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Search results 1 to 100 out of 730 for Lrrk2

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Kim KS
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson's disease.
Volume: 115
Issue: 22
Pages: E5164-E5173
Publication
First Author: Shin N
Year: 2008
Journal: Exp Cell Res
Title: LRRK2 regulates synaptic vesicle endocytosis.
Volume: 314
Issue: 10
Pages: 2055-65
Publication  
First Author: Bang Y
Year: 2016
Journal: Mol Cell Neurosci
Title: LRRK2 interferes with aggresome formation for autophagic clearance.
Volume: 75
Pages: 71-80
Publication
First Author: Bichler Z
Year: 2013
Journal: PLoS One
Title: Non-motor and motor features in LRRK2 transgenic mice.
Volume: 8
Issue: 7
Pages: e70249
Publication
First Author: Fraser KB
Year: 2013
Journal: Hum Mol Genet
Title: LRRK2 secretion in exosomes is regulated by 14-3-3.
Volume: 22
Issue: 24
Pages: 4988-5000
Publication
First Author: Moehle MS
Year: 2012
Journal: J Neurosci
Title: LRRK2 inhibition attenuates microglial inflammatory responses.
Volume: 32
Issue: 5
Pages: 1602-11
Publication
First Author: Smith WW
Year: 2006
Journal: Nat Neurosci
Title: Kinase activity of mutant LRRK2 mediates neuronal toxicity.
Volume: 9
Issue: 10
Pages: 1231-3
Publication
First Author: Dächsel JC
Year: 2010
Journal: Parkinsonism Relat Disord
Title: A comparative study of Lrrk2 function in primary neuronal cultures.
Volume: 16
Issue: 10
Pages: 650-5
Publication
First Author: Ferrazza R
Year: 2016
Journal: Biochem Biophys Res Commun
Title: LRRK2 deficiency impacts ceramide metabolism in brain.
Volume: 478
Issue: 3
Pages: 1141-6
Publication
First Author: Winner B
Year: 2011
Journal: Neurobiol Dis
Title: Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice.
Volume: 41
Issue: 3
Pages: 706-16
Publication  
First Author: Beccano-Kelly DA
Year: 2014
Journal: Front Cell Neurosci
Title: Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice.
Volume: 8
Pages: 301
Publication
First Author: Lavalley NJ
Year: 2016
Journal: Hum Mol Genet
Title: 14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening.
Volume: 25
Issue: 1
Pages: 109-22
Publication
First Author: Liu W
Year: 2017
Journal: J Exp Med
Title: LRRK2 promotes the activation of NLRC4 inflammasome during Salmonella Typhimurium infection.
Volume: 214
Issue: 10
Pages: 3051-3066
Publication    
First Author: Chen C
Year: 2020
Journal: Elife
Title: Pathway-specific dysregulation of striatal excitatory synapses by LRRK2 mutations.
Volume: 9
Publication
First Author: Moehle MS
Year: 2015
Journal: Hum Mol Genet
Title: The G2019S LRRK2 mutation increases myeloid cell chemotactic responses and enhances LRRK2 binding to actin-regulatory proteins.
Volume: 24
Issue: 15
Pages: 4250-67
Publication      
First Author: Ouyang Y
Year: 2011
Journal: MGI Direct Data Submission
Title: Generation of a new Lrrk2 knockout allele
Publication
First Author: Bae EJ
Year: 2018
Journal: Nat Commun
Title: LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation.
Volume: 9
Issue: 1
Pages: 3465
Publication
First Author: Henderson MX
Year: 2018
Journal: Acta Neuropathol Commun
Title: LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons.
Volume: 6
Issue: 1
Pages: 45
Publication  
First Author: Kim JW
Year: 2021
Journal: eNeuro
Title: Dysregulated mRNA Translation in the G2019S LRRK2 and LRRK2 Knock-Out Mouse Brains.
Volume: 8
Issue: 6
Publication  
First Author: Choi I
Year: 2015
Journal: Nat Commun
Title: LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase.
Volume: 6
Pages: 8255
Publication
First Author: Beccano-Kelly DA
Year: 2015
Journal: Hum Mol Genet
Title: LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory.
Volume: 24
Issue: 5
Pages: 1336-49
Publication
First Author: Arranz AM
Year: 2015
Journal: J Cell Sci
Title: LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism.
Volume: 128
Issue: 3
Pages: 541–52
Publication
First Author: Kett LR
Year: 2012
Journal: Hum Mol Genet
Title: LRRK2 Parkinson disease mutations enhance its microtubule association.
Volume: 21
Issue: 4
Pages: 890-9
Publication
First Author: Bieri G
Year: 2019
Journal: Acta Neuropathol
Title: LRRK2 modifies α-syn pathology and spread in mouse models and human neurons.
Volume: 137
Issue: 6
Pages: 961-980
Publication
First Author: Chen CY
Year: 2012
Journal: Cell Death Differ
Title: (G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.
Volume: 19
Issue: 10
Pages: 1623-33
Publication  
First Author: Chen ZC
Year: 2017
Journal: Sci Signal
Title: Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease.
Volume: 10
Issue: 488
Publication  
First Author: Takagawa T
Year: 2018
Journal: Sci Transl Med
Title: An increase in LRRK2 suppresses autophagy and enhances Dectin-1-induced immunity in a mouse model of colitis.
Volume: 10
Issue: 444
Publication
First Author: Sepulveda B
Year: 2013
Journal: PLoS One
Title: Short- and long-term effects of LRRK2 on axon and dendrite growth.
Volume: 8
Issue: 4
Pages: e61986
Publication
First Author: Lebovitz C
Year: 2021
Journal: Sci Rep
Title: Loss of Parkinson's susceptibility gene LRRK2 promotes carcinogen-induced lung tumorigenesis.
Volume: 11
Issue: 1
Pages: 2097
Publication  
First Author: Kelly K
Year: 2018
Journal: Exp Neurol
Title: The G2019S mutation in LRRK2 imparts resiliency to kinase inhibition.
Volume: 309
Pages: 1-13
Publication
First Author: Chen J
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Role of LRRK2 in manganese-induced neuroinflammation and microglial autophagy.
Volume: 498
Issue: 1
Pages: 171-177
Publication
First Author: Giesert F
Year: 2013
Journal: PLoS One
Title: Expression analysis of Lrrk1, Lrrk2 and Lrrk2 splice variants in mice.
Volume: 8
Issue: 5
Pages: e63778
Publication
First Author: Mandemakers W
Year: 2012
Journal: Neurobiol Dis
Title: LRRK2 expression is enriched in the striosomal compartment of mouse striatum.
Volume: 48
Issue: 3
Pages: 582-93
Publication
First Author: Stafa K
Year: 2014
Journal: Hum Mol Genet
Title: Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily.
Volume: 23
Issue: 8
Pages: 2055-77
Publication
First Author: Parisiadou L
Year: 2014
Journal: Nat Neurosci
Title: LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity.
Volume: 17
Issue: 3
Pages: 367-76
Publication
First Author: Westerlund M
Year: 2008
Journal: Mol Cell Neurosci
Title: Lrrk2 and alpha-synuclein are co-regulated in rodent striatum.
Volume: 39
Issue: 4
Pages: 586-91
Publication  
First Author: Perez Carrion M
Year: 2018
Journal: Front Mol Neurosci
Title: The LRRK2 Variant E193K Prevents Mitochondrial Fission Upon MPP+ Treatment by Altering LRRK2 Binding to DRP1.
Volume: 11
Pages: 64
Publication  
First Author: Biskup S
Year: 2007
Journal: BMC Neurosci
Title: Dynamic and redundant regulation of LRRK2 and LRRK1 expression.
Volume: 8
Pages: 102
GXD Expression      
Probe: MGI:6177334
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6190744
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Lrrk2
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:6177334
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6190744
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Lrrk2
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:6177334
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:6190744
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Lrrk2
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:6177334
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6190744
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Lrrk2
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:6177334
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190744
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Lrrk2
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6177334
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190744
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Lrrk2
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6177334
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190744
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Lrrk2
Detected: true
Specimen Num: 7
Publication
First Author: Nguyen APT
Year: 2018
Journal: Hum Mol Genet
Title: G2019S LRRK2 enhances the neuronal transmission of tau in the mouse brain.
Volume: 27
Issue: 1
Pages: 120-134
Publication
First Author: Parisiadou L
Year: 2009
Journal: J Neurosci
Title: Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis.
Volume: 29
Issue: 44
Pages: 13971-80
Publication
First Author: Rassu M
Year: 2017
Journal: PLoS One
Title: Role of LRRK2 in the regulation of dopamine receptor trafficking.
Volume: 12
Issue: 6
Pages: e0179082
Publication  
First Author: Yun HJ
Year: 2013
Journal: Exp Mol Med
Title: LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25.
Volume: 45
Pages: e36
Publication    
First Author: Khan SS
Year: 2021
Journal: Elife
Title: Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain.
Volume: 10
Publication
First Author: Lim J
Year: 2018
Journal: J Neurosci
Title: LRRK2 G2019S Induces Anxiety/Depression-like Behavior before the Onset of Motor Dysfunction with 5-HT1A Receptor Upregulation in Mice.
Volume: 38
Issue: 7
Pages: 1611-1621
Publication
First Author: Dorval V
Year: 2014
Journal: PLoS One
Title: Gene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse models.
Volume: 9
Issue: 1
Pages: e85510
Publication
First Author: West AB
Year: 2014
Journal: J Comp Neurol
Title: Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents.
Volume: 522
Issue: 11
Pages: 2465-80
Publication
First Author: Tong Y
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice.
Volume: 106
Issue: 34
Pages: 14622-7
Publication
First Author: Pan PY
Year: 2017
Journal: J Neurosci
Title: Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain Neurons.
Volume: 37
Issue: 47
Pages: 11366-11376
Publication  
First Author: Giesert F
Year: 2017
Journal: Neurobiol Dis
Title: The pathogenic LRRK2 R1441C mutation induces specific deficits modeling the prodromal phase of Parkinson's disease in the mouse.
Volume: 105
Pages: 179-193
Publication
First Author: Sheng Z
Year: 2012
Journal: Sci Transl Med
Title: Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations.
Volume: 4
Issue: 164
Pages: 164ra161
Publication    
First Author: Steger M
Year: 2016
Journal: Elife
Title: Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.
Volume: 5
Publication  
First Author: Härtlova A
Year: 2018
Journal: EMBO J
Title: LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages.
Volume: 37
Issue: 12
Publication
First Author: Li X
Year: 2010
Journal: J Neurosci
Title: Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S.
Volume: 30
Issue: 5
Pages: 1788-97
Publication
First Author: MacLeod DA
Year: 2013
Journal: Neuron
Title: RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk.
Volume: 77
Issue: 3
Pages: 425-39
Publication
First Author: Henry AG
Year: 2015
Journal: Hum Mol Genet
Title: Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression.
Volume: 24
Issue: 21
Pages: 6013-28
Publication
First Author: Biskup S
Year: 2006
Journal: Ann Neurol
Title: Localization of LRRK2 to membranous and vesicular structures in mammalian brain.
Volume: 60
Issue: 5
Pages: 557-69
Publication      
First Author: Mazza MC
Year: 2020
Journal: bioRxiv
Title: Combined knockout of Lrrk2 and Rab29 does not result in behavioral abnormalities in vivo
Publication    
First Author: Singh F
Year: 2021
Journal: Elife
Title: Pharmacological rescue of impaired mitophagy in Parkinson's disease-related LRRK2 G2019S knock-in mice.
Volume: 10
Publication  
First Author: Maset A
Year: 2021
Journal: Cells
Title: Aberrant Patterns of Sensory-Evoked Activity in the Olfactory Bulb of LRRK2 Knockout Mice.
Volume: 10
Issue: 11
Publication  
First Author: Yue M
Year: 2015
Journal: Neurobiol Dis
Title: Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice.
Volume: 78
Pages: 172-95
Publication
First Author: Andres-Mateos E
Year: 2009
Journal: J Neurosci
Title: Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).
Volume: 29
Issue: 50
Pages: 15846-50
Publication  
First Author: Zhao Y
Year: 2018
Journal: Neurobiol Dis
Title: Nigrostriatal pathology with reduced astrocytes in LRRK2 S910/S935 phosphorylation deficient knockin mice.
Volume: 120
Pages: 76-87
Publication  
First Author: Paus M
Year: 2013
Journal: Brain Res
Title: Enhanced dendritogenesis and axogenesis in hippocampal neuroblasts of LRRK2 knockout mice.
Volume: 1497
Pages: 85-100
Publication
First Author: Kozina E
Year: 2018
Journal: Brain
Title: Mutant LRRK2 mediates peripheral and central immune responses leading to neurodegeneration in vivo.
Volume: 141
Issue: 6
Pages: 1753-1769
Publication    
First Author: Weindel CG
Year: 2020
Journal: Elife
Title: LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis.
Volume: 9
Publication
First Author: Liu Z
Year: 2020
Journal: EMBO J
Title: LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes.
Volume: 39
Issue: 20
Pages: e104862
Publication
First Author: Schapansky J
Year: 2014
Journal: Hum Mol Genet
Title: Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy.
Volume: 23
Issue: 16
Pages: 4201-14
Publication
First Author: Kalogeropulou AF
Year: 2020
Journal: Biochem J
Title: Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity.
Volume: 477
Issue: 22
Pages: 4397-4423
Publication  
First Author: Weng YH
Year: 2016
Journal: Exp Neurol
Title: (R1441C) LRRK2 induces the degeneration of SN dopaminergic neurons and alters the expression of genes regulating neuronal survival in a transgenic mouse model.
Volume: 275 Pt 1
Pages: 104-15
Publication
First Author: Verma M
Year: 2017
Journal: J Neurosci
Title: Mitochondrial Calcium Dysregulation Contributes to Dendrite Degeneration Mediated by PD/LBD-Associated LRRK2 Mutants.
Volume: 37
Issue: 46
Pages: 11151-11165
Publication
First Author: Piccoli G
Year: 2011
Journal: J Neurosci
Title: LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool.
Volume: 31
Issue: 6
Pages: 2225-37
Publication
First Author: Cherra SJ 3rd
Year: 2013
Journal: Am J Pathol
Title: Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons.
Volume: 182
Issue: 2
Pages: 474-84
Publication  
First Author: Tian Y
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: LRRK2 plays essential roles in maintaining lung homeostasis and preventing the development of pulmonary fibrosis.
Volume: 118
Issue: 35
Publication
First Author: Pellegrini L
Year: 2018
Journal: Hum Mol Genet
Title: Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice.
Volume: 27
Issue: 18
Pages: 3257-3271
MGI Directed Relationship Property
Name: Non-mouse_Gene_Symbol
Value: LRRK2
MGI Directed Relationship Property
Name: Non-mouse_Gene_Symbol
Value: LRRK2
MGI Directed Relationship Property
Name: Non-mouse_Gene_Symbol
Value: LRRK2
MGI Directed Relationship Property
Name: Non-mouse_Gene_Symbol
Value: LRRK2
MGI Directed Relationship Property
Name: Non-mouse_Gene_Symbol
Value: LRRK2
MGI Directed Relationship Property
Name: Non-mouse_Gene_Symbol
Value: LRRK2
MGI Directed Relationship Property
Name: Non-mouse_Gene_Symbol
Value: LRRK2
MGI Directed Relationship Property
Name: Non-mouse_Gene_Symbol
Value: LRRK2
MGI Directed Relationship Property
Name: Non-mouse_Gene_Symbol
Value: LRRK2
MGI Directed Relationship Property
Name: Non-mouse_Gene_Symbol
Value: LRRK2
MGI Directed Relationship Property
Name: Non-mouse_Gene_Symbol
Value: LRRK2
MGI Directed Relationship Property
Name: Non-mouse_Gene_Symbol
Value: LRRK2
MGI Directed Relationship Property
Name: Non-mouse_Gene_Symbol
Value: LRRK2
MGI Directed Relationship Property
Name: Non-mouse_Gene_Symbol
Value: LRRK2