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Search results 1 to 100 out of 563 for Mpl

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0.099s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Danio rerio
Gene
Type: gene
Organism: Rattus norvegicus
Protein Domain
Type: Family
Description: The tripeptide L-ananyl-gamma-D-glutamyl-meso-diaminopimelic acid is efficiently re-cycled during the formation of bacterial cell wall murein. Murein peptide ligase (also known as UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase) is an essential enzyme in this process which links the tripeptide to UDP-N-acetylmuramate [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Mengin-Lecreulx D
Year: 1996
Journal: J Bacteriol
Title: Identification of the mpl gene encoding UDP-N-acetylmuramate: L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase in Escherichia coli and its role in recycling of cell wall peptidoglycan.
Volume: 178
Issue: 18
Pages: 5347-52
Publication
First Author: Chan ER
Year: 2009
Journal: Exp Hematol
Title: An ENU-induced recessive mutation in Mpl leads to thrombocytopenia with overdominance.
Volume: 37
Issue: 2
Pages: 276-84
Publication  
First Author: Rommel MGE
Year: 2020
Journal: Exp Hematol
Title: Signaling properties of murine MPL and MPL mutants after stimulation with thrombopoietin and romiplostim.
Volume: 85
Pages: 33-46.e6
Publication
First Author: Gaur M
Year: 2001
Journal: Blood
Title: Characterization of Mpl mutants using primary megakaryocyte-lineage cells from mpl(-/-) mice: a new system for Mpl structure-function studies.
Volume: 97
Issue: 6
Pages: 1653-61
Publication
First Author: Petit-Cocault L
Year: 2007
Journal: Development
Title: Dual role of Mpl receptor during the establishment of definitive hematopoiesis.
Volume: 134
Issue: 16
Pages: 3031-40
Publication
First Author: Ng AP
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation.
Volume: 111
Issue: 16
Pages: 5884-9
Publication
First Author: Landrette SF
Year: 2011
Journal: Leukemia
Title: The transcription factor PlagL2 activates Mpl transcription and signaling in hematopoietic progenitor and leukemia cells.
Volume: 25
Issue: 4
Pages: 655-62
Publication  
First Author: Kaushansky K
Year: 1994
Journal: Stem Cells
Title: The mpl ligand: molecular and cellular biology of the critical regulator of megakaryocyte development.
Volume: 12 Suppl 1
Pages: 91-6; discussion 96-7
Publication
First Author: Tiedt R
Year: 2009
Journal: Blood
Title: Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes.
Volume: 113
Issue: 8
Pages: 1768-77
Publication
First Author: Scott CL
Year: 2000
Journal: Exp Hematol
Title: Granulocyte-macrophage colony-stimulating factor is not responsible for residual thrombopoiesis in mpl null mice.
Volume: 28
Issue: 9
Pages: 1001-7
Publication
First Author: Favale F
Year: 2016
Journal: Blood
Title: An incomplete trafficking defect to the cell-surface leads to paradoxical thrombocytosis for human and murine MPL P106L.
Volume: 128
Issue: 26
Pages: 3146-3158
Publication
First Author: Lannutti BJ
Year: 2009
Journal: Blood
Title: Incomplete restoration of Mpl expression in the mpl-/- mouse produces partial correction of the stem cell-repopulating defect and paradoxical thrombocytosis.
Volume: 113
Issue: 8
Pages: 1778-85
Publication
First Author: Drachman JG
Year: 2002
Journal: J Biol Chem
Title: Studies with chimeric Mpl/JAK2 receptors indicate that both JAK2 and the membrane-proximal domain of Mpl are required for cellular proliferation.
Volume: 277
Issue: 26
Pages: 23544-53
Publication
First Author: Fleury M
Year: 2010
Journal: Int J Dev Biol
Title: Mpl receptor defect leads to earlier appearance of hematopoietic cells/hematopoietic stem cells in the Aorta-Gonad-Mesonephros region, with increased apoptosis.
Volume: 54
Issue: 6-7
Pages: 1067-74
Publication
First Author: Vigon I
Year: 1993
Journal: Oncogene
Title: Characterization of the murine Mpl proto-oncogene, a member of the hematopoietic cytokine receptor family: molecular cloning, chromosomal location and evidence for a function in cell growth.
Volume: 8
Issue: 10
Pages: 2607-15
Author
Publication
First Author: Strzalkowska A
Year: 2011
Journal: Exp Anim
Title: Quantitative trait loci analysis for peripheral blood parameters in a (BALB/cW × C57BL/6J-Mpl (hlb219)/J) F(2) mice.
Volume: 60
Issue: 4
Pages: 405-16
Publication
First Author: Yorgan T
Year: 2018
Journal: Biochem Biophys Res Commun
Title: The high bone mass phenotype of Lrp5-mutant mice is not affected by megakaryocyte depletion.
Volume: 497
Issue: 2
Pages: 659-666
Protein
Organism: Mus musculus
Length: 632  
Fragment?: true
Protein
Organism: Mus musculus
Length: 623  
Fragment?: true
Protein
Organism: Mus musculus
Length: 624  
Fragment?: true
Publication
First Author: Chen S
Year: 2016
Journal: Blood
Title: Sympathetic stimulation facilitates thrombopoiesis by promoting megakaryocyte adhesion, migration, and proplatelet formation.
Volume: 127
Issue: 8
Pages: 1024-35
Publication  
First Author: Liu HD
Year: 2016
Journal: J Hematol Oncol
Title: H2S protects against fatal myelosuppression by promoting the generation of megakaryocytes/platelets.
Volume: 9
Pages: 13
Publication
First Author: Vainchenker W
Year: 1995
Journal: Thromb Haemost
Title: c-mpl, the thrombopoietin receptor.
Volume: 74
Issue: 1
Pages: 526-8
Publication
First Author: Chen S
Year: 2018
Journal: Blood
Title: IGF-1 facilitates thrombopoiesis primarily through Akt activation.
Volume: 132
Issue: 2
Pages: 210-222
Publication
First Author: Sabath DF
Year: 2002
Journal: Biochim Biophys Acta
Title: Identification and characterization of an isoform of murine Mpl.
Volume: 1574
Issue: 3
Pages: 383-6
Publication
First Author: Heckl D
Year: 2011
Journal: Blood
Title: Lentiviral gene transfer regenerates hematopoietic stem cells in a mouse model for Mpl-deficient aplastic anemia.
Volume: 117
Issue: 14
Pages: 3737-47
Publication
First Author: Gainsford T
Year: 2000
Journal: Blood
Title: The residual megakaryocyte and platelet production in c-mpl-deficient mice is not dependent on the actions of interleukin-6, interleukin-11, or leukemia inhibitory factor.
Volume: 95
Issue: 2
Pages: 528-34
Publication
First Author: Au AE
Year: 2017
Journal: Sci Rep
Title: Altered B-lymphopoiesis in mice with deregulated thrombopoietin signaling.
Volume: 7
Issue: 1
Pages: 14953
Publication
First Author: Tonelli R
Year: 2000
Journal: Hum Genet
Title: Compound heterozygosity for two different amino-acid substitution mutations in the thrombopoietin receptor (c-mpl gene) in congenital amegakaryocytic thrombocytopenia (CAMT).
Volume: 107
Issue: 3
Pages: 225-33
Publication
First Author: Alexander WS
Year: 1995
Journal: Oncogene
Title: Structure and transcription of the genomic locus encoding murine c-Mpl, a receptor for thrombopoietin.
Volume: 10
Issue: 4
Pages: 795-803
Publication
First Author: Yan XQ
Year: 1999
Journal: Exp Hematol
Title: Ectopic overexpression of c-mpl by retroviral-mediated gene transfer suppressed megakaryopoiesis but enhanced erythropoiesis in mice.
Volume: 27
Issue: 9
Pages: 1409-17
Publication
First Author: Zhang Y
Year: 2018
Journal: Stem Cells
Title: JAK2V617F Megakaryocytes Promote Hematopoietic Stem/Progenitor Cell Expansion in Mice Through Thrombopoietin/MPL Signaling.
Volume: 36
Issue: 11
Pages: 1676-1684
Publication
First Author: Du C
Year: 2017
Journal: Leukemia
Title: Estrogen promotes megakaryocyte polyploidization via estrogen receptor beta-mediated transcription of GATA1.
Volume: 31
Issue: 4
Pages: 945-956
Publication
First Author: de Graaf CA
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Regulation of hematopoietic stem cells by their mature progeny.
Volume: 107
Issue: 50
Pages: 21689-94
Publication
First Author: Tong W
Year: 2007
Journal: Exp Hematol
Title: Signals emanating from the membrane proximal region of the thrombopoietin receptor (mpl) support hematopoietic stem cell self-renewal.
Volume: 35
Issue: 9
Pages: 1447-55
Publication
First Author: Kohlscheen S
Year: 2015
Journal: PLoS One
Title: Inhibition of Thrombopoietin/Mpl Signaling in Adult Hematopoiesis Identifies New Candidates for Hematopoietic Stem Cell Maintenance.
Volume: 10
Issue: 7
Pages: e0131866
Publication
First Author: Xu L
Year: 2020
Journal: Nat Cell Biol
Title: Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions.
Volume: 22
Issue: 10
Pages: 1162-1169
Publication
First Author: Zingariello M
Year: 2017
Journal: Blood Cancer J
Title: The thrombopoietin/MPL axis is activated in the Gata1low mouse model of myelofibrosis and is associated with a defective RPS14 signature.
Volume: 7
Issue: 6
Pages: e572
Publication
First Author: Stoffel R
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Permissive role of thrombopoietin and granulocyte colony-stimulating factor receptors in hematopoietic cell fate decisions in vivo.
Volume: 96
Issue: 2
Pages: 698-702
Publication
First Author: Skoda RC
Year: 1993
Journal: EMBO J
Title: Murine c-mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal.
Volume: 12
Issue: 7
Pages: 2645-53
Publication
First Author: Pestina TI
Year: 2003
Journal: Exp Hematol
Title: Differential role of Stat5 isoforms in effecting hematopoietic recovery induced by Mpl-ligand in lethally myelosuppressed mice.
Volume: 31
Issue: 12
Pages: 1198-205
Publication
First Author: Spivak JL
Year: 2020
Journal: PLoS One
Title: Thrombopoietin is required for full phenotype expression in a JAK2V617F transgenic mouse model of polycythemia vera.
Volume: 15
Issue: 6
Pages: e0232801
Publication
First Author: Sangkhae V
Year: 2014
Journal: Blood
Title: The thrombopoietin receptor, MPL, is critical for development of a JAK2V617F-induced myeloproliferative neoplasm.
Volume: 124
Issue: 26
Pages: 3956-63
Publication
First Author: Takyar S
Year: 2013
Journal: J Exp Med
Title: VEGF controls lung Th2 inflammation via the miR-1-Mpl (myeloproliferative leukemia virus oncogene)-P-selectin axis.
Volume: 210
Issue: 10
Pages: 1993-2010
Publication
First Author: Tong W
Year: 2004
Journal: J Exp Med
Title: Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis.
Volume: 200
Issue: 5
Pages: 569-80
Publication
First Author: Drachman JG
Year: 1995
Journal: J Biol Chem
Title: The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl.
Volume: 270
Issue: 10
Pages: 4979-82
Publication
First Author: Potts KS
Year: 2015
Journal: Blood
Title: Mouse prenatal platelet-forming lineages share a core transcriptional program but divergent dependence on MPL.
Volume: 126
Issue: 6
Pages: 807-16
Publication  
First Author: Ivanova A
Year: 2010
Journal: BMC Dev Biol
Title: Expression pattern of the thrombopoietin receptor (Mpl) in the murine central nervous system.
Volume: 10
Pages: 77
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Gurney AL
Year: 1994
Journal: Science
Title: Thrombocytopenia in c-mpl-deficient mice.
Volume: 265
Issue: 5177
Pages: 1445-7
Publication
First Author: Lefrançais E
Year: 2017
Journal: Nature
Title: The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors.
Volume: 544
Issue: 7648
Pages: 105-109
Publication
First Author: Fielder PJ
Year: 1996
Journal: Blood
Title: Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets.
Volume: 87
Issue: 6
Pages: 2154-61
Publication  
First Author: Kao YR
Year: 2018
Journal: Sci Transl Med
Title: Thrombopoietin receptor-independent stimulation of hematopoietic stem cells by eltrombopag.
Volume: 10
Issue: 458
Publication
First Author: Luoh SM
Year: 2000
Journal: Mol Cell Biol
Title: Role of the distal half of the c-Mpl intracellular domain in control of platelet production by thrombopoietin in vivo.
Volume: 20
Issue: 2
Pages: 507-15
Publication
First Author: Alexander WS
Year: 1996
Journal: Blood
Title: Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl.
Volume: 87
Issue: 6
Pages: 2162-70
Publication
First Author: Kimura S
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin.
Volume: 95
Issue: 3
Pages: 1195-200
Publication
First Author: Winter O
Year: 2010
Journal: Blood
Title: Megakaryocytes constitute a functional component of a plasma cell niche in the bone marrow.
Volume: 116
Issue: 11
Pages: 1867-75
Publication
First Author: McMorran BJ
Year: 2009
Journal: Science
Title: Platelets kill intraerythrocytic malarial parasites and mediate survival to infection.
Volume: 323
Issue: 5915
Pages: 797-800
Publication
First Author: Storan MJ
Year: 2015
Journal: Stem Cells
Title: Brief Report: Factors Released by Megakaryocytes Thrombin Cleave Osteopontin to Negatively Regulate Hematopoietic Stem Cells.
Volume: 33
Issue: 7
Pages: 2351-7
Publication
First Author: Du J
Year: 2012
Journal: Stem Cells
Title: Signaling profiling at the single-cell level identifies a distinct signaling signature in murine hematopoietic stem cells.
Volume: 30
Issue: 7
Pages: 1447-54
Publication
First Author: Levin J
Year: 2001
Journal: Blood
Title: Thrombocytopenic c-mpl(-/-) mice can produce a normal level of platelets after administration of 5-fluorouracil: the effect of age on the response.
Volume: 98
Issue: 4
Pages: 1019-27
Publication
First Author: Wendling F
Year: 1989
Journal: Blood
Title: Factor-independent erythropoietic progenitor cells in leukemia induced by the myeloproliferative leukemia virus.
Volume: 73
Issue: 5
Pages: 1161-7
Publication
First Author: Kaushansky K
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: Thrombopoietin, the Mp1 ligand, is essential for full megakaryocyte development.
Volume: 92
Issue: 8
Pages: 3234-8
Publication
First Author: Broudy VC
Year: 1995
Journal: J Leukoc Biol
Title: Thrombopoietin, the c-mpl ligand, is a major regulator of platelet production.
Volume: 57
Issue: 5
Pages: 719-25
Publication
First Author: Ihara K
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Identification of mutations in the c-mpl gene in congenital amegakaryocytic thrombocytopenia.
Volume: 96
Issue: 6
Pages: 3132-6
Publication
First Author: Ziegler S
Year: 2002
Journal: Blood
Title: A 2-kb c-mpl promoter fragment is sufficient to direct expression to the megakaryocytic lineage and sites of embryonic hematopoiesis in transgenic mice.
Volume: 100
Issue: 3
Pages: 1072-4
Publication
First Author: Fox NE
Year: 2009
Journal: Exp Hematol
Title: Compound heterozygous c-Mpl mutations in a child with congenital amegakaryocytic thrombocytopenia: functional characterization and a review of the literature.
Volume: 37
Issue: 4
Pages: 495-503
Publication
First Author: Staerk J
Year: 2011
Journal: EMBO J
Title: Orientation-specific signalling by thrombopoietin receptor dimers.
Volume: 30
Issue: 21
Pages: 4398-413
Publication
First Author: Defour JP
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Tryptophan at the transmembrane-cytosolic junction modulates thrombopoietin receptor dimerization and activation.
Volume: 110
Issue: 7
Pages: 2540-5
GXD Expression      
Probe: MGI:2659163
Assay Type: Northern blot
Annotation Date: 2003-05-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2660583
Age: postnatal adult
Specimen Label: spleen
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:2659175
Assay Type: Nuclease S1
Annotation Date: 2003-05-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2660585
Age: postnatal
Specimen Label: sp-400
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:2659175
Assay Type: Nuclease S1
Annotation Date: 2003-05-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2660585
Age: postnatal
Specimen Label: sp-100
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:2659175
Assay Type: Nuclease S1
Annotation Date: 2003-05-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2660586
Age: postnatal
Specimen Label: sp-100
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:2659175
Assay Type: Nuclease S1
Annotation Date: 2003-05-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2660586
Age: postnatal
Specimen Label: sp-200
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:5905298
Assay Type: RT-PCR
Annotation Date: 2017-07-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876726
Stage: TS26
Assay Id: MGI:5905306
Age: embryonic day 18.5
Image: 1
Specimen Label: 1
Detected: true
Specimen Num: 12
GXD Expression    
Probe: MGI:5905298
Assay Type: RT-PCR
Annotation Date: 2017-07-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876726
Stage: TS26
Assay Id: MGI:5905306
Age: embryonic day 18.5
Image: 1
Specimen Label: 2
Detected: true
Specimen Num: 13