|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 86 out of 86 for Jmy

0.033s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Family
Description: Junction-mediating and regulatory protein (JMY) is a vertebrate protein that was first identified as a transcriptional co-activator of p53 []. It is a regulator of both transcription and actin filament assembly [, , ]. In the nucleus it acts as a transcriptional coactivator and promotes programmed cell death in response to DNA damage [], whereas in the cytoplasm it promotes actin filament assembly []. JMY can either initiate actin filament formation by binding and activating the Arp2/3 complex or nucleate filaments directly in a SPIRE-like fashion [, ]. In both cases, the JMY's actin-regulatory activity relies on a cluster of three actin-binding WH2 domains at its C terminus [].
Publication
First Author: Zuchero JB
Year: 2009
Journal: Nat Cell Biol
Title: p53-cofactor JMY is a multifunctional actin nucleation factor.
Volume: 11
Issue: 4
Pages: 451-9
Publication
First Author: Coutts AS
Year: 2007
Journal: EMBO Rep
Title: Mdm2 targets the p53 transcription cofactor JMY for degradation.
Volume: 8
Issue: 1
Pages: 84-90
Publication
First Author: Shikama N
Year: 1999
Journal: Mol Cell
Title: A novel cofactor for p300 that regulates the p53 response.
Volume: 4
Issue: 3
Pages: 365-76
Publication
First Author: Zuchero JB
Year: 2012
Journal: Mol Biol Cell
Title: Actin binding to WH2 domains regulates nuclear import of the multifunctional actin regulator JMY.
Volume: 23
Issue: 5
Pages: 853-63
Publication
First Author: Liu Y
Year: 2020
Journal: FEBS J
Title: JMY expression by Sertoli cells contributes to mediating spermatogenesis in mice.
Volume: 287
Issue: 24
Pages: 5478-5497
Publication
First Author: Lin Z
Year: 2014
Journal: PLoS One
Title: JMY functions as actin nucleation-promoting factor and mediator for p53-mediated DNA damage in porcine oocytes.
Volume: 9
Issue: 10
Pages: e109385
Protein
Organism: Mus musculus
Length: 446  
Fragment?: false
Protein
Organism: Mus musculus
Length: 983  
Fragment?: false
Protein
Organism: Mus musculus
Length: 983  
Fragment?: false
Publication
First Author: Campellone KG
Year: 2010
Journal: Nat Rev Mol Cell Biol
Title: A nucleator arms race: cellular control of actin assembly.
Volume: 11
Issue: 4
Pages: 237-51
Gene
Type: gene
Organism: Drosophila melanogaster
Publication
First Author: Liu J
Year: 2012
Journal: PLoS One
Title: Nucleation promoting factors regulate the expression and localization of Arp2/3 complex during meiosis of mouse oocytes.
Volume: 7
Issue: 12
Pages: e52277
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression    
Probe: MGI:5817978
Assay Type: RT-PCR
Annotation Date: 2017-01-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598827
Stage: TS27
Assay Id: MGI:5818010
Age: postnatal day 1
Image: 7
Specimen Label: Kbtbd5+/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5817978
Assay Type: RT-PCR
Annotation Date: 2017-01-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598827
Stage: TS27
Assay Id: MGI:5818010
Age: postnatal day 1
Image: 7
Specimen Label: Kbtbd5-/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5817978
Assay Type: RT-PCR
Annotation Date: 2017-01-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598827
Stage: TS27
Assay Id: MGI:5818019
Age: postnatal day 1
Image: 8
Specimen Label: Kbtbd5+/+;E2F1-/-
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5817978
Assay Type: RT-PCR
Annotation Date: 2017-01-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598827
Stage: TS27
Assay Id: MGI:5818019
Age: postnatal day 1
Image: 8
Specimen Label: Kbtbd5-/-;E2F1-/-
Detected: true
Specimen Num: 2
Publication
First Author: Demonacos C
Year: 2001
Journal: Mol Cell
Title: A TPR motif cofactor contributes to p300 activity in the p53 response.
Volume: 8
Issue: 1
Pages: 71-84
Publication
First Author: Gong W
Year: 2015
Journal: J Biol Chem
Title: Kelch Repeat and BTB Domain Containing Protein 5 (Kbtbd5) Regulates Skeletal Muscle Myogenesis through the E2F1-DP1 Complex.
Volume: 290
Issue: 24
Pages: 15350-61
Publication
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Author
Author
Publication
First Author: Hu X
Year: 2019
Journal: J Cell Biol
Title: LC3 and STRAP regulate actin filament assembly by JMY during autophagosome formation.
Volume: 218
Issue: 1
Pages: 251-266
Publication
First Author: Schl├╝ter K
Year: 2014
Journal: Eur J Cell Biol
Title: JMY is involved in anterograde vesicle trafficking from the trans-Golgi network.
Volume: 93
Issue: 5-6
Pages: 194-204
Interaction Experiment
Description: Mdm2 targets the p53 transcription cofactor JMY for degradation.
Publication
First Author: Davey RA
Year: 2017
Journal: Endocrinology
Title: Androgen Action via the Androgen Receptor in Neurons Within the Brain Positively Regulates Muscle Mass in Male Mice.
Volume: 158
Issue: 10
Pages: 3684-3695
Publication
First Author: Fan Q
Year: 2021
Journal: Oncogene
Title: Statins repress hedgehog signaling in medulloblastoma with no bone toxicities.
Volume: 40
Issue: 12
Pages: 2258-2272
Publication
First Author: Du F
Year: 2019
Journal: Clin Cancer Res
Title: Leukotriene Synthesis Is Critical for Medulloblastoma Progression.
Volume: 25
Issue: 21
Pages: 6475-6486
Publication
First Author: Liu Y
Year: 2017
Journal: Cancer Res
Title: Astrocytes Promote Medulloblastoma Progression through Hedgehog Secretion.
Volume: 77
Issue: 23
Pages: 6692-6703
Protein Domain
Type: Domain
Description: JMY (junction-mediating and -regulatory protein) []and WHAMM (WASP homologue-associated protein with actin, membranes and microtubules) []are two nucleation-promoting factors (NPFs) with similar domain architecture. JMY was originally identified as a transcriptional co-factor in the p53-response to DNA damage. Aside from this nuclear function, JMY is involved in cytoskeleton remodelling and trans-Golgi transport []. WHAMM binds microtubules and is involved in ER to cis-Golgi transport []. JMY and WHAMM show similar localisation and could be involved in similar processes []. This middle domain is the coiled-coil region that putatively binds microtubules to the scaffold. This ability to interact with microtubules plays a role in membrane tubulation.
Publication
First Author: Kast DJ
Year: 2015
Journal: Curr Biol
Title: WHAMM Directs the Arp2/3 Complex to the ER for Autophagosome Biogenesis through an Actin Comet Tail Mechanism.
Volume: 25
Issue: 13
Pages: 1791-7
Protein
Organism: Mus musculus
Length: 248  
Fragment?: false
Publication
First Author: Campellone KG
Year: 2008
Journal: Cell
Title: WHAMM is an Arp2/3 complex activator that binds microtubules and functions in ER to Golgi transport.
Volume: 134
Issue: 1
Pages: 148-61
Protein Domain
Type: Domain
Description: This is the N-terminal domain of WHAMM (WASP homologue-associated protein with actin, membranes and microtubules) and JMY (junction-mediating and -regulatory protein), two nucleation-promoting factors (NPFs) with similar domain architecture []. The function of this conserved region is not known; there are two highly conserved tryptophan residues.
Protein
Organism: Mus musculus
Length: 793  
Fragment?: false
Publication
First Author: Adams CJ
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure.
Volume: 109
Issue: 10
Pages: 3778-83
Publication
First Author: Kabrawala S
Year: 2020
Journal: PLoS Genet
Title: WHIMP links the actin nucleation machinery to Src-family kinase signaling during protrusion and motility.
Volume: 16
Issue: 3
Pages: e1008694