Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Lysosomal-trafficking regulator (LYST) is a large BEACH domain-containing protein that affects lysosome size and quantity []. LYST controls the terminal maturation of perforin-containing vesicles into secretory granules []. Mutations in the LYST gene causes Chediak-Higashi syndrome, which is a rare autosomal-recessive syndrome characterised by hypopigmentation, severe immune deficiency, a bleeding tendency and progressive neurological dysfunction [, ]. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Barbosa MD |
Year: |
1996 |
Journal: |
Nature |
Title: |
Identification of the homologous beige and Chediak-Higashi syndrome genes. |
Volume: |
382 |
Issue: |
6588 |
Pages: |
262-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gwynn B |
Year: |
2006 |
Journal: |
MGI Direct Data Submission |
Title: |
ENU induced mutation at Lyst locus |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Holland P |
Year: |
2014 |
Journal: |
Traffic |
Title: |
LYST affects lysosome size and quantity, but not trafficking or degradation through autophagy or endocytosis. |
Volume: |
15 |
Issue: |
12 |
Pages: |
1390-405 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sepulveda FE |
Year: |
2015 |
Journal: |
Traffic |
Title: |
LYST controls the biogenesis of the endosomal compartment required for secretory lysosome function. |
Volume: |
16 |
Issue: |
2 |
Pages: |
191-203 |
|
•
•
•
•
•
|
Publication |
First Author: |
Misumi DJ |
Year: |
1997 |
Journal: |
Genomics |
Title: |
The physical and genetic map surrounding the Lyst gene on mouse chromosome 13. |
Volume: |
40 |
Issue: |
1 |
Pages: |
147-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lyst MJ |
Year: |
2018 |
Journal: |
Cell Rep |
Title: |
Affinity for DNA Contributes to NLS Independent Nuclear Localization of MeCP2. |
Volume: |
24 |
Issue: |
9 |
Pages: |
2213-2220 |
|
•
•
•
•
•
|
Publication |
First Author: |
Samples RM |
Year: |
2006 |
Journal: |
MGI Direct Data Submission |
Title: |
Beige 16 Jackson: a remutation of the Lyst gene |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Blasius AL |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Charlotte gray is an allele of Lyst and displays pigmentation defects: Record for "charlotte gray" updated January 9th, 2009 |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Trantow CM |
Year: |
2009 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
Lyst mutation in mice recapitulates iris defects of human exfoliation syndrome. |
Volume: |
50 |
Issue: |
3 |
Pages: |
1205-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Westphal A |
Year: |
2017 |
Journal: |
J Exp Med |
Title: |
Lysosomal trafficking regulator Lyst links membrane trafficking to toll-like receptor-mediated inflammatory responses. |
Volume: |
214 |
Issue: |
1 |
Pages: |
227-244 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ji X |
Year: |
2022 |
Journal: |
PLoS One |
Title: |
Deficiency in Lyst function leads to accumulation of secreted proteases and reduced retinal adhesion. |
Volume: |
17 |
Issue: |
3 |
Pages: |
e0254469 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lyst MJ |
Year: |
2013 |
Journal: |
Nat Neurosci |
Title: |
Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor. |
Volume: |
16 |
Issue: |
7 |
Pages: |
898-902 |
|
•
•
•
•
•
|
Publication |
First Author: |
Peters LL |
Year: |
2003 |
Journal: |
MGI Direct Data Submission |
Title: |
A remutation at the beige (Lyst) locus arising in an ethylnitrosourea mutagenesis screen |
|
|
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
140
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Shimazaki H |
Year: |
2014 |
Journal: |
J Neurol Neurosurg Psychiatry |
Title: |
Autosomal-recessive complicated spastic paraplegia with a novel lysosomal trafficking regulator gene mutation. |
Volume: |
85 |
Issue: |
9 |
Pages: |
1024-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Runkel F |
Year: |
2006 |
Journal: |
Mamm Genome |
Title: |
Grey, a novel mutation in the murine Lyst gene, causes the beige phenotype by skipping of exon 25. |
Volume: |
17 |
Issue: |
3 |
Pages: |
203-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Eidenschenk C |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Grey wolf is an allele of Lyst and a model for Chediak-Higashi Syndrome |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Rutschmann S |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Souris is an allele of Lyst and is a model for Chediak-Higashi Syndrome |
|
|
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1310
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
521
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
580
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
698
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
3788
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
3787
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Reyna C |
Year: |
2016 |
Journal: |
MGI Direct Data Submission |
Title: |
Mutagenetix entry for charzard |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ishikawa A |
Year: |
2019 |
Journal: |
MGI Direct Data Submission |
Title: |
A new spontaneous mutant allele at the lysosomal trafficking regulator locus in mice. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Prince L |
Year: |
2018 |
Journal: |
MGI Direct Data Submission |
Title: |
Mutagenetix entry for charcoal. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Reyna C |
Year: |
2016 |
Journal: |
MGI Direct Data Submission |
Title: |
Mutagenetix entry for vulpix |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hedberg-Buenz A |
Year: |
2019 |
Journal: |
Sci Rep |
Title: |
Mouse models and strain-dependency of Chédiak-Higashi syndrome-associated neurologic dysfunction. |
Volume: |
9 |
Issue: |
1 |
Pages: |
6752 |
|
•
•
•
•
•
|
Publication |
First Author: |
Introne W |
Year: |
1999 |
Journal: |
Mol Genet Metab |
Title: |
Clinical, molecular, and cell biological aspects of Chediak-Higashi syndrome. |
Volume: |
68 |
Issue: |
2 |
Pages: |
283-303 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jessen B |
Year: |
2011 |
Journal: |
Blood |
Title: |
Subtle differences in CTL cytotoxicity determine susceptibility to hemophagocytic lymphohistiocytosis in mice and humans with Chediak-Higashi syndrome. |
Volume: |
118 |
Issue: |
17 |
Pages: |
4620-9 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Barbosa MD |
Year: |
1997 |
Journal: |
Hum Mol Genet |
Title: |
Identification of mutations in two major mRNA isoforms of the Chediak-Higashi syndrome gene in human and mouse. |
Volume: |
6 |
Issue: |
7 |
Pages: |
1091-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang D |
Year: |
2015 |
Journal: |
MGI Direct Data Submission |
Title: |
Mutagenetix entry for lightspeed. (Last updated March 25, 2015) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Z |
Year: |
2015 |
Journal: |
MGI Direct Data Submission |
Title: |
Mutagenetix entry for Swallow |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Lutzner MA |
Year: |
1967 |
Journal: |
J Hered |
Title: |
Giant granules in leukocytes of the beige mouse. |
Volume: |
58 |
Issue: |
6 |
Pages: |
299-300 |
|
•
•
•
•
•
|
Publication |
First Author: |
Perou CM |
Year: |
1997 |
Journal: |
J Biol Chem |
Title: |
The Beige/Chediak-Higashi syndrome gene encodes a widely expressed cytosolic protein. |
Volume: |
272 |
Issue: |
47 |
Pages: |
29790-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Starcher B |
Year: |
1989 |
Journal: |
Exp Lung Res |
Title: |
The beige mouse: role of neutrophil elastase in the development of pulmonary emphysema. |
Volume: |
15 |
Issue: |
5 |
Pages: |
785-800 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mathiasen JR |
Year: |
1987 |
Journal: |
Life Sci |
Title: |
C57BL/6J-bgJ (beige) mice: differential sensitivity in the tail flick test to centrally administered mu- and delta-opioid receptor agonists. |
Volume: |
40 |
Issue: |
20 |
Pages: |
1989-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
McLeod R |
Year: |
1984 |
Journal: |
J Infect Dis |
Title: |
Immune response of mice to ingested Toxoplasma gondii: a model of toxoplasma infection acquired by ingestion. |
Volume: |
149 |
Issue: |
2 |
Pages: |
234-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oliver C |
Year: |
1973 |
Journal: |
J Histochem Cytochem |
Title: |
Distribution of anomalous lysosomes in the beige mouse: a homologue of Chediak-Higashi syndrome. |
Volume: |
21 |
Issue: |
3 |
Pages: |
218-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takeuchi K |
Year: |
1986 |
Journal: |
J Exp Med |
Title: |
Lysosomal elastase and cathepsin G in beige mice. Neutrophils of beige (Chediak-Higashi) mice selectively lack lysosomal elastase and cathepsin G. |
Volume: |
163 |
Issue: |
3 |
Pages: |
665-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Malkinson AM |
Year: |
1983 |
Journal: |
J Natl Cancer Inst |
Title: |
Major effect on susceptibility to urethan-induced pulmonary adenoma by a single gene in BALB/cBy mice. |
Volume: |
70 |
Issue: |
5 |
Pages: |
931-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jensen BL |
Year: |
1997 |
Journal: |
Cell Tissue Res |
Title: |
Giant renin secretory granules in beige mouse renal afferent arterioles. |
Volume: |
288 |
Issue: |
2 |
Pages: |
399-406 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chi EY |
Year: |
1978 |
Journal: |
J Histochem Cytochem |
Title: |
Mast cell granule formation in the beige mouse. |
Volume: |
26 |
Issue: |
2 |
Pages: |
131-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gallin JI |
Year: |
1974 |
Journal: |
Blood |
Title: |
Granulocyte function in the Chediak-Higashi syndrome of mice. |
Volume: |
43 |
Issue: |
2 |
Pages: |
201-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Clark EA |
Year: |
1982 |
|
Title: |
The beige (bg) gene influences the development of autoimmune disease in SB/Le male mice |
|
|
Pages: |
301-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Whitney PL |
Year: |
1992 |
Journal: |
Exp Lung Res |
Title: |
Soluble beta-galactoside specific lectin is developmentally regulated in lungs of neonatal black mice and beige mice. |
Volume: |
18 |
Issue: |
4 |
Pages: |
553-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Talmadge JE |
Year: |
1980 |
Journal: |
Nature |
Title: |
Role of NK cells in tumour growth and metastasis in beige mice. |
Volume: |
284 |
Issue: |
5757 |
Pages: |
622-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oliver JM |
Year: |
1976 |
Journal: |
Am J Pathol |
Title: |
Impaired microtubule function correctable by cyclic GMP and cholinergic agonists in the Chediak-Higashi syndrome. |
Volume: |
85 |
Issue: |
2 |
Pages: |
395-418 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kärre K |
Year: |
1980 |
Journal: |
Nature |
Title: |
Low natural in vivo resistance to syngeneic leukaemias in natural killer-deficient mice. |
Volume: |
284 |
Issue: |
5757 |
Pages: |
624-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Feith GW |
Year: |
1993 |
Journal: |
Kidney Int |
Title: |
Lack of albuminuria in the early heterologous phase of anti-GBM nephritis in beige mice. |
Volume: |
43 |
Issue: |
4 |
Pages: |
824-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Prueitt JL |
Year: |
1978 |
Journal: |
J Lipid Res |
Title: |
Pulmonary surface-active materials in the Chediak-Higashi syndrome. |
Volume: |
19 |
Issue: |
4 |
Pages: |
410-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Elin RJ |
Year: |
1974 |
Journal: |
Infect Immun |
Title: |
Infection and immunoglobulin concentrations in Chediak-Higashi mice. |
Volume: |
10 |
Issue: |
1 |
Pages: |
88-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rasmussen KR |
Year: |
1992 |
Journal: |
Infect Immun |
Title: |
Experimental Cryptosporidium parvum infections in immunosuppressed adult mice. |
Volume: |
60 |
Issue: |
4 |
Pages: |
1648-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Haliotis T |
Year: |
1985 |
Journal: |
Int J Cancer |
Title: |
Spontaneous and induced primary oncogenesis in natural killer (NK)-cell-deficient beige mutant mice. |
Volume: |
35 |
Issue: |
4 |
Pages: |
505-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oliver C |
Year: |
1975 |
Journal: |
Lab Invest |
Title: |
Formation of anomalous lysosomes in monocytes, neutrophils, and eosinophils from bone marrow of mice with Chédiak-Higashi syndrome. |
Volume: |
32 |
Issue: |
1 |
Pages: |
17-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Roder JC |
Year: |
1979 |
Journal: |
J Immunol |
Title: |
The beige mutation in the mouse. I. A stem cell predetermined impairment in natural killer cell function. |
Volume: |
123 |
Issue: |
5 |
Pages: |
2168-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guo H |
Year: |
1992 |
Journal: |
Tokai J Exp Clin Med |
Title: |
Cytoarchitectonic abnormalities in cerebellum and hippocampal formation of beige mutant mouse. |
Volume: |
17 |
Issue: |
1 |
Pages: |
53-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kaido T |
Year: |
1993 |
Journal: |
Int J Cancer |
Title: |
Sensitized T lymphocytes render DBA/2 beige mice responsive to IFN alpha/beta therapy of Friend erythroleukemia visceral metastases. |
Volume: |
54 |
Issue: |
3 |
Pages: |
475-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Enriquez FJ |
Year: |
1991 |
Journal: |
J Protozool |
Title: |
Cryptosporidium infections in inbred strains of mice. |
Volume: |
38 |
Issue: |
6 |
Pages: |
100S-102S |
|
•
•
•
•
•
|
Publication |
First Author: |
Swank RT |
Year: |
1978 |
Journal: |
Am J Pathol |
Title: |
Turnover of kidney beta-glucuronidase in normal and Chédiak-Higashi (beige) mice. |
Volume: |
92 |
Issue: |
3 |
Pages: |
755-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cavarra E |
Year: |
1999 |
Journal: |
Am J Respir Cell Mol Biol |
Title: |
Neutrophil influx into the lungs of beige mice is followed by elastolytic damage and emphysema. |
Volume: |
20 |
Issue: |
2 |
Pages: |
264-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takeuchi K |
Year: |
2000 |
Journal: |
Biochim Biophys Acta |
Title: |
A hyperosmotic stress-induced mRNA of carp cell encodes Na(+)- and Cl(-)-dependent high affinity taurine transporter. |
Volume: |
1464 |
Issue: |
2 |
Pages: |
219-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Willingham MC |
Year: |
1981 |
Journal: |
Exp Cell Res |
Title: |
The origin and fate of large dense bodies in beige mouse fibroblasts. Lysosomal fusion and exocytosis. |
Volume: |
136 |
Issue: |
1 |
Pages: |
157-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Roths JB |
Year: |
1982 |
Journal: |
Jackson Lab Ann Rep |
Title: |
The beige mutation retards the progression of autoimmune disease. |
Volume: |
53 |
|
Pages: |
65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kirkpatrick CE |
Year: |
1982 |
Journal: |
Infect Immun |
Title: |
Leishmaniasis in beige mice. |
Volume: |
38 |
Issue: |
3 |
Pages: |
1208-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shellam GR |
Year: |
1981 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Increased susceptibility to cytomegalovirus infection in beige mutant mice. |
Volume: |
78 |
Issue: |
8 |
Pages: |
5104-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pope BL |
Year: |
1994 |
Journal: |
Cell Immunol |
Title: |
Murine strain variation in the natural killer cell and proliferative responses to the immunostimulatory compound 7-allyl-8-oxoguanosine: role of cytokines. |
Volume: |
159 |
Issue: |
2 |
Pages: |
194-210 |
|
•
•
•
•
•
|
Publication |
First Author: |
Perou CM |
Year: |
1993 |
Journal: |
Somat Cell Mol Genet |
Title: |
Complementation analysis of Chediak-Higashi syndrome: the same gene may be responsible for the defect in all patients and species. |
Volume: |
19 |
Issue: |
5 |
Pages: |
459-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tanaka E |
Year: |
1994 |
Journal: |
Exp Lung Res |
Title: |
Effects of the beige mutation on respiratory tract infection with Pseudomonas aeruginosa in mice. |
Volume: |
20 |
Issue: |
4 |
Pages: |
351-66 |
|
•
•
•
•
•
|