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Search results 1 to 100 out of 121 for Hrg

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0.039s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Drosophila melanogaster
Gene
Type: gene
Organism: Rattus norvegicus
Protein Domain
Type: Family
Description: Haems are metalloporphyrins that serve as prosthetic groups for a variety of biological processes, including respiration, gas sensing, xenobiotic detoxification, cell differentiation, circadian clock control, metabolic reprogramming and microRNA processing. Haem is usually synthesised by a multistep biosynthetic pathway. The cellular pathways and molecules that mediate intracellular haem trafficking are still largely unknown [].Caenorhabditis elegans and related helminths are natural haem auxotrophs that acquire environmental haem for incorporation into haemoproteins. In C.elegans, it has been shown that HRG-1 proteins are essential for haem homeostasis. In worms, depletion of hrg-1, or its paralogue hrg-4, results in the disruption of organismal haem sensing, and an abnormal response to haem analogues [].HRG-1 and HRG-4 are transmembrane (TM) proteins that reside in distinct intracellular compartments. Transient knockdown of hrg-1 in zebrafish leads to hydrocephalus, yolk tube malformations and profound defects in erythropoiesis-phenotypes that are fully rescued by worm HRG-1. Human and worm proteins have been shown to co-localise, and bind and transport haem, thus establishing an evolutionarily conserved function for HRG-1 [].Sequence analysis of HRG-1 has identified 4 predicted TM domains, and a conserved tyrosine and acidic-di-leucine-based sorting signal in the cytoplasmic C terminus. In addition, residues that could potentially either directly bind haem (H90 in TM2) or interact with the haem side chains (FARKY) are situated in the C-terminal tail [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Protein
Organism: Mus musculus
Length: 146  
Fragment?: false
Protein
Organism: Mus musculus
Length: 88  
Fragment?: true
Protein
Organism: Mus musculus
Length: 60  
Fragment?: false
Publication
First Author: Rajagopal A
Year: 2008
Journal: Nature
Title: Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins.
Volume: 453
Issue: 7198
Pages: 1127-31
Publication
First Author: Tugues S
Year: 2012
Journal: Cancer Res
Title: Genetic deficiency in plasma protein HRG enhances tumor growth and metastasis by exacerbating immune escape and vessel abnormalization.
Volume: 72
Issue: 8
Pages: 1953-63
Publication
First Author: Cedervall J
Year: 2013
Journal: Angiogenesis
Title: HRG regulates tumor progression, epithelial to mesenchymal transition and metastasis via platelet-induced signaling in the pre-tumorigenic microenvironment.
Volume: 16
Issue: 4
Pages: 889-902
Gene
Type: gene
Organism: Homo sapiens
Allele
Name: histidine-rich glycoprotein; targeted mutation 1, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Inducible, Recombinase, Reporter
Strain
Attribute String: targeted mutation, mutant strain, coisogenic
Strain
Attribute String: mutant strain, coisogenic, targeted mutation
DO Term
Publication
First Author: Tsuchida-Straeten N
Year: 2005
Journal: J Thromb Haemost
Title: Enhanced blood coagulation and fibrinolysis in mice lacking histidine-rich glycoprotein (HRG).
Volume: 3
Issue: 5
Pages: 865-72
Publication
First Author: Shannon O
Year: 2010
Journal: Blood
Title: Histidine-rich glycoprotein promotes bacterial entrapment in clots and decreases mortality in a mouse model of sepsis.
Volume: 116
Issue: 13
Pages: 2365-72
Publication
First Author: Hulett MD
Year: 2000
Journal: Immunol Cell Biol
Title: Murine histidine-rich glycoprotein: cloning, characterization and cellular origin.
Volume: 78
Issue: 3
Pages: 280-7
Publication
First Author: Rydengård V
Year: 2008
Journal: PLoS Pathog
Title: Histidine-rich glycoprotein protects from systemic Candida infection.
Volume: 4
Issue: 8
Pages: e1000116
Publication
First Author: Thulin A
Year: 2009
Journal: Mol Cancer Res
Title: Activated platelets provide a functional microenvironment for the antiangiogenic fragment of histidine-rich glycoprotein.
Volume: 7
Issue: 11
Pages: 1792-802
Publication
First Author: Ringvall M
Year: 2011
Journal: PLoS One
Title: Enhanced platelet activation mediates the accelerated angiogenic switch in mice lacking histidine-rich glycoprotein.
Volume: 6
Issue: 1
Pages: e14526
Publication
First Author: Vu TT
Year: 2015
Journal: Blood
Title: Arterial thrombosis is accelerated in mice deficient in histidine-rich glycoprotein.
Volume: 125
Issue: 17
Pages: 2712-9
Publication
First Author: Deuschle U
Year: 2015
Journal: Int J Cancer
Title: The nuclear bile acid receptor FXR controls the liver derived tumor suppressor histidine-rich glycoprotein.
Volume: 136
Issue: 11
Pages: 2693-704
Publication  
First Author: Roche F
Year: 2015
Journal: Matrix Biol
Title: Histidine-rich glycoprotein blocks collagen-binding integrins and adhesion of endothelial cells through low-affinity interaction with α2 integrin.
Volume: 48
Pages: 89-99
Publication
First Author: Hale JS
Year: 2012
Journal: PLoS One
Title: Context dependent role of the CD36--thrombospondin--histidine-rich glycoprotein axis in tumor angiogenesis and growth.
Volume: 7
Issue: 7
Pages: e40033
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Claesson-Welsh L
Year: 2012
Journal: Ups J Med Sci
Title: Blood vessels as targets in tumor therapy.
Volume: 117
Issue: 2
Pages: 178-86
Publication
First Author: Hsu SJ
Year: 2004
Journal: Genome
Title: Identification of Fetuin-B as a member of a cystatin-like gene family on mouse chromosome 16 with tumor suppressor activity.
Volume: 47
Issue: 5
Pages: 931-46
Publication
First Author: Simantov R
Year: 2005
Journal: Matrix Biol
Title: The antiangiogenic effect of thrombospondin-2 is mediated by CD36 and modulated by histidine-rich glycoprotein.
Volume: 24
Issue: 1
Pages: 27-34
Publication
First Author: White C
Year: 2013
Journal: Cell Metab
Title: HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis.
Volume: 17
Issue: 2
Pages: 261-70
Publication  
First Author: Naba A
Year: 2017
Journal: Sci Rep
Title: Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Volume: 7
Pages: 40495
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication
First Author: Rolny C
Year: 2011
Journal: Cancer Cell
Title: HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF.
Volume: 19
Issue: 1
Pages: 31-44
Publication
First Author: Balañá ME
Year: 1999
Journal: Oncogene
Title: Interactions between progestins and heregulin (HRG) signaling pathways: HRG acts as mediator of progestins proliferative effects in mouse mammary adenocarcinomas.
Volume: 18
Issue: 46
Pages: 6370-9
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Family
Description: This entry represents a predicted immunity protein with an all α-helical fold and a conserved HRG motif. These proteins are present in heterogeneous polyimmunity loci in polymorphic toxin systems [].
Publication
First Author: van den Berg EA
Year: 1990
Journal: Genomics
Title: Assignment of the human gene for histidine-rich glycoprotein to chromosome 3.
Volume: 7
Issue: 2
Pages: 276-9
Publication
First Author: O'Shea S
Year: 2001
Journal: Am J Pathol
Title: Effects of in vivo heregulin beta1 treatment in wild-type and ErbB gene-targeted mice depend on receptor levels and pregnancy.
Volume: 158
Issue: 5
Pages: 1871-80
Publication
First Author: Kärrlander M
Year: 2009
Journal: PLoS One
Title: Histidine-rich glycoprotein can prevent development of mouse experimental glioblastoma.
Volume: 4
Issue: 12
Pages: e8536
Publication
First Author: Zhang Y
Year: 2004
Journal: J Biol Chem
Title: Heregulin regulates the ability of the ErbB3-binding protein Ebp1 to bind E2F promoter elements and repress E2F-mediated transcription.
Volume: 279
Issue: 25
Pages: 26126-33
Publication
First Author: Zhou X
Year: 2020
Journal: Nat Commun
Title: Cellular and molecular properties of neural progenitors in the developing mammalian hypothalamus.
Volume: 11
Issue: 1
Pages: 4063
Publication
First Author: Murata T
Year: 2001
Journal: Dev Biol
Title: The hiiragi gene encodes a poly(A) polymerase, which controls the formation of the wing margin in Drosophila melanogaster.
Volume: 233
Issue: 1
Pages: 137-47
Publication  
First Author: Elizalde PV
Year: 1997
Journal: Medicina (B Aires)
Title: [Growth hormones and oncogenes in mammary adenocarcinomas induced by medroxyprogesterone acetate in BALB/c mice].
Volume: 57 Suppl 2
Pages: 70-4
Publication
First Author: Gao S
Year: 2019
Journal: Br J Pharmacol
Title: Histidine-rich glycoprotein ameliorates endothelial barrier dysfunction through regulation of NF-κB and MAPK signal pathway.
Volume: 176
Issue: 15
Pages: 2808-2824
Publication
First Author: Weinstein EJ
Year: 2000
Journal: Cancer Res
Title: The extracellular region of heregulin is sufficient to promote mammary gland proliferation and tumorigenesis but not apoptosis.
Volume: 60
Issue: 14
Pages: 3856-61
Publication
First Author: Labriola L
Year: 2003
Journal: Mol Cell Biol
Title: Heregulin induces transcriptional activation of the progesterone receptor by a mechanism that requires functional ErbB-2 and mitogen-activated protein kinase activation in breast cancer cells.
Volume: 23
Issue: 3
Pages: 1095-111
Publication
First Author: Kim A
Year: 2005
Journal: Breast Cancer Res
Title: Functional interaction between mouse erbB3 and wild-type rat c-neu in transgenic mouse mammary tumor cells.
Volume: 7
Issue: 5
Pages: R708-18
Protein
Organism: Mus musculus
Length: 433  
Fragment?: true
Protein
Organism: Mus musculus
Length: 477  
Fragment?: true
Protein
Organism: Mus musculus
Length: 690  
Fragment?: true
Publication
First Author: Valente RH
Year: 2001
Journal: Eur J Biochem
Title: BJ46a, a snake venom metalloproteinase inhibitor. Isolation, characterization, cloning and insights into its mechanism of action.
Volume: 268
Issue: 10
Pages: 3042-52
Publication
First Author: Yamakawa Y
Year: 1992
Journal: J Biochem
Title: Primary structure of the antihemorrhagic factor in serum of the Japanese Habu: a snake venom metalloproteinase inhibitor with a double-headed cystatin domain.
Volume: 112
Issue: 5
Pages: 583-9
Publication
First Author: Ray S
Year: 2003
Journal: Biochim Biophys Acta
Title: Members of the cystatin superfamily interact with MMP-9 and protect it from autolytic degradation without affecting its gelatinolytic activities.
Volume: 1652
Issue: 2
Pages: 91-102
Protein Domain
Type: Conserved_site
Description: The cystatins are a superfamily of similar proteins present in mammals, birds, fish, insects, plants and protozoa. In general they are potent peptidase inhibitors [, , , ]belonging to MEROPS inhibitor family I25, clan IH. The type 1 cystatins or stefins (A and B) are mainly intracellular, the type 2 cystatins (C, D, E/M, F, G, S, SN and SA) are extracellular, and the type 3 cystatins (L- and H-kininogens) are intravascular proteins. All true cystatins inhibit cysteine peptidases of the papain family (MEROPS peptidase family C1), and some also inhibit legumain family enzymes (MEROPS peptidase family C13). These peptidases play key roles in physiological processes, such as intracellular protein degradation (cathepsins B, H and L), are pivotal in the remodelling of bone (cathepsin K), and may be important in the control of antigen presentation (cathepsin S, mammalian legumain). Moreover, the activities of such peptidases are increased in pathophysiological conditions, such as cancer metastasis and inflammation. Additionally, such peptidases are essential for several pathogenic parasites and bacteria. Thus in animals cystatins not only have capacity to regulate normal body processes and perhaps cause disease when down-regulated, but in other organisms may also participate in defence against biotic and abiotic stress.This family of proteinase inhibitors are cystatins belonging to MEROPS inhibitor family I25 (clan IH), subfamily I25C. They are primarily metalloprotease inhibitors, which include snake venom anti-hemorrhagic factors and the mammalian fetuins, for example:Anti-hemorrhagic factor BJ46a, which is a potent inhibitor of atrolysin and jararhagin (MEROPS peptidase family M12) from the venomous snake Bothrops jararaca [].Anti-hemorrhagic factor, HSF, from the Japanese Habu snake (Trimeresurus flavoviridis). HSF contains two N-terminal cystatin domains which show a remarkable sequence homology (about 50%) to those of plasma glycoproteins such as alpha 2-HS (human) and fetuin (bovine) and to a lesser extent to that of HRG (human). In spite of the presence of cystatin domains, HSF does not inhibit cysteine proteinases such as papain and cathepsin B but does inhibit several metalloproteases in Habu venom [].Mammalian fetuins have been demonstrated to bind to matrix metalloproteinase (MMPs, MEROPS peptidase family M10). This binding protects the MMPs from autolytic degradation without interfering with their enzymatic activity [].Fetuins are known to consist of three domains: two tandemly arranged N-terminal cystatin domains (D1 and D2) and an unrelated domain (D3) located in the C-terminal region [, ]. When compared with the other members of this family, D3, especially its N-terminal half, varies greatly due to deletions, insertions or substitutions. Sequence comparisons suggest that the conformation of the human alpha2HS glycoprotein differs greatly from that of other members of this family. Human fetuin is a heterodimer of chains A and B, which are derived by cleavage of a connecting peptide from a common precursor. It is synthesised in the liver and selectively concentrated in bone matrix. It has a wide functional diversity having been shown to be involved in immune response, bone formation and resorption. Mammalian fetuin also called alpha-2-HS-glycoprotein, bone sialic acid-containing protein (BSP), countertrypin or PP63, is expressed in a tissue- and development-specific pattern, which seems to be significantly different between species [, ].
Protein
Organism: Mus musculus
Length: 845  
Fragment?: false
Publication
First Author: Yang F
Year: 1992
Journal: Biochim Biophys Acta
Title: Human alpha 2-HS-glycoprotein/bovine fetuin homologue in mice: identification and developmental regulation of the gene.
Volume: 1130
Issue: 2
Pages: 149-56
Protein
Organism: Mus musculus
Length: 345  
Fragment?: false
Protein
Organism: Mus musculus
Length: 388  
Fragment?: false
Protein
Organism: Mus musculus
Length: 308  
Fragment?: false