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Search results 1 to 100 out of 106 for Myo9b

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0.053s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: rat
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Domain
Type: Family
Description: Unconventional myosin-IXb (MYO9B) belongs to class IX myosin that contains an extra Rho-specific GAP (GTPase-activating protein) domain in the tail region []. MYO9B plays an important part in spatially coordinated cell shape changes and motility []. In humans, there are two proteins in class IX, MYO9A and MYO9B. Class IX myosins may carry its own Rho-GAP tail using its motor head domain to sites that require down-regulation of Rho-dependent signalling [].Myosin constitutes a large superfamily of actin-dependent molecular motors. Myosin binds to actins and moves along actin filaments by using the energy from ATP hydrolysis. Myosin is involved in muscular contraction, cytokinesis, membrane trafficking and signal transduction [, ]. Myosins are typically composed of three functional domains:Motor head domain whose core sequence is highly conserved in all the myosin classes. This domain binds to actin and uses ATP hydrolysis to generate force to move along actin filaments. Neck domain composed of a long helix of variable length depending on the number of IQ motifs (has a consensus sequence of IQXXXRGXXXR) []. This domain acts as a linker and as a lever arm. The neck domain also serves as a binding site for moysin light chains, which are calmodulin-like proteins that have regulatory functions. Tail domain is the most diverse domain and vary in length and in sequence. Many myosin tails form coiled-coil structure that allow the molecules to dimerise and produce two-headed molecules. This domain mediates interaction with cargo molecules and/or other myosin subunits.
Publication
First Author: Hanley PJ
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Motorized RhoGAP myosin IXb (Myo9b) controls cell shape and motility.
Volume: 107
Issue: 27
Pages: 12145-50
Publication
First Author: Hemkemeyer SA
Year: 2022
Journal: Dev Dyn
Title: The RhoGAP-myosin Myo9b regulates ocular lens pit morphogenesis.
Volume: 251
Issue: 11
Pages: 1897-1907
Publication
First Author: Grewal PK
Year: 1999
Journal: Gene
Title: Cloning of the murine unconventional myosin gene Myo9b and identification of alternative splicing.
Volume: 240
Issue: 2
Pages: 389-98
Publication
First Author: Zhang J
Year: 2023
Journal: Nat Commun
Title: Myo9b mutations are associated with altered dendritic cell functions and increased susceptibility to autoimmune diabetes onset.
Volume: 14
Issue: 1
Pages: 5977
Protein
Organism: Mus musculus/domesticus
Length: 258  
Fragment?: true
Publication
First Author: Post PL
Year: 2002
Journal: J Biol Chem
Title: Myosin-IXb is a single-headed and processive motor.
Volume: 277
Issue: 14
Pages: 11679-83
Protein
Organism: Mus musculus/domesticus
Length: 787  
Fragment?: true
Publication
First Author: Cheney RE
Year: 1992
Journal: Curr Opin Cell Biol
Title: Unconventional myosins.
Volume: 4
Issue: 1
Pages: 27-35
Publication  
First Author: Mooseker MS
Year: 1995
Journal: Annu Rev Cell Dev Biol
Title: Unconventional myosins.
Volume: 11
Pages: 633-75
Publication
First Author: Sellers JR
Year: 2000
Journal: Biochim Biophys Acta
Title: Myosins: a diverse superfamily.
Volume: 1496
Issue: 1
Pages: 3-22
Protein
Organism: Mus musculus/domesticus
Length: 957  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 454  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 2114  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2128  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1975  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1963  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1961  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1963  
Fragment?: false
Publication
First Author: Moalli F
Year: 2018
Journal: J Exp Med
Title: The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8+ T cells.
Volume: 215
Issue: 7
Pages: 1869-1890
Publication
First Author: Xu Y
Year: 2014
Journal: J Immunol
Title: Dendritic cell motility and T cell activation requires regulation of Rho-cofilin signaling by the Rho-GTPase activating protein myosin IXb.
Volume: 192
Issue: 8
Pages: 3559-68
Publication
First Author: van den Boom F
Year: 2007
Journal: Mol Biol Cell
Title: The Myosin IXb motor activity targets the myosin IXb RhoGAP domain as cargo to sites of actin polymerization.
Volume: 18
Issue: 4
Pages: 1507-18
Publication
First Author: Yi FS
Year: 2020
Journal: J Immunol
Title: TSAd Plays a Major Role in Myo9b-Mediated Suppression of Malignant Pleural Effusion by Regulating TH1/TH17 Cell Response.
Volume: 205
Issue: 10
Pages: 2926-2935
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:2669598
Assay Type: RT-PCR
Annotation Date: 2003-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2669621
Age: postnatal adult
Specimen Label: brain
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:2669598
Assay Type: RT-PCR
Annotation Date: 2003-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:2669621
Age: postnatal adult
Specimen Label: cerebellum
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:2669598
Assay Type: RT-PCR
Annotation Date: 2003-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619421
Stage: TS21
Assay Id: MGI:2669621
Age: embryonic day 13.5
Specimen Label: inner ear-13.5dpc
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:2669598
Assay Type: RT-PCR
Annotation Date: 2003-08-19
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1666917
Stage: TS17
Assay Id: MGI:2669621
Age: embryonic day 10.5
Specimen Label: otic vesicle-10.5dpc
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:2669598
Assay Type: RT-PCR
Annotation Date: 2003-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2669621
Age: postnatal adult
Specimen Label: heart
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:2669598
Assay Type: RT-PCR
Annotation Date: 2003-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:2669621
Age: postnatal adult
Specimen Label: muscle
Detected: true
Specimen Num: 6
GXD Expression        
Probe: MGI:2669598
Assay Type: RT-PCR
Annotation Date: 2003-08-19
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:2669621
Age: embryonic day 10.5
Specimen Label: embryo-10.5dpc
Specimen Num: 7
GXD Expression      
Probe: MGI:2669599
Assay Type: RT-PCR
Annotation Date: 2003-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2669622
Age: postnatal adult
Specimen Label: brain
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:2669599
Assay Type: RT-PCR
Annotation Date: 2003-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:2669622
Age: postnatal adult
Specimen Label: muscle
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:2669600
Assay Type: RT-PCR
Annotation Date: 2003-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2669632
Age: postnatal adult
Specimen Label: brain
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:2669600
Assay Type: RT-PCR
Annotation Date: 2003-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:2669632
Age: postnatal adult
Specimen Label: muscle
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:2669601
Assay Type: RT-PCR
Annotation Date: 2003-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2669641
Age: postnatal adult
Specimen Label: brain
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:2669601
Assay Type: RT-PCR
Annotation Date: 2003-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:2669641
Age: postnatal adult
Specimen Label: muscle
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:2669602
Assay Type: RT-PCR
Annotation Date: 2003-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619421
Stage: TS21
Assay Id: MGI:2669642
Age: embryonic day 13.5
Specimen Label: inner ear cDNA
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7488136
Assay Type: Western blot
Annotation Date: 2023-06-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:7488137
Age: postnatal adult
Image: 1
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7488136
Assay Type: Western blot
Annotation Date: 2023-06-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:7488137
Age: postnatal adult
Image: 1
Specimen Label: -/-
Detected: false
Specimen Num: 2
Publication
First Author: Königs V
Year: 2014
Journal: J Biol Chem
Title: Mouse macrophages completely lacking Rho subfamily GTPases (RhoA, RhoB, and RhoC) have severe lamellipodial retraction defects, but robust chemotactic navigation and altered motility.
Volume: 289
Issue: 44
Pages: 30772-30784
Publication
First Author: Contos JJ
Year: 2000
Journal: Genomics
Title: Genomic characterization of the lysophosphatidic acid receptor gene, lp(A2)/Edg4, and identification of a frameshift mutation in a previously characterized cDNA.
Volume: 64
Issue: 2
Pages: 155-69
Publication
First Author: Oliver TN
Year: 1999
Journal: Cell Mol Life Sci
Title: Tails of unconventional myosins.
Volume: 56
Issue: 3-4
Pages: 243-57
Publication
First Author: Whitmer JD
Year: 1996
Journal: Genomics
Title: Chromosomal location of three unconventional myosin heavy chain genes in the mouse.
Volume: 38
Issue: 2
Pages: 235-7
Publication
First Author: Lutz CM
Year: 1997
Journal: Genomics
Title: Neuropeptide Y receptor genes on human chromosome 4q31-q32 map to conserved linkage groups on mouse chromosomes 3 and 8.
Volume: 41
Issue: 3
Pages: 498-500
Publication
First Author: Lutz CM
Year: 1997
Journal: Genomics
Title: Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY.
Volume: 46
Issue: 2
Pages: 287-90
Publication
First Author: Hasson T
Year: 1996
Journal: Genomics
Title: Mapping of unconventional myosins in mouse and human.
Volume: 36
Issue: 3
Pages: 431-9
Publication      
First Author: The Jackson Laboratory DNA Panel Mapping Resource
Year: 1999
Journal: Database Release
Title: JAX Interspecific Backcross BSS and BSB Public Mapping Data
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform