| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shen X |
| Year: |
2009 |
| Journal: |
Cell |
| Title: |
Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. |
| Volume: |
139 |
| Issue: |
7 |
| Pages: |
1303-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Okazaki N |
| Year: |
2003 |
| Journal: |
DNA Res |
| Title: |
Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. |
| Volume: |
10 |
| Issue: |
4 |
| Pages: |
167-80 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Strausberg RL |
| Year: |
2002 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
| Volume: |
99 |
| Issue: |
26 |
| Pages: |
16899-903 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2003 |
| Journal: |
Database Download |
| Title: |
Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ko MS |
| Year: |
2000 |
| Journal: |
Development |
| Title: |
Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. |
| Volume: |
127 |
| Issue: |
8 |
| Pages: |
1737-49 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stryke D |
| Year: |
2003 |
| Journal: |
Nucleic Acids Res |
| Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
| Volume: |
31 |
| Issue: |
1 |
| Pages: |
278-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI and IMPC |
| Year: |
2018 |
| Journal: |
Database Release |
| Title: |
MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hansen GM |
| Year: |
2008 |
| Journal: |
Genome Res |
| Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
| Volume: |
18 |
| Issue: |
10 |
| Pages: |
1670-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carninci P |
| Year: |
2005 |
| Journal: |
Science |
| Title: |
The transcriptional landscape of the mammalian genome. |
| Volume: |
309 |
| Issue: |
5740 |
| Pages: |
1559-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGD Nomenclature Committee |
| Year: |
1995 |
|
| Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
| Year: |
2008 |
| Journal: |
Database Download |
| Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cyagen Biosciences Inc. |
| Year: |
2022 |
|
| Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
GOA curators |
| Year: |
2016 |
|
| Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
| Year: |
2011 |
|
| Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2003 |
|
| Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
| Year: |
2004 |
| Journal: |
Database Release |
| Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
GemPharmatech |
| Year: |
2020 |
|
| Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2010 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI Genome Annotation Group and UniGene Staff |
| Year: |
2015 |
| Journal: |
Database Download |
| Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics and Ensembl Genome Database Project |
| Year: |
2026 |
| Journal: |
Database Release |
| Title: |
MGI Strain Genome Feature and Gene Model Load from Ensembl. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ma T |
| Year: |
2023 |
| Journal: |
Front Plant Sci |
| Title: |
Arabidopsis LFR, a SWI/SNF complex component, interacts with ICE1 and activates ICE1 and CBF3 expression in cold acclimation. |
| Volume: |
14 |
|
| Pages: |
1097158 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This entry represents the C-terminal domain of little elongation complex subunit 1 (Ice1) found in insects. The full-length Ice1 protein is a component of the little elongation complex (LEC), which is required to regulate small nuclear RNA gene transcription by RNA polymerase II and III [, ]. Ice1 acts as a scaffold protein that promotes LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies. The complete protein is located in the nucleus and belongs to the ICE1 family. The specific function of this domain remains to be determined. This domain contains a TPR-like fold. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This entry represents the first TPR-like domain of little elongation complex subunit 1 (Ice1). The specific function of this domain remains to be determined.The full-length Ice1 protein is a component of the little elongation complex (LEC), which is required to regulate small nuclear RNA gene transcription by RNA polymerase II and III [, ]. Ice1 acts as a scaffold protein that promotes LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies. The complete protein is located in the nucleus and belongs to the ICE1 family. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Smith ER |
| Year: |
2011 |
| Journal: |
Mol Cell |
| Title: |
The little elongation complex regulates small nuclear RNA transcription. |
| Volume: |
44 |
| Issue: |
6 |
| Pages: |
954-65 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hu D |
| Year: |
2013 |
| Journal: |
Mol Cell |
| Title: |
The little elongation complex functions at initiation and elongation phases of snRNA gene transcription. |
| Volume: |
51 |
| Issue: |
4 |
| Pages: |
493-505 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
2241
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
117
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
107
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
242
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This domain is found at the C-terminal end of ICE1 mainly in animals. This domain is predicted to adopt an all-�� configuration.Little elongation complex subunit 1 (ICE1) acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at small nuclear RNA (snRNA) genes in subnuclear bodies. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dong CH |
| Year: |
2006 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
The negative regulator of plant cold responses, HOS1, is a RING E3 ligase that mediates the ubiquitination and degradation of ICE1. |
| Volume: |
103 |
| Issue: |
21 |
| Pages: |
8281-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee JH |
| Year: |
2012 |
| Journal: |
Plant Cell Physiol |
| Title: |
The E3 ubiquitin ligase HOS1 regulates low ambient temperature-responsive flowering in Arabidopsis thaliana. |
| Volume: |
53 |
| Issue: |
10 |
| Pages: |
1802-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cheng Z |
| Year: |
2020 |
| Journal: |
Plant Cell |
| Title: |
Nup96 and HOS1 Are Mutually Stabilized and Gate CONSTANS Protein Level, Conferring Long-Day Photoperiodic Flowering Regulation in Arabidopsis. |
| Volume: |
32 |
| Issue: |
2 |
| Pages: |
374-391 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shkryl Y |
| Year: |
2021 |
| Journal: |
Plants (Basel) |
| Title: |
CRISPR/Cas9-Mediated Knockout of HOS1 Reveals Its Role in the Regulation of Secondary Metabolism in Arabidopsis thaliana. |
| Volume: |
10 |
| Issue: |
1 |
|
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
HOS1 is an E3 ubiquitin-protein ligase that acts as a common regulator in the signalling pathways that control flowering time [, ]. It mediates ubiquitination and subsequent proteasomal degradation of the transcription factor ICE1 under cold treatment []. In Arabidopsis, CONSTANS (CO) activates transcription of the floral integrators, FLOWERING LOCUS T (FT) and TWIN SISTER OF FT (TSF) genes, which in turn govern the flowering time []. Together with Nup96, HOS1 regulates CO protein turnover and thereby prevents precocious flowering in long-day conditions []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sorensen AM |
| Year: |
2003 |
| Journal: |
Plant J |
| Title: |
The Arabidopsis ABORTED MICROSPORES (AMS) gene encodes a MYC class transcription factor. |
| Volume: |
33 |
| Issue: |
2 |
| Pages: |
413-23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kanaoka MM |
| Year: |
2008 |
| Journal: |
Plant Cell |
| Title: |
SCREAM/ICE1 and SCREAM2 specify three cell-state transitional steps leading to arabidopsis stomatal differentiation. |
| Volume: |
20 |
| Issue: |
7 |
| Pages: |
1775-85 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Colangelo EP |
| Year: |
2004 |
| Journal: |
Plant Cell |
| Title: |
The essential basic helix-loop-helix protein FIT1 is required for the iron deficiency response. |
| Volume: |
16 |
| Issue: |
12 |
| Pages: |
3400-12 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
de Marcos A |
| Year: |
2017 |
| Journal: |
Plant Physiol |
| Title: |
A Mutation in the bHLH Domain of the SPCH Transcription Factor Uncovers a BR-Dependent Mechanism for Stomatal Development. |
| Volume: |
174 |
| Issue: |
2 |
| Pages: |
823-842 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Miyamoto K |
| Year: |
2013 |
| Journal: |
Protoplasma |
| Title: |
Stress-induced expression of the transcription factor RERJ1 is tightly regulated in response to jasmonic acid accumulation in rice. |
| Volume: |
250 |
| Issue: |
1 |
| Pages: |
241-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
He Q |
| Year: |
2021 |
| Journal: |
Plant J |
| Title: |
OsbHLH6 interacts with OsSPX4 and regulates the phosphate starvation response in rice. |
| Volume: |
105 |
| Issue: |
3 |
| Pages: |
649-667 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry includes bHLH transcription factors from plants that play diverse roles in plant development and responses. ICE1 is involved in regulating cold-induced transcription of CBF/DREB1 genes, and stomatal differentiation [, ]. Transcription factor FIT is involved in iron acquisition []while AMS (ABORTED MICROSPORES) plays a crucial role in tapetum development and it is required for male fertility and pollen differentiation, especially during the post-meiotic transcriptional regulation of microspore development within the developing anther []. Transcription factor BHLB6 is involved in phosphate starvation response []and acts as a positive regulator of phosphate homeostasis and phosphate signalling by antagonising SPX4. It also playa a role as transcriptional activator in the regulation of jasmonate-mediated stress-inducible gene expression[]. The family is characterised by the ability to bind specific DNA sequences, often containing E-box motifs, and to function as dimers, which is crucial for their regulatory roles. |
|
•
•
•
•
•
|