Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
Homo sapiens |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
Drosophila melanogaster |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
Rattus norvegicus |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Haems are metalloporphyrins that serve as prosthetic groups for a variety of biological processes, including respiration, gas sensing, xenobiotic detoxification, cell differentiation, circadian clock control, metabolic reprogramming and microRNA processing. Haem is usually synthesised by a multistep biosynthetic pathway. The cellular pathways and molecules that mediate intracellular haem trafficking are still largely unknown [].Caenorhabditis elegans and related helminths are natural haem auxotrophs that acquire environmental haem for incorporation into haemoproteins. In C.elegans, it has been shown that HRG-1 proteins are essential for haem homeostasis. In worms, depletion of hrg-1, or its paralogue hrg-4, results in the disruption of organismal haem sensing, and an abnormal response to haem analogues [].HRG-1 and HRG-4 are transmembrane (TM) proteins that reside in distinct intracellular compartments. Transient knockdown of hrg-1 in zebrafish leads to hydrocephalus, yolk tube malformations and profound defects in erythropoiesis-phenotypes that are fully rescued by worm HRG-1. Human and worm proteins have been shown to co-localise, and bind and transport haem, thus establishing an evolutionarily conserved function for HRG-1 [].Sequence analysis of HRG-1 has identified 4 predicted TM domains, and a conserved tyrosine and acidic-di-leucine-based sorting signal in the cytoplasmic C terminus. In addition, residues that could potentially either directly bind haem (H90 in TM2) or interact with the haem side chains (FARKY) are situated in the C-terminal tail []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
146
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
88
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
60
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Rajagopal A |
Year: |
2008 |
Journal: |
Nature |
Title: |
Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins. |
Volume: |
453 |
Issue: |
7198 |
Pages: |
1127-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tugues S |
Year: |
2012 |
Journal: |
Cancer Res |
Title: |
Genetic deficiency in plasma protein HRG enhances tumor growth and metastasis by exacerbating immune escape and vessel abnormalization. |
Volume: |
72 |
Issue: |
8 |
Pages: |
1953-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cedervall J |
Year: |
2013 |
Journal: |
Angiogenesis |
Title: |
HRG regulates tumor progression, epithelial to mesenchymal transition and metastasis via platelet-induced signaling in the pre-tumorigenic microenvironment. |
Volume: |
16 |
Issue: |
4 |
Pages: |
889-902 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
Homo sapiens |
|
•
•
•
•
•
|
Allele |
Name: |
histidine-rich glycoprotein; targeted mutation 1, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Inducible, Recombinase, Reporter |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, mutant strain, coisogenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant strain, coisogenic, targeted mutation |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Tsuchida-Straeten N |
Year: |
2005 |
Journal: |
J Thromb Haemost |
Title: |
Enhanced blood coagulation and fibrinolysis in mice lacking histidine-rich glycoprotein (HRG). |
Volume: |
3 |
Issue: |
5 |
Pages: |
865-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shannon O |
Year: |
2010 |
Journal: |
Blood |
Title: |
Histidine-rich glycoprotein promotes bacterial entrapment in clots and decreases mortality in a mouse model of sepsis. |
Volume: |
116 |
Issue: |
13 |
Pages: |
2365-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hulett MD |
Year: |
2000 |
Journal: |
Immunol Cell Biol |
Title: |
Murine histidine-rich glycoprotein: cloning, characterization and cellular origin. |
Volume: |
78 |
Issue: |
3 |
Pages: |
280-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rydengård V |
Year: |
2008 |
Journal: |
PLoS Pathog |
Title: |
Histidine-rich glycoprotein protects from systemic Candida infection. |
Volume: |
4 |
Issue: |
8 |
Pages: |
e1000116 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thulin A |
Year: |
2009 |
Journal: |
Mol Cancer Res |
Title: |
Activated platelets provide a functional microenvironment for the antiangiogenic fragment of histidine-rich glycoprotein. |
Volume: |
7 |
Issue: |
11 |
Pages: |
1792-802 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ringvall M |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
Enhanced platelet activation mediates the accelerated angiogenic switch in mice lacking histidine-rich glycoprotein. |
Volume: |
6 |
Issue: |
1 |
Pages: |
e14526 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vu TT |
Year: |
2015 |
Journal: |
Blood |
Title: |
Arterial thrombosis is accelerated in mice deficient in histidine-rich glycoprotein. |
Volume: |
125 |
Issue: |
17 |
Pages: |
2712-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Deuschle U |
Year: |
2015 |
Journal: |
Int J Cancer |
Title: |
The nuclear bile acid receptor FXR controls the liver derived tumor suppressor histidine-rich glycoprotein. |
Volume: |
136 |
Issue: |
11 |
Pages: |
2693-704 |
|
•
•
•
•
•
|
Publication |
First Author: |
Roche F |
Year: |
2015 |
Journal: |
Matrix Biol |
Title: |
Histidine-rich glycoprotein blocks collagen-binding integrins and adhesion of endothelial cells through low-affinity interaction with α2 integrin. |
Volume: |
48 |
|
Pages: |
89-99 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hale JS |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Context dependent role of the CD36--thrombospondin--histidine-rich glycoprotein axis in tumor angiogenesis and growth. |
Volume: |
7 |
Issue: |
7 |
Pages: |
e40033 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Claesson-Welsh L |
Year: |
2012 |
Journal: |
Ups J Med Sci |
Title: |
Blood vessels as targets in tumor therapy. |
Volume: |
117 |
Issue: |
2 |
Pages: |
178-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hsu SJ |
Year: |
2004 |
Journal: |
Genome |
Title: |
Identification of Fetuin-B as a member of a cystatin-like gene family on mouse chromosome 16 with tumor suppressor activity. |
Volume: |
47 |
Issue: |
5 |
Pages: |
931-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Simantov R |
Year: |
2005 |
Journal: |
Matrix Biol |
Title: |
The antiangiogenic effect of thrombospondin-2 is mediated by CD36 and modulated by histidine-rich glycoprotein. |
Volume: |
24 |
Issue: |
1 |
Pages: |
27-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
White C |
Year: |
2013 |
Journal: |
Cell Metab |
Title: |
HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis. |
Volume: |
17 |
Issue: |
2 |
Pages: |
261-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Naba A |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. |
Volume: |
7 |
|
Pages: |
40495 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lennon G |
Year: |
1999 |
Journal: |
Database Download |
Title: |
WashU-HHMI Mouse EST Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Velocigene |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2001 |
|
Title: |
Gene Ontology Annotation by the MGI Curatorial Staff |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
|
Title: |
Human to Mouse ISO GO annotation transfer |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2000 |
|
Title: |
Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gaudet P |
Year: |
2011 |
Journal: |
Brief Bioinform |
Title: |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. |
Volume: |
12 |
Issue: |
5 |
Pages: |
449-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Rolny C |
Year: |
2011 |
Journal: |
Cancer Cell |
Title: |
HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF. |
Volume: |
19 |
Issue: |
1 |
Pages: |
31-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Balañá ME |
Year: |
1999 |
Journal: |
Oncogene |
Title: |
Interactions between progestins and heregulin (HRG) signaling pathways: HRG acts as mediator of progestins proliferative effects in mouse mammary adenocarcinomas. |
Volume: |
18 |
Issue: |
46 |
Pages: |
6370-9 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents a predicted immunity protein with an all α-helical fold and a conserved HRG motif. These proteins are present in heterogeneous polyimmunity loci in polymorphic toxin systems []. |
|
•
•
•
•
•
|
Publication |
First Author: |
van den Berg EA |
Year: |
1990 |
Journal: |
Genomics |
Title: |
Assignment of the human gene for histidine-rich glycoprotein to chromosome 3. |
Volume: |
7 |
Issue: |
2 |
Pages: |
276-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
O'Shea S |
Year: |
2001 |
Journal: |
Am J Pathol |
Title: |
Effects of in vivo heregulin beta1 treatment in wild-type and ErbB gene-targeted mice depend on receptor levels and pregnancy. |
Volume: |
158 |
Issue: |
5 |
Pages: |
1871-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kärrlander M |
Year: |
2009 |
Journal: |
PLoS One |
Title: |
Histidine-rich glycoprotein can prevent development of mouse experimental glioblastoma. |
Volume: |
4 |
Issue: |
12 |
Pages: |
e8536 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Y |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
Heregulin regulates the ability of the ErbB3-binding protein Ebp1 to bind E2F promoter elements and repress E2F-mediated transcription. |
Volume: |
279 |
Issue: |
25 |
Pages: |
26126-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou X |
Year: |
2020 |
Journal: |
Nat Commun |
Title: |
Cellular and molecular properties of neural progenitors in the developing mammalian hypothalamus. |
Volume: |
11 |
Issue: |
1 |
Pages: |
4063 |
|
•
•
•
•
•
|
Publication |
First Author: |
Murata T |
Year: |
2001 |
Journal: |
Dev Biol |
Title: |
The hiiragi gene encodes a poly(A) polymerase, which controls the formation of the wing margin in Drosophila melanogaster. |
Volume: |
233 |
Issue: |
1 |
Pages: |
137-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Elizalde PV |
Year: |
1997 |
Journal: |
Medicina (B Aires) |
Title: |
[Growth hormones and oncogenes in mammary adenocarcinomas induced by medroxyprogesterone acetate in BALB/c mice]. |
Volume: |
57 Suppl 2 |
|
Pages: |
70-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gao S |
Year: |
2019 |
Journal: |
Br J Pharmacol |
Title: |
Histidine-rich glycoprotein ameliorates endothelial barrier dysfunction through regulation of NF-κB and MAPK signal pathway. |
Volume: |
176 |
Issue: |
15 |
Pages: |
2808-2824 |
|
•
•
•
•
•
|
Publication |
First Author: |
Weinstein EJ |
Year: |
2000 |
Journal: |
Cancer Res |
Title: |
The extracellular region of heregulin is sufficient to promote mammary gland proliferation and tumorigenesis but not apoptosis. |
Volume: |
60 |
Issue: |
14 |
Pages: |
3856-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Labriola L |
Year: |
2003 |
Journal: |
Mol Cell Biol |
Title: |
Heregulin induces transcriptional activation of the progesterone receptor by a mechanism that requires functional ErbB-2 and mitogen-activated protein kinase activation in breast cancer cells. |
Volume: |
23 |
Issue: |
3 |
Pages: |
1095-111 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim A |
Year: |
2005 |
Journal: |
Breast Cancer Res |
Title: |
Functional interaction between mouse erbB3 and wild-type rat c-neu in transgenic mouse mammary tumor cells. |
Volume: |
7 |
Issue: |
5 |
Pages: |
R708-18 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
433
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
477
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
690
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Valente RH |
Year: |
2001 |
Journal: |
Eur J Biochem |
Title: |
BJ46a, a snake venom metalloproteinase inhibitor. Isolation, characterization, cloning and insights into its mechanism of action. |
Volume: |
268 |
Issue: |
10 |
Pages: |
3042-52 |
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•
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Publication |
First Author: |
Yamakawa Y |
Year: |
1992 |
Journal: |
J Biochem |
Title: |
Primary structure of the antihemorrhagic factor in serum of the Japanese Habu: a snake venom metalloproteinase inhibitor with a double-headed cystatin domain. |
Volume: |
112 |
Issue: |
5 |
Pages: |
583-9 |
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Publication |
First Author: |
Ray S |
Year: |
2003 |
Journal: |
Biochim Biophys Acta |
Title: |
Members of the cystatin superfamily interact with MMP-9 and protect it from autolytic degradation without affecting its gelatinolytic activities. |
Volume: |
1652 |
Issue: |
2 |
Pages: |
91-102 |
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Protein Domain |
Type: |
Conserved_site |
Description: |
The cystatins are a superfamily of similar proteins present in mammals, birds, fish, insects, plants and protozoa. In general they are potent peptidase inhibitors [, , , ]belonging to MEROPS inhibitor family I25, clan IH. The type 1 cystatins or stefins (A and B) are mainly intracellular, the type 2 cystatins (C, D, E/M, F, G, S, SN and SA) are extracellular, and the type 3 cystatins (L- and H-kininogens) are intravascular proteins. All true cystatins inhibit cysteine peptidases of the papain family (MEROPS peptidase family C1), and some also inhibit legumain family enzymes (MEROPS peptidase family C13). These peptidases play key roles in physiological processes, such as intracellular protein degradation (cathepsins B, H and L), are pivotal in the remodelling of bone (cathepsin K), and may be important in the control of antigen presentation (cathepsin S, mammalian legumain). Moreover, the activities of such peptidases are increased in pathophysiological conditions, such as cancer metastasis and inflammation. Additionally, such peptidases are essential for several pathogenic parasites and bacteria. Thus in animals cystatins not only have capacity to regulate normal body processes and perhaps cause disease when down-regulated, but in other organisms may also participate in defence against biotic and abiotic stress.This family of proteinase inhibitors are cystatins belonging to MEROPS inhibitor family I25 (clan IH), subfamily I25C. They are primarily metalloprotease inhibitors, which include snake venom anti-hemorrhagic factors and the mammalian fetuins, for example:Anti-hemorrhagic factor BJ46a, which is a potent inhibitor of atrolysin and jararhagin (MEROPS peptidase family M12) from the venomous snake Bothrops jararaca [].Anti-hemorrhagic factor, HSF, from the Japanese Habu snake (Trimeresurus flavoviridis). HSF contains two N-terminal cystatin domains which show a remarkable sequence homology (about 50%) to those of plasma glycoproteins such as alpha 2-HS (human) and fetuin (bovine) and to a lesser extent to that of HRG (human). In spite of the presence of cystatin domains, HSF does not inhibit cysteine proteinases such as papain and cathepsin B but does inhibit several metalloproteases in Habu venom [].Mammalian fetuins have been demonstrated to bind to matrix metalloproteinase (MMPs, MEROPS peptidase family M10). This binding protects the MMPs from autolytic degradation without interfering with their enzymatic activity [].Fetuins are known to consist of three domains: two tandemly arranged N-terminal cystatin domains (D1 and D2) and an unrelated domain (D3) located in the C-terminal region [, ]. When compared with the other members of this family, D3, especially its N-terminal half, varies greatly due to deletions, insertions or substitutions. Sequence comparisons suggest that the conformation of the human alpha2HS glycoprotein differs greatly from that of other members of this family. Human fetuin is a heterodimer of chains A and B, which are derived by cleavage of a connecting peptide from a common precursor. It is synthesised in the liver and selectively concentrated in bone matrix. It has a wide functional diversity having been shown to be involved in immune response, bone formation and resorption. Mammalian fetuin also called alpha-2-HS-glycoprotein, bone sialic acid-containing protein (BSP), countertrypin or PP63, is expressed in a tissue- and development-specific pattern, which seems to be significantly different between species [, ]. |
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Protein |
Organism: |
Mus musculus |
Length: |
845
 |
Fragment?: |
false |
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•
•
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Publication |
First Author: |
Yang F |
Year: |
1992 |
Journal: |
Biochim Biophys Acta |
Title: |
Human alpha 2-HS-glycoprotein/bovine fetuin homologue in mice: identification and developmental regulation of the gene. |
Volume: |
1130 |
Issue: |
2 |
Pages: |
149-56 |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
345
 |
Fragment?: |
false |
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•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
388
 |
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
308
 |
Fragment?: |
false |
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•
•
•
•
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