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Search results 1 to 100 out of 433 for Grm5

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
2915 | GRM5
Type: gene
Organism: human
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Gene
705445 | GRM5
Type: gene
Organism: macaque, rhesus
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Gene
100485273 | grm5
Type: gene
Organism: frog, western clawed
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Gene
24418 | Grm5
Type: gene
Organism: rat
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Gene
451472 | GRM5
Type: gene
Organism: chimpanzee
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Gene
485146 | GRM5
Type: gene
Organism: dog, domestic
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Gene
100336861 | GRM5
Type: gene
Organism: cattle
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Gene
373933 | GRM5
Type: gene
Organism: chicken
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Protein Coding Gene
MGI:1351342 | Grm5
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
440040 | GRM5P1
Type: gene
Organism: human
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Gene
100873989 | GRM5-AS1
Type: gene
Organism: human
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Publication
34029630 | J:311119
 
First Author: Xu J
Year: 2021
Journal: Behav Brain Res
Title: Genetic disruption of Grm5 causes complex alterations in motor activity, anxiety and social behaviors.
Volume: 411
Pages: 113378
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Publication
16040064 | J:179570
 
First Author: MarĂ­n YE
Year: 2005
Journal: Neuropharmacology
Title: Grm5 expression is not required for the oncogenic role of Grm1 in melanocytes.
Volume: 49 Suppl 1
Pages: 70-9
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GXD Expression
GXD Expression
   
Probe: MGI:6174451
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190465
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Grm5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6174451
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190465
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Grm5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6174451
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190465
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Grm5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6174451
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190465
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Grm5
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6174451
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190465
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Grm5
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6174451
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190465
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Grm5
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6174451
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190465
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Grm5
Detected: true
Specimen Num: 7
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Protein
B7ZMP7
Organism: Mus musculus/domesticus
Length: 977  
Fragment?: false
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Protein
Q4VA56
Organism: Mus musculus/domesticus
Length: 1065  
Fragment?: true
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Publication
28982591 | J:260245
First Author: Bossi S
Year: 2018
Journal: Neurobiol Dis
Title: Genetic inactivation of mGlu5 receptor improves motor coordination in the Grm1crv4 mouse model of SCAR13 ataxia.
Volume: 109
Issue: Pt A
Pages: 44-53
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Strain
MGI:5450931 | B6;129P2-Grm8<tm1Dgen>/H
Attribute String: targeted mutation, mutant stock
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Strain
MGI:5450926 | B6;129P2-Grm5<tm1Dgen>/H
Attribute String: mutant stock, targeted mutation
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Publication
35746896 | J:335422
First Author: Å pirkovĂ¡ A
Year: 2022
Journal: Biol Reprod
Title: Glutamate can act as a signaling molecule in mouse preimplantation embryos†.
Volume: 107
Issue: 4
Pages: 916-927
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Protein Coding Gene
MGP_CAROLIEiJ_G0029969 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0032491 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0032465 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032401 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032476 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0032191 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1351342 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0032974 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0031518 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0032157 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032310 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0032266 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0032399 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0032300 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0032996 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0031236 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0031635 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0013189 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0031079 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
31420117 | J:282634
First Author: Holz A
Year: 2019
Journal: Neuron
Title: Enhanced mGlu5 Signaling in Excitatory Neurons Promotes Rapid Antidepressant Effects via AMPA Receptor Activation.
Volume: 104
Issue: 2
Pages: 338-352.e7
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Publication
35984881 | J:343467
First Author: Liang W
Year: 2022
Journal: Sci Adv
Title: Loss of schizophrenia-related miR-501-3p in mice impairs sociability and memory by enhancing mGluR5-mediated glutamatergic transmission.
Volume: 8
Issue: 33
Pages: eabn7357
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Publication
34070808 | J:308417
 
First Author: MartĂ­n-Belmonte A
Year: 2021
Journal: Int J Mol Sci
Title: The Density of Group I mGlu5 Receptors Is Reduced along the Neuronal Surface of Hippocampal Cells in a Mouse Model of Alzheimer's Disease.
Volume: 22
Issue: 11
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Publication
24886239 | J:316460
 
First Author: Hamilton A
Year: 2014
Journal: Mol Brain
Title: Metabotropic glutamate receptor 5 knockout reduces cognitive impairment and pathogenesis in a mouse model of Alzheimer's disease.
Volume: 7
Pages: 40
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Publication
37507231 | J:355559
First Author: Meng A
Year: 2023
Journal: J Neurosci
Title: mGluR5 in Astrocytes in the Ventromedial Hypothalamus Regulates Pituitary Adenylate Cyclase-Activating Polypeptide Neurons and Glucose Homeostasis.
Volume: 43
Issue: 33
Pages: 5918-5935
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Publication
24885390 | J:310946
 
First Author: Overk CR
Year: 2014
Journal: Mol Neurodegener
Title: Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5--implications for dementia with Lewy bodies.
Volume: 9
Pages: 18
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Publication
34360592 | J:341667
 
First Author: Zangrandi L
Year: 2021
Journal: Int J Mol Sci
Title: Loss of mGluR5 in D1 Receptor-Expressing Neurons Improves Stress Coping.
Volume: 22
Issue: 15
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Publication
22902169 | J:271823
First Author: Parkitna JR
Year: 2013
Journal: Biol Psychiatry
Title: Novelty-seeking behaviors and the escalation of alcohol drinking after abstinence in mice are controlled by metabotropic glutamate receptor 5 on neurons expressing dopamine d1 receptors.
Volume: 73
Issue: 3
Pages: 263-70
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Publication
24672017 | J:271824
First Author: Fieblinger T
Year: 2014
Journal: J Neurosci
Title: Mechanisms of dopamine D1 receptor-mediated ERK1/2 activation in the parkinsonian striatum and their modulation by metabotropic glutamate receptor type 5.
Volume: 34
Issue: 13
Pages: 4728-40
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Publication
30259400 | J:342309
First Author: GarcĂ­a-Montes JR
Year: 2019
Journal: Mol Neurobiol
Title: Genetic Knockdown of mGluR5 in Striatal D1R-Containing Neurons Attenuates L-DOPA-Induced Dyskinesia in Aphakia Mice.
Volume: 56
Issue: 6
Pages: 4037-4050
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Publication
19321764 | J:147275
First Author: Xu J
Year: 2009
Journal: J Neurosci
Title: mGluR5 has a critical role in inhibitory learning.
Volume: 29
Issue: 12
Pages: 3676-84
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Publication
38117654 | J:344307
First Author: Lao-Peregrin C
Year: 2024
Journal: Cell Rep
Title: Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalk.
Volume: 43
Issue: 1
Pages: 113595
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Publication
33731684 | J:313867
First Author: Kasten CR
Year: 2021
Journal: Transl Psychiatry
Title: BNST specific mGlu5 receptor knockdown regulates sex-dependent expression of negative affect produced by adolescent ethanol exposure and adult stress.
Volume: 11
Issue: 1
Pages: 178
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Publication
25505329 | J:218839
First Author: Xu J
Year: 2014
Journal: J Neurosci
Title: Hippocampal metaplasticity is required for the formation of temporal associative memories.
Volume: 34
Issue: 50
Pages: 16762-73
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Publication
25957750 | J:321657
First Author: Tan SZ
Year: 2015
Journal: Neurochem Res
Title: Spatial Learning Requires mGlu5 Signalling in the Dorsal Hippocampus.
Volume: 40
Issue: 6
Pages: 1303-10
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Publication
11528416 | J:97288
First Author: Chiamulera C
Year: 2001
Journal: Nat Neurosci
Title: Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice.
Volume: 4
Issue: 9
Pages: 873-4
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Publication
14699440 | J:101782
First Author: Brody SA
Year: 2004
Journal: Mol Psychiatry
Title: Assessment of a prepulse inhibition deficit in a mutant mouse lacking mGlu5 receptors.
Volume: 9
Issue: 1
Pages: 35-41
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Publication
30401923 | J:268239
First Author: Zeleznikow-Johnston AM
Year: 2018
Journal: Sci Rep
Title: Touchscreen testing reveals clinically relevant cognitive abnormalities in a mouse model of schizophrenia lacking metabotropic glutamate receptor 5.
Volume: 8
Issue: 1
Pages: 16412
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Publication
33962661 | J:306997
First Author: Imbriglio T
Year: 2021
Journal: Mol Brain
Title: Developmental up-regulation of NMDA receptors in the prefrontal cortex and hippocampus of mGlu5 receptor knock-out mice.
Volume: 14
Issue: 1
Pages: 77
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Publication
23861896 | J:204284
First Author: Chesworth R
Year: 2013
Journal: PLoS One
Title: The metabotropic glutamate 5 receptor modulates extinction and reinstatement of methamphetamine-seeking in mice.
Volume: 8
Issue: 7
Pages: e68371
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Publication
37566031 | J:339587
 
First Author: Torazza C
Year: 2023
Journal: Cells
Title: Genetic Downregulation of the Metabotropic Glutamate Receptor Type 5 Dampens the Reactive and Neurotoxic Phenotype of Adult ALS Astrocytes.
Volume: 12
Issue: 15
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Publication
23228523 | J:197069
 
First Author: Inta D
Year: 2013
Journal: Behav Brain Res
Title: Significant increase in anxiety during aging in mGlu5 receptor knockout mice.
Volume: 241
Pages: 27-31
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Publication
38053635 | J:343642
First Author: Ng AN
Year: 2023
Journal: iScience
Title: Amyloid-β(1-42) oligomers enhance mGlu(5)R-dependent synaptic weakening via NMDAR activation and complement C5aR1 signaling.
Volume: 26
Issue: 12
Pages: 108412
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Publication
16424079 | J:135799
First Author: Storto M
Year: 2006
Journal: Mol Pharmacol
Title: Insulin secretion is controlled by mGlu5 metabotropic glutamate receptors.
Volume: 69
Issue: 4
Pages: 1234-41
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Publication
11431513 | J:103903
First Author: Huber KM
Year: 2001
Journal: J Neurophysiol
Title: Chemical induction of mGluR5- and protein synthesis--dependent long-term depression in hippocampal area CA1.
Volume: 86
Issue: 1
Pages: 321-5
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Publication
30971312 | J:290274
First Author: Lim J
Year: 2019
Journal: Mol Brain
Title: Assessment of mGluR5 KO mice under conditions of low stress using a rodent touchscreen apparatus reveals impaired behavioural flexibility driven by perseverative responses.
Volume: 12
Issue: 1
Pages: 37
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Publication
35643779 | J:325700
First Author: de Souza JM
Year: 2022
Journal: Sci Rep
Title: mGluR5 ablation leads to age-related synaptic plasticity impairments and does not improve Huntington's disease phenotype.
Volume: 12
Issue: 1
Pages: 8982
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Publication
28645622 | J:254297
 
First Author: Bonifacino T
Year: 2017
Journal: Neuropharmacology
Title: In-vivo effects of knocking-down metabotropic glutamate receptor 5 in the SOD1G93A mouse model of amyotrophic lateral sclerosis.
Volume: 123
Pages: 433-445
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Publication
30873001 | J:284451
 
First Author: Ramos-Prats A
Year: 2019
Journal: Front Mol Neurosci
Title: An Appraisal of the Influence of the Metabotropic Glutamate 5 (mGlu5) Receptor on Sociability and Anxiety.
Volume: 12
Pages: 30
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Publication
25639954 | J:220016
First Author: Uematsu K
Year: 2015
Journal: J Neurochem
Title: Protein kinase A directly phosphorylates metabotropic glutamate receptor 5 to modulate its function.
Volume: 132
Issue: 6
Pages: 677-86
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Publication
28980941 | J:248313
   
First Author: Holst SC
Year: 2017
Journal: Elife
Title: Cerebral mGluR5 availability contributes to elevated sleep need and behavioral adjustment after sleep deprivation.
Volume: 6
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Publication
10454358 | J:51151
First Author: Jia Z
Year: 1998
Journal: Learn Mem
Title: Selective abolition of the NMDA component of long-term potentiation in mice lacking mGluR5.
Volume: 5
Issue: 4-5
Pages: 331-43
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Publication
28855570 | J:256640
First Author: Yang T
Year: 2017
Journal: Sci Rep
Title: Metabotropic glutamate receptor 5 deficiency inhibits neutrophil infiltration after traumatic brain injury in mice.
Volume: 7
Issue: 1
Pages: 9998
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Publication
33195226 | J:308434
 
First Author: Gubert C
Year: 2020
Journal: Front Cell Dev Biol
Title: Microbiome Profiling Reveals Gut Dysbiosis in the Metabotropic Glutamate Receptor 5 Knockout Mouse Model of Schizophrenia.
Volume: 8
Pages: 582320
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Publication
23165119 | J:206552
 
First Author: Xiao XL
Year: 2013
Journal: Brain Res
Title: Metabotropic glutamate receptor 5 (mGluR5) regulates proliferation and differentiation of neuronal progenitors in the developmental hippocampus.
Volume: 1493
Pages: 1-12
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Publication
35379852 | J:325581
First Author: Santos RPM
Year: 2022
Journal: Sci Rep
Title: Metabotropic glutamate receptor 5 knockout rescues obesity phenotype in a mouse model of Huntington's disease.
Volume: 12
Issue: 1
Pages: 5621
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Publication
19519626 | J:150200
First Author: She WC
Year: 2009
Journal: Eur J Neurosci
Title: Roles of mGluR5 in synaptic function and plasticity of the mouse thalamocortical pathway.
Volume: 29
Issue: 7
Pages: 1379-96
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Publication
18625255 | J:179420
First Author: Musante V
Year: 2008
Journal: Neuropharmacology
Title: Presynaptic mGlu1 and mGlu5 autoreceptors facilitate glutamate exocytosis from mouse cortical nerve endings.
Volume: 55
Issue: 4
Pages: 474-82
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Publication
26005851 | J:224479
First Author: Shin S
Year: 2015
Journal: Nat Neurosci
Title: mGluR5 in the nucleus accumbens is critical for promoting resilience to chronic stress.
Volume: 18
Issue: 7
Pages: 1017-24
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Publication
25666312 | J:329072
First Author: Burrows EL
Year: 2015
Journal: Neuropsychopharmacology
Title: Environmental Enrichment Ameliorates Behavioral Impairments Modeling Schizophrenia in Mice Lacking Metabotropic Glutamate Receptor 5.
Volume: 40
Issue: 8
Pages: 1947-56
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Publication
12473093 | J:108073
First Author: Brodkin J
Year: 2002
Journal: Eur J Neurosci
Title: Reduced stress-induced hyperthermia in mGluR5 knockout mice.
Volume: 16
Issue: 11
Pages: 2241-4
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Publication
24576814 | J:329081
 
First Author: Bird MK
Year: 2014
Journal: Drug Alcohol Depend
Title: The mGlu5 receptor regulates extinction of cocaine-driven behaviours.
Volume: 137
Pages: 83-9
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Publication
15947794 | J:116384
First Author: Di Giorgi-Gerevini V
Year: 2005
Journal: Cell Death Differ
Title: Endogenous activation of metabotropic glutamate receptors supports the proliferation and survival of neural progenitor cells.
Volume: 12
Issue: 8
Pages: 1124-33
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Publication
26417096 | J:227065
First Author: Sidorov MS
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Metabotropic glutamate receptor signaling is required for NMDA receptor-dependent ocular dominance plasticity and LTD in visual cortex.
Volume: 112
Issue: 41
Pages: 12852-7
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Publication
34199502 | J:320577
 
First Author: Gonzalez-Lozano MA
Year: 2021
Journal: Cells
Title: Reduced mGluR5 Activity Modulates Mitochondrial Function.
Volume: 10
Issue: 6
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Publication
20657349 | J:180856
First Author: Downing C
Year: 2010
Journal: Pharmacogenet Genomics
Title: The metabotropic glutamate receptor subtype 5 mediates sensitivity to the sedative properties of ethanol.
Volume: 20
Issue: 9
Pages: 553-64
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Publication
21152045 | J:167278
First Author: Olsen CM
Year: 2010
Journal: PLoS One
Title: Operant sensation seeking requires metabotropic glutamate receptor 5 (mGluR5).
Volume: 5
Issue: 11
Pages: e15085
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Publication
19169252 | J:146136
First Author: Sidiropoulou K
Year: 2009
Journal: Nat Neurosci
Title: Dopamine modulates an mGluR5-mediated depolarization underlying prefrontal persistent activity.
Volume: 12
Issue: 2
Pages: 190-9
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Publication
22819970 | J:188790
First Author: Chen CC
Year: 2012
Journal: Neurosci Lett
Title: mGluR5 knockout mice display increased dendritic spine densities.
Volume: 524
Issue: 1
Pages: 65-8
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Publication
30930274 | J:285631
 
First Author: Carvalho TG
Year: 2019
Journal: Neurochem Int
Title: Metabotropic glutamate receptor 5 ablation accelerates age-related neurodegeneration and neuroinflammation.
Volume: 126
Pages: 218-228
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Publication
12660307 | J:124739
First Author: Kinney GG
Year: 2003
Journal: J Pharmacol Exp Ther
Title: Metabotropic glutamate subtype 5 receptors modulate locomotor activity and sensorimotor gating in rodents.
Volume: 306
Issue: 1
Pages: 116-23
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Publication
33540617 | J:307550
 
First Author: Fultz EK
Year: 2021
Journal: Int J Mol Sci
Title: ERK-Directed Phosphorylation of mGlu5 Gates Methamphetamine Reward and Reinforcement in Mouse.
Volume: 22
Issue: 3
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Publication
23291536 | J:214204
 
First Author: Parmentier-Batteur S
Year: 2014
Journal: Neuropharmacology
Title: Mechanism based neurotoxicity of mGlu5 positive allosteric modulators--development challenges for a promising novel antipsychotic target.
Volume: 82
Pages: 161-73
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Publication
29136107 | J:287853
First Author: Stansley BJ
Year: 2018
Journal: Cereb Cortex
Title: Contextual Fear Extinction Induces Hippocampal Metaplasticity Mediated by Metabotropic Glutamate Receptor 5.
Volume: 28
Issue: 12
Pages: 4291-4304
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Publication
18784306 | J:141261
First Author: Grueter BA
Year: 2008
Journal: J Neurosci
Title: In vivo metabotropic glutamate receptor 5 (mGluR5) antagonism prevents cocaine-induced disruption of postsynaptically maintained mGluR5-dependent long-term depression.
Volume: 28
Issue: 37
Pages: 9261-70
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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