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Search results 1 to 100 out of 2634 for Lef1

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Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
51176 | LEF1
Type: gene
Organism: human
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Gene
100493178 | lef1
Type: gene
Organism: frog, western clawed
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Gene
161452 | Lef1
Type: gene
Organism: rat
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Gene
461425 | LEF1
Type: gene
Organism: chimpanzee
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Gene
478507 | LEF1
Type: gene
Organism: dog, domestic
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Gene
535399 | LEF1
Type: gene
Organism: cattle
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Gene
395865 | LEF1
Type: gene
Organism: chicken
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Gene
30701 | lef1
Type: gene
Organism: zebrafish
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Gene
695776 | LEF1
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR028769 | LEF1
Type: Family
Description: Lymphoid enhancer-binding factor 1 (LEF-1) belongs to the LEF-1/TCFs (T cell factors) family of transcription factors []. LEF-1 participates in the Wnt signalling pathway, performing its function in complexes with beta-catenin [, , ]. LEF-1 may also acquire diverse regulatory functions by association with Wnt/beta-catenin-independent stimuli, such as the TGF-beta and Notch pathways [, ].
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Protein Coding Gene
MGI:96770 | Lef1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
14691138 | J:87103
First Author: Nawshad A
Year: 2003
Journal: J Cell Biol
Title: TGFbeta3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development.
Volume: 163
Issue: 6
Pages: 1291-301
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Publication
16678815 | J:110699
First Author: Boras-Granic K
Year: 2006
Journal: Dev Biol
Title: Lef1 is required for the transition of Wnt signaling from mesenchymal to epithelial cells in the mouse embryonic mammary gland.
Volume: 295
Issue: 1
Pages: 219-31
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Gene
641518 | LEF1-AS1
Type: gene
Organism: human
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Publication
10933391 | J:63678
First Author: Reya T
Year: 2000
Journal: Immunity
Title: Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism.
Volume: 13
Issue: 1
Pages: 15-24
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GXD Expression
GXD Expression
 
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3271120
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4450873
Age: embryonic day 12.5
Image: Lef1 - E12.5
Note: Staining is either absent or ubiquitous in the postmitotic neurons in the cortical plate of the cerebral cortex.
Specimen Label: Lef1 - E12.5
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3271122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4450873
Age: embryonic day 14.5
Image: Lef1 - E14.5
Note: Staining is either absent or ubiquitous in the postmitotic neurons in the cortical plate of the cerebral cortex.
Specimen Label: Lef1 - E14.5
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3271124
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4450873
Age: embryonic day 16.5
Image: Lef1 - E16.5
Note: Staining is either absent or ubiquitous in the postmitotic neurons in the cortical plate of the cerebral cortex.
Specimen Label: Lef1 - E16.5
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3271224
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4450873
Age: embryonic day 16.5
Image: Lef1 - E16.5
Note: Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone of the cerebral cortex.
Specimen Label: Lef1 - E16.5
Specimen Num: 12
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GXD Expression
GXD Expression
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1754320
Pattern: Non-Uniform
Stage: TS20
Assay Id: MGI:4450873
Age: embryonic day 12.5
Image: Lef1 - E12.5
Note: There is moderate staining in the ventricular zone of the prethalamus. Staining is either absent or ubiquitous in the ventricular zone of the dorsal thalamus.
Specimen Label: Lef1 - E12.5
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1754322
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4450873
Age: embryonic day 14.5
Image: Lef1 - E14.5
Note: Staining is either absent or ubiquitous in the ventricular zone of the dorsal thalamus and prethalamus.
Specimen Label: Lef1 - E14.5
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1754324
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4450873
Age: embryonic day 16.5
Image: Lef1 - E16.5
Note: Staining is either absent or ubiquitous in the ventricular zone of the dorsal thalamus and prethalamus.
Specimen Label: Lef1 - E16.5
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1753720
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4450873
Age: embryonic day 12.5
Image: Lef1 - E12.5
Note: Staining is either absent or ubiquitous in the mantle zone of the dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH and anterior and posterior IDs.
Specimen Label: Lef1 - E12.5
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1753722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4450873
Age: embryonic day 14.5
Image: Lef1 - E14.5
Note: Staining is either absent or ubiquitous in the mantle zone of the dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH and anterior and posterior IDs.
Specimen Label: Lef1 - E14.5
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1753724
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4450873
Age: embryonic day 16.5
Image: Lef1 - E16.5
Note: Staining is either absent or ubiquitous in the mantle zone of the dorsal and ventral POAs, the PVH, SCH, DMH, VMH and ARH nuclei, the AVH, the DAH and the PH.
Specimen Label: Lef1 - E16.5
Specimen Num: 12
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GXD Expression
GXD Expression
Probe: MGI:5629674
Assay Type: Immunohistochemistry
Annotation Date: 2023-03-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685717
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7448480
Age: embryonic day 10.5
Image: 3B E10.5 LEF1
Note: Expression in gonadal progenitors,
Specimen Label: 3B E10.5 LEF1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3271820
Pattern: Non-Uniform
Stage: TS20
Assay Id: MGI:4450873
Age: embryonic day 12.5
Image: Lef1 - E12.5
Note: There is strong staining in the mantle zone of the premam zone. Staining is either absent or ubiquitous in the mantle zone of the mam and supramam zones and the TT.
Specimen Label: Lef1 - E12.5
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3271822
Pattern: Non-Uniform
Stage: TS22
Assay Id: MGI:4450873
Age: embryonic day 14.5
Image: Lef1 - E14.5
Note: There is strong staining in the mantle zone of the premam zone. Staining is either absent or ubiquitous in the mantle zone of the TT and mam and supramam zones.
Specimen Label: Lef1 - E14.5
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3271824
Pattern: Non-Uniform
Stage: TS24
Assay Id: MGI:4450873
Age: embryonic day 16.5
Image: Lef1 - E16.5
Note: There is strong staining in the mantle zone of the premam zone. Staining is either absent or ubiquitous in the mantle zone of the mam and supramam zones.
Specimen Label: Lef1 - E16.5
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1753920
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4450873
Age: embryonic day 12.5
Image: Lef1 - E12.5
Note: Staining is either absent or ubiquitous in the ventricular zone of the dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH and anterior and posterior IDs.
Specimen Label: Lef1 - E12.5
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1753922
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4450873
Age: embryonic day 14.5
Image: Lef1 - E14.5
Note: Staining is either absent or ubiquitous in the ventricular zone of the dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH and anterior and posterior IDs.
Specimen Label: Lef1 - E14.5
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1753924
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4450873
Age: embryonic day 16.5
Image: Lef1 - E16.5
Note: Staining is either absent or ubiquitous in the ventricular zone of the dorsal and ventral POAs, the PVH, SCH, DMH, VMH and ARH nuclei, the AVH, the DAH and the PH.
Specimen Label: Lef1 - E16.5
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1691119
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:4450873
Age: embryonic day 11.5
Image: Lef1 - E11.5
Note: Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone and cortical plate of the cerebral cortex and in the mantle zone of the ganglionic eminences.
Specimen Label: Lef1 - E11.5
Specimen Num: 9
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GXD Expression
GXD Expression
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1754724
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4450873
Age: embryonic day 16.5
Image: Lef1 - E16.5
Note: There is moderate staining in the ventricular zone of the cerebral cortex.
Specimen Label: Lef1 - E16.5
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3271024
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4450873
Age: embryonic day 16.5
Image: Lef1 - E16.5
Note: Staining is either absent or ubiquitous in the ventricular zone of the premam, mam and supramam zones.
Specimen Label: Lef1 - E16.5
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3266524
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4450873
Age: embryonic day 16.5
Image: Lef1 - E16.5
Note: Staining is either absent or ubiquitous in the ventricular and mantle zones of the ganglionic eminences.
Specimen Label: Lef1 - E16.5
Specimen Num: 12
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GXD Expression
GXD Expression
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1754120
Pattern: Non-Uniform
Stage: TS20
Assay Id: MGI:4450873
Age: embryonic day 12.5
Image: Lef1 - E12.5
Note: There is strong staining in the mantle zone of the dorsal thalamus. Staining is either absent or ubiquitous in the mantle zone of the prethalamus.
Specimen Label: Lef1 - E12.5
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1754122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4450873
Age: embryonic day 14.5
Image: Lef1 - E14.5
Note: Staining is either absent or ubiquitous in the mantle zone of the dorsal thalamus and prethalamus.
Specimen Label: Lef1 - E14.5
Specimen Num: 11
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GXD Expression
GXD Expression
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Very strong
Sex: Not Specified
Emaps: EMAPS:1754124
Pattern: Non-Uniform
Stage: TS24
Assay Id: MGI:4450873
Age: embryonic day 16.5
Image: Lef1 - E16.5
Note: There is very strong staining in the mantle zone of the dorsal thalamus. Staining is either absent or ubiquitous in the mantle zone of the prethalamus
Specimen Label: Lef1 - E16.5
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3271220
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4450873
Age: embryonic day 12.5
Image: Lef1 - E12.5
Note: Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone of the cerebral cortex.
Specimen Label: Lef1 - E12.5
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3271222
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4450873
Age: embryonic day 14.5
Image: Lef1 - E14.5
Note: Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone of the cerebral cortex.
Specimen Label: Lef1 - E14.5
Specimen Num: 11
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GXD Expression
GXD Expression
Probe: MGI:5629674
Assay Type: Immunohistochemistry
Annotation Date: 2021-08-17
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:2767824
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:6740179
Age: embryonic day 16.5
Image: 5A Lef1 Six2Cre Brg1flx/flx
Note: Authors report a 50% reduction in Lef1/NCAM+ differentiating structures.
Specimen Label: 5A Lef1 Six2Cre Brg1flx/flx
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:5629674
Assay Type: Immunohistochemistry
Annotation Date: 2021-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2767824
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6740179
Age: embryonic day 16.5
Image: 5A Lef1 Brg1flx/flx
Specimen Label: 5A Lef1 Brg1flx/flx
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691319
Pattern: Non-Uniform
Stage: TS19
Assay Id: MGI:4450873
Age: embryonic day 11.5
Image: Lef1 - E11.5
Note: There is strong staining in the ventricular zone of the cerebral cortex. Staining is either absent or ubiquitous in the ventricular zone of the ganglionic eminences.
Specimen Label: Lef1 - E11.5
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:5629674
Assay Type: Immunohistochemistry
Annotation Date: 2023-03-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3589915
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:7448480
Age: embryonic day 9.0
Image: 3B E9.0 LEF1
Specimen Label: 3B E9.0 LEF1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1690819
Pattern: Non-Uniform
Stage: TS19
Assay Id: MGI:4450873
Age: embryonic day 11.5
Image: Lef1 - E11.5
Note: There is weak staining in the VZ of the dorsal thalamus & prethalamus. Staining is either absent or ubiquitous in the VZ of the dorsal & ventral POAs, the PVH, VMH & ARH nuclei, the AVH, anterior & posterior IDs, the premam, mam & supramam zones & the TT.
Specimen Label: Lef1 - E11.5
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1754720
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4450873
Age: embryonic day 12.5
Image: Lef1 - E12.5
Note: There is strong staining in the ventricular zone of the cerebral cortex.
Specimen Label: Lef1 - E12.5
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Very strong
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4450873
Age: embryonic day 14.5
Image: Lef1 - E14.5
Note: There is very strong staining in the ventricular zone of the cerebral cortex.
Specimen Label: Lef1 - E14.5
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3271020
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4450873
Age: embryonic day 12.5
Image: Lef1 - E12.5
Note: Staining is either absent or ubiquitous in the ventricular zone of the premam, mam and supramam zones and the TT.
Specimen Label: Lef1 - E12.5
Specimen Num: 10
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•
GXD Expression
GXD Expression
 
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3271022
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4450873
Age: embryonic day 14.5
Image: Lef1 - E14.5
Note: Staining is either absent or ubiquitous in the ventricular zone of the premam, mam and supramam zones and the TT.
Specimen Label: Lef1 - E14.5
Specimen Num: 11
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•
GXD Expression
GXD Expression
 
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3266520
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4450873
Age: embryonic day 12.5
Image: Lef1 - E12.5
Note: Staining is either absent or ubiquitous in the ventricular and mantle zones of the ganglionic eminences.
Specimen Label: Lef1 - E12.5
Specimen Num: 10
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•
GXD Expression
GXD Expression
 
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3266522
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4450873
Age: embryonic day 14.5
Image: Lef1 - E14.5
Note: Staining is either absent or ubiquitous in the ventricular and mantle zones of the ganglionic eminences.
Specimen Label: Lef1 - E14.5
Specimen Num: 11
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•
GXD Expression
GXD Expression
Probe: MGI:551815
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1690619
Pattern: Non-Uniform
Stage: TS19
Assay Id: MGI:4450873
Age: embryonic day 11.5
Image: Lef1 - E11.5
Note: There is strong staining in the MZ of the dorsal thalamus, prethalamus & premam zone. Staining is either absent or ubiquitous in the MZ of the dorsal & ventral POAs, the PVH, VMH & ARH nuclei, the AVH, anterior & posterior IDs, mam & supramam zones & TT.
Specimen Label: Lef1 - E11.5
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
Probe: MGI:5629674
Assay Type: Immunohistochemistry
Annotation Date: 2023-03-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1738319
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:7448480
Age: embryonic day 11.5
Image: 3B E11.5 LEF1
Note: Expression in gonadal progenitors,
Specimen Label: 3B E11.5 LEF1
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5629674
Assay Type: Immunohistochemistry
Annotation Date: 2023-03-28
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3812819
Stage: TS19
Assay Id: MGI:7448480
Age: embryonic day 11.5
Image: 3B E11.5 LEF1
Note: No expression in adrenal progenitors.
Specimen Label: 3B E11.5 LEF1
Detected: false
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:5629674
Assay Type: Immunohistochemistry
Annotation Date: 2023-03-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3812717
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:7448480
Age: embryonic day 10.5
Image: 3B E10.5 LEF1
Note: No expression in adrenal progenitors.
Specimen Label: 3B E10.5 LEF1
Detected: true
Specimen Num: 2
•
•
•
•
•
Publication
17945188 | J:127429
First Author: Yun K
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Lef1 regulates COX-2 transcription in chondrocytes.
Volume: 364
Issue: 2
Pages: 270-5
•
•
•
•
•
Protein
P27782
Organism: Mus musculus/domesticus
Length: 397  
Fragment?: false
•
•
•
•
•
Protein
D3Z654
Organism: Mus musculus/domesticus
Length: 369  
Fragment?: false
•
•
•
•
•
Protein
Q3TYB0
Organism: Mus musculus/domesticus
Length: 397  
Fragment?: false
•
•
•
•
•
Protein
Q8C402
Organism: Mus musculus/domesticus
Length: 331  
Fragment?: false
•
•
•
•
•
Protein
Q8BGZ9
Organism: Mus musculus/domesticus
Length: 384  
Fragment?: false
•
•
•
•
•
Protein
Q3TEN5
Organism: Mus musculus/domesticus
Length: 174  
Fragment?: false
•
•
•
•
•
Publication
10209158 | -
First Author: Eastman Q
Year: 1999
Journal: Curr Opin Cell Biol
Title: Regulation of LEF-1/TCF transcription factors by Wnt and other signals.
Volume: 11
Issue: 2
Pages: 233-40
•
•
•
•
•
Publication
10756202 | -
First Author: Hovanes K
Year: 2000
Journal: Nucleic Acids Res
Title: The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing.
Volume: 28
Issue: 9
Pages: 1994-2003
•
•
•
•
•
Publication
11604490 | -
First Author: Ross DA
Year: 2001
Journal: Mol Cell Biol
Title: The notch intracellular domain can function as a coactivator for LEF-1.
Volume: 21
Issue: 22
Pages: 7537-44
•
•
•
•
•
Publication
30886049 | J:278300
 
First Author: Oulès B
Year: 2019
Journal: EMBO J
Title: Mutant Lef1 controls Gata6 in sebaceous gland development and cancer.
Volume: 38
Issue: 9
•
•
•
•
•
Publication
22792274 | J:189507
First Author: Shelton DN
Year: 2012
Journal: PLoS One
Title: The role of LEF1 in endometrial gland formation and carcinogenesis.
Volume: 7
Issue: 7
Pages: e40312
•
•
•
•
•
Publication
15649466 | J:96501
First Author: Sasaki T
Year: 2005
Journal: Dev Biol
Title: LEF1 is a critical epithelial survival factor during tooth morphogenesis.
Volume: 278
Issue: 1
Pages: 130-43
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:1320980
Assay Type: RNA in situ
Annotation Date: 1999-01-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1763920
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:1320985
Age: embryonic day 12.5
Image: 7A/B
Note: Lef1 is expressed in epithelial thickenings.
Specimen Label: 7A/B
Detected: true
Specimen Num: 1
•
•
•
•
•
Publication
35594394 | J:325392
First Author: Elayyan J
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: Lef1 ablation alleviates cartilage mineralization following posttraumatic osteoarthritis induction.
Volume: 119
Issue: 21
Pages: e2116855119
•
•
•
•
•
Publication
32990218 | J:332710
   
First Author: Phan QM
Year: 2020
Journal: Elife
Title: Lef1 expression in fibroblasts maintains developmental potential in adult skin to regenerate wounds.
Volume: 9
•
•
•
•
•
Publication
11445543 | J:127975
First Author: Merrill BJ
Year: 2001
Journal: Genes Dev
Title: Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin.
Volume: 15
Issue: 13
Pages: 1688-705
•
•
•
•
•
Publication
26490636 | J:234060
First Author: Berga-Bolaños R
Year: 2015
Journal: Mol Immunol
Title: Cell-autonomous requirement for TCF1 and LEF1 in the development of Natural Killer T cells.
Volume: 68
Issue: 2 Pt B
Pages: 484-9
•
•
•
•
•
Publication
11731474 | J:73179
First Author: Sachdev S
Year: 2001
Journal: Genes Dev
Title: PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies.
Volume: 15
Issue: 23
Pages: 3088-103
•
•
•
•
•
Publication
27111144 | J:259386
First Author: Xing S
Year: 2016
Journal: Nat Immunol
Title: Tcf1 and Lef1 transcription factors establish CD8(+) T cell identity through intrinsic HDAC activity.
Volume: 17
Issue: 6
Pages: 695-703
•
•
•
•
•
Publication
31216480 | J:278725
First Author: Yang BH
Year: 2019
Journal: Cell Rep
Title: TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases.
Volume: 27
Issue: 12
Pages: 3629-3645.e6
•
•
•
•
•
Publication
8647435 | J:33601
First Author: Kratochwil K
Year: 1996
Journal: Genes Dev
Title: Lef1 expression is activated by BMP-4 and regulates inductive tissue interactions in tooth and hair development.
Volume: 10
Issue: 11
Pages: 1382-94
•
•
•
•
•
Publication
35639980 | J:354889
First Author: Ievlev V
Year: 2022
Journal: Stem Cells
Title: Sox9 and Lef1 Regulate the Fate and Behavior of Airway Glandular Progenitors in Response to Injury.
Volume: 40
Issue: 8
Pages: 778-790
•
•
•
•
•
Publication
27044748 | J:331295
First Author: Yu S
Year: 2016
Journal: J Biol Chem
Title: Hematopoietic and Leukemic Stem Cells Have Distinct Dependence on Tcf1 and Lef1 Transcription Factors.
Volume: 291
Issue: 21
Pages: 11148-60
•
•
•
•
•
Publication
24847765 | J:320407
First Author: Steinke FC
Year: 2014
Journal: Immunol Res
Title: From inception to output, Tcf1 and Lef1 safeguard development of T cells and innate immune cells.
Volume: 59
Issue: 1-3
Pages: 45-55
•
•
•
•
•
Publication
15750622 | J:98773
First Author: Cui Q
Year: 2005
Journal: Oncogene
Title: Selective inhibition of TGF-beta responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP.
Volume: 24
Issue: 24
Pages: 3864-74
•
•
•
•
•
Publication
16892173 | J:111643
First Author: Boras-Granic K
Year: 2006
Journal: Int J Dev Biol
Title: Genetic interaction between Lef1 and Alx4 is required for early embryonic development.
Volume: 50
Issue: 7
Pages: 601-10
•
•
•
•
•
Publication
30837262 | J:275219
First Author: Xing S
Year: 2019
Journal: J Exp Med
Title: Tcf1 and Lef1 are required for the immunosuppressive function of regulatory T cells.
Volume: 216
Issue: 4
Pages: 847-866
•
•
•
•
•
Publication
19412553 | J:148889
First Author: Noh T
Year: 2009
Journal: PLoS One
Title: Lef1 haploinsufficient mice display a low turnover and low bone mass phenotype in a gender- and age-specific manner.
Volume: 4
Issue: 5
Pages: e5438
•
•
•
•
•
Publication
25545010 | J:225380
First Author: Lieven O
Year: 2014
Journal: PLoS One
Title: Differential binding of Lef1 and Msx1/2 transcription factors to Dkk1 CNEs correlates with reporter gene expression in vivo.
Volume: 9
Issue: 12
Pages: e115442
•
•
•
•
•
Publication
12502739 | J:80990
First Author: Kratochwil K
Year: 2002
Journal: Genes Dev
Title: FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1(-/-) mice.
Volume: 16
Issue: 24
Pages: 3173-85
•
•
•
•
•
Publication
21523854 | J:172277
First Author: Mohri Y
Year: 2011
Journal: Dev Dyn
Title: Lgr4-deficient mice showed premature differentiation of ureteric bud with reduced expression of Wnt effector Lef1 and Gata3.
Volume: 240
Issue: 6
Pages: 1626-34
•
•
•
•
•
Publication
23152144 | J:197885
First Author: Nagalski A
Year: 2013
Journal: Brain Struct Funct
Title: Postnatal isoform switch and protein localization of LEF1 and TCF7L2 transcription factors in cortical, thalamic, and mesencephalic regions of the adult mouse brain.
Volume: 218
Issue: 6
Pages: 1531-49
•
•
•
•
•
ncRNA Gene
MGI:5663489 | Lef1os1
Type: antisense_lncRNA_gene
Organism: mouse, laboratory
•
•
•
•
•
Publication
21938009 | J:183190
First Author: Fehrenschild D
Year: 2012
Journal: J Invest Dermatol
Title: TCF/Lef1-mediated control of lipid metabolism regulates skin barrier function.
Volume: 132
Issue: 2
Pages: 337-45
•
•
•
•
•
Protein Domain
IPR016658 | DNA_primase_LEF1
Type: Family
Description: Baculovirus late expression factor 1 (LEF-1) has been shown to have primase activity [].
•
•
•
•
•
Publication
7537238 | J:24350
First Author: Zhou P
Year: 1995
Journal: Genes Dev
Title: Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate.
Volume: 9
Issue: 6
Pages: 700-13
•
•
•
•
•
Publication
11782404 | J:73649
First Author: Niemann C
Year: 2002
Journal: Development
Title: Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours.
Volume: 129
Issue: 1
Pages: 95-109
•
•
•
•
•
Publication
17409394 | J:120821
First Author: Niemann C
Year: 2007
Journal: Cancer Res
Title: Dual role of inactivating Lef1 mutations in epidermis: tumor promotion and specification of tumor type.
Volume: 67
Issue: 7
Pages: 2916-21
•
•
•
•
•
Allele
Lef1os1<+> | MGI:5664743
   
Name: LEF1 opposite strand RNA 1; wild type
•
•
•
•
•
HT Experiment
GSE73238 | Impact of Tcf1 and Lef1 deficiency on mature CD8 thymocytes
Series Id: E-GEOD-73238
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
•
•
•
•
•
Publication
12646922 | J:82378
First Author: Jamora C
Year: 2003
Journal: Nature
Title: Links between signal transduction, transcription and adhesion in epithelial bud development.
Volume: 422
Issue: 6929
Pages: 317-22
•
•
•
•
•
Publication
25897173 | J:222696
First Author: Carr T
Year: 2015
Journal: J Exp Med
Title: The transcription factor lymphoid enhancer factor 1 controls invariant natural killer T cell expansion and Th2-type effector differentiation.
Volume: 212
Issue: 5
Pages: 793-807
•
•
•
•
•
Publication
35371057 | J:322995
 
First Author: Carr T
Year: 2022
Journal: Front Immunol
Title: Oncogenic and Tumor Suppressor Functions for Lymphoid Enhancer Factor 1 in E2a-/- T Acute Lymphoblastic Leukemia.
Volume: 13
Pages: 845488
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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