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Search results 1 to 100 out of 1939 for Lck

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Garvin AM
Year: 1988
Journal: Mol Cell Biol
Title: Structure of the murine lck gene and its rearrangement in a murine lymphoma cell line.
Volume: 8
Issue: 8
Pages: 3058-64
Publication
First Author: Voronova AF
Year: 1987
Journal: Mol Cell Biol
Title: Two lck transcripts containing different 5' untranslated regions are present in T cells.
Volume: 7
Issue: 12
Pages: 4407-13
Publication
First Author: Carow B
Year: 2016
Journal: J Immunol
Title: lck-Driven Cre Expression Alters T Cell Development in the Thymus and the Frequencies and Functions of Peripheral T Cell Subsets.
Volume: 197
Issue: 6
Pages: 2261-8
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Cao Y
Year: 2011
Journal: EMBO J
Title: LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection.
Volume: 30
Issue: 10
Pages: 2083-93
Publication
First Author: Tran DD
Year: 2005
Journal: Immunity
Title: CAML is a p56Lck-interacting protein that is required for thymocyte development.
Volume: 23
Issue: 2
Pages: 139-52
Publication
First Author: Abraham KM
Year: 1991
Journal: Proc Natl Acad Sci U S A
Title: Thymic tumorigenesis induced by overexpression of p56lck.
Volume: 88
Issue: 9
Pages: 3977-81
Publication
First Author: Molina TJ
Year: 1992
Journal: Nature
Title: Profound block in thymocyte development in mice lacking p56lck.
Volume: 357
Issue: 6374
Pages: 161-4
Publication
First Author: Wildin RS
Year: 1995
Journal: J Immunol
Title: Functional dissection of the murine lck distal promoter.
Volume: 155
Issue: 3
Pages: 1286-95
Publication
First Author: Omri B
Year: 1996
Journal: J Neurochem
Title: The Lck tyrosine kinase is expressed in brain neurons.
Volume: 67
Issue: 4
Pages: 1360-4
Publication
First Author: Marth JD
Year: 1985
Journal: Cell
Title: A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA.
Volume: 43
Issue: 2 Pt 1
Pages: 393-404
Publication
First Author: Voronova AF
Year: 1986
Journal: Nature
Title: Expression of a new tyrosine protein kinase is stimulated by retrovirus promoter insertion.
Volume: 319
Issue: 6055
Pages: 682-5
Publication
First Author: Tsun A
Year: 2011
Journal: J Cell Biol
Title: Centrosome docking at the immunological synapse is controlled by Lck signaling.
Volume: 192
Issue: 4
Pages: 663-74
Publication
First Author: Kemp KL
Year: 2010
Journal: J Immunol
Title: Lck mediates Th2 differentiation through effects on T-bet and GATA-3.
Volume: 184
Issue: 8
Pages: 4178-84
Publication
First Author: Wildin RS
Year: 1991
Journal: J Exp Med
Title: Developmental regulation of lck gene expression in T lymphocytes.
Volume: 173
Issue: 2
Pages: 383-93
Publication
First Author: Lefebvre DC
Year: 2003
Journal: Biochim Biophys Acta
Title: The noncatalytic domains of Lck regulate its dephosphorylation by CD45.
Volume: 1650
Issue: 1-2
Pages: 40-9
Publication
First Author: Lo WL
Year: 2018
Journal: Nat Immunol
Title: Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT.
Volume: 19
Issue: 7
Pages: 733-741
Publication
First Author: Groves T
Year: 1996
Journal: Immunity
Title: Fyn can partially substitute for Lck in T lymphocyte development.
Volume: 5
Issue: 5
Pages: 417-28
Publication
First Author: Kemp KL
Year: 2010
Journal: Eur J Immunol
Title: Lck regulates IL-10 expression in memory-like Th1 cells.
Volume: 40
Issue: 11
Pages: 3210-9
Publication
First Author: Wei Q
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Lck bound to coreceptor is less active than free Lck.
Volume: 117
Issue: 27
Pages: 15809-15817
Publication
First Author: Lefebvre DC
Year: 2010
Journal: Mol Immunol
Title: CD44 interacts directly with Lck in a zinc-dependent manner.
Volume: 47
Issue: 10
Pages: 1882-9
Publication
First Author: Legname G
Year: 2000
Journal: Immunity
Title: Inducible expression of a p56Lck transgene reveals a central role for Lck in the differentiation of CD4 SP thymocytes.
Volume: 12
Issue: 5
Pages: 537-46
Publication
First Author: Tewari K
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Differential requirement for Lck during primary and memory CD8+ T cell responses.
Volume: 103
Issue: 44
Pages: 16388-93
Publication
First Author: Marhäll A
Year: 2017
Journal: Sci Rep
Title: The Src family kinase LCK cooperates with oncogenic FLT3/ITD in cellular transformation.
Volume: 7
Issue: 1
Pages: 13734
Publication
First Author: Salmond RJ
Year: 2011
Journal: Blood
Title: Mislocalization of Lck impairs thymocyte differentiation and can promote development of thymomas.
Volume: 117
Issue: 1
Pages: 108-17
Publication
First Author: Mombaerts P
Year: 1994
Journal: Immunity
Title: An activated lck transgene promotes thymocyte development in RAG-1 mutant mice.
Volume: 1
Issue: 4
Pages: 261-7
Publication
First Author: Adler HT
Year: 1988
Journal: J Virol
Title: Transcriptional activation of lck by retrovirus promoter insertion between two lymphoid-specific promoters.
Volume: 62
Issue: 11
Pages: 4113-22
Publication
First Author: Adler HT
Year: 1992
Journal: Oncogene
Title: Generation and characterization of transforming variants of the lck tyrosine protein kinase.
Volume: 7
Issue: 6
Pages: 1191-9
Publication
First Author: Trobridge PA
Year: 2001
Journal: Eur J Immunol
Title: Lck plays a critical role in Ca(2+) mobilization and CD28 costimulation in mature primary T cells.
Volume: 31
Issue: 12
Pages: 3567-79
Publication  
First Author: Märklin M
Year: 2020
Journal: Front Immunol
Title: Genetic Loss of LCK Kinase Leads to Acceleration of Chronic Lymphocytic Leukemia.
Volume: 11
Pages: 1995
Publication
First Author: Pathan NI
Year: 1996
Journal: J Biol Chem
Title: The protein-tyrosine kinase Lck associates with and is phosphorylated by Cdc2.
Volume: 271
Issue: 44
Pages: 27517-23
Publication
First Author: Trobridge PA
Year: 2001
Journal: J Immunol
Title: Positive and negative selection of thymocytes depends on Lck interaction with the CD4 and CD8 coreceptors.
Volume: 166
Issue: 2
Pages: 809-18
Publication
First Author: Yu XZ
Year: 2004
Journal: J Immunol
Title: Lck is required for activation-induced T cell death after TCR ligation with partial agonists.
Volume: 172
Issue: 3
Pages: 1437-43
Publication
First Author: Van Laethem F
Year: 2013
Journal: Cell
Title: Lck availability during thymic selection determines the recognition specificity of the T cell repertoire.
Volume: 154
Issue: 6
Pages: 1326-41
Publication
First Author: Lovatt M
Year: 2006
Journal: Mol Cell Biol
Title: Lck regulates the threshold of activation in primary T cells, while both Lck and Fyn contribute to the magnitude of the extracellular signal-related kinase response.
Volume: 26
Issue: 22
Pages: 8655-65
Publication
First Author: Rudd ML
Year: 2006
Journal: Mol Cell Biol
Title: Lck SH3 domain function is required for T-cell receptor signals regulating thymocyte development.
Volume: 26
Issue: 21
Pages: 7892-900
Publication
First Author: Mori T
Year: 1992
Journal: Biochem Biophys Res Commun
Title: Expression of the signal transducing regions of CD4-like and lck genes in murine egg.
Volume: 182
Issue: 2
Pages: 527-33
Publication
First Author: Courtney AH
Year: 2017
Journal: Mol Cell
Title: A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45.
Volume: 67
Issue: 3
Pages: 498-511.e6
Publication
First Author: Lin K
Year: 2000
Journal: J Exp Med
Title: Lck domains differentially contribute to pre-T cell receptor (TCR)- and TCR-alpha/beta-regulated developmental transitions.
Volume: 191
Issue: 4
Pages: 703-16
Publication
First Author: Yu CL
Year: 1997
Journal: J Immunol
Title: Constitutive activation of the Janus kinase-STAT pathway in T lymphoma overexpressing the Lck protein tyrosine kinase.
Volume: 159
Issue: 11
Pages: 5206-10
Publication
First Author: Hawash IY
Year: 2002
Journal: J Biol Chem
Title: The Lck SH3 domain negatively regulates localization to lipid rafts through an interaction with c-Cbl.
Volume: 277
Issue: 7
Pages: 5683-91
Publication
First Author: Dobbins J
Year: 2016
Journal: Sci Signal
Title: Binding of the cytoplasmic domain of CD28 to the plasma membrane inhibits Lck recruitment and signaling.
Volume: 9
Issue: 438
Pages: ra75
Publication
First Author: Straus DB
Year: 1992
Journal: Cell
Title: Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor.
Volume: 70
Issue: 4
Pages: 585-93
Publication
First Author: Chae HD
Year: 2010
Journal: PLoS One
Title: RhoH regulates subcellular localization of ZAP-70 and Lck in T cell receptor signaling.
Volume: 5
Issue: 11
Pages: e13970
Publication
First Author: Laird RM
Year: 2010
Journal: PLoS One
Title: Roles of the Src tyrosine kinases Lck and Fyn in regulating gammadeltaTCR signal strength.
Volume: 5
Issue: 1
Pages: e8899
Publication
First Author: Semple K
Year: 2011
Journal: Blood
Title: Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling.
Volume: 117
Issue: 11
Pages: 3096-103
Publication
First Author: Page ST
Year: 1997
Journal: Eur J Immunol
Title: Differential contribution of Lck and Fyn protein tyrosine kinases to intraepithelial lymphocyte development.
Volume: 27
Issue: 2
Pages: 554-62
Publication
First Author: Harr MW
Year: 2010
Journal: Cell Death Differ
Title: Inhibition of Lck enhances glucocorticoid sensitivity and apoptosis in lymphoid cell lines and in chronic lymphocytic leukemia.
Volume: 17
Issue: 9
Pages: 1381-91
Publication
First Author: van Oers NS
Year: 1996
Journal: Immunity
Title: alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases.
Volume: 5
Issue: 5
Pages: 429-36
Publication
First Author: Lee JM
Year: 1996
Journal: Oncogene
Title: Association of CD45 with Lck and components of the Ras signalling pathway in pervanadate-treated mouse T-cell lines.
Volume: 12
Issue: 2
Pages: 253-63
Publication
First Author: Wang Y
Year: 2005
Journal: J Biol Chem
Title: Expression of CD45 lacking the catalytic protein tyrosine phosphatase domain modulates Lck phosphorylation and T cell activation.
Volume: 280
Issue: 14
Pages: 14318-24
Publication
First Author: Chiang YJ
Year: 2016
Journal: Eur J Immunol
Title: T-cell development is regulated by the coordinated function of proximal and distal Lck promoters active at different developmental stages.
Volume: 46
Issue: 10
Pages: 2401-2408
Publication
First Author: Filipp D
Year: 2004
Journal: J Immunol
Title: Enrichment of lck in lipid rafts regulates colocalized fyn activation and the initiation of proximal signals through TCR alpha beta.
Volume: 172
Issue: 7
Pages: 4266-74
Publication
First Author: Wu G
Year: 1996
Journal: Int Immunol
Title: Lck dependence of signaling pathways activated by gamma-irradiation and CD3 epsilon engagement in RAG-1(-/-)-immature thymocytes.
Volume: 8
Issue: 7
Pages: 1159-64
Publication
First Author: Kabouridis PS
Year: 2003
Journal: Biochem J
Title: Selective interaction of LAT (linker of activated T cells) with the open-active form of Lck in lipid rafts reveals a new mechanism for the regulation of Lck in T cells.
Volume: 371
Issue: Pt 3
Pages: 907-15
Publication
First Author: Stephen TL
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Subcellular distribution of Lck during CD4 T-cell maturation in the thymic medulla regulates the T-cell activation threshold.
Volume: 109
Issue: 19
Pages: 7415-20
Publication
First Author: Granum S
Year: 2014
Journal: Sci Signal
Title: The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192.
Volume: 7
Issue: 355
Pages: ra118
Publication
First Author: Zhou RW
Year: 2014
Journal: Nat Immunol
Title: N-glycosylation bidirectionally extends the boundaries of thymocyte positive selection by decoupling Lck from Ca²⁺ signaling.
Volume: 15
Issue: 11
Pages: 1038-45
Publication
First Author: Zhang DJ
Year: 2005
Journal: J Immunol
Title: Selective expression of the Cre recombinase in late-stage thymocytes using the distal promoter of the Lck gene.
Volume: 174
Issue: 11
Pages: 6725-31
Publication
First Author: Yasuda K
Year: 2002
Journal: J Immunol
Title: Cutting edge: Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells.
Volume: 169
Issue: 6
Pages: 2813-7
Publication
First Author: Bachmaier K
Year: 2000
Journal: Nature
Title: Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b.
Volume: 403
Issue: 6766
Pages: 211-6
Publication
First Author: Seddon B
Year: 2000
Journal: Science
Title: Long-term survival but impaired homeostatic proliferation of Naïve T cells in the absence of p56lck.
Volume: 290
Issue: 5489
Pages: 127-31
Publication
First Author: Seddon B
Year: 2002
Journal: J Immunol
Title: TCR signals mediated by Src family kinases are essential for the survival of naive T cells.
Volume: 169
Issue: 6
Pages: 2997-3005
Publication
First Author: Leung BL
Year: 1999
Journal: J Immunol
Title: TCR alpha beta-independent CD28 signaling and costimulation require non-CD4-associated Lck.
Volume: 163
Issue: 3
Pages: 1334-41
Publication
First Author: Fiala GJ
Year: 2019
Journal: J Immunol
Title: Proximal Lck Promoter-Driven Cre Function Is Limited in Neonatal and Ineffective in Adult γδ T Cell Development.
Volume: 203
Issue: 2
Pages: 569-579
Publication
First Author: Molina TJ
Year: 1998
Journal: J Immunol
Title: Differential requirement for p56lck in fetal and adult thymopoiesis.
Volume: 160
Issue: 8
Pages: 3828-34
Publication
First Author: Marth JD
Year: 1986
Journal: Proc Natl Acad Sci U S A
Title: Localization of a lymphocyte-specific protein tyrosine kinase gene (lck) at a site of frequent chromosomal abnormalities in human lymphomas.
Volume: 83
Issue: 19
Pages: 7400-4
Publication
First Author: Dal Porto JM
Year: 2004
Journal: Immunity
Title: Regulation of BCR signal transduction in B-1 cells requires the expression of the Src family kinase Lck.
Volume: 21
Issue: 3
Pages: 443-53
Publication
First Author: Campi G
Year: 2005
Journal: J Exp Med
Title: Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling.
Volume: 202
Issue: 8
Pages: 1031-6
Publication
First Author: Schoenborn JR
Year: 2011
Journal: Sci Signal
Title: Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling.
Volume: 4
Issue: 190
Pages: ra59
Publication
First Author: Tan TCJ
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Suboptimal T-cell receptor signaling compromises protein translation, ribosome biogenesis, and proliferation of mouse CD8 T cells.
Volume: 114
Issue: 30
Pages: E6117-E6126
Publication
First Author: Morahan G
Year: 1993
Journal: Genomics
Title: Localization of the mouse Na+/H+ exchanger gene on distal chromosome 4.
Volume: 15
Issue: 1
Pages: 231-2
Publication
First Author: Torre S
Year: 2015
Journal: Infect Immun
Title: THEMIS is required for pathogenesis of cerebral malaria and protection against pulmonary tuberculosis.
Volume: 83
Issue: 2
Pages: 759-68
Publication
First Author: Kumar L
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function.
Volume: 102
Issue: 52
Pages: 19063-8
Publication
First Author: Fusaki N
Year: 1997
Journal: J Biol Chem
Title: Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling.
Volume: 272
Issue: 10
Pages: 6214-9
Publication
First Author: Macdonald A
Year: 2004
Journal: J Gen Virol
Title: The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity.
Volume: 85
Issue: Pt 3
Pages: 721-9
Publication
First Author: De Cunto G
Year: 2016
Journal: Am J Pathol
Title: Severe Reduction in Number and Function of Peripheral T Cells Does Not Afford Protection toward Emphysema and Bronchial Remodeling Induced in Mice by Cigarette Smoke.
Volume: 186
Issue: 7
Pages: 1814-24
Publication
First Author: Caserta S
Year: 2010
Journal: J Immunol
Title: Reduced functional avidity promotes central and effector memory CD4 T cell responses to tumor-associated antigens.
Volume: 185
Issue: 11
Pages: 6545-54
Publication
First Author: Molina TJ
Year: 1993
Journal: J Immunol
Title: Peripheral T cells in mice lacking p56lck do not express significant antiviral effector functions.
Volume: 151
Issue: 2
Pages: 699-706
Publication
First Author: Wen T
Year: 1995
Journal: Eur J Immunol
Title: Allo-skin graft rejection, tumor rejection and natural killer activity in mice lacking p56lck.
Volume: 25
Issue: 11
Pages: 3155-9
Publication
First Author: Omri B
Year: 1998
Journal: Oncogene
Title: Retinal dysplasia in mice lacking p56lck.
Volume: 16
Issue: 18
Pages: 2351-6
Publication
First Author: Ericsson PO
Year: 1995
Journal: Int Immunol
Title: The protein tyrosine kinase p56lck regulates TCR expression and T cell selection.
Volume: 7
Issue: 4
Pages: 617-24
Publication
First Author: McCoy ME
Year: 2010
Journal: J Immunol
Title: Th2-specific immunity and function of peripheral T cells is regulated by the p56Lck Src homology 3 domain.
Volume: 185
Issue: 6
Pages: 3285-94
Publication
First Author: Marth JD
Year: 1988
Journal: Mol Cell Biol
Title: Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck).
Volume: 8
Issue: 2
Pages: 540-50
Publication
First Author: Rozdzial MM
Year: 1998
Journal: J Immunol
Title: pp56Lck mediates TCR zeta-chain binding to the microfilament cytoskeleton.
Volume: 161
Issue: 10
Pages: 5491-9
Publication
First Author: Bae ON
Year: 2012
Journal: J Neurosci
Title: Lymphocyte cell kinase activation mediates neuroprotection during ischemic preconditioning.
Volume: 32
Issue: 21
Pages: 7278-86
Publication
First Author: Linette GP
Year: 1995
Journal: Blood
Title: Peripheral T-cell lymphoma in lckpr-bcl-2 transgenic mice.
Volume: 86
Issue: 4
Pages: 1255-60
Publication      
First Author: Wang KW
Year: 2014
Journal: MGI Direct Data Submission
Title: Direct data submission for mutagenetix entry for swan
Gene
Type: gene
Organism: Rattus norvegicus
Publication
First Author: Reiley WW
Year: 2006
Journal: Nat Immunol
Title: Regulation of T cell development by the deubiquitinating enzyme CYLD.
Volume: 7
Issue: 4
Pages: 411-7
Publication
First Author: Veillette A
Year: 1988
Journal: Cell
Title: The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck.
Volume: 55
Issue: 2
Pages: 301-8
Publication
First Author: Ulivieri C
Year: 2003
Journal: Eur J Immunol
Title: Normal B-1 cell development but defective BCR signaling in Lck-/- mice.
Volume: 33
Issue: 2
Pages: 441-5
Publication  
First Author: Li JP
Year: 2014
Journal: Nat Commun
Title: The phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and autoimmunity by inactivating Lck.
Volume: 5
Pages: 3618
Publication
First Author: Seavitt JR
Year: 1999
Journal: Mol Cell Biol
Title: Expression of the p56(Lck) Y505F mutation in CD45-deficient mice rescues thymocyte development.
Volume: 19
Issue: 6
Pages: 4200-8
Publication
First Author: Fujise S
Year: 1996
Journal: J Immunol
Title: The role of p56lck in the development of gamma delta T cells and their function during an infection by Listeria monocytogenes.
Volume: 157
Issue: 1
Pages: 247-54
Publication
First Author: Yamada H
Year: 1997
Journal: Immunology
Title: p56lck is not essential for the T-cell response to allo-MHC antigens.
Volume: 92
Issue: 1
Pages: 33-8