to Outflow Tract Development of Mouse Heart via Modulation of FGF Signaling.
Volume: 10
Issue: 8
Pages: e0136518
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Publication
28859094 | J:243870
First Author: He H
Year: 2017
Journal: PLoS Genet
Title: Epithelial heparan sulfate regulates Sonic Hedgehog signaling in lung development.
Volume: 13
Issue: 8
Pages: e1006992
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Publication
29700203 | J:263185
 
First Author: Huang M
Year: 2018
Journal: J Cell Sci
Title: Multiple roles of epithelial heparan sulfate in stomach morphogenesis.
Volume: 131
Issue: 10
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Protein Coding Gene
MGP_CAROLIEiJ_G0019786 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0021843 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0021803 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0021784 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0021810 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0021584 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_894663 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0022249 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0021101 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0021553 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0021677 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0021655 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0021747 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0021679 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0022272 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0020846 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0021156 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0019796 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0020683 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
24835176 | J:211254
First Author: Nonaka M
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Synthetic di-sulfated iduronic acid attenuates asthmatic response by blocking T-cell recruitment to inflammatory sites.
Volume: 111
Issue: 22
Pages: 8173-8
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Publication
32810562 | J:299689
First Author: Yokoyama M
Year: 2020
Journal: Biochim Biophys Acta Gen Subj
Title: Heparan sulfate controls skeletal muscle differentiation and motor functions.
Volume: 1864
Issue: 12
Pages: 129707
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Publication
20463653 | J:184264
First Author: Chen S
Year: 2010
Journal: Kidney Int
Title: Podocytes require the engagement of cell surface heparan sulfate proteoglycans for adhesion to extracellular matrices.
Volume: 78
Issue: 11
Pages: 1088-99
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Publication
25053416 | J:216871
First Author: Coulson-Thomas VJ
Year: 2014
Journal: J Biol Chem
Title: Heparan sulfate regulates hair follicle and sebaceous gland morphogenesis and homeostasis.
Volume: 289
Issue: 36
Pages: 25211-26
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Publication
22411800 | J:182220
First Author: Irie F
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Autism-like socio-communicative deficits and stereotypies in mice lacking heparan sulfate.
Volume: 109
Issue: 13
Pages: 5052-6
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Publication
23744737 | J:205081
First Author: Yamamoto S
Year: 2013
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Heparan sulfate on intestinal epithelial cells plays a critical role in intestinal crypt homeostasis via Wnt/β-catenin signaling.
Volume: 305
Issue: 3
Pages: G241-9
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Publication
23733868 | J:205359
First Author: Tsuboi K
Year: 2013
Journal: J Immunol
Title: Role of high endothelial venule-expressed heparan sulfate in chemokine presentation and lymphocyte homing.
Volume: 191
Issue: 1
Pages: 448-55
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Publication
36439118 | J:331954
 
First Author: Herrera-Heredia SA
Year: 2022
Journal: Front Immunol
Title: Heparin is required for the formation of granules in connective tissue mast cells.
Volume: 13
Pages: 1000405
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Publication
20022960 | J:160035
First Author: Kraushaar DC
Year: 2010
Journal: J Biol Chem
Title: Heparan sulfate is required for embryonic stem cells to exit from self-renewal.
Volume: 285
Issue: 8
Pages: 5907-16
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Publication
21148566 | J:286759
First Author: Holley RJ
Year: 2011
Journal: J Biol Chem
Title: Influencing hematopoietic differentiation of mouse embryonic stem cells using soluble heparin and heparan sulfate saccharides.
Volume: 286
Issue: 8
Pages: 6241-52
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GXD Expression
GXD Expression
     
Probe: MGI:5697388
Assay Type: RT-PCR
Annotation Date: 2015-11-30
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:160397
Stage: TS07
Assay Id: MGI:5697391
Age: embryonic day 5.5
Specimen Label: None
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:5697388
Assay Type: RT-PCR
Annotation Date: 2015-11-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160399
Stage: TS09
Assay Id: MGI:5697391
Age: embryonic day 6.5
Specimen Label: None
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:5697388
Assay Type: RT-PCR
Annotation Date: 2015-11-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:5697391
Age: embryonic day 7.5
Specimen Label: None
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5697389
Assay Type: Northern blot
Annotation Date: 2015-11-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5697392
Age: postnatal adult
Specimen Label: None
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5697389
Assay Type: Northern blot
Annotation Date: 2015-11-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:5697392
Age: postnatal adult
Specimen Label: None
Detected: true
Specimen Num: 2
•
•
•
•
•




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