Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5556219 |
Assay Type: |
Northern blot |
Annotation Date: |
2014-04-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1737323 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5556256 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Fgfr3 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
140
|
Fragment?: |
false |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6386983 |
Assay Type: |
RNase protection |
Annotation Date: |
2020-01-30 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1783828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6387000 |
Age: |
postnatal adult |
Image: |
S2 |
|
Specimen Label: |
Fgfr3 null |
Detected: |
false |
Specimen Num: |
5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Su N |
Year: |
2010 |
Journal: |
Int J Biol Sci |
Title: |
Generation of Fgfr3 conditional knockout mice. |
Volume: |
6 |
Issue: |
4 |
Pages: |
327-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Moldrich RX |
Year: |
2011 |
Journal: |
Dev Dyn |
Title: |
Fgfr3 regulates development of the caudal telencephalon. |
Volume: |
240 |
Issue: |
6 |
Pages: |
1586-99 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xie Y |
Year: |
2017 |
Journal: |
Int J Biol Sci |
Title: |
FGFR3 deficient mice have accelerated fracture repair. |
Volume: |
13 |
Issue: |
8 |
Pages: |
1029-1037 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee YC |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Knock-in human FGFR3 achondroplasia mutation as a mouse model for human skeletal dysplasia. |
Volume: |
7 |
|
Pages: |
43220 |
|
•
•
•
•
•
|
Publication |
First Author: |
Garcia S |
Year: |
2013 |
Journal: |
Sci Transl Med |
Title: |
Postnatal soluble FGFR3 therapy rescues achondroplasia symptoms and restores bone growth in mice. |
Volume: |
5 |
Issue: |
203 |
Pages: |
203ra124 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shazeeb MS |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
Skeletal Characterization of the Fgfr3 Mouse Model of Achondroplasia Using Micro-CT and MRI Volumetric Imaging. |
Volume: |
8 |
Issue: |
1 |
Pages: |
469 |
|
•
•
•
•
•
|
Publication |
First Author: |
Julien A |
Year: |
2020 |
Journal: |
Stem Cell Reports |
Title: |
FGFR3 in Periosteal Cells Drives Cartilage-to-Bone Transformation in Bone Repair. |
Volume: |
15 |
Issue: |
4 |
Pages: |
955-967 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou S |
Year: |
2015 |
Journal: |
PLoS Genet |
Title: |
FGFR3 Deficiency Causes Multiple Chondroma-like Lesions by Upregulating Hedgehog Signaling. |
Volume: |
11 |
Issue: |
6 |
Pages: |
e1005214 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wen X |
Year: |
2016 |
Journal: |
J Biol Chem |
Title: |
Chondrocyte FGFR3 Regulates Bone Mass by Inhibiting Osteogenesis. |
Volume: |
291 |
Issue: |
48 |
Pages: |
24912-24921 |
|
•
•
•
•
•
|
Publication |
First Author: |
Foth M |
Year: |
2018 |
Journal: |
J Pathol |
Title: |
FGFR3 mutation increases bladder tumourigenesis by suppressing acute inflammation. |
Volume: |
246 |
Issue: |
3 |
Pages: |
331-343 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3687188 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-11-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1910624 |
Pattern: |
Regionally restricted |
Stage: |
TS24 |
Assay Id: |
MGI:3687189 |
Age: |
embryonic day 16.5 |
|
Note: |
Expression was low in prechondrocytes and epiphyseal reserve chondroblasts and upregulated in columnar chondroblasts. |
Specimen Label: |
7 FGFR3 top |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3687188 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-11-09 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1910624 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:3687189 |
Age: |
embryonic day 16.5 |
|
|
Specimen Label: |
7 FGFR3 bottom |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6451700 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2020-08-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3286620 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:6451703 |
Age: |
embryonic day 12.5 |
|
|
Specimen Label: |
S1 FGFR3 E12.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6451700 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2020-08-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3286621 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6451703 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
S1 FGFR3 E13.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6451700 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2020-08-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3286020 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:6451703 |
Age: |
embryonic day 12.5 |
|
Note: |
Expression on basal surface of distal airway epithelium. |
Specimen Label: |
S1 FGFR3 E12.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6451700 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2020-08-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3286021 |
Pattern: |
Regionally restricted |
Stage: |
TS21 |
Assay Id: |
MGI:6451703 |
Age: |
embryonic day 13.5 |
|
Note: |
Expression on basal surface of distal airway epithelium. |
Specimen Label: |
S1 FGFR3 E13.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Di Rocco F |
Year: |
2014 |
Journal: |
Hum Mol Genet |
Title: |
FGFR3 mutation causes abnormal membranous ossification in achondroplasia. |
Volume: |
23 |
Issue: |
11 |
Pages: |
2914-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu S |
Year: |
2008 |
Journal: |
J Am Soc Nephrol |
Title: |
FGFR3 and FGFR4 do not mediate renal effects of FGF23. |
Volume: |
19 |
Issue: |
12 |
Pages: |
2342-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Loisay L |
Year: |
2023 |
Journal: |
JCI Insight |
Title: |
Hypochondroplasia gain-of-function mutation in FGFR3 causes defective bone mineralization in mice. |
Volume: |
8 |
Issue: |
12 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Chen J |
Year: |
2005 |
Journal: |
Blood |
Title: |
Constitutively activated FGFR3 mutants signal through PLCgamma-dependent and -independent pathways for hematopoietic transformation. |
Volume: |
106 |
Issue: |
1 |
Pages: |
328-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang JY |
Year: |
2020 |
Journal: |
Sci Rep |
Title: |
Enhanced FGFR3 activity in postmitotic principal neurons during brain development results in cortical dysplasia and axonal tract abnormality. |
Volume: |
10 |
Issue: |
1 |
Pages: |
18508 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pannier S |
Year: |
2010 |
Journal: |
Bone |
Title: |
Delayed bone age due to a dual effect of FGFR3 mutation in Achondroplasia. |
Volume: |
47 |
Issue: |
5 |
Pages: |
905-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Osawa Y |
Year: |
2017 |
Journal: |
Bone |
Title: |
Activated FGFR3 promotes bone formation via accelerating endochondral ossification in mouse model of distraction osteogenesis. |
Volume: |
105 |
|
Pages: |
42-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
Su N |
Year: |
2008 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Gain-of-function mutation of FGFR3 results in impaired fracture healing due to inhibition of chondrocyte differentiation. |
Volume: |
376 |
Issue: |
3 |
Pages: |
454-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kimura T |
Year: |
2018 |
Journal: |
Osteoarthritis Cartilage |
Title: |
Proposal of patient-specific growth plate cartilage xenograft model for FGFR3 chondrodysplasia. |
Volume: |
26 |
Issue: |
11 |
Pages: |
1551-1561 |
|
•
•
•
•
•
|
Publication |
First Author: |
Arnaud-Dabernat S |
Year: |
2007 |
Journal: |
Diabetes |
Title: |
FGFR3 is a negative regulator of the expansion of pancreatic epithelial cells. |
Volume: |
56 |
Issue: |
1 |
Pages: |
96-106 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kang W |
Year: |
2019 |
Journal: |
Stem Cell Reports |
Title: |
Transient Redirection of SVZ Stem Cells to Oligodendrogenesis by FGFR3 Activation Promotes Remyelination. |
Volume: |
12 |
Issue: |
6 |
Pages: |
1223-1231 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou S |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
Conditional Deletion of Fgfr3 in Chondrocytes leads to Osteoarthritis-like Defects in Temporomandibular Joint of Adult Mice. |
Volume: |
6 |
|
Pages: |
24039 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mugniery E |
Year: |
2012 |
Journal: |
Hum Mol Genet |
Title: |
An activating Fgfr3 mutation affects trabecular bone formation via a paracrine mechanism during growth. |
Volume: |
21 |
Issue: |
11 |
Pages: |
2503-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen L |
Year: |
1999 |
Journal: |
J Clin Invest |
Title: |
Gly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesis. |
Volume: |
104 |
Issue: |
11 |
Pages: |
1517-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Iwata T |
Year: |
2001 |
Journal: |
Hum Mol Genet |
Title: |
Highly activated Fgfr3 with the K644M mutation causes prolonged survival in severe dwarf mice. |
Volume: |
10 |
Issue: |
12 |
Pages: |
1255-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lorget F |
Year: |
2012 |
Journal: |
Am J Hum Genet |
Title: |
Evaluation of the therapeutic potential of a CNP analog in a Fgfr3 mouse model recapitulating achondroplasia. |
Volume: |
91 |
Issue: |
6 |
Pages: |
1108-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cornille M |
Year: |
2022 |
Journal: |
J Exp Med |
Title: |
FGFR3 overactivation in the brain is responsible for memory impairments in Crouzon syndrome mouse model. |
Volume: |
219 |
Issue: |
4 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Dunois-Lardé C |
Year: |
2005 |
Journal: |
Mol Carcinog |
Title: |
Absence of FGFR3 mutations in urinary bladder tumours of rats and mice treated with N-butyl-N-(-4-hydroxybutyl)nitrosamine. |
Volume: |
42 |
Issue: |
3 |
Pages: |
142-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Usha AP |
Year: |
1997 |
Journal: |
Anim Genet |
Title: |
Dwarfism in Dexter cattle is not caused by the mutations in FGFR3 responsible for achondroplasia in humans. |
Volume: |
28 |
Issue: |
1 |
Pages: |
55-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Qi H |
Year: |
2014 |
Journal: |
Biochim Biophys Acta |
Title: |
FGFR3 induces degradation of BMP type I receptor to regulate skeletal development. |
Volume: |
1843 |
Issue: |
7 |
Pages: |
1237-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matsushita T |
Year: |
2009 |
Journal: |
Hum Mol Genet |
Title: |
FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway. |
Volume: |
18 |
Issue: |
2 |
Pages: |
227-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Martin L |
Year: |
2018 |
Journal: |
Hum Mol Genet |
Title: |
Constitutively-active FGFR3 disrupts primary cilium length and IFT20 trafficking in various chondrocyte models of achondroplasia. |
Volume: |
27 |
Issue: |
1 |
Pages: |
1-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Inglis-Broadgate SL |
Year: |
2005 |
Journal: |
Dev Biol |
Title: |
FGFR3 regulates brain size by controlling progenitor cell proliferation and apoptosis during embryonic development. |
Volume: |
279 |
Issue: |
1 |
Pages: |
73-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
de Frutos CA |
Year: |
2007 |
Journal: |
Dev Cell |
Title: |
Snail1 is a transcriptional effector of FGFR3 signaling during chondrogenesis and achondroplasias. |
Volume: |
13 |
Issue: |
6 |
Pages: |
872-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jin M |
Year: |
2012 |
Journal: |
Hum Mol Genet |
Title: |
A novel FGFR3-binding peptide inhibits FGFR3 signaling and reverses the lethal phenotype of mice mimicking human thanatophoric dysplasia. |
Volume: |
21 |
Issue: |
26 |
Pages: |
5443-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li H |
Year: |
2011 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
Compound deletion of Fgfr3 and Fgfr4 partially rescues the Hyp mouse phenotype. |
Volume: |
300 |
Issue: |
3 |
Pages: |
E508-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang Q |
Year: |
2001 |
Journal: |
Development |
Title: |
Differential regulation of endochondral bone growth and joint development by FGFR1 and FGFR3 tyrosine kinase domains. |
Volume: |
128 |
Issue: |
19 |
Pages: |
3867-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kuang L |
Year: |
2020 |
Journal: |
Ann Rheum Dis |
Title: |
FGFR3 deficiency enhances CXCL12-dependent chemotaxis of macrophages via upregulating CXCR7 and aggravates joint destruction in mice. |
Volume: |
79 |
Issue: |
1 |
Pages: |
112-122 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ota S |
Year: |
2016 |
Journal: |
Hum Mol Genet |
Title: |
HDAC6 deficiency or inhibition blocks FGFR3 accumulation and improves bone growth in a model of achondroplasia. |
Volume: |
25 |
Issue: |
19 |
Pages: |
4227-4243 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hayashi T |
Year: |
2007 |
Journal: |
Dev Dyn |
Title: |
Loss of Fgfr3 leads to excess hair cell development in the mouse organ of Corti. |
Volume: |
236 |
Issue: |
2 |
Pages: |
525-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Iwata T |
Year: |
2000 |
Journal: |
Hum Mol Genet |
Title: |
A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos. |
Volume: |
9 |
Issue: |
11 |
Pages: |
1603-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pannier S |
Year: |
2009 |
Journal: |
Biochim Biophys Acta |
Title: |
Activating Fgfr3 Y367C mutation causes hearing loss and inner ear defect in a mouse model of chondrodysplasia. |
Volume: |
1792 |
Issue: |
2 |
Pages: |
140-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jonquoy A |
Year: |
2012 |
Journal: |
Hum Mol Genet |
Title: |
A novel tyrosine kinase inhibitor restores chondrocyte differentiation and promotes bone growth in a gain-of-function Fgfr3 mouse model. |
Volume: |
21 |
Issue: |
4 |
Pages: |
841-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Logié A |
Year: |
2005 |
Journal: |
Hum Mol Genet |
Title: |
Activating mutations of the tyrosine kinase receptor FGFR3 are associated with benign skin tumors in mice and humans. |
Volume: |
14 |
Issue: |
9 |
Pages: |
1153-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ran Q |
Year: |
2021 |
Journal: |
Transplant Cell Ther |
Title: |
Loss of FGFR3 Accelerates Bone Marrow Suppression-Induced Hematopoietic Stem and Progenitor Cell Expansion by Activating FGFR1-ELK1-Cyclin D1 Signaling. |
Volume: |
27 |
Issue: |
1 |
Pages: |
45.e1-45.e10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou ZQ |
Year: |
2015 |
Journal: |
Hum Mol Genet |
Title: |
Mutant activated FGFR3 impairs endochondral bone growth by preventing SOX9 downregulation in differentiating chondrocytes. |
Volume: |
24 |
Issue: |
6 |
Pages: |
1764-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Blak AA |
Year: |
2007 |
Journal: |
Dev Biol |
Title: |
Fgfr2 and Fgfr3 are not required for patterning and maintenance of the midbrain and anterior hindbrain. |
Volume: |
303 |
Issue: |
1 |
Pages: |
231-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pringle NP |
Year: |
2003 |
Journal: |
Development |
Title: |
Fgfr3 expression by astrocytes and their precursors: evidence that astrocytes and oligodendrocytes originate in distinct neuroepithelial domains. |
Volume: |
130 |
Issue: |
1 |
Pages: |
93-102 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172902 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:6190278 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Fgfr3 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172902 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6190278 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Fgfr3 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172902 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:6190278 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Fgfr3 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172902 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6190278 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Fgfr3 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172902 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190278 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Fgfr3 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172902 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190278 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Fgfr3 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172902 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190278 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Fgfr3 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Su N |
Year: |
2010 |
Journal: |
Hum Mol Genet |
Title: |
Gain-of-function mutation in FGFR3 in mice leads to decreased bone mass by affecting both osteoblastogenesis and osteoclastogenesis. |
Volume: |
19 |
Issue: |
7 |
Pages: |
1199-210 |
|
•
•
•
•
•
|
Publication |
First Author: |
Perez-Castro AV |
Year: |
1997 |
Journal: |
Genomics |
Title: |
Genomic organization of the human fibroblast growth factor receptor 3 (FGFR3) gene and comparative sequence analysis with the mouse Fgfr3 gene. |
Volume: |
41 |
Issue: |
1 |
Pages: |
10-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shung CY |
Year: |
2012 |
Journal: |
Hum Mol Genet |
Title: |
Disruption of a Sox9-β-catenin circuit by mutant Fgfr3 in thanatophoric dysplasia type II. |
Volume: |
21 |
Issue: |
21 |
Pages: |
4628-44 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7733440 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-10-02 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691022 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:7734645 |
Age: |
embryonic day 14.5 |
|
Note: |
Fgfr3 was strongly expressed in the posterior region and not observed in the olfactory bulb. |
Specimen Label: |
1F |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ahmad I |
Year: |
2011 |
Journal: |
Dis Model Mech |
Title: |
K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder. |
Volume: |
4 |
Issue: |
4 |
Pages: |
548-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jungnickel J |
Year: |
2005 |
Journal: |
Neuroscience |
Title: |
Regulation of neuronal death and calcitonin gene-related peptide by fibroblast growth factor-2 and FGFR3 after peripheral nerve injury: evidence from mouse mutants. |
Volume: |
134 |
Issue: |
4 |
Pages: |
1343-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Harris BS |
Year: |
2011 |
Journal: |
MGI Direct Data Submission |
Title: |
A new spontaneous mutation in Fgfr3 |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Nakajima A |
Year: |
2003 |
Journal: |
Endocrinology |
Title: |
Expression of fibroblast growth factor receptor-3 (FGFR3), signal transducer and activator of transcription-1, and cyclin-dependent kinase inhibitor p21 during endochondral ossification: differential role of FGFR3 in skeletal development and fracture repair. |
Volume: |
144 |
Issue: |
10 |
Pages: |
4659-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gonçalves D |
Year: |
2020 |
Journal: |
PLoS One |
Title: |
In vitro and in vivo characterization of Recifercept, a soluble fibroblast growth factor receptor 3, as treatment for achondroplasia. |
Volume: |
15 |
Issue: |
12 |
Pages: |
e0244368 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamashita A |
Year: |
2014 |
Journal: |
Nature |
Title: |
Statin treatment rescues FGFR3 skeletal dysplasia phenotypes. |
Volume: |
513 |
Issue: |
7519 |
Pages: |
507-11 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
529 |
Description: |
Phosphotyrosine; by FGFR3 |
Type: |
modified residue |
End: |
529 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang Y |
Year: |
1999 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A mouse model for achondroplasia produced by targeting fibroblast growth factor receptor 3. |
Volume: |
96 |
Issue: |
8 |
Pages: |
4455-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wagner BM |
Year: |
2021 |
Journal: |
JCI Insight |
Title: |
Prevention of guanylyl cyclase-B dephosphorylation rescues achondroplastic dwarfism. |
Volume: |
6 |
Issue: |
9 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Segev O |
Year: |
2000 |
Journal: |
Hum Mol Genet |
Title: |
Restrained chondrocyte proliferation and maturation with abnormal growth plate vascularization and ossification in human FGFR-3(G380R) transgenic mice. |
Volume: |
9 |
Issue: |
2 |
Pages: |
249-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Naski MC |
Year: |
1998 |
Journal: |
Development |
Title: |
Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3. |
Volume: |
125 |
Issue: |
24 |
Pages: |
4977-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Davidson D |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
Fibroblast growth factor (FGF) 18 signals through FGF receptor 3 to promote chondrogenesis. |
Volume: |
280 |
Issue: |
21 |
Pages: |
20509-15 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6386981 |
Assay Type: |
RNase protection |
Annotation Date: |
2020-01-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1783828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6386998 |
Age: |
postnatal adult |
Image: |
S2 |
|
Specimen Label: |
Fgfr3 null |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6386982 |
Assay Type: |
RNase protection |
Annotation Date: |
2020-01-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1783828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6386999 |
Age: |
postnatal adult |
Image: |
S2 |
|
Specimen Label: |
Fgfr3 null |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Colvin JS |
Year: |
1996 |
Journal: |
Nat Genet |
Title: |
Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3. |
Volume: |
12 |
Issue: |
4 |
Pages: |
390-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cho JY |
Year: |
2004 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia. |
Volume: |
101 |
Issue: |
2 |
Pages: |
609-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin T |
Year: |
2003 |
Journal: |
Hum Mol Genet |
Title: |
A central nervous system specific mouse model for thanatophoric dysplasia type II. |
Volume: |
12 |
Issue: |
21 |
Pages: |
2863-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jungnickel J |
Year: |
2004 |
Journal: |
Mol Cell Neurosci |
Title: |
Fibroblast growth factor receptor 3 signaling regulates injury-related effects in the peripheral nervous system. |
Volume: |
25 |
Issue: |
1 |
Pages: |
21-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Twigg SR |
Year: |
2009 |
Journal: |
Dev Dyn |
Title: |
Skeletal analysis of the Fgfr3(P244R) mouse, a genetic model for the Muenke craniosynostosis syndrome. |
Volume: |
238 |
Issue: |
2 |
Pages: |
331-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Perez-Castro AV |
Year: |
1995 |
Journal: |
Genomics |
Title: |
Genomic organization of the mouse fibroblast growth factor receptor 3 (Fgfr3) gene. |
Volume: |
30 |
Issue: |
2 |
Pages: |
157-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wuechner C |
Year: |
1996 |
Journal: |
Int J Dev Biol |
Title: |
Developmental expression of splicing variants of fibroblast growth factor receptor 3 (FGFR3) in mouse. |
Volume: |
40 |
Issue: |
6 |
Pages: |
1185-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Piombo V |
Year: |
2018 |
Journal: |
Bone |
Title: |
Signaling systems affecting the severity of multiple osteochondromas. |
Volume: |
111 |
|
Pages: |
71-81 |
|
•
•
•
•
•
|