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Search results 1 to 100 out of 1662 for Gsk3b

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
2932 | GSK3B
Type: gene
Organism: human
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Gene
100489648 | gsk3b
Type: gene
Organism: frog, western clawed
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Gene
84027 | Gsk3b
Type: gene
Organism: rat
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Gene
478575 | GSK3B
Type: gene
Organism: dog, domestic
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Gene
790875 | GSK3B
Type: gene
Organism: cattle
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Gene
100616510 | GSK3B
Type: gene
Organism: chimpanzee
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Gene
713114 | GSK3B
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR033573 | GSK3B
Type: Family
Description: GSK3B is a serine/threonine kinase that regulates many biological processes such as muscle differentiation [], tau-microtubule interactions [], Wnt signalling []and epithelial-mesenchymal transition during embryonic development []. It has been implicated in various diseases such as diabetes, inflammation, cancer, Alzheimer's and bipolar disorder [].
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Protein Coding Gene
MGI:1861437 | Gsk3b
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
Probe: MGI:6502586
Assay Type: RNA in situ
Annotation Date: 2021-01-28
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1859021
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:6502634
Age: embryonic day 13.5
Image: 4A Gsk3b WT
Note: Strongest expression in retinal ganglion cell layer.
Specimen Label: 4A Gsk3b WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:6502586
Assay Type: RNA in situ
Annotation Date: 2021-01-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1859021
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:6502634
Age: embryonic day 13.5
Image: 4A Gsk3b Vax2-/-
Note: Expression lost specifically in the ventral retina.
Specimen Label: 4A Gsk3b Vax2-/-
Detected: true
Specimen Num: 2
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Protein
Q9WV60
Organism: Mus musculus/domesticus
Length: 420  
Fragment?: false
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Gene
51527 | GSKIP
Type: gene
Organism: human
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Gene
107986119 | GSK3B-DT
Type: gene
Organism: human
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Publication
26785133 | -
First Author: Litwiniuk A
Year: 2016
Journal: PLoS One
Title: FOXO1 and GSK-3β Are Main Targets of Insulin-Mediated Myogenesis in C2C12 Muscle Cells.
Volume: 11
Issue: 1
Pages: e0146726
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Publication
14690523 | -
First Author: Cho JH
Year: 2004
Journal: J Neurochem
Title: Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3beta (GSK3beta) plays a critical role in regulating tau's ability to bind and stabilize microtubules.
Volume: 88
Issue: 2
Pages: 349-58
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Publication
15647282 | -
First Author: Yook JI
Year: 2005
Journal: J Biol Chem
Title: Wnt-dependent regulation of the E-cadherin repressor snail.
Volume: 280
Issue: 12
Pages: 11740-8
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Publication
15448698 | -
First Author: Zhou BP
Year: 2004
Journal: Nat Cell Biol
Title: Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition.
Volume: 6
Issue: 10
Pages: 931-40
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Publication
19366350 | -
First Author: Rayasam GV
Year: 2009
Journal: Br J Pharmacol
Title: Glycogen synthase kinase 3: more than a namesake.
Volume: 156
Issue: 6
Pages: 885-98
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GXD Expression
GXD Expression
   
Probe: MGI:4358280
Assay Type: RNA in situ
Annotation Date: 2009-09-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666820
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4358444
Age: embryonic day 12.5
Specimen Label: S2 Gsk3b
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4358280
Assay Type: RNA in situ
Annotation Date: 2009-09-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757720
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4358444
Age: embryonic day 12.5
Specimen Label: S2 Gsk3b
Detected: true
Specimen Num: 1
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Publication
29761559 | J:266215
First Author: Xing B
Year: 2018
Journal: Glia
Title: Conditional depletion of GSK3b protects oligodendrocytes from apoptosis and lessens demyelination in the acute cuprizone model.
Volume: 66
Issue: 9
Pages: 1999-2012
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Protein
Q3TB31
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: true
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Protein
E9QAQ5
Organism: Mus musculus/domesticus
Length: 433  
Fragment?: false
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Protein
Q5KU03
Organism: Mus musculus/domesticus
Length: 420  
Fragment?: false
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Publication
29742424 | J:270944
First Author: Jorge-Torres OC
Year: 2018
Journal: Cell Rep
Title: Inhibition of Gsk3b Reduces Nfkb1 Signaling and Rescues Synaptic Activity to Improve the Rett Syndrome Phenotype in Mecp2-Knockout Mice.
Volume: 23
Issue: 6
Pages: 1665-1677
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GXD Expression
GXD Expression
   
Probe: MGI:6174482
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190475
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Gsk3b
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6174482
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190475
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Gsk3b
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6174482
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190475
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Gsk3b
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6174482
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190475
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Gsk3b
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6174482
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190475
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Gsk3b
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6174482
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190475
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Gsk3b
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6174482
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190475
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Gsk3b
Detected: true
Specimen Num: 7
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Publication
26582204 | J:228948
First Author: Deák VA
Year: 2016
Journal: J Biol Chem
Title: The A-kinase Anchoring Protein GSKIP Regulates GSK3β Activity and Controls Palatal Shelf Fusion in Mice.
Volume: 291
Issue: 2
Pages: 681-90
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Gene
362778 | Gskip
Type: gene
Organism: rat
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Gene
453144 | GSKIP
Type: gene
Organism: chimpanzee
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Gene
611079 | GSKIP
Type: gene
Organism: dog, domestic
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Gene
616052 | GSKIP
Type: gene
Organism: cattle
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Gene
423442 | GSKIP
Type: gene
Organism: chicken
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Gene
406744 | gskip
Type: gene
Organism: zebrafish
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Gene
704018 | GSKIP
Type: gene
Organism: macaque, rhesus
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Gene
100125074 | gskip
Type: gene
Organism: frog, western clawed
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Protein Coding Gene
MGI:1914037 | Gskip
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
120103165 | Gskip-ps1
Type: gene
Organism: rat
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Gene
432046 | gskip.L
Type: gene
Organism: frog, African clawed
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Publication
26496802 | J:227917
 
First Author: Shen W
Year: 2015
Journal: Nat Commun
Title: Inhibition of DYRK1A and GSK3B induces human β-cell proliferation.
Volume: 6
Pages: 8372
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Publication
30502054 | J:302999
 
First Author: Urbanska M
Year: 2019
Journal: EBioMedicine
Title: GSK3β activity alleviates epileptogenesis and limits GluA1 phosphorylation.
Volume: 39
Pages: 377-387
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Publication
25394490 | J:258908
First Author: Credle JJ
Year: 2015
Journal: Cell Death Differ
Title: GSK-3β dysregulation contributes to parkinson's-like pathophysiology with associated region-specific phosphorylation and accumulation of tau and α-synuclein.
Volume: 22
Issue: 5
Pages: 838-51
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Publication
23570858 | J:197904
 
First Author: Kondratiuk I
Year: 2013
Journal: Behav Brain Res
Title: Glycogen synthase kinase-3beta affects size of dentate gyrus and species-typical behavioral tasks in transgenic and knockout mice.
Volume: 248
Pages: 46-50
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Publication
11007782 | J:100971
First Author: Spittaels K
Year: 2000
Journal: J Biol Chem
Title: Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice.
Volume: 275
Issue: 52
Pages: 41340-9
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Publication
22057101 | J:180612
First Author: Wakatsuki S
Year: 2011
Journal: Nat Cell Biol
Title: ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation.
Volume: 13
Issue: 12
Pages: 1415-23
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Publication
18258852 | J:132009
First Author: Terwel D
Year: 2008
Journal: Am J Pathol
Title: Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice.
Volume: 172
Issue: 3
Pages: 786-98
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Publication
22826345 | J:287783
First Author: Latapy C
Year: 2012
Journal: Philos Trans R Soc Lond B Biol Sci
Title: Selective deletion of forebrain glycogen synthase kinase 3β reveals a central role in serotonin-sensitive anxiety and social behaviour.
Volume: 367
Issue: 1601
Pages: 2460-74
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Publication
23904355 | J:203283
First Author: Gillespie JR
Year: 2013
Journal: Endocrinology
Title: GSK-3β function in bone regulates skeletal development, whole-body metabolism, and male life span.
Volume: 154
Issue: 10
Pages: 3702-18
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Publication
18802478 | J:142731
First Author: Kapoor M
Year: 2008
Journal: J Clin Invest
Title: GSK-3beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism.
Volume: 118
Issue: 10
Pages: 3279-90
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Publication
22761446 | J:190241
First Author: Itoh S
Year: 2012
Journal: J Biol Chem
Title: GSK-3α and GSK-3β proteins are involved in early stages of chondrocyte differentiation with functional redundancy through RelA protein phosphorylation.
Volume: 287
Issue: 35
Pages: 29227-36
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Publication
21821916 | J:178255
First Author: O'Brien WT
Year: 2011
Journal: J Clin Invest
Title: Glycogen synthase kinase-3 is essential for β-arrestin-2 complex formation and lithium-sensitive behaviors in mice.
Volume: 121
Issue: 9
Pages: 3756-62
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Publication
21325041 | J:173862
First Author: Gillespie JR
Year: 2011
Journal: Endocrinology
Title: Deletion of glycogen synthase kinase-3β in cartilage results in up-regulation of glycogen synthase kinase-3α protein expression.
Volume: 152
Issue: 5
Pages: 1755-66
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Publication
25833158 | J:222416
First Author: Monteiro da Rocha A
Year: 2015
Journal: Biol Reprod
Title: Loss of glycogen synthase kinase 3 isoforms during murine oocyte growth induces offspring cardiac dysfunction.
Volume: 92
Issue: 5
Pages: 127
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Publication
32961796 | J:304181
 
First Author: Yang YL
Year: 2020
Journal: Int J Mol Sci
Title: miR-29a Modulates GSK3β/SIRT1-Linked Mitochondrial Proteostatic Stress to Ameliorate Mouse Non-Alcoholic Steatohepatitis.
Volume: 21
Issue: 18
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Publication
22832527 | J:316737
 
First Author: Mozhui K
Year: 2011
Journal: Transl Psychiatry
Title: Genetic regulation of Nrxn1 [corrected] expression: an integrative cross-species analysis of schizophrenia candidate genes.
Volume: 1
Pages: e25
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Publication
32581704 | J:294791
 
First Author: Li J
Year: 2020
Journal: Front Mol Neurosci
Title: GSK-3β Contributes to Parkinsonian Dopaminergic Neuron Death: Evidence From Conditional Knockout Mice and Tideglusib.
Volume: 13
Pages: 81
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Publication
31540917 | J:284136
 
First Author: Ocasio JK
Year: 2019
Journal: Development
Title: GSK-3 modulates SHH-driven proliferation in postnatal cerebellar neurogenesis and medulloblastoma.
Volume: 146
Issue: 20
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HT Sample
GSM800682 1
       
Organism Name: mouse, laboratory
Notes: treated with Gsk3b inhibitor
Curation Status: Not curated (Treated sample)
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HT Sample
GSM800683 1
       
Organism Name: mouse, laboratory
Notes: treated with Gsk3b inhibitor
Curation Status: Not curated (Treated sample)
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HT Sample
GSM800684 1
       
Organism Name: mouse, laboratory
Notes: treated with Gsk3b inhibitor
Curation Status: Not curated (Treated sample)
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HT Sample
GSM800700 1
       
Organism Name: mouse, laboratory
Notes: treated with Gsk3b inhibitor
Curation Status: Not curated (Treated sample)
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HT Sample
GSM800701 1
       
Organism Name: mouse, laboratory
Notes: treated with Gsk3b inhibitor
Curation Status: Not curated (Treated sample)
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HT Sample
GSM800702 1
       
Organism Name: mouse, laboratory
Notes: treated with Gsk3b inhibitor
Curation Status: Not curated (Treated sample)
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Publication
26063791 | J:225600
 
First Author: Georgy SR
Year: 2015
Journal: J Natl Cancer Inst
Title: Identification of a Novel Proto-oncogenic Network in Head and Neck Squamous Cell Carcinoma.
Volume: 107
Issue: 9
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Publication
18327788 | J:133340
First Author: Steuber-Buchberger P
Year: 2008
Journal: Genesis
Title: Simultaneous Cre-mediated conditional knockdown of two genes in mice.
Volume: 46
Issue: 3
Pages: 144-51
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Protein Coding Gene
MGP_CAROLIEiJ_G0020736 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0022808 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0022773 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0022745 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0022774 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0022538 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1861437 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0023221 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0022064 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0022509 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0022641 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0022616 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0022709 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0022635 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0023236 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0021804 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0022108 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0016436 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0021635 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
10894547 | J:63274
First Author: Hoeflich KP
Year: 2000
Journal: Nature
Title: Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation.
Volume: 406
Issue: 6791
Pages: 86-90
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Publication
22732552 | J:186410
First Author: Yao XQ
Year: 2012
Journal: FEBS Lett
Title: Glycogen synthase kinase-3β regulates leucine-309 demethylation of protein phosphatase-2A via PPMT1 and PME-1.
Volume: 586
Issue: 16
Pages: 2522-8
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Publication
17293880 | J:119186
First Author: Liu KJ
Year: 2007
Journal: Nature
Title: Chemical rescue of cleft palate and midline defects in conditional GSK-3beta mice.
Volume: 446
Issue: 7131
Pages: 79-82
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Publication
23919927 | J:202353
 
First Author: Lavoie J
Year: 2013
Journal: Behav Brain Res
Title: Glycogen synthase kinase-3β haploinsufficiency lengthens the circadian locomotor activity period in mice.
Volume: 253
Pages: 262-5
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Publication
24923837 | J:224584
 
First Author: Liz MA
Year: 2014
Journal: BMC Biol
Title: Neuronal deletion of GSK3β increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2.
Volume: 12
Pages: 47
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Publication
15282284 | J:97268
First Author: O'Brien WT
Year: 2004
Journal: J Neurosci
Title: Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium.
Volume: 24
Issue: 30
Pages: 6791-8
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Publication
16713974 | J:113359
First Author: Hu X
Year: 2006
Journal: Immunity
Title: IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins.
Volume: 24
Issue: 5
Pages: 563-74
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Publication
24099767 | J:211406
First Author: Arioka M
Year: 2013
Journal: Biochem Biophys Res Commun
Title: Acceleration of bone development and regeneration through the Wnt/β-catenin signaling pathway in mice heterozygously deficient for GSK-3β.
Volume: 440
Issue: 4
Pages: 677-82
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Publication
11226152 | J:67070
First Author: Lucas JJ
Year: 2001
Journal: EMBO J
Title: Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice.
Volume: 20
Issue: 1-2
Pages: 27-39
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Publication
23257288 | J:193849
First Author: Fuster-Matanzo A
Year: 2013
Journal: Hum Mol Genet
Title: Dual effects of increased glycogen synthase kinase-3β activity on adult neurogenesis.
Volume: 22
Issue: 7
Pages: 1300-15
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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