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Search results 1 to 100 out of 112 for Lsm8

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Type Details Score
Gene
51691 | LSM8
Type: gene
Organism: human
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Gene
613630 | LSM8
Type: gene
Organism: cattle
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Gene
100685900 | LSM8
Type: gene
Organism: dog, domestic
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Gene
417765 | LSM8
Type: gene
Organism: chicken
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Gene
566017 | lsm8
Type: gene
Organism: zebrafish
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Gene
708569 | LSM8
Type: gene
Organism: macaque, rhesus
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Gene
100486227 | lsm8
Type: gene
Organism: frog, western clawed
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Gene
296913 | Lsm8
Type: gene
Organism: rat
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Gene
475298 | LSM8
Type: gene
Organism: dog, domestic
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Gene
736972 | LSM8
Type: gene
Organism: chimpanzee
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Protein Domain
IPR034103 | Lsm8
Type: Domain
Description: This entry represents Sm-like protein Lsm8. It is found in the nuclear Lsm2-8 complex, which associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 snRNP, U4/U6.U5 snRNP, and free U6 snRNP). The Lsm2-8 complex binds and stabilizes the 3'-terminal poly(U) tract of U6 snRNA and facilitates the assembly of U4-U6 di-snRNP and U4-U6-U5 tri-snRNP [, , ]. The Sm and the Lsm proteins, characterised by the Sm-domain, have RNA-related functions. The Sm heptamer ring associates with four (U1, U2, U4, U5) snRNPs, while Lsm2-8 heptamer is part of the U6 snRNP. Another Lsm heptameric complex, Lsm1-7, which differs from Lsm2-8 by one Lsm protein, functions in mRNA decapping, a crucial step in the mRNA degradation pathway [].
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Protein Coding Gene
MGI:1923772 | Lsm8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
A0A0N4SUZ3
Organism: Mus musculus/domesticus
Length: 100  
Fragment?: false
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Protein
Q6ZWM4
Organism: Mus musculus/domesticus
Length: 96  
Fragment?: false
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Publication
24240276 | -
First Author: Zhou L
Year: 2014
Journal: Nature
Title: Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA.
Volume: 506
Issue: 7486
Pages: 116-20
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Publication
15916535 | -
First Author: Beggs JD
Year: 2005
Journal: Biochem Soc Trans
Title: Lsm proteins and RNA processing.
Volume: 33
Issue: Pt 3
Pages: 433-8
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Publication
22615807 | -
First Author: Wu D
Year: 2012
Journal: PLoS One
Title: Crystal structures of Lsm3, Lsm4 and Lsm5/6/7 from Schizosaccharomyces pombe.
Volume: 7
Issue: 5
Pages: e36768
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Publication
24513854 | -
First Author: Zhou L
Year: 2014
Journal: Cell Res
Title: Crystal structure and biochemical analysis of the heptameric Lsm1-7 complex.
Volume: 24
Issue: 4
Pages: 497-500
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Protein Coding Gene
MGP_CAROLIEiJ_G0028125 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0030477 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0030450 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0030377 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0030459 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0030173 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1923772 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0030914 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0029575 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0030151 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0030295 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0030249 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0030382 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0030285 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0030944 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0029289 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0029651 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0021881 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0029125 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:7522112
Assay Type: RT-PCR
Annotation Date: 2023-08-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3747121
Stage: TS21
Assay Id: MGI:7522170
Age: embryonic day 13.5
Specimen Label: Evf2 +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7522112
Assay Type: RT-PCR
Annotation Date: 2023-08-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3747121
Stage: TS21
Assay Id: MGI:7522170
Age: embryonic day 13.5
Specimen Label: Evf2 TS/TS
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7522112
Assay Type: RT-PCR
Annotation Date: 2023-08-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3747121
Stage: TS21
Assay Id: MGI:7522190
Age: embryonic day 13.5
Specimen Label: Evf2 +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7522112
Assay Type: RT-PCR
Annotation Date: 2023-08-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3747121
Stage: TS21
Assay Id: MGI:7522190
Age: embryonic day 13.5
Specimen Label: Evf2 TS/+
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7522112
Assay Type: RT-PCR
Annotation Date: 2023-08-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3747121
Stage: TS21
Assay Id: MGI:7522178
Age: embryonic day 13.5
Specimen Label: Evf1 +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7522112
Assay Type: RT-PCR
Annotation Date: 2023-08-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3747121
Stage: TS21
Assay Id: MGI:7522178
Age: embryonic day 13.5
Specimen Label: Evf1 TS/TS
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7522112
Assay Type: RT-PCR
Annotation Date: 2023-08-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3746921
Stage: TS21
Assay Id: MGI:7522203
Age: embryonic day 13.5
Specimen Label: Evf2 +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7522112
Assay Type: RT-PCR
Annotation Date: 2023-08-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3746921
Stage: TS21
Assay Id: MGI:7522203
Age: embryonic day 13.5
Specimen Label: Evf2 TS/TS
Detected: true
Specimen Num: 2
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Publication
30146317 | J:265948
First Author: Cajigas I
Year: 2018
Journal: Mol Cell
Title: The Evf2 Ultraconserved Enhancer lncRNA Functionally and Spatially Organizes Megabase Distant Genes in the Developing Forebrain.
Volume: 71
Issue: 6
Pages: 956-972.e9
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Publication
32017896 | J:286260
First Author: Wang X
Year: 2020
Journal: Mol Cell
Title: LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice.
Volume: 77
Issue: 5
Pages: 999-1013.e6
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Publication
33593819 | J:303700
 
First Author: Cajigas I
Year: 2021
Journal: Development
Title: Sox2-Evf2 lncRNA-mediated mechanisms of chromosome topological control in developing forebrain.
Volume: 148
Issue: 6
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Gene
100855556 | LOC100855556
Type: gene
Organism: dog, domestic
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Gene
697125 | LOC697125
Type: gene
Organism: macaque, rhesus
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Gene
119877253 | LOC119877253
Type: gene
Organism: dog, domestic
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UniProt Feature
UniProt Feature
Begin: 2
Description: U6 snRNA-associated Sm-like protein LSm8
Type: chain
End: 96
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Gene
108351336 | LOC108351336
Type: gene
Organism: rat
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Gene
108711139 | lsm8.L
Type: gene
Organism: frog, African clawed
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Gene
414679 | lsm8.S
Type: gene
Organism: frog, African clawed
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Allele
Lsm8<+> | MGI:3048936
   
Name: LSM8 homolog, U6 small nuclear RNA associated; wild type
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Allele
Lsm8<Gt(OST313304)Lex> | MGI:4276164
 
Name: LSM8 homolog, U6 small nuclear RNA associated; gene trap OST313304, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Lsm8<Gt(OST173330)Lex> | MGI:4215026
 
Name: LSM8 homolog, U6 small nuclear RNA associated; gene trap OST173330, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Lsm8<em2Cya> | MGI:7584879
Name: LSM8 homolog, U6 small nuclear RNA associated; endonuclease-mediated mutation 2, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Lsm8<Gt(277E12)Cmhd> | MGI:4967108
 
Name: LSM8 homolog, U6 small nuclear RNA associated; gene trap 277E12, Centre for Modeling Human Disease
Allele Type: Gene trapped
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Allele
Lsm8<em1(IMPC)Mbp> | MGI:6276931
Name: LSM8 homolog, U6 small nuclear RNA associated; endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6347944 | C57BL/6NCrl-Lsm8<em1(IMPC)Mbp>/Mmucd
Attribute String: mutant strain, coisogenic, endonuclease-mediated mutation
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Strain
MGI:6407913 | C57BL/6N-Lsm8<em1(IMPC)Mbp>/MbpMmucd
Attribute String: coisogenic, targeted mutation
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Strain
MGI:7590473 | C57BL/6J-Lsm8<em2Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Lsm8/Lsm8
Background: C57BL/6N-Lsm8/MbpMmucd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lsm8/Lsm8<+>
Background: C57BL/6N-Lsm8/MbpMmucd
Zygosity: ht
Has Mutant Allele: true
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Publication
23620288 | -
First Author: Golisz A
Year: 2013
Journal: Nucleic Acids Res
Title: Arabidopsis thaliana LSM proteins function in mRNA splicing and degradation.
Volume: 41
Issue: 12
Pages: 6232-49
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Protein Domain
IPR016487 | Lsm6/sSmF
Type: Family
Description: Small nuclear ribonucleoproteins (snRNPs) are components of major and minor spliceosomes that play an important role in the splicing of cellular pre-mRNAs. snRNPs contain a common core, composed of seven Sm proteins bound to snRNA. Five small snRNPs (U1, U2, U4 and U5) share the Sm heptamer ring composed of SmB/B', SmD1/2/3, SmE, SmF, and SmG (also known as snRNP-G), while U6 snRNP has aheptamer ring consist of seven Sm-like (Lsm) proteins: Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7 and Lsm8 []. This entry includes the snRNP heptamer ring components SmF (small nuclear ribonucleoprotein F), Lsm6 and LSM36B from Arabidopsis[].
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Protein
Q9CR79
Organism: Mus musculus/domesticus
Length: 71  
Fragment?: true
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Protein
Q9CRP6
Organism: Mus musculus/domesticus
Length: 70  
Fragment?: true
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Protein Domain
IPR044642 | PTHR15588
Type: Family
Description: This entry represents Sm-like protein Lsm1 and Lsm8. Lsm8 is found in the nuclear Lsm2-8 complex, which associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 snRNP, U4/U6.U5 snRNP, and free U6 snRNP). The Lsm2-8 complex binds and stabilizes the 3'-terminal poly(U) tract of U6 snRNA and facilitates the assembly of U4-U6 di-snRNP and U4-U6-U5 tri-snRNP [, , ].Lsm1 can be found in the cytoplasmic Lsm1-7 complex, which associates with deadenylated mRNA and promotes decapping in the 5'-3' mRNA decay pathway [, ]. The Sm and the Lsm proteins, characterised by the Sm-domain, have RNA-related functions. The Sm heptamer ring associates with four (U1, U2, U4, U5) snRNPs, while Lsm2-8 heptamer is part of the U6 snRNP. Another Lsm heptameric complex, Lsm1-7, which differs from Lsm2-8 by one Lsm protein, functions in mRNA decapping, a crucial step in the mRNA degradation pathway [].
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Protein
P62313
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: false
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