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Search results 1 to 100 out of 121 for Hrg

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Type Details Score
Gene
3273 | HRG
Type: gene
Organism: Homo sapiens
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Gene
FBgn0015949 | hrg
Type: gene
Organism: Drosophila melanogaster
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Gene
RGD:619808 | Hrg
Type: gene
Organism: Rattus norvegicus
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Protein Domain
IPR026218 | HRG
Type: Family
Description: Haems are metalloporphyrins that serve as prosthetic groups for a variety of biological processes, including respiration, gas sensing, xenobiotic detoxification, cell differentiation, circadian clock control, metabolic reprogramming and microRNA processing. Haem is usually synthesised by a multistep biosynthetic pathway. The cellular pathways and molecules that mediate intracellular haem trafficking are still largely unknown [].Caenorhabditis elegans and related helminths are natural haem auxotrophs that acquire environmental haem for incorporation into haemoproteins. In C.elegans, it has been shown that HRG-1 proteins are essential for haem homeostasis. In worms, depletion of hrg-1, or its paralogue hrg-4, results in the disruption of organismal haem sensing, and an abnormal response to haem analogues [].HRG-1 and HRG-4 are transmembrane (TM) proteins that reside in distinct intracellular compartments. Transient knockdown of hrg-1 in zebrafish leads to hydrocephalus, yolk tube malformations and profound defects in erythropoiesis-phenotypes that are fully rescued by worm HRG-1. Human and worm proteins have been shown to co-localise, and bind and transport haem, thus establishing an evolutionarily conserved function for HRG-1 [].Sequence analysis of HRG-1 has identified 4 predicted TM domains, and a conserved tyrosine and acidic-di-leucine-based sorting signal in the cytoplasmic C terminus. In addition, residues that could potentially either directly bind haem (H90 in TM2) or interact with the haem side chains (FARKY) are situated in the C-terminal tail [].
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Protein Coding Gene
MGI:2146636 | Hrg
Type: protein_coding_gene
Organism: Mus musculus
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Protein
Q9D8M3
Organism: Mus musculus
Length: 146  
Fragment?: false
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Protein
A0A2R8VHT5
Organism: Mus musculus
Length: 88  
Fragment?: true
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Protein
D6RG96
Organism: Mus musculus
Length: 60  
Fragment?: false
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Publication
18418376 | -
First Author: Rajagopal A
Year: 2008
Journal: Nature
Title: Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins.
Volume: 453
Issue: 7198
Pages: 1127-31
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Publication
22374984 | J:185672
First Author: Tugues S
Year: 2012
Journal: Cancer Res
Title: Genetic deficiency in plasma protein HRG enhances tumor growth and metastasis by exacerbating immune escape and vessel abnormalization.
Volume: 72
Issue: 8
Pages: 1953-63
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Publication
23793459 | J:318843
First Author: Cedervall J
Year: 2013
Journal: Angiogenesis
Title: HRG regulates tumor progression, epithelial to mesenchymal transition and metastasis via platelet-induced signaling in the pre-tumorigenic microenvironment.
Volume: 16
Issue: 4
Pages: 889-902
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Gene
105374258 | HRG-AS1
Type: gene
Organism: Homo sapiens
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Allele
Hrg<tm1(EGFP/cre/ERT2)Wtsi> | MGI:5633767
Name: histidine-rich glycoprotein; targeted mutation 1, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Inducible, Recombinase, Reporter
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Strain
MGI:5659586 | C57BL/6NTac-Hrg<tm1(EGFP/Cre/ERT2)Wtsi>/Wtsi
Attribute String: targeted mutation, mutant strain, coisogenic
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Strain
MGI:6122923 | C57BL/6NTac-Hrg<tm1(EGFP/cre/ERT2)Wtsi>/WtsiIeg
Attribute String: mutant strain, coisogenic, targeted mutation
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DO Term
DOID:0111903 | thrombophilia due to HRG deficiency
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Publication
15869579 | J:134621
First Author: Tsuchida-Straeten N
Year: 2005
Journal: J Thromb Haemost
Title: Enhanced blood coagulation and fibrinolysis in mice lacking histidine-rich glycoprotein (HRG).
Volume: 3
Issue: 5
Pages: 865-72
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Publication
20587784 | J:164612
First Author: Shannon O
Year: 2010
Journal: Blood
Title: Histidine-rich glycoprotein promotes bacterial entrapment in clots and decreases mortality in a mouse model of sepsis.
Volume: 116
Issue: 13
Pages: 2365-72
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Publication
10849117 | J:71004
First Author: Hulett MD
Year: 2000
Journal: Immunol Cell Biol
Title: Murine histidine-rich glycoprotein: cloning, characterization and cellular origin.
Volume: 78
Issue: 3
Pages: 280-7
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Publication
18797515 | J:177146
First Author: Rydengård V
Year: 2008
Journal: PLoS Pathog
Title: Histidine-rich glycoprotein protects from systemic Candida infection.
Volume: 4
Issue: 8
Pages: e1000116
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Publication
19903770 | J:205242
First Author: Thulin A
Year: 2009
Journal: Mol Cancer Res
Title: Activated platelets provide a functional microenvironment for the antiangiogenic fragment of histidine-rich glycoprotein.
Volume: 7
Issue: 11
Pages: 1792-802
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Publication
21264222 | J:169468
First Author: Ringvall M
Year: 2011
Journal: PLoS One
Title: Enhanced platelet activation mediates the accelerated angiogenic switch in mice lacking histidine-rich glycoprotein.
Volume: 6
Issue: 1
Pages: e14526
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Publication
25691157 | J:222032
First Author: Vu TT
Year: 2015
Journal: Blood
Title: Arterial thrombosis is accelerated in mice deficient in histidine-rich glycoprotein.
Volume: 125
Issue: 17
Pages: 2712-9
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Publication
25363753 | J:221989
First Author: Deuschle U
Year: 2015
Journal: Int J Cancer
Title: The nuclear bile acid receptor FXR controls the liver derived tumor suppressor histidine-rich glycoprotein.
Volume: 136
Issue: 11
Pages: 2693-704
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Publication
26051322 | J:229434
 
First Author: Roche F
Year: 2015
Journal: Matrix Biol
Title: Histidine-rich glycoprotein blocks collagen-binding integrins and adhesion of endothelial cells through low-affinity interaction with α2 integrin.
Volume: 48
Pages: 89-99
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Publication
22808089 | J:189632
First Author: Hale JS
Year: 2012
Journal: PLoS One
Title: Context dependent role of the CD36--thrombospondin--histidine-rich glycoprotein axis in tumor angiogenesis and growth.
Volume: 7
Issue: 7
Pages: e40033
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Protein Coding Gene
MGP_CAROLIEiJ_G0020610 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0022676 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_AJ_G0022637 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_AKRJ_G0022612 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_BALBcJ_G0022642 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_C3HHeJ_G0022406 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGI_C57BL6J_2146636 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_C57BL6NJ_G0023092 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_CASTEiJ_G0021936 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_CBAJ_G0022378 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_DBA2J_G0022510 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_FVBNJ_G0022486 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_LPJ_G0022578 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_NODShiLtJ_G0022505 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_NZOHlLtJ_G0023103 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_PWKPhJ_G0021676 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_WSBEiJ_G0021979 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_PahariEiJ_G0016314 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0021506 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
22348394 | J:185006
First Author: Claesson-Welsh L
Year: 2012
Journal: Ups J Med Sci
Title: Blood vessels as targets in tumor therapy.
Volume: 117
Issue: 2
Pages: 178-86
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Publication
15499407 | J:93229
First Author: Hsu SJ
Year: 2004
Journal: Genome
Title: Identification of Fetuin-B as a member of a cystatin-like gene family on mouse chromosome 16 with tumor suppressor activity.
Volume: 47
Issue: 5
Pages: 931-46
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Publication
15748999 | J:96478
First Author: Simantov R
Year: 2005
Journal: Matrix Biol
Title: The antiangiogenic effect of thrombospondin-2 is mediated by CD36 and modulated by histidine-rich glycoprotein.
Volume: 24
Issue: 1
Pages: 27-34
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Publication
23395172 | J:203507
First Author: White C
Year: 2013
Journal: Cell Metab
Title: HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis.
Volume: 17
Issue: 2
Pages: 261-70
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Publication
28071719 | J:265607
 
First Author: Naba A
Year: 2017
Journal: Sci Rep
Title: Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Volume: 7
Pages: 40495
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:72247
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
21873635 | J:265628
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
21215706 | J:168255
First Author: Rolny C
Year: 2011
Journal: Cancer Cell
Title: HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF.
Volume: 19
Issue: 1
Pages: 31-44
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Publication
10597237 | J:58616
First Author: Balañá ME
Year: 1999
Journal: Oncogene
Title: Interactions between progestins and heregulin (HRG) signaling pathways: HRG acts as mediator of progestins proliferative effects in mouse mammary adenocarcinomas.
Volume: 18
Issue: 46
Pages: 6370-9
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Protein Coding Gene
MGI:96083 | Nrg1
Type: protein_coding_gene
Organism: Mus musculus
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Protein Domain
IPR029075 | Imm48
Type: Family
Description: This entry represents a predicted immunity protein with an all α-helical fold and a conserved HRG motif. These proteins are present in heterogeneous polyimmunity loci in polymorphic toxin systems [].
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Publication
2347592 | J:10537
First Author: van den Berg EA
Year: 1990
Journal: Genomics
Title: Assignment of the human gene for histidine-rich glycoprotein to chromosome 3.
Volume: 7
Issue: 2
Pages: 276-9
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Publication
11337386 | J:69103
First Author: O'Shea S
Year: 2001
Journal: Am J Pathol
Title: Effects of in vivo heregulin beta1 treatment in wild-type and ErbB gene-targeted mice depend on receptor levels and pregnancy.
Volume: 158
Issue: 5
Pages: 1871-80
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Publication
20046875 | J:155939
First Author: Kärrlander M
Year: 2009
Journal: PLoS One
Title: Histidine-rich glycoprotein can prevent development of mouse experimental glioblastoma.
Volume: 4
Issue: 12
Pages: e8536
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Publication
15073182 | J:91050
First Author: Zhang Y
Year: 2004
Journal: J Biol Chem
Title: Heregulin regulates the ability of the ErbB3-binding protein Ebp1 to bind E2F promoter elements and repress E2F-mediated transcription.
Volume: 279
Issue: 25
Pages: 26126-33
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Publication
32792525 | J:299732
First Author: Zhou X
Year: 2020
Journal: Nat Commun
Title: Cellular and molecular properties of neural progenitors in the developing mammalian hypothalamus.
Volume: 11
Issue: 1
Pages: 4063
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Publication
11319863 | J:69283
First Author: Murata T
Year: 2001
Journal: Dev Biol
Title: The hiiragi gene encodes a poly(A) polymerase, which controls the formation of the wing margin in Drosophila melanogaster.
Volume: 233
Issue: 1
Pages: 137-47
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Publication
9580484 | J:43369
 
First Author: Elizalde PV
Year: 1997
Journal: Medicina (B Aires)
Title: [Growth hormones and oncogenes in mammary adenocarcinomas induced by medroxyprogesterone acetate in BALB/c mice].
Volume: 57 Suppl 2
Pages: 70-4
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Publication
31093964 | J:277337
First Author: Gao S
Year: 2019
Journal: Br J Pharmacol
Title: Histidine-rich glycoprotein ameliorates endothelial barrier dysfunction through regulation of NF-κB and MAPK signal pathway.
Volume: 176
Issue: 15
Pages: 2808-2824
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Publication
10919660 | J:64655
First Author: Weinstein EJ
Year: 2000
Journal: Cancer Res
Title: The extracellular region of heregulin is sufficient to promote mammary gland proliferation and tumorigenesis but not apoptosis.
Volume: 60
Issue: 14
Pages: 3856-61
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Publication
12529413 | J:81646
First Author: Labriola L
Year: 2003
Journal: Mol Cell Biol
Title: Heregulin induces transcriptional activation of the progesterone receptor by a mechanism that requires functional ErbB-2 and mitogen-activated protein kinase activation in breast cancer cells.
Volume: 23
Issue: 3
Pages: 1095-111
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Publication
16168116 | J:101435
First Author: Kim A
Year: 2005
Journal: Breast Cancer Res
Title: Functional interaction between mouse erbB3 and wild-type rat c-neu in transgenic mouse mammary tumor cells.
Volume: 7
Issue: 5
Pages: R708-18
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Protein
F6UV57
Organism: Mus musculus
Length: 433  
Fragment?: true
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Protein
F6YCM8
Organism: Mus musculus
Length: 477  
Fragment?: true
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Protein
F8WIH0
Organism: Mus musculus
Length: 690  
Fragment?: true
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Publication
11358523 | -
First Author: Valente RH
Year: 2001
Journal: Eur J Biochem
Title: BJ46a, a snake venom metalloproteinase inhibitor. Isolation, characterization, cloning and insights into its mechanism of action.
Volume: 268
Issue: 10
Pages: 3042-52
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Publication
1478916 | -
First Author: Yamakawa Y
Year: 1992
Journal: J Biochem
Title: Primary structure of the antihemorrhagic factor in serum of the Japanese Habu: a snake venom metalloproteinase inhibitor with a double-headed cystatin domain.
Volume: 112
Issue: 5
Pages: 583-9
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Publication
14644044 | -
First Author: Ray S
Year: 2003
Journal: Biochim Biophys Acta
Title: Members of the cystatin superfamily interact with MMP-9 and protect it from autolytic degradation without affecting its gelatinolytic activities.
Volume: 1652
Issue: 2
Pages: 91-102
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Protein Domain
IPR001363 | Prot_inh_fetuin_CS
Type: Conserved_site
Description: The cystatins are a superfamily of similar proteins present in mammals, birds, fish, insects, plants and protozoa. In general they are potent peptidase inhibitors [, , , ]belonging to MEROPS inhibitor family I25, clan IH. The type 1 cystatins or stefins (A and B) are mainly intracellular, the type 2 cystatins (C, D, E/M, F, G, S, SN and SA) are extracellular, and the type 3 cystatins (L- and H-kininogens) are intravascular proteins. All true cystatins inhibit cysteine peptidases of the papain family (MEROPS peptidase family C1), and some also inhibit legumain family enzymes (MEROPS peptidase family C13). These peptidases play key roles in physiological processes, such as intracellular protein degradation (cathepsins B, H and L), are pivotal in the remodelling of bone (cathepsin K), and may be important in the control of antigen presentation (cathepsin S, mammalian legumain). Moreover, the activities of such peptidases are increased in pathophysiological conditions, such as cancer metastasis and inflammation. Additionally, such peptidases are essential for several pathogenic parasites and bacteria. Thus in animals cystatins not only have capacity to regulate normal body processes and perhaps cause disease when down-regulated, but in other organisms may also participate in defence against biotic and abiotic stress.This family of proteinase inhibitors are cystatins belonging to MEROPS inhibitor family I25 (clan IH), subfamily I25C. They are primarily metalloprotease inhibitors, which include snake venom anti-hemorrhagic factors and the mammalian fetuins, for example:Anti-hemorrhagic factor BJ46a, which is a potent inhibitor of atrolysin and jararhagin (MEROPS peptidase family M12) from the venomous snake Bothrops jararaca [].Anti-hemorrhagic factor, HSF, from the Japanese Habu snake (Trimeresurus flavoviridis). HSF contains two N-terminal cystatin domains which show a remarkable sequence homology (about 50%) to those of plasma glycoproteins such as alpha 2-HS (human) and fetuin (bovine) and to a lesser extent to that of HRG (human). In spite of the presence of cystatin domains, HSF does not inhibit cysteine proteinases such as papain and cathepsin B but does inhibit several metalloproteases in Habu venom [].Mammalian fetuins have been demonstrated to bind to matrix metalloproteinase (MMPs, MEROPS peptidase family M10). This binding protects the MMPs from autolytic degradation without interfering with their enzymatic activity [].Fetuins are known to consist of three domains: two tandemly arranged N-terminal cystatin domains (D1 and D2) and an unrelated domain (D3) located in the C-terminal region [, ]. When compared with the other members of this family, D3, especially its N-terminal half, varies greatly due to deletions, insertions or substitutions. Sequence comparisons suggest that the conformation of the human alpha2HS glycoprotein differs greatly from that of other members of this family. Human fetuin is a heterodimer of chains A and B, which are derived by cleavage of a connecting peptide from a common precursor. It is synthesised in the liver and selectively concentrated in bone matrix. It has a wide functional diversity having been shown to be involved in immune response, bone formation and resorption. Mammalian fetuin also called alpha-2-HS-glycoprotein, bone sialic acid-containing protein (BSP), countertrypin or PP63, is expressed in a tissue- and development-specific pattern, which seems to be significantly different between species [, ].
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Protein
Q3URD3
Organism: Mus musculus
Length: 845  
Fragment?: false
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•
•
•
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Publication
1373325 | J:31552
First Author: Yang F
Year: 1992
Journal: Biochim Biophys Acta
Title: Human alpha 2-HS-glycoprotein/bovine fetuin homologue in mice: identification and developmental regulation of the gene.
Volume: 1130
Issue: 2
Pages: 149-56
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•
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Protein
P29699
Organism: Mus musculus
Length: 345  
Fragment?: false
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•
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•
Protein
Q9QXC1
Organism: Mus musculus
Length: 388  
Fragment?: false
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•
•
•
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Protein
Q6YJU1
Organism: Mus musculus
Length: 308  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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