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Search results 1 to 100 out of 370 for Fgf20

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Family
Description: Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs have internal pseudo-threefold symmetry (β-trefoil topology) []. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active [].This entry represents fibroblast growth factor 20 (FGF20). It is involved in embryonic development, cell growth, morphogenesis, tissue repair, and tumour growth and invasion [, , ]. FGF20 is expressed in normal brain, particularly the cerebellum [], and has been shown to enhance the survival of midbrain dopaminergic neurons in vitro [].
Publication
First Author: Yang LM
Year: 2019
Journal: PLoS Genet
Title: Sox2 and FGF20 interact to regulate organ of Corti hair cell and supporting cell development in a spatially-graded manner.
Volume: 15
Issue: 7
Pages: e1008254
Publication
First Author: Yang LM
Year: 2018
Journal: Dev Cell
Title: FGF20-Expressing, Wnt-Responsive Olfactory Epithelial Progenitors Regulate Underlying Turbinate Growth to Optimize Surface Area.
Volume: 46
Issue: 5
Pages: 564-580.e5
Publication
First Author: Mok KW
Year: 2019
Journal: Dev Cell
Title: Dermal Condensate Niche Fate Specification Occurs Prior to Formation and Is Placode Progenitor Dependent.
Volume: 48
Issue: 1
Pages: 32-48.e5
Publication
First Author: Yang LM
Year: 2020
Journal: Dev Dyn
Title: Analysis of FGF20-regulated genes in organ of Corti progenitors by translating ribosome affinity purification.
Volume: 249
Issue: 10
Pages: 1217-1242
Publication
First Author: Volovelsky O
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Hamartin regulates cessation of mouse nephrogenesis independently of Mtor.
Volume: 115
Issue: 23
Pages: 5998-6003
Publication  
First Author: Duvall K
Year: 2022
Journal: Development
Title: Revisiting the role of Notch in nephron segmentation confirms a role for proximal fate selection during mouse and human nephrogenesis.
Volume: 149
Issue: 10
Publication
First Author: Jansson L
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: β-Catenin is required for radial cell patterning and identity in the developing mouse cochlea.
Volume: 116
Issue: 42
Pages: 21054-21060
Publication    
First Author: Huh SH
Year: 2015
Journal: Elife
Title: Cochlear progenitor number is controlled through mesenchymal FGF receptor signaling.
Volume: 4
GXD Expression    
Probe: MGI:4868264
Assay Type: RNA in situ
Annotation Date: 2011-02-01
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:2851823
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:4881488
Age: embryonic day 15.5
Note: The staining observed with this probe generally appeared to be non-specific. However, the staining was strongest in the renal interstitium, suggesting that there might be some specific staining in this tissue.
Specimen Label: Table S4 - Fgf20
Specimen Num: 1
Publication
First Author: Häärä O
Year: 2012
Journal: Development
Title: Ectodysplasin regulates activator-inhibitor balance in murine tooth development through Fgf20 signaling.
Volume: 139
Issue: 17
Pages: 3189-99
Publication
First Author: Hayashi T
Year: 2008
Journal: J Neurosci
Title: Fgf20 is required for sensory epithelial specification in the developing cochlea.
Volume: 28
Issue: 23
Pages: 5991-9
Publication    
First Author: Biggs LC
Year: 2018
Journal: Elife
Title: Hair follicle dermal condensation forms via Fgf20 primed cell cycle exit, cell motility, and aggregation.
Volume: 7
Publication
First Author: Barak H
Year: 2012
Journal: Dev Cell
Title: FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man.
Volume: 22
Issue: 6
Pages: 1191-207
Publication
First Author: Huh SH
Year: 2012
Journal: PLoS Biol
Title: Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal.
Volume: 10
Issue: 1
Pages: e1001231
Publication
First Author: Huh SH
Year: 2013
Journal: Genes Dev
Title: Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles.
Volume: 27
Issue: 4
Pages: 450-8
Publication    
First Author: Itoh N
Year: 2000
Journal: GenBank Submission
Title: Mus musculus Fgf20 mRNA for fibroblast growth factor 20, complete cds
Pages: AB049218
Publication
First Author: Elo T
Year: 2017
Journal: Sci Rep
Title: Ectodysplasin target gene Fgf20 regulates mammary bud growth and ductal invasion and branching during puberty.
Volume: 7
Issue: 1
Pages: 5049
Allele
Name: fibroblast growth factor 20; targeted mutation 2.1, David M Ornitz
Allele Type: Targeted
Attribute String: Recombinase, Reporter
Publication
First Author: Kirikoshi H
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Molecular cloning and characterization of human FGF-20 on chromosome 8p21.3-p22.
Volume: 274
Issue: 2
Pages: 337-43
Publication
First Author: Ohmachi S
Year: 2000
Journal: Biochem Biophys Res Commun
Title: FGF-20, a novel neurotrophic factor, preferentially expressed in the substantia nigra pars compacta of rat brain.
Volume: 277
Issue: 2
Pages: 355-60
Publication
First Author: Jeffers M
Year: 2001
Journal: Cancer Res
Title: Identification of a novel human fibroblast growth factor and characterization of its role in oncogenesis.
Volume: 61
Issue: 7
Pages: 3131-8
Protein
Organism: Mus musculus
Length: 211  
Fragment?: false
Protein
Organism: Mus musculus
Length: 211  
Fragment?: false
Protein
Organism: Mus musculus
Length: 157  
Fragment?: false
Protein
Organism: Mus musculus
Length: 211  
Fragment?: false
Publication
First Author: Zhang X
Year: 2006
Journal: J Biol Chem
Title: Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.
Volume: 281
Issue: 23
Pages: 15694-700
Publication  
First Author: Burgess WH
Year: 1989
Journal: Annu Rev Biochem
Title: The heparin-binding (fibroblast) growth factor family of proteins.
Volume: 58
Pages: 575-606
Publication
First Author: Wilkie AO
Year: 1995
Journal: Curr Biol
Title: Functions of fibroblast growth factors and their receptors.
Volume: 5
Issue: 5
Pages: 500-7
Publication
First Author: Thomas KA
Year: 1988
Journal: Trends Biochem Sci
Title: Transforming potential of fibroblast growth factor genes.
Volume: 13
Issue: 9
Pages: 327-8
Publication
First Author: Ornitz DM
Year: 2001
Journal: Genome Biol
Title: Fibroblast growth factors.
Volume: 2
Issue: 3
Pages: REVIEWS3005
Publication
First Author: Plotnikov AN
Year: 2000
Journal: Cell
Title: Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Volume: 101
Issue: 4
Pages: 413-24
Publication
First Author: Blaber M
Year: 1996
Journal: Biochemistry
Title: X-ray crystal structure of human acidic fibroblast growth factor.
Volume: 35
Issue: 7
Pages: 2086-94
Publication
First Author: Vlodavsky I
Year: 1990
Journal: Cancer Metastasis Rev
Title: Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis.
Volume: 9
Issue: 3
Pages: 203-26
Publication
First Author: Green PJ
Year: 1996
Journal: Bioessays
Title: Promiscuity of fibroblast growth factor receptors.
Volume: 18
Issue: 8
Pages: 639-46
Publication
First Author: Yardley N
Year: 2012
Journal: Dev Biol
Title: FGF signaling transforms non-neural ectoderm into neural crest.
Volume: 372
Issue: 2
Pages: 166-77
Publication
First Author: Böttcher RT
Year: 2005
Journal: Endocr Rev
Title: Fibroblast growth factor signaling during early vertebrate development.
Volume: 26
Issue: 1
Pages: 63-77
Publication
First Author: Koga C
Year: 1999
Journal: Biochem Biophys Res Commun
Title: Characterization of a novel member of the FGF family, XFGF-20, in Xenopus laevis.
Volume: 261
Issue: 3
Pages: 756-65
Publication
First Author: Nakamizo S
Year: 2013
Journal: Skin Pharmacol Physiol
Title: Topical treatment with basic fibroblast growth factor promotes wound healing and barrier recovery induced by skin abrasion.
Volume: 26
Issue: 1
Pages: 22-9
Publication
First Author: Kumar SB
Year: 2013
Journal: Curr Pharm Des
Title: Fibroblast growth factor receptor inhibitors.
Volume: 19
Issue: 4
Pages: 687-701
Publication
First Author: Amaya E
Year: 1991
Journal: Cell
Title: Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos.
Volume: 66
Issue: 2
Pages: 257-70
Publication
First Author: Borland CZ
Year: 2001
Journal: Bioessays
Title: Fibroblast growth factor signaling in Caenorhabditis elegans.
Volume: 23
Issue: 12
Pages: 1120-30
Publication
First Author: Coumoul X
Year: 2003
Journal: Birth Defects Res C Embryo Today
Title: Roles of FGF receptors in mammalian development and congenital diseases.
Volume: 69
Issue: 4
Pages: 286-304
Publication
First Author: Sutherland D
Year: 1996
Journal: Cell
Title: branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching.
Volume: 87
Issue: 6
Pages: 1091-101
Publication
First Author: Chen S
Year: 2015
Journal: Dev Cell
Title: Intrinsic Age-Dependent Changes and Cell-Cell Contacts Regulate Nephron Progenitor Lifespan.
Volume: 35
Issue: 1
Pages: 49-62
Publication
First Author: Chen Y
Year: 2022
Journal: Cell Death Dis
Title: Fibroblast growth factor 20 attenuates pathological cardiac hypertrophy by activating the SIRT1 signaling pathway.
Volume: 13
Issue: 3
Pages: 276
Publication
First Author: Lavine KJ
Year: 2005
Journal: Dev Cell
Title: Endocardial and epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivo.
Volume: 8
Issue: 1
Pages: 85-95
Publication
First Author: Munnamalai V
Year: 2012
Journal: J Neurosci
Title: Notch prosensory effects in the Mammalian cochlea are partially mediated by Fgf20.
Volume: 32
Issue: 37
Pages: 12876-84
Publication
First Author: Xiao Y
Year: 2016
Journal: PLoS Genet
Title: A Cascade of Wnt, Eda, and Shh Signaling Is Essential for Touch Dome Merkel Cell Development.
Volume: 12
Issue: 7
Pages: e1006150
Publication  
First Author: Levy R
Year: 2015
Journal: BMC Genomics
Title: Collaborative cross mice in a genetic association study reveal new candidate genes for bone microarchitecture.
Volume: 16
Pages: 1013
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression    
Probe: MGI:2664760
Assay Type: RT-PCR
Annotation Date: 2003-07-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1922525
Stage: TS25
Assay Id: MGI:2664804
Age: embryonic day 17.5
Image: 1
Specimen Label: Fgf-20
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:5562440
Assay Type: RT-PCR
Annotation Date: 2014-05-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610520
Stage: TS20
Assay Id: MGI:5562652
Age: embryonic day 12.5
Image: 1
Specimen Label: heart E12.5
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5562440
Assay Type: RT-PCR
Annotation Date: 2014-05-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610522
Stage: TS22
Assay Id: MGI:5562652
Age: embryonic day 14.5
Image: 1
Specimen Label: heart E14.5
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5562440
Assay Type: RT-PCR
Annotation Date: 2014-05-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610524
Stage: TS24
Assay Id: MGI:5562652
Age: embryonic day 16.5
Image: 1
Specimen Label: heart E16.5
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:5562440
Assay Type: RT-PCR
Annotation Date: 2014-05-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610526
Stage: TS26
Assay Id: MGI:5562652
Age: embryonic day 18.5
Image: 1
Specimen Label: heart E18.5
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:5562440
Assay Type: RT-PCR
Annotation Date: 2014-05-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:5562652
Age: postnatal day 1
Image: 1
Specimen Label: heart P1
Detected: false
Specimen Num: 5
GXD Expression    
Probe: MGI:5562440
Assay Type: RT-PCR
Annotation Date: 2014-05-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5562652
Age: postnatal day 7
Image: 1
Specimen Label: heart P7
Detected: false
Specimen Num: 6
GXD Expression    
Probe: MGI:5562440
Assay Type: RT-PCR
Annotation Date: 2014-05-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5562652
Age: postnatal day 56
Image: 1
Specimen Label: heart P56
Detected: false
Specimen Num: 7
GXD Expression    
Probe: MGI:5562440
Assay Type: RT-PCR
Annotation Date: 2014-05-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610520
Stage: TS20
Assay Id: MGI:5562656
Age: embryonic day 12.5
Image: 1
Specimen Label: E12.5
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5562440
Assay Type: RT-PCR
Annotation Date: 2014-05-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610522
Stage: TS22
Assay Id: MGI:5562656
Age: embryonic day 14.5
Image: 1
Specimen Label: E14.5
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5562440
Assay Type: RT-PCR
Annotation Date: 2014-05-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610524
Stage: TS24
Assay Id: MGI:5562656
Age: embryonic day 16.5
Image: 1
Specimen Label: E16.5
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:5562440
Assay Type: RT-PCR
Annotation Date: 2014-05-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610526
Stage: TS26
Assay Id: MGI:5562656
Age: embryonic day 18.5
Image: 1
Specimen Label: E18.5
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:5810430
Assay Type: RT-PCR
Annotation Date: 2016-11-30
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1718519
Stage: TS19
Assay Id: MGI:5810452
Age: embryonic day 11.5
Image: 1
Specimen Label: E11.5
Specimen Num: 1
GXD Expression      
Probe: MGI:5810430
Assay Type: RT-PCR
Annotation Date: 2016-11-30
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1718520
Stage: TS20
Assay Id: MGI:5810452
Age: embryonic day 12.5
Image: 1
Specimen Label: E12.5
Specimen Num: 2
GXD Expression      
Probe: MGI:5810430
Assay Type: RT-PCR
Annotation Date: 2016-11-30
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1718521
Stage: TS21
Assay Id: MGI:5810452
Age: embryonic day 13.5
Image: 1
Specimen Label: E13.5
Specimen Num: 3
GXD Expression      
Probe: MGI:5810430
Assay Type: RT-PCR
Annotation Date: 2016-11-30
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1718522
Stage: TS22
Assay Id: MGI:5810452
Age: embryonic day 14.4
Image: 1
Specimen Label: E14.5
Specimen Num: 4
GXD Expression  
Probe: MGI:2665355
Assay Type: RNA in situ
Annotation Date: 2003-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1922825
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:2665356
Age: embryonic day 17.5
Image: 2G
Specimen Label: 2G
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:2665355
Assay Type: RNA in situ
Annotation Date: 2003-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1922625
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:2665356
Age: embryonic day 17.5
Image: 2G
Specimen Label: 2G
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:2665355
Assay Type: RNA in situ
Annotation Date: 2003-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1922425
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:2665356
Age: embryonic day 17.5
Image: 2G
Specimen Label: 2G
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:2665355
Assay Type: RNA in situ
Annotation Date: 2003-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1922525
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:2665356
Age: embryonic day 17.5
Image: 2G
Specimen Label: 2G
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:2665355
Assay Type: RNA in situ
Annotation Date: 2003-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1922725
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:2665356
Age: embryonic day 17.5
Image: 2G
Specimen Label: 2G
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:2665355
Assay Type: RNA in situ
Annotation Date: 2003-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1922525
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:2665356
Age: embryonic day 17.5
Image: 2I
Specimen Label: 2I
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:2665355
Assay Type: RNA in situ
Annotation Date: 2003-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1922825
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:2665356
Age: embryonic day 17.5
Image: 2H
Specimen Label: 2H
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2665355
Assay Type: RNA in situ
Annotation Date: 2003-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1922625
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:2665356
Age: embryonic day 17.5
Image: 2H
Specimen Label: 2H
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2665355
Assay Type: RNA in situ
Annotation Date: 2003-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1922425
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:2665356
Age: embryonic day 17.5
Image: 2H
Specimen Label: 2H
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2665355
Assay Type: RNA in situ
Annotation Date: 2003-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1922525
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:2665356
Age: embryonic day 17.5
Image: 2H
Specimen Label: 2H
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2665355
Assay Type: RNA in situ
Annotation Date: 2003-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1922725
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:2665356
Age: embryonic day 17.5
Image: 2H
Specimen Label: 2H
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:2665355
Assay Type: RNA in situ
Annotation Date: 2003-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1801625
Pattern: Regionally restricted
Stage: TS25
Assay Id: MGI:2665356
Age: embryonic day 17.5
Image: 2G
Note: Expression is in the rims.
Specimen Label: 2G
Detected: true
Specimen Num: 1