| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Greene TA |
| Year: |
2003 |
| Journal: |
J Biol Chem |
| Title: |
Cloning and characterization of ALX, an adaptor downstream of CD28. |
| Volume: |
278 |
| Issue: |
46 |
| Pages: |
45128-34 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Herrin BR |
| Year: |
2005 |
| Journal: |
J Biol Chem |
| Title: |
The adaptor protein HSH2 attenuates apoptosis in response to ligation of the B cell antigen receptor complex on the B lymphoma cell line, WEHI-231. |
| Volume: |
280 |
| Issue: |
5 |
| Pages: |
3507-15 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Herrin BR |
| Year: |
2006 |
| Journal: |
J Immunol |
| Title: |
Expression of the adaptor protein hematopoietic Src homology 2 is up-regulated in response to stimuli that promote survival and differentiation of B cells. |
| Volume: |
176 |
| Issue: |
7 |
| Pages: |
4163-72 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
King RG |
| Year: |
2011 |
| Journal: |
J Immunol |
| Title: |
Differential expression of the adaptor protein HSH2 controls the quantitative and qualitative nature of the humoral response. |
| Volume: |
187 |
| Issue: |
7 |
| Pages: |
3565-77 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4418652 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2010-01-26 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1610528 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:4418653 |
| Age: |
postnatal |
| Image: |
2 |
|
| Specimen Label: |
heart |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4418652 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2010-01-26 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689428 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:4418653 |
| Age: |
postnatal |
| Image: |
2 |
|
| Specimen Label: |
brain |
| Detected: |
false |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4418652 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2010-01-26 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684628 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:4418653 |
| Age: |
postnatal |
| Image: |
2 |
|
| Specimen Label: |
liver |
| Detected: |
false |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4418652 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2010-01-26 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1876728 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:4418653 |
| Age: |
postnatal |
| Image: |
2 |
|
| Specimen Label: |
spleen |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4418652 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2010-01-26 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1737328 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:4418653 |
| Age: |
postnatal |
| Image: |
2 |
|
| Specimen Label: |
kidney |
| Detected: |
false |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4418652 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2010-01-26 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672828 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:4418653 |
| Age: |
postnatal |
| Image: |
2 |
|
| Specimen Label: |
lung |
| Detected: |
false |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4418652 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2010-01-26 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1876828 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:4418653 |
| Age: |
postnatal |
| Image: |
2 |
|
| Specimen Label: |
thymus |
| Detected: |
true |
| Specimen Num: |
8 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4418652 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2010-01-26 |
| Strength: |
Absent |
| Sex: |
Male |
| Emaps: |
EMAPS:1797228 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:4418653 |
| Age: |
postnatal |
| Image: |
2 |
|
| Specimen Label: |
testis |
| Detected: |
false |
| Specimen Num: |
9 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4418652 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2010-01-26 |
| Strength: |
Absent |
| Sex: |
Female |
| Emaps: |
EMAPS:1796228 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:4418653 |
| Age: |
postnatal |
| Image: |
2 |
|
| Specimen Label: |
ovary |
| Detected: |
false |
| Specimen Num: |
10 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4418652 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2010-01-26 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1603917 |
|
| Stage: |
TS17 |
| Assay Id: |
MGI:4418653 |
| Age: |
embryonic day 10.0-11.0 |
| Image: |
2 |
|
| Specimen Label: |
embryo |
| Detected: |
false |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Perchonock CE |
| Year: |
2007 |
| Journal: |
J Immunol |
| Title: |
The related adaptors, adaptor in lymphocytes of unknown function X and Rlk/Itk-binding protein, have nonredundant functions in lymphocytes. |
| Volume: |
179 |
| Issue: |
3 |
| Pages: |
1768-75 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
de Ara?jo S |
| Year: |
2022 |
| Journal: |
Cells |
| Title: |
Annexin A1-FPR2/ALX Signaling Axis Regulates Acute Inflammation during Chikungunya Virus Infection. |
| Volume: |
11 |
| Issue: |
17 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
McArthur S |
| Year: |
2020 |
| Journal: |
J Clin Invest |
| Title: |
Annexin A1 drives macrophage skewing to accelerate muscle regeneration through AMPK activation. |
| Volume: |
130 |
| Issue: |
3 |
| Pages: |
1156-1167 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Smith HK |
| Year: |
2015 |
| Journal: |
FASEB J |
| Title: |
Targeting formyl peptide receptor 2 reduces leukocyte-endothelial interactions in a murine model of stroke. |
| Volume: |
29 |
| Issue: |
5 |
| Pages: |
2161-71 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Perchonock CE |
| Year: |
2006 |
| Journal: |
Mol Cell Biol |
| Title: |
Negative regulation of interleukin-2 and p38 mitogen-activated protein kinase during T-cell activation by the adaptor ALX. |
| Volume: |
26 |
| Issue: |
16 |
| Pages: |
6005-15 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gobbetti T |
| Year: |
2014 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis. |
| Volume: |
111 |
| Issue: |
52 |
| Pages: |
18685-90 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kang JW |
| Year: |
2016 |
| Journal: |
Biochim Biophys Acta |
| Title: |
Resolvin D1 protects the liver from ischemia/reperfusion injury by enhancing M2 macrophage polarization and efferocytosis. |
| Volume: |
1861 |
| Issue: |
9 Pt A |
| Pages: |
1025-1035 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wellcome Trust Sanger Institute |
| Year: |
2009 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Magdaleno S |
| Year: |
2006 |
| Journal: |
PLoS Biol |
| Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
| Volume: |
4 |
| Issue: |
4 |
| Pages: |
e86 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carninci P |
| Year: |
2005 |
| Journal: |
Science |
| Title: |
The transcriptional landscape of the mammalian genome. |
| Volume: |
309 |
| Issue: |
5740 |
| Pages: |
1559-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Skarnes WC |
| Year: |
2011 |
| Journal: |
Nature |
| Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
| Volume: |
474 |
| Issue: |
7351 |
| Pages: |
337-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGD Nomenclature Committee |
| Year: |
1995 |
|
| Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shanghai Model Organisms Center |
| Year: |
2017 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cyagen Biosciences Inc. |
| Year: |
2022 |
|
| Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2003 |
|
| Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
GemPharmatech |
| Year: |
2020 |
|
| Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
| Year: |
2001 |
|
| Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI Genome Annotation Group and UniGene Staff |
| Year: |
2015 |
| Journal: |
Database Download |
| Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics and Ensembl Genome Database Project |
| Year: |
2026 |
| Journal: |
Database Release |
| Title: |
MGI Strain Genome Feature and Gene Model Load from Ensembl. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shapiro MJ |
| Year: |
2004 |
| Journal: |
J Biol Chem |
| Title: |
The ALX Src homology 2 domain is both necessary and sufficient to inhibit T cell receptor/CD28-mediated up-regulation of RE/AP. |
| Volume: |
279 |
| Issue: |
39 |
| Pages: |
40647-52 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Oda T |
| Year: |
2001 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
HSH2: a novel SH2 domain-containing adapter protein involved in tyrosine kinase signaling in hematopoietic cells. |
| Volume: |
288 |
| Issue: |
5 |
| Pages: |
1078-86 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
HSH2D (hematopoietic SH2 domain-containing protein, also known as ALX) is an adapter protein involved in tyrosine kinase and CD28 signaling [, ]. It is expressed exclusively in hematopoietic cells. It contains an Src homology 2 (SH2) domain, four PXXP polyproline sequences, and two likely sites of tyrosine phosphorylation. The SH2 domain plays a critical role in ALX function downstream of CD28 [].This entry represents the Src homology 2 (SH2) domain of HSH2. |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
334
 |
| Fragment?: |
false |
|
•
•
•
•
•
|