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Search results 1 to 100 out of 400 for Mus81

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Type Details Score
Gene
Type: gene
Organism: Drosophila melanogaster
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Gene
Type: gene
Organism: Saccharomyces cerevisiae
Protein Domain
Type: Family
Description: Budding yeast Mus81 complexes with Mms4 (EME1 or EME2 in humans) to form a structure-specific endonuclease that targets branched DNA structures with a 5'-end at the branch nick [, ]. Its typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions [, ].Similar to MUS81-EME1, human MUS81-EME2 cleaves 3'-flaps, replication forks and nicked Holliday junctions, and exhibits limited endonuclease activity with intact Holliday junctions. However, MUS81-EME2 can also cleave a variety of DNA structures including D-loop recombination intermediates and nicked duplex [, ].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: McPherson JP
Year: 2004
Journal: Science
Title: Involvement of mammalian Mus81 in genome integrity and tumor suppression.
Volume: 304
Issue: 5678
Pages: 1822-6
Publication
First Author: Dendouga N
Year: 2005
Journal: Mol Cell Biol
Title: Disruption of murine Mus81 increases genomic instability and DNA damage sensitivity but does not promote tumorigenesis.
Volume: 25
Issue: 17
Pages: 7569-79
Protein
Organism: Mus musculus
Length: 130  
Fragment?: true
Publication
First Author: Shin YK
Year: 2012
Journal: FEBS J
Title: Human MUS81 complexes stimulate flap endonuclease 1.
Volume: 279
Issue: 13
Pages: 2412-30
Publication
First Author: Chen XB
Year: 2001
Journal: Mol Cell
Title: Human Mus81-associated endonuclease cleaves Holliday junctions in vitro.
Volume: 8
Issue: 5
Pages: 1117-27
Protein
Organism: Mus musculus
Length: 551  
Fragment?: false
Protein
Organism: Mus musculus
Length: 502  
Fragment?: false
Publication
First Author: Ghamrasni SE
Year: 2016
Journal: Oncogene
Title: Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation.
Volume: 35
Issue: 37
Pages: 4836-45
Protein
Organism: Mus musculus
Length: 389  
Fragment?: true
Publication
First Author: Pamidi A
Year: 2007
Journal: Cancer Res
Title: Functional interplay of p53 and Mus81 in DNA damage responses and cancer.
Volume: 67
Issue: 18
Pages: 8527-35
Publication
First Author: Tamblyn L
Year: 2009
Journal: Mutat Res
Title: A role for Mus81 in the repair of chromium-induced DNA damage.
Volume: 660
Issue: 1-2
Pages: 57-65
Publication
First Author: Larin M
Year: 2014
Journal: Nucleic Acids Res
Title: Fanconi anemia signaling and Mus81 cooperate to safeguard development and crosslink repair.
Volume: 42
Issue: 15
Pages: 9807-20
Publication
First Author: El Ghamrasni S
Year: 2015
Journal: Oncogene
Title: Cooperation of Blm and Mus81 in development, fertility, genomic integrity and cancer suppression.
Volume: 34
Issue: 14
Pages: 1780-9
Publication
First Author: Gaskell LJ
Year: 2007
Journal: EMBO J
Title: Mus81 cleavage of Holliday junctions: a failsafe for processing meiotic recombination intermediates?
Volume: 26
Issue: 7
Pages: 1891-901
Publication
First Author: Mayle R
Year: 2015
Journal: Science
Title: DNA REPAIR. Mus81 and converging forks limit the mutagenicity of replication fork breakage.
Volume: 349
Issue: 6249
Pages: 742-7
Publication
First Author: El Ghamrasni S
Year: 2011
Journal: PLoS Genet
Title: Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer.
Volume: 7
Issue: 5
Pages: e1001385
Publication
First Author: Boon RA
Year: 2011
Journal: Circ Res
Title: MicroRNA-29 in aortic dilation: implications for aneurysm formation.
Volume: 109
Issue: 10
Pages: 1115-9
Publication  
First Author: Fugger K
Year: 2013
Journal: Nat Commun
Title: FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress.
Volume: 4
Pages: 1423
Publication
First Author: Fu Y
Year: 2003
Journal: DNA Repair (Amst)
Title: Functional domains required for the Saccharomyces cerevisiae Mus81-Mms4 endonuclease complex formation and nuclear localization.
Volume: 2
Issue: 12
Pages: 1435-47
Publication
First Author: Pepe A
Year: 2014
Journal: Nucleic Acids Res
Title: Substrate specificity of the MUS81-EME2 structure selective endonuclease.
Volume: 42
Issue: 6
Pages: 3833-45
Publication
First Author: Amangyeld T
Year: 2014
Journal: Nucleic Acids Res
Title: Human MUS81-EME2 can cleave a variety of DNA structures including intact Holliday junction and nicked duplex.
Volume: 42
Issue: 9
Pages: 5846-62
Publication
First Author: Moltzer E
Year: 2011
Journal: PLoS One
Title: Impaired vascular contractility and aortic wall degeneration in fibulin-4 deficient mice: effect of angiotensin II type 1 (AT1) receptor blockade.
Volume: 6
Issue: 8
Pages: e23411
Publication
First Author: Ramnath NW
Year: 2014
Journal: PLoS One
Title: Extracellular matrix defects in aneurysmal Fibulin-4 mice predispose to lung emphysema.
Volume: 9
Issue: 9
Pages: e106054
Publication
First Author: Hanada K
Year: 2007
Journal: Circ Res
Title: Perturbations of vascular homeostasis and aortic valve abnormalities in fibulin-4 deficient mice.
Volume: 100
Issue: 5
Pages: 738-46
Publication  
First Author: Burger J
Year: 2019
Journal: Cell Signal
Title: Fibulin-4 deficiency differentially affects cytoskeleton structure and dynamics as well as TGFβ signaling.
Volume: 58
Pages: 65-78
Publication
First Author: Chang JH
Year: 2008
Journal: Genes Dev
Title: Crystal structure of the Mus81-Eme1 complex.
Volume: 22
Issue: 8
Pages: 1093-106
Publication
First Author: van der Pluijm I
Year: 2018
Journal: Cardiovasc Res
Title: Decreased mitochondrial respiration in aneurysmal aortas of Fibulin-4 mutant mice is linked to PGC1A regulation.
Volume: 114
Issue: 13
Pages: 1776-1793
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Bultmann-Mellin I
Year: 2016
Journal: Dis Model Mech
Title: Function of Ltbp-4L and fibulin-4 in survival and elastogenesis in mice.
Volume: 9
Issue: 11
Pages: 1367-1374
Publication
First Author: Previato de Almeida L
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Shugoshin protects centromere pairing and promotes segregation of nonexchange partner chromosomes in meiosis.
Volume: 116
Issue: 19
Pages: 9417-9422
Publication
First Author: Vannier JB
Year: 2012
Journal: Cell
Title: RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity.
Volume: 149
Issue: 4
Pages: 795-806
Publication
First Author: Ciccia A
Year: 2007
Journal: Mol Cell
Title: Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM.
Volume: 25
Issue: 3
Pages: 331-43
Publication
First Author: Mistry H
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Interplay between Np95 and Eme1 in the DNA damage response.
Volume: 375
Issue: 3
Pages: 321-5
Publication
First Author: Castor D
Year: 2013
Journal: Mol Cell
Title: Cooperative control of holliday junction resolution and DNA repair by the SLX1 and MUS81-EME1 nucleases.
Volume: 52
Issue: 2
Pages: 221-33
Publication
First Author: Thongthip S
Year: 2016
Journal: Genes Dev
Title: Fan1 deficiency results in DNA interstrand cross-link repair defects, enhanced tissue karyomegaly, and organ dysfunction.
Volume: 30
Issue: 6
Pages: 645-59
Publication
First Author: Jacome A
Year: 2015
Journal: EMBO J
Title: NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity.
Volume: 34
Issue: 21
Pages: 2604-19
Publication
First Author: Crossan GP
Year: 2011
Journal: Nat Genet
Title: Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia.
Volume: 43
Issue: 2
Pages: 147-52
Publication      
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication      
First Author: GemPharmatech
Year: 2020
Journal: website
Title: GemPharmatech website
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
UniProt Feature
Begin: 1
Description: Crossover junction endonuclease MUS81
Type: chain
End: 551
Allele
Name: MUS81 structure-specific endonuclease subunit; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Protein
Organism: Mus musculus
Length: 97  
Fragment?: false
Publication
First Author: Rondinelli B
Year: 2017
Journal: Nat Cell Biol
Title: EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation.
Volume: 19
Issue: 11
Pages: 1371-1378
Allele
Name: MUS81 structure-specific endonuclease subunit; targeted mutation 1, Jeroen Essers
Allele Type: Targeted
Attribute String: Null/knockout