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Search results 1 to 100 out of 269 for Fkbp5

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: FKBP5 (also known as FKBP51) is an immunophilin that binds immunosuppressive drugs such as FK506 []. It has been shown to have peptidyl prolyl cis/trans isomerase activity []. It associates with heat shock protein 90 (Hsp90) and appears in functionally mature steroid receptor complexes []. It has been linked to depression [, ].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 456  
Fragment?: false
Publication
First Author: Menke A
Year: 2013
Journal: Genes Brain Behav
Title: Genetic variation in FKBP5 associated with the extent of stress hormone dysregulation in major depression.
Volume: 12
Issue: 3
Pages: 289-96
Publication  
First Author: Szczepankiewicz A
Year: 2014
Journal: J Affect Disord
Title: FKBP5 polymorphism is associated with major depression but not with bipolar disorder.
Volume: 164
Pages: 33-7
Publication
First Author: Sinars CR
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes.
Volume: 100
Issue: 3
Pages: 868-73
Publication
First Author: Kang CB
Year: 2008
Journal: Neurosignals
Title: FKBP family proteins: immunophilins with versatile biological functions.
Volume: 16
Issue: 4
Pages: 318-25
Publication
First Author: Pirkl F
Year: 2001
Journal: J Mol Biol
Title: Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40.
Volume: 308
Issue: 4
Pages: 795-806
Publication
First Author: Wang X
Year: 2023
Journal: Circ Res
Title: Downregulation of FKBP5 Promotes Atrial Arrhythmogenesis.
Volume: 133
Issue: 1
Pages: e1-e16
Protein
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: false
Publication  
First Author: Qiu B
Year: 2019
Journal: Neuroscience
Title: Loss of FKBP5 Affects Neuron Synaptic Plasticity: An Electrophysiology Insight.
Volume: 402
Pages: 23-36
Publication
First Author: Ruiz-Estevez M
Year: 2018
Journal: Cell Rep
Title: Promotion of Myoblast Differentiation by Fkbp5 via Cdk4 Isomerization.
Volume: 25
Issue: 9
Pages: 2537-2551.e8
Publication
First Author: Kollmannsberger LK
Year: 2013
Journal: G3 (Bethesda)
Title: Increased glyoxalase-1 levels in Fkbp5 knockout mice caused by glyoxalase-1 gene duplication.
Volume: 3
Issue: 8
Pages: 1311-3
Publication
First Author: Yeh WC
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: Identification and characterization of an immunophilin expressed during the clonal expansion phase of adipocyte differentiation.
Volume: 92
Issue: 24
Pages: 11081-5
Publication
First Author: Baughman G
Year: 1995
Journal: Mol Cell Biol
Title: FKBP51, a novel T-cell-specific immunophilin capable of calcineurin inhibition.
Volume: 15
Issue: 8
Pages: 4395-402
Protein
Organism: Mus musculus/domesticus
Length: 456  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 248  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 456  
Fragment?: false
Publication
First Author: Choi K
Year: 2021
Journal: FASEB J
Title: Myelination defects in the medial prefrontal cortex of Fkbp5 knockout mice.
Volume: 35
Issue: 2
Pages: e21297
Publication
First Author: Sabbagh JJ
Year: 2014
Journal: PLoS One
Title: Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency.
Volume: 9
Issue: 9
Pages: e107241
Publication
First Author: Zhang L
Year: 2017
Journal: Biochem Biophys Res Commun
Title: Loss of FKBP5 impedes adipocyte differentiation under both normoxia and hypoxic stress.
Volume: 485
Issue: 4
Pages: 761-767
Publication
First Author: Zheng D
Year: 2016
Journal: J Biol Chem
Title: MicroRNA-511 Binds to FKBP5 mRNA, Which Encodes a Chaperone Protein, and Regulates Neuronal Differentiation.
Volume: 291
Issue: 34
Pages: 17897-906
Publication
First Author: Sun X
Year: 2023
Journal: Cell Death Dis
Title: FKBP5 activates mitophagy by ablating PPAR-γ to shape a benign remyelination environment.
Volume: 14
Issue: 11
Pages: 736
Publication  
First Author: Ryu H
Year: 2021
Journal: Neuroscience
Title: The Impact of FKBP5 Deficiency in Glucocorticoid Receptor Mediated Regulation of Synaptic Transmission in the Medial Prefrontal Cortex.
Volume: 457
Pages: 20-26
Publication  
First Author: Qiu B
Year: 2016
Journal: Int J Mol Sci
Title: The FKBP5 Gene Affects Alcohol Drinking in Knockout Mice and Is Implicated in Alcohol Drinking in Humans.
Volume: 17
Issue: 8
Publication
First Author: Nold V
Year: 2021
Journal: Eur J Neurosci
Title: FKBP5 polymorphisms induce differential glucocorticoid responsiveness in primary CNS cells - First insights from novel humanized mice.
Volume: 53
Issue: 2
Pages: 402-415
Publication  
First Author: Williams KE
Year: 2023
Journal: Cells
Title: Sex-Specific Impact of Fkbp5 on Hippocampal Response to Acute Alcohol Injection: Involvement in Alterations of Metabolism-Related Pathways.
Volume: 13
Issue: 1
Publication
First Author: Chen X
Year: 2023
Journal: Free Radic Biol Med
Title: FKBP5 regulates trophoblast-macrophage crosstalk in recurrent spontaneous abortion through PI3K/AKT and NF-κB signaling pathways.
Volume: 209
Issue: Pt 1
Pages: 55-69
Publication
First Author: Häusl AS
Year: 2021
Journal: Mol Psychiatry
Title: The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus of male mice.
Volume: 26
Issue: 7
Pages: 3060-3076
Publication
First Author: Davies TH
Year: 2002
Journal: J Biol Chem
Title: A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins.
Volume: 277
Issue: 7
Pages: 4597-600
Publication
First Author: Kang HJ
Year: 2020
Journal: Sci Rep
Title: FKBP5-associated miRNA signature as a putative biomarker for PTSD in recently traumatized individuals.
Volume: 10
Issue: 1
Pages: 3353
Publication  
First Author: Guzeloglu-Kayisli O
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Decidual cell FKBP51-progesterone receptor binding mediates maternal stress-induced preterm birth.
Volume: 118
Issue: 11
Publication
First Author: Kwon J
Year: 2019
Journal: Mol Brain
Title: Identification of stress resilience module by weighted gene co-expression network analysis in Fkbp5-deficient mice.
Volume: 12
Issue: 1
Pages: 99
Publication  
First Author: Brix LM
Year: 2022
Journal: Mol Metab
Title: Contribution of the co-chaperone FKBP51 in the ventromedial hypothalamus to metabolic homeostasis in male and female mice.
Volume: 65
Pages: 101579
Publication  
First Author: Blair LJ
Year: 2019
Journal: eNeuro
Title: The Disease-Associated Chaperone FKBP51 Impairs Cognitive Function by Accelerating AMPA Receptor Recycling.
Volume: 6
Issue: 1
Publication
First Author: O'Leary JC 3rd
Year: 2011
Journal: PLoS One
Title: A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51.
Volume: 6
Issue: 9
Pages: e24840
Publication
First Author: Engelhardt C
Year: 2021
Journal: J Magn Reson Imaging
Title: Lack of FKBP51 Shapes Brain Structure and Connectivity in Male Mice.
Volume: 53
Issue: 5
Pages: 1358-1365
Publication
First Author: Balsevich G
Year: 2017
Journal: Nat Commun
Title: Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function.
Volume: 8
Issue: 1
Pages: 1725
Publication
First Author: Hartmann J
Year: 2021
Journal: Cell Rep
Title: Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to stress via regulation of FKBP5.
Volume: 35
Issue: 9
Pages: 109185
Publication
First Author: Gassen NC
Year: 2015
Journal: Sci Signal
Title: Chaperoning epigenetics: FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine.
Volume: 8
Issue: 404
Pages: ra119
Publication
First Author: Gan YL
Year: 2022
Journal: J Neuroinflammation
Title: FKBP51 mediates resilience to inflammation-induced anxiety through regulation of glutamic acid decarboxylase 65 expression in mouse hippocampus.
Volume: 19
Issue: 1
Pages: 152
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Stechschulte LA
Year: 2014
Journal: Mol Endocrinol
Title: FKBP51 controls cellular adipogenesis through p38 kinase-mediated phosphorylation of GRα and PPARγ.
Volume: 28
Issue: 8
Pages: 1265-75
Publication
First Author: Albu S
Year: 2014
Journal: J Sleep Res
Title: Deficiency of FK506-binding protein (FKBP) 51 alters sleep architecture and recovery sleep responses to stress in mice.
Volume: 23
Issue: 2
Pages: 176-85
Publication
First Author: Hoeijmakers L
Year: 2014
Journal: PLoS One
Title: Depletion of FKBP51 in female mice shapes HPA axis activity.
Volume: 9
Issue: 4
Pages: e95796
Publication
First Author: Martinelli S
Year: 2021
Journal: Nat Commun
Title: Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion.
Volume: 12
Issue: 1
Pages: 4643
Publication  
First Author: Brix LM
Year: 2022
Journal: Psychoneuroendocrinology
Title: The co-chaperone FKBP51 modulates HPA axis activity and age-related maladaptation of the stress system in pituitary proopiomelanocortin cells.
Volume: 138
Pages: 105670
Publication
First Author: Häusl AS
Year: 2022
Journal: Sci Adv
Title: Mediobasal hypothalamic FKBP51 acts as a molecular switch linking autophagy to whole-body metabolism.
Volume: 8
Issue: 10
Pages: eabi4797
Publication
First Author: Scammell JG
Year: 2001
Journal: Gen Comp Endocrinol
Title: Overexpression of the FK506-binding immunophilin FKBP51 is the common cause of glucocorticoid resistance in three New World primates.
Volume: 124
Issue: 2
Pages: 152-65
Publication
First Author: Denny WB
Year: 2000
Journal: Endocrinology
Title: Squirrel monkey immunophilin FKBP51 is a potent inhibitor of glucocorticoid receptor binding.
Volume: 141
Issue: 11
Pages: 4107-13
Publication
First Author: Nair SC
Year: 1997
Journal: Mol Cell Biol
Title: Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor.
Volume: 17
Issue: 2
Pages: 594-603
Publication
First Author: Jinwal UK
Year: 2010
Journal: J Neurosci
Title: The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules.
Volume: 30
Issue: 2
Pages: 591-9
Publication
First Author: Akiyama T
Year: 2014
Journal: PLoS One
Title: Mitochondria-nucleus shuttling FK506-binding protein 51 interacts with TRAF proteins and facilitates the RIG-I-like receptor-mediated expression of type I IFN.
Volume: 9
Issue: 5
Pages: e95992
GXD Expression    
Probe: MGI:1205130
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:1205132
Age: postnatal week 6-8
Image: st96_395
Specimen Label: None
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:1205130
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:1205132
Age: postnatal week 6-8
Image: st96_395
Specimen Label: None
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:1205130
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3284528
Stage: TS28
Assay Id: MGI:1205132
Age: postnatal week 6-8
Image: st96_395
Specimen Label: None
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:1205130
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1697428
Stage: TS28
Assay Id: MGI:1205132
Age: postnatal week 6-8
Image: st96_395
Specimen Label: None
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:1205130
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1754928
Stage: TS28
Assay Id: MGI:1205132
Age: postnatal week 6-8
Image: st96_395
Specimen Label: None
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:1205130
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3280928
Stage: TS28
Assay Id: MGI:1205132
Age: postnatal week 6-8
Image: st96_395
Specimen Label: None
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:1205130
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:1205132
Age: postnatal week 6-8
Image: st96_395
Specimen Label: None
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:1205130
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:1205132
Age: postnatal week 6-8
Image: st96_395
Specimen Label: None
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:1205130
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3599828
Stage: TS28
Assay Id: MGI:1205132
Age: postnatal week 6-8
Image: st96_395
Specimen Label: None
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:1205130
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:1205132
Age: postnatal week 6-8
Image: st96_395
Specimen Label: None
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:1205130
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:1205132
Age: postnatal week 6-8
Image: st96_395
Specimen Label: None
Detected: true
Specimen Num: 11
GXD Expression    
Probe: MGI:1205130
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:1205132
Age: postnatal week 6-8
Image: st96_395
Specimen Label: None
Detected: true
Specimen Num: 12
GXD Expression    
Probe: MGI:1205130
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:1205132
Age: postnatal week 6-8
Image: st96_395
Specimen Label: None
Detected: true
Specimen Num: 13
GXD Expression    
Probe: MGI:1205130
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:1205132
Age: postnatal week 6-8
Image: st96_395
Specimen Label: None
Detected: true
Specimen Num: 14
GXD Expression    
Probe: MGI:1205130
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:1205132
Age: postnatal week 6-8
Image: st96_395
Specimen Label: None
Detected: true
Specimen Num: 15
GXD Expression    
Probe: MGI:1205130
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1720228
Stage: TS28
Assay Id: MGI:1205132
Age: postnatal week 6-8
Image: st96_395
Specimen Label: None
Detected: true
Specimen Num: 16
GXD Expression    
Probe: MGI:1205130
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:1750328
Stage: TS28
Assay Id: MGI:1205132
Age: postnatal week 6-8
Image: st96_395
Specimen Label: None
Detected: false
Specimen Num: 17
GXD Expression    
Probe: MGI:1205130
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:1205132
Age: postnatal week 6-8
Image: st96_395
Specimen Label: None
Detected: true
Specimen Num: 18
GXD Expression    
Probe: MGI:1205130
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1832128
Stage: TS28
Assay Id: MGI:1205132
Age: postnatal week 6-8
Image: st96_395
Specimen Label: None
Detected: true
Specimen Num: 19
GXD Expression    
Probe: MGI:1205130
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1842628
Stage: TS28
Assay Id: MGI:1205132
Age: postnatal week 6-8
Image: st96_395
Specimen Label: None
Detected: true
Specimen Num: 20