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Search results 1 to 100 out of 599 for Mafa

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: Maf transcription factors form a distinct family of the basic leucine zipper (bZip) transcription factors. The Maf family is divided into two subclasses, large Mafs (c-maf, mafB, and mafA/L-maf, nrl) and small Mafs (MafF, MafK and MafG). Both subclasses contain leucine-zipper motifs, which allow homodimerisation as well as heterodimerisation with a variety of other bZip proteins. In contrast to the small Mafs, the large Maf proteins contain a transactivator domain in their amino terminus []. The small Maf proteins might contribute to oncogenic processes by participating in antioxidant responses, while large Maf proteins have been directly implicated in carcinogenesis []. This entry represents MafA. MafA plays a critical role in the regulation of crystalline genes and lens development [, ]. It also binds the insulin enhancer element RIPE3b and regulates the insulin gene transcription [, , ].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Zhang C
Year: 2005
Journal: Mol Cell Biol
Title: MafA is a key regulator of glucose-stimulated insulin secretion.
Volume: 25
Issue: 12
Pages: 4969-76
Publication
First Author: Zhao L
Year: 2005
Journal: J Biol Chem
Title: The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription.
Volume: 280
Issue: 12
Pages: 11887-94
Publication      
First Author: Birchmeier C
Year: 2016
Journal: MGI Direct Data Submission
Title: Submission for a Mafa-cre
Publication
First Author: Arcourt A
Year: 2017
Journal: Neuron
Title: Touch Receptor-Derived Sensory Information Alleviates Acute Pain Signaling and Fine-Tunes Nociceptive Reflex Coordination.
Volume: 93
Issue: 1
Pages: 179-193
GXD Expression
Probe: MGI:6449789
Assay Type: Immunohistochemistry
Annotation Date: 2020-08-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3292723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:6449813
Age: embryonic day 15.5
Image: S1 E15.5 MafA
Note: Expression overlaps with that of Myt1.
Specimen Label: S1 E15.5 MafA
Detected: true
Specimen Num: 5
GXD Expression
Probe: MGI:6449789
Assay Type: Immunohistochemistry
Annotation Date: 2020-08-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750321
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:6449813
Age: embryonic day 13.5
Image: S1 E13.5 MafA
Note: Expression overlaps with that of Myt1.
Specimen Label: S1 E13.5 MafA
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5789282
Assay Type: RT-PCR
Annotation Date: 2016-08-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716320
Stage: TS20
Assay Id: MGI:5789314
Age: embryonic day 12.5
Specimen Label: mafA
Detected: true
Specimen Num: 1
Protein
Organism: Mus musculus
Length: 359  
Fragment?: false
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Eychène A
Year: 2008
Journal: Nat Rev Cancer
Title: A new MAFia in cancer.
Volume: 8
Issue: 9
Pages: 683-93
Publication
First Author: Ogino H
Year: 1998
Journal: Science
Title: Induction of lens differentiation by activation of a bZIP transcription factor, L-Maf.
Volume: 280
Issue: 5360
Pages: 115-8
Publication
First Author: Olbrot M
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA.
Volume: 99
Issue: 10
Pages: 6737-42
Publication
First Author: Benkhelifa S
Year: 1998
Journal: Oncogene
Title: mafA, a novel member of the maf proto-oncogene family, displays developmental regulation and mitogenic capacity in avian neuroretina cells.
Volume: 17
Issue: 2
Pages: 247-54
Publication
First Author: Kataoka K
Year: 2002
Journal: J Biol Chem
Title: MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene.
Volume: 277
Issue: 51
Pages: 49903-10
Allele
Name: v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian); targeted mutation 1.1, Carmen Birchmeier
Allele Type: Targeted
Attribute String: Recombinase
Publication
First Author: Lecoin L
Year: 2010
Journal: Dev Neurobiol
Title: MafA transcription factor identifies the early ret-expressing sensory neurons.
Volume: 70
Issue: 7
Pages: 485-97
Publication
First Author: Kajihara M
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Mouse MafA, homologue of zebrafish somite Maf 1, contributes to the specific transcriptional activity through the insulin promoter.
Volume: 312
Issue: 3
Pages: 831-42
Publication
First Author: Matsuoka TA
Year: 2003
Journal: Mol Cell Biol
Title: Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells.
Volume: 23
Issue: 17
Pages: 6049-62
Publication
First Author: Eto K
Year: 2014
Journal: PLoS One
Title: MafA is required for postnatal proliferation of pancreatic β-cells.
Volume: 9
Issue: 8
Pages: e104184
Publication
First Author: Singh T
Year: 2019
Journal: Sci Rep
Title: Loss of MafA and MafB expression promotes islet inflammation.
Volume: 9
Issue: 1
Pages: 9074
Publication
First Author: Hang Y
Year: 2014
Journal: Diabetes
Title: The MafA transcription factor becomes essential to islet β-cells soon after birth.
Volume: 63
Issue: 6
Pages: 1994-2005
GXD Expression
Probe: MGI:6449762
Assay Type: Immunohistochemistry
Annotation Date: 2020-08-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750321
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:6449800
Age: embryonic day 13.5
Image: S1 E13.5 MafA
Note: Expression overlaps with expression of Mafa.
Specimen Label: S1 E13.5 MafA
Detected: true
Specimen Num: 21
GXD Expression  
Probe: MGI:6449762
Assay Type: Immunohistochemistry
Annotation Date: 2020-08-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3292723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6449800
Age: embryonic day 15.5
Image: S1 E15.5 MafA
Specimen Label: S1 E15.5 MafA
Detected: true
Specimen Num: 25
Publication
First Author: Kitamura YI
Year: 2005
Journal: Cell Metab
Title: FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction.
Volume: 2
Issue: 3
Pages: 153-63
Publication
First Author: Matsuoka TA
Year: 2010
Journal: Diabetes
Title: Regulation of MafA expression in pancreatic beta-cells in db/db mice with diabetes.
Volume: 59
Issue: 7
Pages: 1709-20
Publication
First Author: Nishimura W
Year: 2009
Journal: Dev Biol
Title: Expression of MafA in pancreatic progenitors is detrimental for pancreatic development.
Volume: 333
Issue: 1
Pages: 108-20
Publication
First Author: Artner I
Year: 2008
Journal: J Endocrinol
Title: MafA is a dedicated activator of the insulin gene in vivo.
Volume: 198
Issue: 2
Pages: 271-9
Publication
First Author: Matsuoka TA
Year: 2015
Journal: J Biol Chem
Title: Preserving Mafa expression in diabetic islet β-cells improves glycemic control in vivo.
Volume: 290
Issue: 12
Pages: 7647-57
Publication
First Author: Nishimura W
Year: 2015
Journal: Diabetologia
Title: MafA is critical for maintenance of the mature beta cell phenotype in mice.
Volume: 58
Issue: 3
Pages: 566-74
Publication
First Author: Bourane S
Year: 2009
Journal: Neuron
Title: Low-threshold mechanoreceptor subtypes selectively express MafA and are specified by Ret signaling.
Volume: 64
Issue: 6
Pages: 857-70
Publication  
First Author: Luan C
Year: 2019
Journal: Commun Biol
Title: The calcium channel subunit gamma-4 is regulated by MafA and necessary for pancreatic beta-cell specification.
Volume: 2
Pages: 106
Publication
First Author: Noso S
Year: 2010
Journal: Diabetes
Title: Insulin transactivator MafA regulates intrathymic expression of insulin and affects susceptibility to type 1 diabetes.
Volume: 59
Issue: 10
Pages: 2579-87
Publication
First Author: Artner I
Year: 2010
Journal: Diabetes
Title: MafA and MafB regulate genes critical to beta-cells in a unique temporal manner.
Volume: 59
Issue: 10
Pages: 2530-9
Publication
First Author: Nishimura W
Year: 2006
Journal: Dev Biol
Title: A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells.
Volume: 293
Issue: 2
Pages: 526-39
Publication
First Author: Matsuoka TA
Year: 2017
Journal: Diabetes
Title: Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet α-Cells Into β-Cells In Vivo.
Volume: 66
Issue: 5
Pages: 1293-1300
Publication
First Author: Yamamoto K
Year: 2013
Journal: J Biol Chem
Title: A novel function of Onecut1 protein as a negative regulator of MafA gene expression.
Volume: 288
Issue: 30
Pages: 21648-58
Publication
First Author: Scoville DW
Year: 2015
Journal: Diabetes
Title: MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function.
Volume: 64
Issue: 11
Pages: 3772-83
Publication
First Author: Harmon JS
Year: 2009
Journal: Endocrinology
Title: beta-Cell-specific overexpression of glutathione peroxidase preserves intranuclear MafA and reverses diabetes in db/db mice.
Volume: 150
Issue: 11
Pages: 4855-62
Publication
First Author: Zhu K
Year: 2020
Journal: Nat Commun
Title: Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice.
Volume: 11
Issue: 1
Pages: 484
Publication
First Author: Ganic E
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Islet-specific monoamine oxidase A and B expression depends on MafA transcriptional activity and is compromised in type 2 diabetes.
Volume: 468
Issue: 4
Pages: 629-35
Publication
First Author: Matsuoka TA
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: The MafA transcription factor appears to be responsible for tissue-specific expression of insulin.
Volume: 101
Issue: 9
Pages: 2930-3
Publication
First Author: Lecoin L
Year: 2022
Journal: Nat Commun
Title: Mafa-dependent GABAergic activity promotes mouse neonatal apneas.
Volume: 13
Issue: 1
Pages: 3284
Publication
First Author: Shimohata H
Year: 2009
Journal: Biochem Biophys Res Commun
Title: MafA-deficient and beta cell-specific MafK-overexpressing hybrid transgenic mice develop human-like severe diabetic nephropathy.
Volume: 389
Issue: 2
Pages: 235-40
Publication
First Author: He KH
Year: 2014
Journal: Dev Biol
Title: Differentiation of pancreatic endocrine progenitors reversibly blocked by premature induction of MafA.
Volume: 385
Issue: 1
Pages: 2-12
Publication
First Author: Kanai K
Year: 2010
Journal: Genes Cells
Title: SUMOylation negatively regulates transcriptional and oncogenic activities of MafA.
Volume: 15
Issue: 9
Pages: 971-82
Publication
First Author: Nishimura W
Year: 2015
Journal: Endocr J
Title: Generation and characterization of MafA-Kusabira Orange mice.
Volume: 62
Issue: 1
Pages: 37-51
Publication
First Author: Ganic E
Year: 2016
Journal: Cell Rep
Title: MafA-Controlled Nicotinic Receptor Expression Is Essential for Insulin Secretion and Is Impaired in Patients with Type 2 Diabetes.
Volume: 14
Issue: 8
Pages: 1991-2002
Publication
First Author: Xu G
Year: 2013
Journal: Nat Med
Title: Thioredoxin-interacting protein regulates insulin transcription through microRNA-204.
Volume: 19
Issue: 9
Pages: 1141-6
Publication  
First Author: Deng Z
Year: 2020
Journal: Int J Mol Sci
Title: An Inducible Diabetes Mellitus Murine Model Based on MafB Conditional Knockout under MafA-Deficient Condition.
Volume: 21
Issue: 16
Publication
First Author: Nomoto H
Year: 2015
Journal: Endocrinology
Title: Inhibition of Small Maf Function in Pancreatic β-Cells Improves Glucose Tolerance Through the Enhancement of Insulin Gene Transcription and Insulin Secretion.
Volume: 156
Issue: 10
Pages: 3570-80
Publication
First Author: Takeuchi T
Year: 2009
Journal: Genes Cells
Title: Neither MafA/L-Maf nor MafB is essential for lens development in mice.
Volume: 14
Issue: 8
Pages: 941-7
Publication  
First Author: Xiafukaiti G
Year: 2019
Journal: Mol Cell Biol
Title: MafB Is Important for Pancreatic β-Cell Maintenance under a MafA-Deficient Condition.
Volume: 39
Issue: 17
Publication
First Author: Abdellatif AM
Year: 2015
Journal: Exp Anim
Title: Role of large MAF transcription factors in the mouse endocrine pancreas.
Volume: 64
Issue: 3
Pages: 305-12
Publication
First Author: Guo S
Year: 2013
Journal: J Clin Invest
Title: Inactivation of specific β cell transcription factors in type 2 diabetes.
Volume: 123
Issue: 8
Pages: 3305-16
Publication
First Author: Galloway JR
Year: 2015
Journal: Mol Endocrinol
Title: SSBP3 Interacts With Islet-1 and Ldb1 to Impact Pancreatic β-Cell Target Genes.
Volume: 29
Issue: 12
Pages: 1774-86
Publication
First Author: ZeRuth GT
Year: 2013
Journal: Mol Endocrinol
Title: The Krüppel-like protein Gli-similar 3 (Glis3) functions as a key regulator of insulin transcription.
Volume: 27
Issue: 10
Pages: 1692-705
Publication
First Author: Doyle MJ
Year: 2007
Journal: Development
Title: Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet.
Volume: 134
Issue: 3
Pages: 515-23
Publication
First Author: Kang HS
Year: 2009
Journal: Mol Cell Biol
Title: Transcription factor Glis3, a novel critical player in the regulation of pancreatic beta-cell development and insulin gene expression.
Volume: 29
Issue: 24
Pages: 6366-79
Publication
First Author: Artner I
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: MafB is required for islet beta cell maturation.
Volume: 104
Issue: 10
Pages: 3853-8
Publication
First Author: Wang Y
Year: 2020
Journal: Diabetes
Title: m6A mRNA Methylation Controls Functional Maturation in Neonatal Murine β-Cells.
Volume: 69
Issue: 8
Pages: 1708-1722
Publication
First Author: Murakami-Kawaguchi S
Year: 2014
Journal: Cell Tissue Res
Title: Expression of Ins1 and Ins2 genes in mouse fetal liver.
Volume: 355
Issue: 2
Pages: 303-14
Publication
First Author: Hu J
Year: 2012
Journal: J Neurosci
Title: c-Maf is required for the development of dorsal horn laminae III/IV neurons and mechanoreceptive DRG axon projections.
Volume: 32
Issue: 16
Pages: 5362-73
Publication
First Author: Conrad E
Year: 2016
Journal: Am J Physiol Endocrinol Metab
Title: The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cells.
Volume: 310
Issue: 1
Pages: E91-E102
Publication
First Author: Paul L
Year: 2016
Journal: Diabetes
Title: Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-Cells.
Volume: 65
Issue: 3
Pages: 687-98
Publication
First Author: Nishimura W
Year: 2008
Journal: Dev Biol
Title: Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice.
Volume: 314
Issue: 2
Pages: 443-56
Publication
First Author: Plank JL
Year: 2011
Journal: Dev Biol
Title: Influence and timing of arrival of murine neural crest on pancreatic beta cell development and maturation.
Volume: 349
Issue: 2
Pages: 321-30
Publication
First Author: Shawki HH
Year: 2018
Journal: PLoS One
Title: MAFB is dispensable for the fetal testis morphogenesis and the maintenance of spermatogenesis in adult mice.
Volume: 13
Issue: 1
Pages: e0190800
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:5641701
Assay Type: RT-PCR
Annotation Date: 2015-06-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5641703
Age: postnatal week 27
Specimen Label: Spleen
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:5641701
Assay Type: RT-PCR
Annotation Date: 2015-06-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5641703
Age: postnatal week 27
Specimen Label: Kidney
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:3826419
Assay Type: RT-PCR
Annotation Date: 2009-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3295228
Stage: TS28
Assay Id: MGI:3826495
Age: postnatal adult
Image: 4
Specimen Label: Ducts
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:5641701
Assay Type: RT-PCR
Annotation Date: 2015-06-24
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3588828
Stage: TS28
Assay Id: MGI:5641703
Age: postnatal week 27
Specimen Label: Muscle
Detected: false
Specimen Num: 8
GXD Expression      
Probe: MGI:5641701
Assay Type: RT-PCR
Annotation Date: 2015-06-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:5641703
Age: postnatal week 27
Specimen Label: Lung
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5641701
Assay Type: RT-PCR
Annotation Date: 2015-06-24
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5641703
Age: postnatal week 27
Specimen Label: Heart
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:5641701
Assay Type: RT-PCR
Annotation Date: 2015-06-24
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:5641703
Age: postnatal week 27
Specimen Label: Liver
Detected: false
Specimen Num: 5
GXD Expression    
Probe: MGI:3826419
Assay Type: RT-PCR
Annotation Date: 2009-01-15
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750321
Stage: TS21
Assay Id: MGI:3826495
Age: embryonic day 13.5
Image: 4
Specimen Label: TS21
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:3826419
Assay Type: RT-PCR
Annotation Date: 2009-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750323
Stage: TS23
Assay Id: MGI:3826495
Age: embryonic day 15.5
Image: 4
Specimen Label: TS23
Detected: true
Specimen Num: 3