Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Killer cell lectin-like receptor subfamily G member 1 (KLRG1) is a co-inhibitory receptor inhibiting the activity of T and NK cells []. Its ligands include E-cadherin and N-cadherin. Binding of E-cadherin to KLRG1 has been shown to inhibits effector T-cell function []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Tata A |
Year: |
2021 |
Journal: |
Oncoimmunology |
Title: |
Combination blockade of KLRG1 and PD-1 promotes immune control of local and disseminated cancers. |
Volume: |
10 |
Issue: |
1 |
Pages: |
1933808 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li Y |
Year: |
2009 |
Journal: |
Immunity |
Title: |
Structure of natural killer cell receptor KLRG1 bound to E-cadherin reveals basis for MHC-independent missing self recognition. |
Volume: |
31 |
Issue: |
1 |
Pages: |
35-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Meinicke H |
Year: |
2017 |
Journal: |
Immunology |
Title: |
KLRG1 impairs regulatory T-cell competitive fitness in the gut. |
Volume: |
152 |
Issue: |
1 |
Pages: |
65-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rosshart S |
Year: |
2008 |
Journal: |
Eur J Immunol |
Title: |
Interaction of KLRG1 with E-cadherin: new functional and structural insights. |
Volume: |
38 |
Issue: |
12 |
Pages: |
3354-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schwartzkopff S |
Year: |
2015 |
Journal: |
Eur J Immunol |
Title: |
TGF-β downregulates KLRG1 expression in mouse and human CD8(+) T cells. |
Volume: |
45 |
Issue: |
8 |
Pages: |
2212-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hofmann M |
Year: |
2012 |
Journal: |
Eur J Immunol |
Title: |
Different inhibitory capacities of human and mouse KLRG1 are linked to distinct disulfide-mediated oligomerizations. |
Volume: |
42 |
Issue: |
9 |
Pages: |
2484-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thimme R |
Year: |
2005 |
Journal: |
J Virol |
Title: |
Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation. |
Volume: |
79 |
Issue: |
18 |
Pages: |
12112-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Banh C |
Year: |
2009 |
Journal: |
Blood |
Title: |
Immunoregulatory functions of KLRG1 cadherin interactions are dependent on forward and reverse signaling. |
Volume: |
114 |
Issue: |
26 |
Pages: |
5299-306 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huntington ND |
Year: |
2007 |
Journal: |
J Immunol |
Title: |
NK cell maturation and peripheral homeostasis is associated with KLRG1 up-regulation. |
Volume: |
178 |
Issue: |
8 |
Pages: |
4764-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gründemann C |
Year: |
2010 |
Journal: |
Eur J Immunol |
Title: |
The NK receptor KLRG1 is dispensable for virus-induced NK and CD8+ T-cell differentiation and function in vivo. |
Volume: |
40 |
Issue: |
5 |
Pages: |
1303-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hochheiser K |
Year: |
2021 |
Journal: |
J Exp Med |
Title: |
Ptpn2 and KLRG1 regulate the generation and function of tissue-resident memory CD8+ T cells in skin. |
Volume: |
218 |
Issue: |
6 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Nakamura S |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
Molecular basis for E-cadherin recognition by killer cell lectin-like receptor G1 (KLRG1). |
Volume: |
284 |
Issue: |
40 |
Pages: |
27327-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Montufar-Solis D |
Year: |
2017 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Involvement of Ly6C, 4-1BB, and KLRG1 in the activation of lamina propria lymphocytes in the small intestine of sanroque mice. |
Volume: |
483 |
Issue: |
1 |
Pages: |
590-595 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
188
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Voehringer D |
Year: |
2001 |
Journal: |
Immunogenetics |
Title: |
Genomic structure, alternative splicing, and physical mapping of the killer cell lectin-like receptor G1 gene (KLRG1), the mouse homologue of MAFA. |
Volume: |
52 |
Issue: |
3-4 |
Pages: |
206-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cyktor JC |
Year: |
2013 |
Journal: |
Infect Immun |
Title: |
Killer cell lectin-like receptor G1 deficiency significantly enhances survival after Mycobacterium tuberculosis infection. |
Volume: |
81 |
Issue: |
4 |
Pages: |
1090-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Corral L |
Year: |
2000 |
Journal: |
Eur J Immunol |
Title: |
NK cell expression of the killer cell lectin-like receptor G1 (KLRG1), the mouse homolog of MAFA, is modulated by MHC class I molecules. |
Volume: |
30 |
Issue: |
3 |
Pages: |
920-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Göthert JR |
Year: |
2013 |
Journal: |
Cancer Immunol Immunother |
Title: |
Expanded CD8+ T cells of murine and human CLL are driven into a senescent KLRG1+ effector memory phenotype. |
Volume: |
62 |
Issue: |
11 |
Pages: |
1697-1709 |
|
•
•
•
•
•
|
Publication |
First Author: |
Herndler-Brandstetter D |
Year: |
2018 |
Journal: |
Immunity |
Title: |
KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity. |
Volume: |
48 |
Issue: |
4 |
Pages: |
716-729.e8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gründemann C |
Year: |
2006 |
Journal: |
J Immunol |
Title: |
Cutting edge: identification of E-cadherin as a ligand for the murine killer cell lectin-like receptor G1. |
Volume: |
176 |
Issue: |
3 |
Pages: |
1311-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Renkema KR |
Year: |
2020 |
Journal: |
J Immunol |
Title: |
KLRG1+ Memory CD8 T Cells Combine Properties of Short-Lived Effectors and Long-Lived Memory. |
Volume: |
205 |
Issue: |
4 |
Pages: |
1059-1069 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cheng G |
Year: |
2012 |
Journal: |
J Immunol |
Title: |
IL-2 receptor signaling is essential for the development of Klrg1+ terminally differentiated T regulatory cells. |
Volume: |
189 |
Issue: |
4 |
Pages: |
1780-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ito M |
Year: |
2006 |
Journal: |
J Exp Med |
Title: |
Killer cell lectin-like receptor G1 binds three members of the classical cadherin family to inhibit NK cell cytotoxicity. |
Volume: |
203 |
Issue: |
2 |
Pages: |
289-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gurram RK |
Year: |
2023 |
Journal: |
Cell Rep |
Title: |
Crosstalk between ILC2s and Th2 cells varies among mouse models. |
Volume: |
42 |
Issue: |
2 |
Pages: |
112073 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tauro S |
Year: |
2013 |
Journal: |
Eur J Immunol |
Title: |
Diversification and senescence of Foxp3+ regulatory T cells during experimental autoimmune encephalomyelitis. |
Volume: |
43 |
Issue: |
5 |
Pages: |
1195-207 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Publication |
First Author: |
Hanke T |
Year: |
1998 |
Journal: |
Eur J Immunol |
Title: |
2F1 antigen, the mouse homolog of the rat "mast cell function-associated antigen", is a lectin-like type II transmembrane receptor expressed by natural killer cells. |
Volume: |
28 |
Issue: |
12 |
Pages: |
4409-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Blaser C |
Year: |
1998 |
Journal: |
J Immunol |
Title: |
Virus-activated CD8 T cells and lymphokine-activated NK cells express the mast cell function-associated antigen, an inhibitory C-type lectin. |
Volume: |
161 |
Issue: |
12 |
Pages: |
6451-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shimizu K |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
KLRG+ invariant natural killer T cells are long-lived effectors. |
Volume: |
111 |
Issue: |
34 |
Pages: |
12474-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Robbins SH |
Year: |
2004 |
Journal: |
J Immunol |
Title: |
Expansion and contraction of the NK cell compartment in response to murine cytomegalovirus infection. |
Volume: |
173 |
Issue: |
1 |
Pages: |
259-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wilson DC |
Year: |
2008 |
Journal: |
J Immunol |
Title: |
IL-12 signaling drives CD8+ T cell IFN-gamma production and differentiation of KLRG1+ effector subpopulations during Toxoplasma gondii Infection. |
Volume: |
180 |
Issue: |
9 |
Pages: |
5935-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vesper AH |
Year: |
2006 |
Journal: |
Endocrinology |
Title: |
Role of prophet of Pit1 (PROP1) in gonadotrope differentiation and puberty. |
Volume: |
147 |
Issue: |
4 |
Pages: |
1654-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Burton OT |
Year: |
2024 |
Journal: |
Immunity |
Title: |
The tissue-resident regulatory TÂ cell pool is shaped by transient multi-tissue migration and a conserved residency program. |
Volume: |
57 |
Issue: |
7 |
Pages: |
1586-1602.e10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin SL |
Year: |
2008 |
Journal: |
Am J Pathol |
Title: |
Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. |
Volume: |
173 |
Issue: |
6 |
Pages: |
1617-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mackay LK |
Year: |
2013 |
Journal: |
Nat Immunol |
Title: |
The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin. |
Volume: |
14 |
Issue: |
12 |
Pages: |
1294-301 |
|
•
•
•
•
•
|
Publication |
First Author: |
Knell J |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
Id2 influences differentiation of killer cell lectin-like receptor G1(hi) short-lived CD8+ effector T cells. |
Volume: |
190 |
Issue: |
4 |
Pages: |
1501-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu M |
Year: |
2021 |
Journal: |
Front Immunol |
Title: |
Single-Cell Sequencing Reveals the Novel Role of Ezh2 in NK Cell Maturation and Function. |
Volume: |
12 |
|
Pages: |
724276 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jänner N |
Year: |
2008 |
Journal: |
Immunology |
Title: |
Restricted expression of C-type lectin-like natural killer receptors by CD8 T cells in the murine small intestine. |
Volume: |
125 |
Issue: |
1 |
Pages: |
38-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Meinicke H |
Year: |
2017 |
Journal: |
Immunology |
Title: |
Tumour-associated changes in intestinal epithelial cells cause local accumulation of KLRG1+ GATA3+ regulatory T cells in mice. |
Volume: |
152 |
Issue: |
1 |
Pages: |
74-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Andrews TD |
Year: |
2012 |
Journal: |
Open Biol |
Title: |
Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models. |
Volume: |
2 |
Issue: |
5 |
Pages: |
120061 |
|
•
•
•
•
•
|
Publication |
First Author: |
Böing M |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
Murine transcription factor Math6 is a regulator of placenta development. |
Volume: |
8 |
Issue: |
1 |
Pages: |
14997 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mathieu C |
Year: |
2015 |
Journal: |
Eur J Immunol |
Title: |
IL-2 and IL-15 regulate CD8+ memory T-cell differentiation but are dispensable for protective recall responses. |
Volume: |
45 |
Issue: |
12 |
Pages: |
3324-38 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nishikii H |
Year: |
2016 |
Journal: |
Blood |
Title: |
DR3 signaling modulates the function of Foxp3+ regulatory T cells and the severity of acute graft-versus-host disease. |
Volume: |
128 |
Issue: |
24 |
Pages: |
2846-2858 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nagashima T |
Year: |
2013 |
Journal: |
J Clin Invest |
Title: |
BMPR2 is required for postimplantation uterine function and pregnancy maintenance. |
Volume: |
123 |
Issue: |
6 |
Pages: |
2539-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Australian Phenomics Facility at The Australian National University |
Year: |
2006 |
Journal: |
MGI Direct Data Submission |
Title: |
Heritable mouse mutants from the ENU mutagenesis program at the Australian Phenomics Facility at The Australian National University |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
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|
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•
•
•
•
•
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
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|
|
•
•
•
•
•
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Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
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•
•
•
•
•
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Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
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|
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•
•
•
•
•
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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•
•
•
•
•
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Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
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|
|
•
•
•
•
•
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Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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|
|
|
•
•
•
•
•
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
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|
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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|
|
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•
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Allele |
Name: |
killer cell lectin-like receptor subfamily G, member 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
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Publication |
First Author: |
Tessmer MS |
Year: |
2007 |
Journal: |
Int Immunol |
Title: |
KLRG1 binds cadherins and preferentially associates with SHIP-1. |
Volume: |
19 |
Issue: |
4 |
Pages: |
391-400 |
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Allele |
Name: |
killer cell lectin-like receptor subfamily G, member 1; endonuclease-mediated mutation 1, Laurent Brossay |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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Allele |
Name: |
killer cell lectin-like receptor subfamily G, member 1; targeted mutation 1.1, Richard A Flavell |
Allele Type: |
Targeted |
Attribute String: |
Recombinase, Reporter |
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Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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MP Term |
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MP Term |
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