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Search results 1 to 100 out of 120 for Fan1

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Hits by Pathway

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Hits by Category

Type Details Score
Gene
22909 | FAN1
Type: gene
Organism: human
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Gene
565458 | fan1
Type: gene
Organism: zebrafish
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Gene
713125 | FAN1
Type: gene
Organism: macaque, rhesus
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Gene
100485224 | fan1
Type: gene
Organism: frog, western clawed
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Gene
309256 | Fan1
Type: gene
Organism: rat
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Gene
453282 | FAN1
Type: gene
Organism: chimpanzee
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Gene
479017 | FAN1
Type: gene
Organism: dog, domestic
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Gene
508171 | FAN1
Type: gene
Organism: cattle
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Gene
415383 | FAN1
Type: gene
Organism: chicken
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Protein Coding Gene
MGI:3045266 | Fan1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
24981866 | J:217316
First Author: Pennell S
Year: 2014
Journal: Cell Rep
Title: FAN1 activity on asymmetric repair intermediates is mediated by an atypical monomeric virus-type replication-repair nuclease domain.
Volume: 8
Issue: 1
Pages: 84-93
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Publication
26797144 | J:229449
First Author: Lachaud C
Year: 2016
Journal: Science
Title: Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability.
Volume: 351
Issue: 6275
Pages: 846-9
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Publication
26980188 | J:232403
First Author: Lachaud C
Year: 2016
Journal: Genes Dev
Title: Karyomegalic interstitial nephritis and DNA damage-induced polyploidy in Fan1 nuclease-defective knock-in mice.
Volume: 30
Issue: 6
Pages: 639-44
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Publication
29990673 | J:267618
 
First Author: Zhao XN
Year: 2018
Journal: DNA Repair (Amst)
Title: FAN1 protects against repeat expansions in a Fragile X mouse model.
Volume: 69
Pages: 1-5
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Publication
26980189 | J:232402
First Author: Thongthip S
Year: 2016
Journal: Genes Dev
Title: Fan1 deficiency results in DNA interstrand cross-link repair defects, enhanced tissue karyomegaly, and organ dysfunction.
Volume: 30
Issue: 6
Pages: 645-59
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Publication
34469738 | J:324645
First Author: Goold R
Year: 2021
Journal: Cell Rep
Title: FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington's disease.
Volume: 36
Issue: 9
Pages: 109649
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Publication
32876667 | J:298297
First Author: Loupe JM
Year: 2020
Journal: Hum Mol Genet
Title: Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out.
Volume: 29
Issue: 18
Pages: 3044-3053
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Publication
26658876 | J:227984
First Author: Kogan JH
Year: 2015
Journal: J Neurosci
Title: Mouse Model of Chromosome 15q13.3 Microdeletion Syndrome Demonstrates Features Related to Autism Spectrum Disorder.
Volume: 35
Issue: 49
Pages: 16282-94
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Publication
27026368 | J:242198
First Author: Airik R
Year: 2016
Journal: J Am Soc Nephrol
Title: A FANCD2/FANCI-Associated Nuclease 1-Knockout Model Develops Karyomegalic Interstitial Nephritis.
Volume: 27
Issue: 12
Pages: 3552-3559
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Protein Coding Gene
MGP_CAROLIEiJ_G0029827 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0032336 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0032315 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032251 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032327 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0032040 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_3045266 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0032820 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0031369 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0032006 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032162 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0032116 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0032242 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0032153 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0032837 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0031089 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0031487 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0013052 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0030930 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
 
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1868128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692889
Age: postnatal adult
Image: UC Davis_1859386
Note: vas deferens
Specimen Label: UC Davis_1859386
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692889
Age: postnatal adult
Image: UC Davis_1859383
Specimen Label: UC Davis_1859383
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692889
Age: postnatal adult
Image: UC Davis_1859384
Specimen Label: UC Davis_1859384
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1929028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692889
Age: postnatal adult
Image: UC Davis_1859385
Specimen Label: UC Davis_1859385
Detected: true
Specimen Num: 3
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Publication
31367016 | J:280245
First Author: Hill RJ
Year: 2019
Journal: Nat Genet
Title: DNA cross-link repair safeguards genomic stability during premeiotic germ cell development.
Volume: 51
Issue: 8
Pages: 1283-1294
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Publication
24569637 | J:237465
First Author: Cheverud JM
Year: 2014
Journal: Heredity (Edinb)
Title: Fine-mapping quantitative trait loci affecting murine external ear tissue regeneration in the LG/J by SM/J advanced intercross line.
Volume: 112
Issue: 5
Pages: 508-18
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Publication
27568566 | J:239017
First Author: Steinmetz CC
Year: 2016
Journal: Cell Rep
Title: Upregulation of μ3A Drives Homeostatic Plasticity by Rerouting AMPAR into the Recycling Endosomal Pathway.
Volume: 16
Issue: 10
Pages: 2711-2722
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Publication
- | J:94077
     
First Author: Mutant Mouse Regional Resource Centers
Year: 2004
Journal: Unpublished
Title: Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC)
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Allele
Fan1<tm1.1Jrou> | MGI:5897147
 
Name: FANCD2/FANCI-associated nuclease 1; targeted mutation 1.1 John Rouse
Allele Type: Targeted
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Protein
Q61553
Organism: Mus musculus/domesticus
Length: 493  
Fragment?: false
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Allele
Fan1<em1Smoc> | MGI:7289597
Name: FANCD2/FANCI-associated nuclease 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Interaction Experiment
Thongthip S (2016)
Description: Fan1 deficiency results in DNA interstrand cross-link repair defects, enhanced tissue karyomegaly, and organ dysfunction.
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Protein Coding Gene
MGI:1352745 | Fscn1
Type: protein_coding_gene
Organism: mouse, laboratory
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Interaction Experiment
Goold R (2021)
Description: FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntingtons disease.
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Allele
Chrna7<em1(Del1263751bp)Smoc> | MGI:7288978
Name: cholinergic receptor, nicotinic, alpha polypeptide 7; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6475249 | C57BL/6-Fan1<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:6354678 | C57BL/6J-Chrna7<em1(Del1263751bp)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Fan1<tm1a(KOMP)Wtsi> | MGI:4940765
Name: FANCD2/FANCI-associated nuclease 1; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Fan1<tm1d(KOMP)Wtsi> | MGI:5796264
Name: FANCD2/FANCI-associated nuclease 1; targeted mutation 1d, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Del(7Chrna7-Fan1)1Mima | MGI:5908016
Name: deletion, Chr 7, Mitsuru Matsumoto 1
Allele Type: Targeted
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Fan1/Fan1
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fan1/Fan1
Background: involves: C57BL/6N * FVB/N
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0060911 | karyomegalic interstitial nephritis
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Genotype
Genotype
Symbol: Fan1/Fan1
Background: 129S1.B6-Fan1
Zygosity: hm
Has Mutant Allele: true
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Protein Domain
IPR033315 | Fan1-like
Type: Family
Description: This entry includes a group of nucleases from bacteria and eukaryotes, including fanconi-associated nuclease 1 (Fan1) from eukaryotes. Fan1 is a structure-selective DNA repair nuclease with 5' flap endonuclease activity, involved in the repair of interstrand DNA crosslinks (ICLs). It is the only VRR-Nuc-domain-containing protein in eukaryotes. It acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions [].The Fan1 bacterial homologue, such as Pseudomonas aeruginosa FAN1 (PaFAN1), also exhibits a strong preference for 5' flap and nicked DNA [].
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Strain
MGI:5908018 | C57BL/6N-Del(7Chrna7-Fan1)1Mima
Attribute String: coisogenic, targeted mutation, deletion
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Genotype
Genotype
Symbol: Del(7Chrna7-Fan1)1Mima/+
Background: C57BL/6N-Del(7Chrna7-Fan1)1Mima
Zygosity: ht
Has Mutant Allele: true
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Publication
25319828 | -
First Author: Gwon GH
Year: 2014
Journal: Genes Dev
Title: Crystal structure of a Fanconi anemia-associated nuclease homolog bound to 5' flap DNA: basis of interstrand cross-link repair by FAN1.
Volume: 28
Issue: 20
Pages: 2276-90
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Publication
37827155 | J:342178
First Author: Gall-Duncan T
Year: 2023
Journal: Cell
Title: Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability.
Volume: 186
Issue: 22
Pages: 4898-4919.e25
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Protein
Q80V62
Organism: Mus musculus/domesticus
Length: 1450  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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