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Search results 1 to 60 out of 60 for Muc6

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Hits by Category

Type Details Score
Gene
4588 | MUC6
Type: gene
Organism: human
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Gene
720883 | MUC6
Type: gene
Organism: macaque, rhesus
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Gene
100493117 | muc6
Type: gene
Organism: frog, western clawed
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Gene
466311 | MUC6
Type: gene
Organism: chimpanzee
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Gene
282586 | Muc6
Type: gene
Organism: rat
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Protein Coding Gene
MGI:2663233 | Muc6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR030124 | MUC6
Type: Family
Description: Mucin-6 (MUC6) is a secretory mucin found at high levels in the normal stomach, where it has a protective function [, ]. It is aberrantly expressed in gastric cancer and other types of carcinomas [, , , ]. MUC6, like other glycosylated mucins, could represent a target for the development of efficient immunotherapies [].The mucin (MUC) family members are high molecular weight proteins that are components of mucus and are synthesised and secreted by specialised cells of the epithelium (goblet cells, cells of mucous glands) or non mucin-secreting cells []. There are two main mucin subfamilies: secreted mucins or gel-forming mucins (MUC2, MUC5AC, MUC5B, MUC6) and membrane-bound mucins (MUC1, MUC3, MUC4, MUC12, MUC17) []. They were thought to have the unique function of protecting and lubricating the epithelial surfaces. However, they also possess other important functions, such as growth,direct implication in the fetal development, the epithelial renewal and differentiation, the epithelial integrity, carcinogenesis, and metastasis [].
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GXD Expression
GXD Expression
     
Probe: MGI:4453822
Assay Type: RT-PCR
Annotation Date: 2010-06-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1702128
Stage: TS28
Assay Id: MGI:4453846
Age: postnatal
Specimen Label: Muc6
Detected: true
Specimen Num: 16
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GXD Expression
GXD Expression
     
Probe: MGI:4453822
Assay Type: RT-PCR
Annotation Date: 2010-06-01
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1880928
Stage: TS28
Assay Id: MGI:4453846
Age: postnatal adult
Specimen Label: Muc6
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:4453822
Assay Type: RT-PCR
Annotation Date: 2010-06-01
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1880927
Stage: TS27
Assay Id: MGI:4453846
Age: postnatal newborn
Specimen Label: Muc6
Detected: false
Specimen Num: 11
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Protein
Q0VAV1
Organism: Mus musculus/domesticus
Length: 1437  
Fragment?: false
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Publication
12676567 | J:82976
First Author: Desseyn JL
Year: 2003
Journal: Genomics
Title: Characterization of mouse muc6 and evidence of conservation of the gel-forming mucin gene cluster between human and mouse.
Volume: 81
Issue: 4
Pages: 433-6
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Publication
15753982 | -
First Author: Hamamoto A
Year: 2005
Journal: Int J Oncol
Title: Aberrant expression of the gastric mucin MUC6 in human pulmonary adenocarcinoma xenografts.
Volume: 26
Issue: 4
Pages: 891-6
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Publication
16807756 | -
First Author: Zheng H
Year: 2006
Journal: J Cancer Res Clin Oncol
Title: MUC6 down-regulation correlates with gastric carcinoma progression and a poor prognosis: an immunohistochemical study with tissue microarrays.
Volume: 132
Issue: 12
Pages: 817-23
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Publication
9650551 | -
First Author: de Bolòs C
Year: 1998
Journal: Int J Cancer
Title: MUC6 expression in breast tissues and cultured cells: abnormal expression in tumors and regulation by steroid hormones.
Volume: 77
Issue: 2
Pages: 193-9
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Publication
12360467 | -
First Author: Kim GE
Year: 2002
Journal: Gastroenterology
Title: Aberrant expression of MUC5AC and MUC6 gastric mucins and sialyl Tn antigen in intraepithelial neoplasms of the pancreas.
Volume: 123
Issue: 4
Pages: 1052-60
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Publication
21193402 | -
First Author: Freire T
Year: 2011
Journal: J Biol Chem
Title: Tn glycosylation of the MUC6 protein modulates its immunogenicity and promotes the induction of Th17-biased T cell responses.
Volume: 286
Issue: 10
Pages: 7797-811
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Publication
10681391 | -
First Author: Reis CA
Year: 2000
Journal: J Histochem Cytochem
Title: Immunohistochemical study of the expression of MUC6 mucin and co-expression of other secreted mucins (MUC5AC and MUC2) in human gastric carcinomas.
Volume: 48
Issue: 3
Pages: 377-88
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Protein Coding Gene
MGI_C57BL6J_2663233 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
Probe: MGI:7462398
Assay Type: RNA in situ
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2718128
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:7463962
Age: postnatal adult
Image: S1I
Note: Expression is seen in isthmus cells of the corpus unit.
Specimen Label: S1I
Detected: true
Specimen Num: 1
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Publication
14984930 | J:88341
First Author: Escande F
Year: 2004
Journal: Biochim Biophys Acta
Title: The mouse secreted gel-forming mucin gene cluster.
Volume: 1676
Issue: 3
Pages: 240-50
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Protein
Q80T03
Organism: Mus musculus/domesticus
Length: 2850  
Fragment?: false
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Protein
Q80Z18
Organism: Mus musculus/domesticus
Length: 1674  
Fragment?: true
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Protein
Q8K3U2
Organism: Mus musculus/domesticus
Length: 313  
Fragment?: true
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Protein
O88714
Organism: Mus musculus/domesticus
Length: 499  
Fragment?: true
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Protein
A0A7N9VSS4
Organism: Mus musculus/domesticus
Length: 4972  
Fragment?: false
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Publication
15190477 | -
First Author: Porchet N
Year: 2004
Journal: Med Sci (Paris)
Title: [MUC genes: mucin or not mucin? That is the question].
Volume: 20
Issue: 5
Pages: 569-74
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Publication
7680650 | -
First Author: Toribara NW
Year: 1993
Journal: J Biol Chem
Title: Human gastric mucin. Identification of a unique species by expression cloning.
Volume: 268
Issue: 8
Pages: 5879-85
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Publication
11578969 | -
 
First Author: Moniaux N
Year: 2001
Journal: Front Biosci
Title: Structural organization and classification of the human mucin genes.
Volume: 6
Pages: D1192-206
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Publication
17360567 | J:119475
First Author: Gavanescu I
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity.
Volume: 104
Issue: 11
Pages: 4583-7
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Publication
32141795 | J:299892
First Author: Mastrodonato M
Year: 2020
Journal: J Histochem Cytochem
Title: High-fat Diet Alters the Glycosylation Patterns of Duodenal Mucins in a Murine Model.
Volume: 68
Issue: 4
Pages: 279-294
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Publication
31422913 | J:287443
First Author: Han S
Year: 2019
Journal: Cell Stem Cell
Title: Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells.
Volume: 25
Issue: 3
Pages: 342-356.e7
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Publication
19110483 | J:154152
First Author: Das B
Year: 2009
Journal: J Histochem Cytochem
Title: Expression of Muc19/Smgc gene products during murine sublingual gland development: cytodifferentiation and maturation of salivary mucous cells.
Volume: 57
Issue: 4
Pages: 383-96
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Publication
22190642 | J:179732
First Author: Stringer EJ
Year: 2012
Journal: Development
Title: Cdx2 determines the fate of postnatal intestinal endoderm.
Volume: 139
Issue: 3
Pages: 465-74
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Publication
34391772 | J:314694
First Author: Douchi D
Year: 2021
Journal: Gastroenterology
Title: Induction of Gastric Cancer by Successive Oncogenic Activation in the Corpus.
Volume: 161
Issue: 6
Pages: 1907-1923.e26
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Publication
- | J:193309
       
First Author: Mouse Genome Informatics Scientfic Curators
Year: 2013
Title: Curated associations of genes in MGI and UniProt sequence records
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
- | J:73796
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
31862898 | J:285283
First Author: Xu YL
Year: 2019
Journal: Cell Death Dis
Title: Retinoid acid induced 16 deficiency aggravates colitis and colitis-associated tumorigenesis in mice.
Volume: 10
Issue: 12
Pages: 958
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Publication
16831596 | J:191930
First Author: Van der Sluis M
Year: 2006
Journal: Gastroenterology
Title: Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection.
Volume: 131
Issue: 1
Pages: 117-29
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Publication
16825704 | J:116875
First Author: Kuver R
Year: 2006
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Absence of CFTR is associated with pleiotropic effects on mucins in mouse gallbladder epithelial cells.
Volume: 291
Issue: 6
Pages: G1148-54
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Publication
20801882 | J:166876
First Author: Horst D
Year: 2010
Journal: J Biol Chem
Title: Requirement of the epithelium-specific Ets transcription factor Spdef for mucous gland cell function in the gastric antrum.
Volume: 285
Issue: 45
Pages: 35047-55
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Publication
24866791 | J:305866
First Author: Liu C
Year: 2014
Journal: Infect Immun
Title: Gastric de novo Muc13 expression and spasmolytic polypeptide-expressing metaplasia during Helicobacter heilmannii infection.
Volume: 82
Issue: 8
Pages: 3227-39
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Publication
15765119 | J:98205
First Author: Kang W
Year: 2005
Journal: Lab Invest
Title: Interferon gamma induction of gastric mucous neck cell hypertrophy.
Volume: 85
Issue: 5
Pages: 702-15
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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