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Search results 1 to 100 out of 109 for Myo9b

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
4650 | MYO9B
Type: gene
Organism: human
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Gene
100492218 | myo9b
Type: gene
Organism: frog, western clawed
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Gene
107966213 | MYO9B
Type: gene
Organism: chimpanzee
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Gene
114669840 | MYO9B
Type: gene
Organism: macaque, rhesus
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Gene
25486 | Myo9b
Type: gene
Organism: rat
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Gene
484844 | MYO9B
Type: gene
Organism: dog, domestic
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Gene
513493 | MYO9B
Type: gene
Organism: cattle
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Gene
420135 | MYO9B
Type: gene
Organism: chicken
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Gene
560956 | myo9b
Type: gene
Organism: zebrafish
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Protein Coding Gene
MGI:106624 | Myo9b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR028557 | MYO9B
Type: Family
Description: Unconventional myosin-IXb (MYO9B) belongs to class IX myosin that contains an extra Rho-specific GAP (GTPase-activating protein) domain in the tail region []. MYO9B plays an important part in spatially coordinated cell shape changes and motility []. In humans, there are two proteins in class IX, MYO9A and MYO9B. Class IX myosins may carry its own Rho-GAP tail using its motor head domain to sites that require down-regulation of Rho-dependent signalling [].Myosin constitutes a large superfamily of actin-dependent molecular motors. Myosin binds to actins and moves along actin filaments by using the energy from ATP hydrolysis. Myosin is involved in muscular contraction, cytokinesis, membrane trafficking and signal transduction [, ]. Myosins are typically composed of three functional domains:Motor head domain whose core sequence is highly conserved in all the myosin classes. This domain binds to actin and uses ATP hydrolysis to generate force to move along actin filaments. Neck domain composed of a long helix of variable length depending on the number of IQ motifs (has a consensus sequence of IQXXXRGXXXR) []. This domain acts as a linker and as a lever arm. The neck domain also serves as a binding site for moysin light chains, which are calmodulin-like proteins that have regulatory functions. Tail domain is the most diverse domain and vary in length and in sequence. Many myosin tails form coiled-coil structure that allow the molecules to dimerise and produce two-headed molecules. This domain mediates interaction with cargo molecules and/or other myosin subunits.
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Publication
20566876 | J:162326
First Author: Hanley PJ
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Motorized RhoGAP myosin IXb (Myo9b) controls cell shape and motility.
Volume: 107
Issue: 27
Pages: 12145-50
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Publication
36008362 | J:331479
First Author: Hemkemeyer SA
Year: 2022
Journal: Dev Dyn
Title: The RhoGAP-myosin Myo9b regulates ocular lens pit morphogenesis.
Volume: 251
Issue: 11
Pages: 1897-1907
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Publication
10580159 | J:58743
First Author: Grewal PK
Year: 1999
Journal: Gene
Title: Cloning of the murine unconventional myosin gene Myo9b and identification of alternative splicing.
Volume: 240
Issue: 2
Pages: 389-98
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Publication
37749140 | J:341223
First Author: Zhang J
Year: 2023
Journal: Nat Commun
Title: Myo9b mutations are associated with altered dendritic cell functions and increased susceptibility to autoimmune diabetes onset.
Volume: 14
Issue: 1
Pages: 5977
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Protein
Q3TRT6
Organism: Mus musculus/domesticus
Length: 258  
Fragment?: true
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Publication
11801597 | -
First Author: Post PL
Year: 2002
Journal: J Biol Chem
Title: Myosin-IXb is a single-headed and processive motor.
Volume: 277
Issue: 14
Pages: 11679-83
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Protein
A0A1D5RLW4
Organism: Mus musculus/domesticus
Length: 787  
Fragment?: true
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Publication
1558751 | -
First Author: Cheney RE
Year: 1992
Journal: Curr Opin Cell Biol
Title: Unconventional myosins.
Volume: 4
Issue: 1
Pages: 27-35
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Publication
8689571 | -
 
First Author: Mooseker MS
Year: 1995
Journal: Annu Rev Cell Dev Biol
Title: Unconventional myosins.
Volume: 11
Pages: 633-75
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Publication
10722873 | J:61347
First Author: Sellers JR
Year: 2000
Journal: Biochim Biophys Acta
Title: Myosins: a diverse superfamily.
Volume: 1496
Issue: 1
Pages: 3-22
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Protein
Q3UFX8
Organism: Mus musculus/domesticus
Length: 957  
Fragment?: true
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Protein
Q3TRQ0
Organism: Mus musculus/domesticus
Length: 454  
Fragment?: true
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Protein
Q9QY06
Organism: Mus musculus/domesticus
Length: 2114  
Fragment?: false
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Protein
E9PZW8
Organism: Mus musculus/domesticus
Length: 2128  
Fragment?: false
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Protein
E9PWZ6
Organism: Mus musculus/domesticus
Length: 1975  
Fragment?: false
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Protein
A0A1D5RLD1
Organism: Mus musculus/domesticus
Length: 1963  
Fragment?: false
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Protein
E9QKV6
Organism: Mus musculus/domesticus
Length: 1961  
Fragment?: false
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Protein
B9EHV1
Organism: Mus musculus/domesticus
Length: 1963  
Fragment?: false
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Publication
29875261 | J:264049
First Author: Moalli F
Year: 2018
Journal: J Exp Med
Title: The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8+ T cells.
Volume: 215
Issue: 7
Pages: 1869-1890
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Publication
24646736 | J:209997
First Author: Xu Y
Year: 2014
Journal: J Immunol
Title: Dendritic cell motility and T cell activation requires regulation of Rho-cofilin signaling by the Rho-GTPase activating protein myosin IXb.
Volume: 192
Issue: 8
Pages: 3559-68
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Publication
17314409 | J:124018
First Author: van den Boom F
Year: 2007
Journal: Mol Biol Cell
Title: The Myosin IXb motor activity targets the myosin IXb RhoGAP domain as cargo to sites of actin polymerization.
Volume: 18
Issue: 4
Pages: 1507-18
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Publication
33046503 | J:304062
First Author: Yi FS
Year: 2020
Journal: J Immunol
Title: TSAd Plays a Major Role in Myo9b-Mediated Suppression of Malignant Pleural Effusion by Regulating TH1/TH17 Cell Response.
Volume: 205
Issue: 10
Pages: 2926-2935
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Protein Coding Gene
MGP_CAROLIEiJ_G0031177 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0033738 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0033721 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0033646 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0033717 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0033427 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_106624 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0034235 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0032752 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0033405 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0033559 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0033501 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0033646 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0033548 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0034252 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0032459 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0032867 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0021642 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0032296 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:2669598
Assay Type: RT-PCR
Annotation Date: 2003-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2669621
Age: postnatal adult
Specimen Label: brain
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:2669598
Assay Type: RT-PCR
Annotation Date: 2003-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:2669621
Age: postnatal adult
Specimen Label: cerebellum
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:2669598
Assay Type: RT-PCR
Annotation Date: 2003-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619421
Stage: TS21
Assay Id: MGI:2669621
Age: embryonic day 13.5
Specimen Label: inner ear-13.5dpc
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:2669598
Assay Type: RT-PCR
Annotation Date: 2003-08-19
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1666917
Stage: TS17
Assay Id: MGI:2669621
Age: embryonic day 10.5
Specimen Label: otic vesicle-10.5dpc
Detected: false
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:2669598
Assay Type: RT-PCR
Annotation Date: 2003-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2669621
Age: postnatal adult
Specimen Label: heart
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:2669598
Assay Type: RT-PCR
Annotation Date: 2003-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:2669621
Age: postnatal adult
Specimen Label: muscle
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
       
Probe: MGI:2669598
Assay Type: RT-PCR
Annotation Date: 2003-08-19
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:2669621
Age: embryonic day 10.5
Specimen Label: embryo-10.5dpc
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:2669599
Assay Type: RT-PCR
Annotation Date: 2003-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2669622
Age: postnatal adult
Specimen Label: brain
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:2669599
Assay Type: RT-PCR
Annotation Date: 2003-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:2669622
Age: postnatal adult
Specimen Label: muscle
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:2669600
Assay Type: RT-PCR
Annotation Date: 2003-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2669632
Age: postnatal adult
Specimen Label: brain
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:2669600
Assay Type: RT-PCR
Annotation Date: 2003-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:2669632
Age: postnatal adult
Specimen Label: muscle
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:2669601
Assay Type: RT-PCR
Annotation Date: 2003-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2669641
Age: postnatal adult
Specimen Label: brain
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:2669601
Assay Type: RT-PCR
Annotation Date: 2003-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:2669641
Age: postnatal adult
Specimen Label: muscle
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:2669602
Assay Type: RT-PCR
Annotation Date: 2003-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619421
Stage: TS21
Assay Id: MGI:2669642
Age: embryonic day 13.5
Specimen Label: inner ear cDNA
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7488136
Assay Type: Western blot
Annotation Date: 2023-06-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:7488137
Age: postnatal adult
Image: 1
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7488136
Assay Type: Western blot
Annotation Date: 2023-06-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:7488137
Age: postnatal adult
Image: 1
Specimen Label: -/-
Detected: false
Specimen Num: 2
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Publication
25213860 | J:338769
First Author: Königs V
Year: 2014
Journal: J Biol Chem
Title: Mouse macrophages completely lacking Rho subfamily GTPases (RhoA, RhoB, and RhoC) have severe lamellipodial retraction defects, but robust chemotactic navigation and altered motility.
Volume: 289
Issue: 44
Pages: 30772-30784
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Publication
10729222 | J:63821
First Author: Contos JJ
Year: 2000
Journal: Genomics
Title: Genomic characterization of the lysophosphatidic acid receptor gene, lp(A2)/Edg4, and identification of a frameshift mutation in a previously characterized cDNA.
Volume: 64
Issue: 2
Pages: 155-69
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Publication
11212352 | J:58855
First Author: Oliver TN
Year: 1999
Journal: Cell Mol Life Sci
Title: Tails of unconventional myosins.
Volume: 56
Issue: 3-4
Pages: 243-57
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Publication
8954808 | J:37258
First Author: Whitmer JD
Year: 1996
Journal: Genomics
Title: Chromosomal location of three unconventional myosin heavy chain genes in the mouse.
Volume: 38
Issue: 2
Pages: 235-7
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Publication
9169155 | J:40158
First Author: Lutz CM
Year: 1997
Journal: Genomics
Title: Neuropeptide Y receptor genes on human chromosome 4q31-q32 map to conserved linkage groups on mouse chromosomes 3 and 8.
Volume: 41
Issue: 3
Pages: 498-500
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Publication
9417917 | J:44721
First Author: Lutz CM
Year: 1997
Journal: Genomics
Title: Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY.
Volume: 46
Issue: 2
Pages: 287-90
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Publication
8884266 | J:35477
First Author: Hasson T
Year: 1996
Journal: Genomics
Title: Mapping of unconventional myosins in mouse and human.
Volume: 36
Issue: 3
Pages: 431-9
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Publication
- | J:29126
     
First Author: The Jackson Laboratory DNA Panel Mapping Resource
Year: 1999
Journal: Database Release
Title: JAX Interspecific Backcross BSS and BSB Public Mapping Data
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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