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Search results 1 to 100 out of 285 for Ifih1

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Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
64135 | IFIH1
Type: gene
Organism: human
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Gene
100488298 | ifih1
Type: gene
Organism: frog, western clawed
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Gene
499801 | Ifih1
Type: gene
Organism: rat
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Gene
488371 | IFIH1
Type: gene
Organism: dog, domestic
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Gene
459692 | IFIH1
Type: gene
Organism: chimpanzee
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Gene
535490 | IFIH1
Type: gene
Organism: cattle
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Gene
424185 | IFIH1
Type: gene
Organism: chicken
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Gene
565759 | ifih1
Type: gene
Organism: zebrafish
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Gene
702024 | IFIH1
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1918836 | Ifih1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
24995871 | J:230149
First Author: Oda H
Year: 2014
Journal: Am J Hum Genet
Title: Aicardi-Gouti?res syndrome is caused by IFIH1 mutations.
Volume: 95
Issue: 1
Pages: 121-5
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Publication
25591872 | J:246937
First Author: Lincez PJ
Year: 2015
Journal: Diabetes
Title: Reduced expression of the MDA5 Gene IFIH1 prevents autoimmune diabetes.
Volume: 64
Issue: 6
Pages: 2184-93
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Publication
22205024 | J:180757
First Author: Crampton SP
Year: 2012
Journal: J Immunol
Title: Ifih1 gene dose effect reveals MDA5-mediated chronic type I IFN gene signature, viral resistance, and accelerated autoimmunity.
Volume: 188
Issue: 3
Pages: 1451-9
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Publication
28553952 | J:257959
First Author: Gorman JA
Year: 2017
Journal: Nat Immunol
Title: The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity.
Volume: 18
Issue: 7
Pages: 744-752
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Publication
28851763 | J:249050
First Author: Dou Y
Year: 2017
Journal: EMBO J
Title: The innate immune receptor MDA5 limits rotavirus infection but promotes cell death and pancreatic?inflammation.
Volume: 36
Issue: 18
Pages: 2742-2757
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Publication
36512407 | J:339647
 
First Author: Blum SI
Year: 2023
Journal: JCI Insight
Title: MDA5-dependent responses contribute to autoimmune diabetes progression and hindrance.
Volume: 8
Issue: 2
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Publication
38487540 | J:360914
 
First Author: Stock AJ
Year: 2024
Journal: Front Immunol
Title: The IFIH1-A946T risk variant promotes diabetes in a sex-dependent manner.
Volume: 15
Pages: 1349601
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Publication
40958051 | J:374930
First Author: Weldy CS
Year: 2025
Journal: Nat Cardiovasc Res
Title: Smooth muscle expression of RNA editing enzyme ADAR1 controls activation of the RNA sensor MDA5 in atherosclerosis.
Volume: 4
Issue: 10
Pages: 1241-1257
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Publication
41895292 | J:388196
First Author: Triana-Martinez F
Year: 2026
Journal: Immunity
Title: p16(High) immune cells control disease tolerance as a defense and health span-extending strategy.
Volume: 59
Issue: 6
Pages: 1633-1650.e9
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Publication
35168003 | J:324284
 
First Author: Ohto T
Year: 2022
Journal: J Autoimmun
Title: Intracellular virus sensor MDA5 mutation develops autoimmune myocarditis and nephritis.
Volume: 127
Pages: 102794
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Publication
38935501 | J:353061
First Author: Gan WL
Year: 2024
Journal: Cell Rep
Title: Hepatocyte-macrophage crosstalk via the PGRN-EGFR axis modulates ADAR1-mediated immunity in the liver.
Volume: 43
Issue: 7
Pages: 114400
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Publication
38427731 | J:347912
First Author: Luca D
Year: 2024
Journal: Sci Adv
Title: Aberrant RNA sensing in regulatory T cells causes systemic autoimmunity.
Volume: 10
Issue: 9
Pages: eadk0820
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Publication
31366715 | J:278687
First Author: Soda N
Year: 2019
Journal: J Immunol
Title: Singleton-Merten Syndrome-like Skeletal Abnormalities in Mice with Constitutively Activated MDA5.
Volume: 203
Issue: 5
Pages: 1356-1368
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Publication
16625202 | J:137522
First Author: Kato H
Year: 2006
Journal: Nature
Title: Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses.
Volume: 441
Issue: 7089
Pages: 101-5
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Publication
31956894 | J:292357
First Author: Bajad P
Year: 2020
Journal: Nucleic Acids Res
Title: An internal deletion of ADAR rescued by MAVS deficiency leads to a minute phenotype.
Volume: 48
Issue: 6
Pages: 3286-3303
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Publication
33165593 | J:300370
First Author: Onizawa H
Year: 2021
Journal: Int Immunol
Title: Aicardi-Gouti?res syndrome-like encephalitis in mutant mice with constitutively active MDA5.
Volume: 33
Issue: 4
Pages: 225-240
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Publication
28874170 | J:317546
First Author: Heraud-Farlow JE
Year: 2017
Journal: Genome Biol
Title: Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis.
Volume: 18
Issue: 1
Pages: 166
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Publication
36000401 | J:363292
First Author: Garcia-Gonzalez C
Year: 2022
Journal: Circ Res
Title: ADAR1 Prevents Autoinflammatory Processes in the Heart Mediated by IRF7.
Volume: 131
Issue: 7
Pages: 580-597
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Protein Coding Gene
MGP_CAROLIEiJ_G0023594 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0025772 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0025748 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0025718 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0025743 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0025504 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1918836 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0026190 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0024968 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0025484 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0025615 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0025577 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0025703 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0025608 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0026247 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0024709 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0025036 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0025045 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0024516 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
22090123 | J:179386
First Author: Jin YH
Year: 2012
Journal: J Virol
Title: Melanoma differentiation-associated gene 5 is critical for protection against Theiler's virus-induced demyelinating disease.
Volume: 86
Issue: 3
Pages: 1531-43
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Publication
18941247 | J:140714
First Author: Tamassia N
Year: 2008
Journal: J Immunol
Title: Activation of an immunoregulatory and antiviral gene expression program in poly(I:C)-transfected human neutrophils.
Volume: 181
Issue: 9
Pages: 6563-73
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Publication
26423942 | J:227926
First Author: Zalinger ZB
Year: 2015
Journal: J Virol
Title: MDA5 Is Critical to Host Defense during Infection with Murine Coronavirus.
Volume: 89
Issue: 24
Pages: 12330-40
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Publication
33767151 | J:340261
First Author: Brown MC
Year: 2021
Journal: Nat Commun
Title: Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling.
Volume: 12
Issue: 1
Pages: 1858
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Publication
42030239 | J:387643
First Author: Abu-Saleh D
Year: 2026
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Global knockout of melanoma differentiation-associated protein 5 protects mice from chronic hypoxia/SU5416-induced pulmonary hypertension.
Volume: 330
Issue: 6
Pages: L713-L723
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Publication
20107606 | J:162177
First Author: Gitlin L
Year: 2010
Journal: PLoS Pathog
Title: Melanoma differentiation-associated gene 5 (MDA5) is involved in the innate immune response to Paramyxoviridae infection in vivo.
Volume: 6
Issue: 1
Pages: e1000734
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Publication
36122455 | J:329992
 
First Author: Lee S
Year: 2022
Journal: Biochem Biophys Res Commun
Title: Attenuation of regulatory T cell function by type I IFN signaling in an MDA5 gain-of-function mutant mouse model.
Volume: 629
Pages: 171-175
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Publication
23328395 | J:193402
First Author: Motz C
Year: 2013
Journal: Science
Title: Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling.
Volume: 339
Issue: 6120
Pages: 690-3
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Publication
19036857 | J:147226
First Author: De Miranda J
Year: 2009
Journal: FASEB J
Title: Astrocytes recognize intracellular polyinosinic-polycytidylic acid via MDA-5.
Volume: 23
Issue: 4
Pages: 1064-71
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Publication
23090998 | J:191237
First Author: Berke IC
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: MDA5 assembles into a polar helical filament on dsRNA.
Volume: 109
Issue: 45
Pages: 18437-41
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Publication
24474800 | J:206642
First Author: Wu J
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality.
Volume: 111
Issue: 4
Pages: E511-20
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Publication
34482560 | J:335378
First Author: Zhang X
Year: 2022
Journal: Hepatology
Title: Melanoma differentiation-Associated gene 5 protects against NASH in mice.
Volume: 75
Issue: 4
Pages: 924-938
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GXD Expression
GXD Expression
   
Probe: MGI:7565718
Assay Type: RT-PCR
Annotation Date: 2024-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:7734901
Age: embryonic day 9.5
Image: 4
Specimen Label: Cmtr2<+/+>
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7565718
Assay Type: RT-PCR
Annotation Date: 2024-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:7734901
Age: embryonic day 9.5
Image: 4
Specimen Label: Cmtr2<+/->
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7565718
Assay Type: RT-PCR
Annotation Date: 2024-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:7734901
Age: embryonic day 9.5
Image: 4
Specimen Label: Cmtr2<-/->
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:7565718
Assay Type: RT-PCR
Annotation Date: 2023-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689417
Stage: TS17
Assay Id: MGI:7565762
Age: embryonic day 10.5
Specimen Label: E10.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7565718
Assay Type: RT-PCR
Annotation Date: 2023-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689422
Stage: TS22
Assay Id: MGI:7565762
Age: embryonic day 14.5
Specimen Label: E14.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7565718
Assay Type: RT-PCR
Annotation Date: 2023-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:7565762
Age: postnatal newborn
Specimen Label: Neonatal
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:7565718
Assay Type: RT-PCR
Annotation Date: 2023-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7565762
Age: postnatal week 2
Specimen Label: Week 2
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:7565718
Assay Type: RT-PCR
Annotation Date: 2023-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7565762
Age: postnatal week 10
Specimen Label: Week 10
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:7565718
Assay Type: RT-PCR
Annotation Date: 2023-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:7565767
Age: postnatal newborn
Specimen Label: Neonatal
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7565718
Assay Type: RT-PCR
Annotation Date: 2023-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7565767
Age: postnatal week 1
Specimen Label: wk 1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7565718
Assay Type: RT-PCR
Annotation Date: 2023-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7565767
Age: postnatal week 2
Specimen Label: wk 2
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:7565718
Assay Type: RT-PCR
Annotation Date: 2023-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7565767
Age: postnatal week 3
Specimen Label: wk 3
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:7565718
Assay Type: RT-PCR
Annotation Date: 2023-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7565767
Age: postnatal week 4
Specimen Label: wk 4
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:7565718
Assay Type: RT-PCR
Annotation Date: 2023-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7565767
Age: postnatal week 5
Specimen Label: wk 5
Detected: true
Specimen Num: 6
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Publication
- | J:74829
   
First Author: Strausberg R
Year: 2002
Journal: GenBank Submission
Title: Mus musculus, simialr to RIKEN cDNA 9130009C22 gene, clone IMAGE: 3990931, mRNA, partial cds
Pages: BC019605
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Publication
- | J:77433
   
First Author: Kang DC
Year: 2002
Journal: GenBank Submission
Title: Mus musculus strain C57BL/6J melanoma differentiation associated gene 5-like protein mRNA, complete cds
Pages: AF374384
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Publication
23966390 | J:310254
First Author: Lazear HM
Year: 2013
Journal: J Virol
Title: Pattern recognition receptor MDA5 modulates CD8+ T cell-dependent clearance of West Nile virus from the central nervous system.
Volume: 87
Issue: 21
Pages: 11401-15
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Publication
28031478 | J:240099
First Author: Lang X
Year: 2017
Journal: J Exp Med
Title: TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity.
Volume: 214
Issue: 2
Pages: 459-473
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Publication
40184173 | J:385563
First Author: Sarkar L
Year: 2025
Journal: Proc Natl Acad Sci U S A
Title: MDA5 ISGylation is crucial for immune signaling to control viral replication and pathogenesis.
Volume: 122
Issue: 14
Pages: e2420190122
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Publication
25451939 | J:218760
First Author: Kitai Y
Year: 2015
Journal: J Biol Chem
Title: Negative regulation of melanoma differentiation-associated gene 5 (MDA5)-dependent antiviral innate immune responses by Arf-like protein 5B.
Volume: 290
Issue: 2
Pages: 1269-80
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Publication
30193849 | J:268028
First Author: Lian H
Year: 2018
Journal: Immunity
Title: The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors.
Volume: 49
Issue: 3
Pages: 438-448.e5
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Publication
12015121 | J:76465
First Author: Kovacsovics M
Year: 2002
Journal: Curr Biol
Title: Overexpression of Helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation.
Volume: 12
Issue: 10
Pages: 838-43
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Publication
21217758 | J:168254
First Author: Z?st R
Year: 2011
Journal: Nat Immunol
Title: Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5.
Volume: 12
Issue: 2
Pages: 137-43
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Publication
22314235 | J:182522
First Author: Berke IC
Year: 2012
Journal: EMBO J
Title: MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA.
Volume: 31
Issue: 7
Pages: 1714-26
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Publication
28625874 | J:307016
 
First Author: Lin B
Year: 2017
Journal: Cytokine
Title: Negative regulation of the RLH signaling by the E3 ubiquitin ligase RNF114.
Volume: 99
Pages: 186-193
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Publication
28484023 | J:242293
First Author: Deng X
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Coronavirus nonstructural protein 15 mediates evasion of dsRNA sensors and limits apoptosis in macrophages.
Volume: 114
Issue: 21
Pages: E4251-E4260
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Publication
30361393 | J:269483
 
First Author: Nakahama T
Year: 2018
Journal: EMBO Rep
Title: ADAR1-mediated RNA editing is required for thymic self-tolerance and inhibition of autoimmunity.
Volume: 19
Issue: 12
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Publication
38128529 | J:344303
First Author: Knebel UE
Year: 2024
Journal: Cell Metab
Title: Disrupted RNA editing in beta cells mimics early-stage type 1 diabetes.
Volume: 36
Issue: 1
Pages: 48-61.e6
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Publication
29723194 | J:262046
First Author: Harris ML
Year: 2018
Journal: PLoS Biol
Title: A direct link between MITF, innate immunity, and hair graying.
Volume: 16
Issue: 5
Pages: e2003648
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Publication
20164430 | J:160108
First Author: Wang Y
Year: 2010
Journal: J Immunol
Title: Cutting edge: polyinosinic:polycytidylic acid boosts the generation of memory CD8 T cells through melanoma differentiation-associated protein 5 expressed in stromal cells.
Volume: 184
Issue: 6
Pages: 2751-5
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Publication
18636103 | J:162720
First Author: McCartney SA
Year: 2008
Journal: PLoS Pathog
Title: MDA-5 recognition of a murine norovirus.
Volume: 4
Issue: 7
Pages: e1000108
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Publication
21637773 | J:176090
First Author: Wang Q
Year: 2011
Journal: PLoS Pathog
Title: MDA5 and TLR3 initiate pro-inflammatory signaling pathways leading to rhinovirus-induced airways inflammation and hyperresponsiveness.
Volume: 7
Issue: 5
Pages: e1002070
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Publication
36975179 | J:338600
First Author: Liang Z
Year: 2023
Journal: EMBO Rep
Title: The phenotype of the most common human ADAR1p150 Z? mutation P193A in mice is partially penetrant.
Volume: 24
Issue: 5
Pages: e55835
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Publication
34969816 | J:320956
 
First Author: Guo X
Year: 2022
Journal: Life Sci Alliance
Title: ADAR1 RNA editing regulates endothelial cell functions via the MDA-5 RNA sensing signaling pathway.
Volume: 5
Issue: 3
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Publication
37421629 | J:354327
First Author: Guo X
Year: 2023
Journal: Cell Rep
Title: ADAR1 Z? domain P195A mutation activates the MDA5-dependent RNA-sensing signaling pathway in brain without decreasing overall RNA editing.
Volume: 42
Issue: 7
Pages: 112733
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Publication
18591409 | J:137451
First Author: Kato H
Year: 2008
Journal: J Exp Med
Title: Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5.
Volume: 205
Issue: 7
Pages: 1601-10
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Publication
23926323 | J:205789
First Author: Lu HL
Year: 2013
Journal: J Immunol
Title: Melanoma differentiation-associated gene 5 senses hepatitis B virus and activates innate immune signaling to suppress virus replication.
Volume: 191
Issue: 6
Pages: 3264-76
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Publication
32396862 | J:328612
First Author: Guallar D
Year: 2020
Journal: Cell Stem Cell
Title: ADAR1-Dependent RNA Editing Promotes MET and iPSC Reprogramming by Alleviating ER Stress.
Volume: 27
Issue: 2
Pages: 300-314.e11
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Publication
23499489 | J:195116
First Author: Wies E
Year: 2013
Journal: Immunity
Title: Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling.
Volume: 38
Issue: 3
Pages: 437-49
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Publication
26275108 | J:226177
First Author: Liddicoat BJ
Year: 2015
Journal: Science
Title: RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself.
Volume: 349
Issue: 6252
Pages: 1115-20
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Publication
31067281 | J:275459
First Author: Veazey JM
Year: 2019
Journal: PLoS One
Title: Distinct roles for MDA5 and TLR3 in the acute response to inhaled double-stranded RNA.
Volume: 14
Issue: 5
Pages: e0216056
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