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Search results 1 to 100 out of 1075 for Lrrk2

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4.554s
Type Details Score
Gene
Type: gene
Organism: frog, western clawed
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Gene
Type: gene
Organism: human
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Gene
Type: gene
Organism: rat
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Gene
Type: gene
Organism: dog, domestic
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Type: gene
Organism: chimpanzee
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Gene
Type: gene
Organism: cattle
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Type: gene
Organism: chicken
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Type: gene
Organism: zebrafish
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Gene
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
Type: gene
Organism: human
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Publication  
First Author: Litteljohn D
Year: 2018
Journal: Brain Behav Immun
Title: The impact of murine LRRK2 G2019S transgene overexpression on acute responses to inflammatory challenge.
Volume: 67
Pages: 246-256
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Publication
First Author: Purlyte E
Year: 2018
Journal: EMBO J
Title: Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.
Volume: 37
Issue: 1
Pages: 1-18
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Publication
First Author: Kim KS
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson's disease.
Volume: 115
Issue: 22
Pages: E5164-E5173
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Publication
First Author: Moehle MS
Year: 2012
Journal: J Neurosci
Title: LRRK2 inhibition attenuates microglial inflammatory responses.
Volume: 32
Issue: 5
Pages: 1602-11
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Publication
First Author: Orenstein SJ
Year: 2013
Journal: Nat Neurosci
Title: Interplay of LRRK2 with chaperone-mediated autophagy.
Volume: 16
Issue: 4
Pages: 394-406
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Publication
First Author: Shin N
Year: 2008
Journal: Exp Cell Res
Title: LRRK2 regulates synaptic vesicle endocytosis.
Volume: 314
Issue: 10
Pages: 2055-65
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Publication
First Author: Yun HJ
Year: 2013
Journal: Exp Mol Med
Title: LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25.
Volume: 45
Issue: 8
Pages: e36
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Publication  
First Author: Bang Y
Year: 2016
Journal: Mol Cell Neurosci
Title: LRRK2 interferes with aggresome formation for autophagic clearance.
Volume: 75
Pages: 71-80
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Publication
First Author: Bichler Z
Year: 2013
Journal: PLoS One
Title: Non-motor and motor features in LRRK2 transgenic mice.
Volume: 8
Issue: 7
Pages: e70249
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Publication
First Author: Fraser KB
Year: 2013
Journal: Hum Mol Genet
Title: LRRK2 secretion in exosomes is regulated by 14-3-3.
Volume: 22
Issue: 24
Pages: 4988-5000
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Publication
First Author: Smith WW
Year: 2006
Journal: Nat Neurosci
Title: Kinase activity of mutant LRRK2 mediates neuronal toxicity.
Volume: 9
Issue: 10
Pages: 1231-3
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Publication
First Author: D?chsel JC
Year: 2010
Journal: Parkinsonism Relat Disord
Title: A comparative study of Lrrk2 function in primary neuronal cultures.
Volume: 16
Issue: 10
Pages: 650-5
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Publication
First Author: Ferrazza R
Year: 2016
Journal: Biochem Biophys Res Commun
Title: LRRK2 deficiency impacts ceramide metabolism in brain.
Volume: 478
Issue: 3
Pages: 1141-6
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Publication
First Author: Winner B
Year: 2011
Journal: Neurobiol Dis
Title: Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice.
Volume: 41
Issue: 3
Pages: 706-16
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Publication
First Author: Xu E
Year: 2022
Journal: Mol Neurodegener
Title: Pathological ??-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain.
Volume: 17
Issue: 1
Pages: 7
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Publication
First Author: Lavalley NJ
Year: 2016
Journal: Hum Mol Genet
Title: 14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening.
Volume: 25
Issue: 1
Pages: 109-22
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Publication    
First Author: Chen C
Year: 2020
Journal: Elife
Title: Pathway-specific dysregulation of striatal excitatory synapses by LRRK2 mutations.
Volume: 9
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Publication
First Author: Liu W
Year: 2017
Journal: J Exp Med
Title: LRRK2 promotes the activation of NLRC4 inflammasome during Salmonella Typhimurium infection.
Volume: 214
Issue: 10
Pages: 3051-3066
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Publication  
First Author: Beccano-Kelly DA
Year: 2014
Journal: Front Cell Neurosci
Title: Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice.
Volume: 8
Pages: 301
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Publication
First Author: Moehle MS
Year: 2015
Journal: Hum Mol Genet
Title: The G2019S LRRK2 mutation increases myeloid cell chemotactic responses and enhances LRRK2 binding to actin-regulatory proteins.
Volume: 24
Issue: 15
Pages: 4250-67
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Publication
First Author: Zach S
Year: 2010
Journal: PLoS One
Title: Signal transduction protein array analysis links LRRK2 to Ste20 kinases and PKC zeta that modulate neuronal plasticity.
Volume: 5
Issue: 10
Pages: e13191
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Publication      
First Author: Ouyang Y
Year: 2011
Journal: MGI Direct Data Submission
Title: Generation of a new Lrrk2 knockout allele
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Publication
First Author: H?big K
Year: 2013
Journal: Biochim Biophys Acta
Title: LRRK2 guides the actin cytoskeleton at growth cones together with ARHGEF7 and Tropomyosin 4.
Volume: 1832
Issue: 12
Pages: 2352-67
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Publication
First Author: Henderson MX
Year: 2018
Journal: Acta Neuropathol Commun
Title: LRRK2 activity does not dramatically alter ?-synuclein pathology in primary neurons.
Volume: 6
Issue: 1
Pages: 45
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Publication
First Author: Bae EJ
Year: 2018
Journal: Nat Commun
Title: LRRK2 kinase regulates ?-synuclein propagation via RAB35 phosphorylation.
Volume: 9
Issue: 1
Pages: 3465
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Publication  
First Author: Kim JW
Year: 2021
Journal: eNeuro
Title: Dysregulated mRNA Translation in the G2019S LRRK2 and LRRK2 Knock-Out Mouse Brains.
Volume: 8
Issue: 6
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Publication  
First Author: Choi I
Year: 2015
Journal: Nat Commun
Title: LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase.
Volume: 6
Pages: 8255
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Publication
First Author: Beccano-Kelly DA
Year: 2015
Journal: Hum Mol Genet
Title: LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory.
Volume: 24
Issue: 5
Pages: 1336-49
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Publication
First Author: Kett LR
Year: 2012
Journal: Hum Mol Genet
Title: LRRK2 Parkinson disease mutations enhance its microtubule association.
Volume: 21
Issue: 4
Pages: 890-9
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GXD Expression      
Probe: MGI:6177334
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6190744
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Lrrk2
Detected: false
Specimen Num: 1
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GXD Expression      
Probe: MGI:6177334
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6190744
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Lrrk2
Detected: false
Specimen Num: 2
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GXD Expression      
Probe: MGI:6177334
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:6190744
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Lrrk2
Detected: false
Specimen Num: 3
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GXD Expression      
Probe: MGI:6177334
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6190744
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Lrrk2
Detected: false
Specimen Num: 4
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GXD Expression    
Probe: MGI:6177334
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190744
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Lrrk2
Detected: true
Specimen Num: 5
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GXD Expression    
Probe: MGI:6177334
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190744
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Lrrk2
Detected: true
Specimen Num: 6
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GXD Expression    
Probe: MGI:6177334
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190744
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Lrrk2
Detected: true
Specimen Num: 7
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Publication
First Author: Arranz AM
Year: 2015
Journal: J Cell Sci
Title: LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism.
Volume: 128
Issue: 3
Pages: 541?52
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Publication  
First Author: Yang K
Year: 2024
Journal: Biochem Biophys Res Commun
Title: LRRK2 G2019S enhances immune response pathways and aggravates asthma in mouse models.
Volume: 734
Pages: 150593
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Publication
First Author: Sepulveda B
Year: 2013
Journal: PLoS One
Title: Short- and long-term effects of LRRK2 on axon and dendrite growth.
Volume: 8
Issue: 4
Pages: e61986
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Publication
First Author: Lebovitz C
Year: 2021
Journal: Sci Rep
Title: Loss of Parkinson's susceptibility gene LRRK2 promotes carcinogen-induced lung tumorigenesis.
Volume: 11
Issue: 1
Pages: 2097
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Publication
First Author: Chen J
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Role of LRRK2 in manganese-induced neuroinflammation and microglial autophagy.
Volume: 498
Issue: 1
Pages: 171-177
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Publication
First Author: Tasegian A
Year: 2021
Journal: Biochem J
Title: Impact of Type II LRRK2 inhibitors on signaling and mitophagy.
Volume: 478
Issue: 19
Pages: 3555-3573
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Publication  
First Author: Kelly K
Year: 2018
Journal: Exp Neurol
Title: The G2019S mutation in LRRK2 imparts resiliency to kinase inhibition.
Volume: 309
Pages: 1-13
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Publication
First Author: Bieri G
Year: 2019
Journal: Acta Neuropathol
Title: LRRK2 modifies ?-syn pathology and spread in mouse models and human neurons.
Volume: 137
Issue: 6
Pages: 961-980
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Publication
First Author: Chen CY
Year: 2012
Journal: Cell Death Differ
Title: (G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.
Volume: 19
Issue: 10
Pages: 1623-33
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Publication
First Author: Giesert F
Year: 2013
Journal: PLoS One
Title: Expression analysis of Lrrk1, Lrrk2 and Lrrk2 splice variants in mice.
Volume: 8
Issue: 5
Pages: e63778
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Publication  
First Author: Takagawa T
Year: 2018
Journal: Sci Transl Med
Title: An increase in LRRK2 suppresses autophagy and enhances Dectin-1-induced immunity in a mouse model of colitis.
Volume: 10
Issue: 444
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Publication
First Author: Mandemakers W
Year: 2012
Journal: Neurobiol Dis
Title: LRRK2 expression is enriched in the striosomal compartment of mouse striatum.
Volume: 48
Issue: 3
Pages: 582-93
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Publication
First Author: Stafa K
Year: 2014
Journal: Hum Mol Genet
Title: Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily.
Volume: 23
Issue: 8
Pages: 2055-77
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Publication
First Author: Liu Q
Year: 2024
Journal: Sci Adv
Title: CalDAG-GEFI acts as a guanine nucleotide exchange factor for LRRK2 to regulate LRRK2 function and neurodegeneration.
Volume: 10
Issue: 47
Pages: eadn5417
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Publication
First Author: Parisiadou L
Year: 2014
Journal: Nat Neurosci
Title: LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity.
Volume: 17
Issue: 3
Pages: 367-76
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Publication  
First Author: Chen ZC
Year: 2017
Journal: Sci Signal
Title: Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease.
Volume: 10
Issue: 488
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Publication
First Author: Westerlund M
Year: 2008
Journal: Mol Cell Neurosci
Title: Lrrk2 and alpha-synuclein are co-regulated in rodent striatum.
Volume: 39
Issue: 4
Pages: 586-91
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Publication  
First Author: Weindel CG
Year: 2026
Journal: J Immunol
Title: LRRK2 kinase activity restricts NRF2-dependent mitochondrial protection in microglia.
Volume: 215
Issue: 1
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Publication
First Author: Chen C
Year: 2025
Journal: Mol Psychiatry
Title: LRRK2 mediates haloperidol-induced changes in indirect pathway striatal projection neurons.
Volume: 30
Issue: 10
Pages: 4473-4486
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Publication  
First Author: Perez Carrion M
Year: 2018
Journal: Front Mol Neurosci
Title: The LRRK2 Variant E193K Prevents Mitochondrial Fission Upon MPP+ Treatment by Altering LRRK2 Binding to DRP1.
Volume: 11
Pages: 64
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Publication  
First Author: Biskup S
Year: 2007
Journal: BMC Neurosci
Title: Dynamic and redundant regulation of LRRK2 and LRRK1 expression.
Volume: 8
Pages: 102
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Publication
First Author: Maloney MT
Year: 2025
Journal: Mol Neurodegener
Title: LRRK2 kinase activity regulates Parkinson's disease-relevant lipids at the lysosome.
Volume: 20
Issue: 1
Pages: 89
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Publication
First Author: Sun S
Year: 2024
Journal: Sci Immunol
Title: Macrophage LRRK2 hyperactivity impairs autophagy and induces Paneth cell dysfunction.
Volume: 9
Issue: 101
Pages: eadi7907
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Publication
First Author: Rassu M
Year: 2017
Journal: PLoS One
Title: Role of LRRK2 in the regulation of dopamine receptor trafficking.
Volume: 12
Issue: 6
Pages: e0179082
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Publication    
First Author: Khan SS
Year: 2021
Journal: Elife
Title: Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain.
Volume: 10
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Publication
First Author: Nguyen APT
Year: 2018
Journal: Hum Mol Genet
Title: G2019S LRRK2 enhances the neuronal transmission of tau in the mouse brain.
Volume: 27
Issue: 1
Pages: 120-134
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GXD Expression  
Probe: MGI:7495561
Assay Type: RNA in situ
Annotation Date: 2023-07-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7506541
Age: postnatal
Note: Striatal cells strongly expressing Lrrk2 were also positive for Ppp1r1b.
Specimen Label: not shown DARPP-32
Detected: true
Specimen Num: 4
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Publication
First Author: Parisiadou L
Year: 2009
Journal: J Neurosci
Title: Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis.
Volume: 29
Issue: 44
Pages: 13971-80
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Publication
First Author: Lim J
Year: 2018
Journal: J Neurosci
Title: LRRK2 G2019S Induces Anxiety/Depression-like Behavior before the Onset of Motor Dysfunction with 5-HT(1A) Receptor Upregulation in Mice.
Volume: 38
Issue: 7
Pages: 1611-1621
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Publication
First Author: Dorval V
Year: 2014
Journal: PLoS One
Title: Gene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse models.
Volume: 9
Issue: 1
Pages: e85510
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Publication
First Author: West AB
Year: 2014
Journal: J Comp Neurol
Title: Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents.
Volume: 522
Issue: 11
Pages: 2465-80
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Publication
First Author: Kozina E
Year: 2018
Journal: Brain
Title: Mutant LRRK2 mediates peripheral and central immune responses leading to neurodegeneration in vivo.
Volume: 141
Issue: 6
Pages: 1753-1769
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Publication
First Author: Fang P
Year: 2024
Journal: Commun Biol
Title: Sex-dependent interactions between prodromal intestinal inflammation and LRRK2 G2019S in mice promote endophenotypes of Parkinson's disease.
Volume: 7
Issue: 1
Pages: 570
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Publication  
First Author: Merchak AR
Year: 2026
Journal: Front Cell Neurosci
Title: LRRK2 G2019S reprograms innate and adaptive immunity to drive context-dependent host defense outcomes.
Volume: 20
Pages: 1860967
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Publication
First Author: Zhang ZW
Year: 2022
Journal: Sci Signal
Title: The APP intracellular domain promotes LRRK2 expression to enable feed-forward neurodegenerative mechanisms in Parkinson's disease.
Volume: 15
Issue: 748
Pages: eabk3411
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Publication
First Author: Pan PY
Year: 2017
Journal: J Neurosci
Title: Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain Neurons.
Volume: 37
Issue: 47
Pages: 11366-11376
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Publication
First Author: Tong Y
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice.
Volume: 106
Issue: 34
Pages: 14622-7
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Publication  
First Author: Giesert F
Year: 2017
Journal: Neurobiol Dis
Title: The pathogenic LRRK2 R1441C mutation induces specific deficits modeling the prodromal phase of Parkinson's disease in the mouse.
Volume: 105
Pages: 179-193
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Publication
First Author: Sheng Z
Year: 2012
Journal: Sci Transl Med
Title: Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations.
Volume: 4
Issue: 164
Pages: 164ra161
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Publication    
First Author: Steger M
Year: 2016
Journal: Elife
Title: Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.
Volume: 5
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Publication
First Author: Lian H
Year: 2023
Journal: Nat Microbiol
Title: Parkinson's disease kinase LRRK2 coordinates a cell-intrinsic itaconate-dependent defence pathway against intracellular Salmonella.
Volume: 8
Issue: 10
Pages: 1880-1895
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Publication  
First Author: H?rtlova A
Year: 2018
Journal: EMBO J
Title: LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages.
Volume: 37
Issue: 12
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Publication
First Author: Li X
Year: 2010
Journal: J Neurosci
Title: Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S.
Volume: 30
Issue: 5
Pages: 1788-97
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Publication
First Author: MacLeod DA
Year: 2013
Journal: Neuron
Title: RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk.
Volume: 77
Issue: 3
Pages: 425-39
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Publication  
First Author: Zhang S
Year: 2023
Journal: Redox Biol
Title: LRRK2 aggravates kidney injury through promoting MFN2 degradation and abnormal mitochondrial integrity.
Volume: 66
Pages: 102860
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Publication
First Author: Biskup S
Year: 2006
Journal: Ann Neurol
Title: Localization of LRRK2 to membranous and vesicular structures in mammalian brain.
Volume: 60
Issue: 5
Pages: 557-569
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Publication
First Author: Andres-Mateos E
Year: 2009
Journal: J Neurosci
Title: Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).
Volume: 29
Issue: 50
Pages: 15846-50
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Publication    
First Author: Singh F
Year: 2021
Journal: Elife
Title: Pharmacological rescue of impaired mitophagy in Parkinson's disease-related LRRK2 G2019S knock-in mice.
Volume: 10
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Publication  
First Author: Maset A
Year: 2021
Journal: Cells
Title: Aberrant Patterns of Sensory-Evoked Activity in the Olfactory Bulb of LRRK2 Knockout Mice.
Volume: 10
Issue: 11
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Publication  
First Author: Paus M
Year: 2013
Journal: Brain Res
Title: Enhanced dendritogenesis and axogenesis in hippocampal neuroblasts of LRRK2 knockout mice.
Volume: 1497
Pages: 85-100
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Publication  
First Author: Zhao Y
Year: 2018
Journal: Neurobiol Dis
Title: Nigrostriatal pathology with reduced astrocytes in LRRK2 S910/S935 phosphorylation deficient knockin mice.
Volume: 120
Pages: 76-87
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Publication    
First Author: Weindel CG
Year: 2020
Journal: Elife
Title: LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis.
Volume: 9
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Publication
First Author: Henry AG
Year: 2015
Journal: Hum Mol Genet
Title: Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression.
Volume: 24
Issue: 21
Pages: 6013-28
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