| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:8209565 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2025-06-06 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:2767822 |
| Pattern: |
Not Specified |
| Stage: |
TS22 |
| Assay Id: |
MGI:8209569 |
| Age: |
embryonic day 14.5 |
| Image: |
7B Nedd4 |
| Note: |
Expression in epithelialized structures. |
| Specimen Label: |
7B Nedd4 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:8209565 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2025-06-06 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3643722 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:8209569 |
| Age: |
embryonic day 14.5 |
| Image: |
7B Nedd4 |
| Note: |
Expression in metanephric mesenchyme. |
| Specimen Label: |
7B Nedd4 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:8209565 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2025-06-06 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:2768122 |
| Pattern: |
Not Specified |
| Stage: |
TS22 |
| Assay Id: |
MGI:8209569 |
| Age: |
embryonic day 14.5 |
| Image: |
7B Nedd4 |
| Note: |
Expression in epithelialized structures. |
| Specimen Label: |
7B Nedd4 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:8233560 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2025-08-07 |
| Strength: |
Absent |
| Sex: |
Male |
| Emaps: |
EMAPS:2910622 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:8233776 |
| Age: |
embryonic day 14.5 |
| Image: |
S1C NEDD4 Cre:flox/flox |
| Note: |
Expression absent in Sertoli cells and Leydig cells. |
| Specimen Label: |
S1C NEDD4 Cre:flox/flox |
| Detected: |
false |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:8233560 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2025-08-07 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1797322 |
| Pattern: |
Not Specified |
| Stage: |
TS22 |
| Assay Id: |
MGI:8233776 |
| Age: |
embryonic day 14.5 |
| Image: |
S1C NEDD4 Cre:flox/flox |
| Note: |
Persistent expression within coelomic epithelium. |
| Specimen Label: |
S1C NEDD4 Cre:flox/flox |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3821167 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2009-01-15 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3564522 |
| Pattern: |
Not Specified |
| Stage: |
TS22 |
| Assay Id: |
MGI:3825728 |
| Age: |
embryonic day 14.5 |
| Image: |
Additional file 4 Nedd4 |
|
| Specimen Label: |
Additional file 4 Nedd4 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:8233560 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2025-08-07 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1738419 |
| Pattern: |
Not Specified |
| Stage: |
TS19 |
| Assay Id: |
MGI:8233776 |
| Age: |
embryonic day 11.5 |
| Image: |
S1A NEDD4 Cre:flox/flox |
| Note: |
Expression detectable in coelomic epithelial cells. |
| Specimen Label: |
S1A NEDD4 Cre:flox/flox |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:8233560 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2025-08-07 |
| Strength: |
Absent |
| Sex: |
Male |
| Emaps: |
EMAPS:2910622 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:8233776 |
| Age: |
embryonic day 14.5 |
| Image: |
S1C NEDD4 Cre:flox/flox |
| Note: |
Expression absent in Sertoli cells and Leydig cells. |
| Specimen Label: |
S1C NEDD4 Cre:flox/flox |
| Detected: |
false |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:8233560 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2025-08-07 |
| Strength: |
Absent |
| Sex: |
Male |
| Emaps: |
EMAPS:2965522 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:8233776 |
| Age: |
embryonic day 14.5 |
| Image: |
S1C NEDD4 Cre:flox/flox |
| Note: |
Expression absent in Sertoli cells and Leydig cells. |
| Specimen Label: |
S1C NEDD4 Cre:flox/flox |
| Detected: |
false |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:8233560 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2025-08-07 |
| Strength: |
Absent |
| Sex: |
Male |
| Emaps: |
EMAPS:2965522 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:8233776 |
| Age: |
embryonic day 14.5 |
| Image: |
S1C NEDD4 Cre:flox/flox |
| Note: |
Expression absent in Sertoli cells and Leydig cells. |
| Specimen Label: |
S1C NEDD4 Cre:flox/flox |
| Detected: |
false |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5306966 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-02-24 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1754422 |
| Pattern: |
Not Specified |
| Stage: |
TS22 |
| Assay Id: |
MGI:5307027 |
| Age: |
embryonic day 14.5 |
| Image: |
S4 Nedd4 ISH |
|
| Specimen Label: |
S4 Nedd4 ISH |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:8233560 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2025-08-07 |
| Strength: |
Absent |
| Sex: |
Male |
| Emaps: |
EMAPS:1842822 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:8233776 |
| Age: |
embryonic day 14.5 |
| Image: |
S2A NEDD4 Control |
| Note: |
Expression absent from chromaffin cells of adrenal medulla. |
| Specimen Label: |
S2A NEDD4 Control |
| Detected: |
false |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:8233560 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2025-08-07 |
| Strength: |
Strong |
| Sex: |
Male |
| Emaps: |
EMAPS:1842722 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:8233776 |
| Age: |
embryonic day 14.5 |
| Image: |
S2A NEDD4 Control |
|
| Specimen Label: |
S2A NEDD4 Control |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:8233560 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2025-08-07 |
| Strength: |
Absent |
| Sex: |
Male |
| Emaps: |
EMAPS:1842722 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:8233776 |
| Age: |
embryonic day 14.5 |
| Image: |
S2A NEDD4 Cre:flox/flox |
| Note: |
Expression absent from Nr5a1-expressing cortical cells. |
| Specimen Label: |
S2A NEDD4 Cre:flox/flox |
| Detected: |
false |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:8233560 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2025-08-07 |
| Strength: |
Weak |
| Sex: |
Male |
| Emaps: |
EMAPS:1797222 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:8233776 |
| Age: |
embryonic day 14.5 |
| Image: |
S1C NEDD4 Cre:flox/flox |
| Note: |
Expression at a much lower level compared to control. |
| Specimen Label: |
S1C NEDD4 Cre:flox/flox |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:8233560 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2025-08-07 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1797222 |
| Pattern: |
Widespread |
| Stage: |
TS22 |
| Assay Id: |
MGI:8233776 |
| Age: |
embryonic day 14.5 |
| Image: |
S1C NEDD4 Control |
| Note: |
Widely expressed in control gonads. |
| Specimen Label: |
S1C NEDD4 Control |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:8233560 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2025-08-07 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1797522 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:8233776 |
| Age: |
embryonic day 14.5 |
| Image: |
S1C NEDD4 Cre:flox/flox |
| Note: |
Expression in germ cells within testis cords. |
| Specimen Label: |
S1C NEDD4 Cre:flox/flox |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:8233560 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2025-08-07 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1738319 |
| Pattern: |
Ubiquitous |
| Stage: |
TS19 |
| Assay Id: |
MGI:8233776 |
| Age: |
embryonic day 11.5 |
| Image: |
S1A NEDD4 Control |
| Note: |
Ubiquitously expressed throughout gonad and surrounding tissues. |
| Specimen Label: |
S1A NEDD4 Control |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:8233560 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2025-08-07 |
| Strength: |
Weak |
| Sex: |
Male |
| Emaps: |
EMAPS:1738319 |
| Pattern: |
Regionally restricted |
| Stage: |
TS19 |
| Assay Id: |
MGI:8233776 |
| Age: |
embryonic day 11.5 |
| Image: |
S1A NEDD4 Cre:flox/flox |
| Note: |
Reduced expression in most, although still observed in some, somatic cells. |
| Specimen Label: |
S1A NEDD4 Cre:flox/flox |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Murillas R |
| Year: |
2002 |
| Journal: |
J Biol Chem |
| Title: |
Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase. |
| Volume: |
277 |
| Issue: |
4 |
| Pages: |
2897-907 |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Goh CP |
| Year: |
2013 |
| Journal: |
Neurosci Lett |
| Title: |
Ndfip1 expression in developing neurons indicates a role for protein ubiquitination by Nedd4 E3 ligases during cortical development. |
| Volume: |
555 |
|
| Pages: |
225-30 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Camera D |
| Year: |
2014 |
| Journal: |
Behav Brain Res |
| Title: |
Subtle gait abnormalities in Nedd4 heterozygous mice. |
| Volume: |
260 |
|
| Pages: |
15-24 |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fotia AB |
| Year: |
2006 |
| Journal: |
Int J Biochem Cell Biol |
| Title: |
The ubiquitin-protein ligases Nedd4 and Nedd4-2 show similar ubiquitin-conjugating enzyme specificities. |
| Volume: |
38 |
| Issue: |
3 |
| Pages: |
472-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lackovic J |
| Year: |
2012 |
| Journal: |
Exp Neurol |
| Title: |
Differential regulation of Nedd4 ubiquitin ligases and their adaptor protein Ndfip1 in a rat model of ischemic stroke. |
| Volume: |
235 |
| Issue: |
1 |
| Pages: |
326-35 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cao XR |
| Year: |
2008 |
| Journal: |
Sci Signal |
| Title: |
Nedd4 controls animal growth by regulating IGF-1 signaling. |
| Volume: |
1 |
| Issue: |
38 |
| Pages: |
ra5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fang DF |
| Year: |
2014 |
| Journal: |
Nat Commun |
| Title: |
NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activation. |
| Volume: |
5 |
|
| Pages: |
4513 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lu C |
| Year: |
2016 |
| Journal: |
Oncogene |
| Title: |
Intestinal knockout of Nedd4 enhances growth of Apc(min) tumors. |
| Volume: |
35 |
| Issue: |
45 |
| Pages: |
5839-5849 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang ZW |
| Year: |
2020 |
| Journal: |
Semin Cancer Biol |
| Title: |
NEDD4 E3 ligase: Functions and mechanism in human cancer. |
| Volume: |
67 |
| Issue: |
Pt 2 |
| Pages: |
92-101 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sanchez-Perez A |
| Year: |
2007 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
GRK2 interacts with and phosphorylates Nedd4 and Nedd4-2. |
| Volume: |
359 |
| Issue: |
3 |
| Pages: |
611-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sun W |
| Year: |
2023 |
| Journal: |
Cell Commun Signal |
| Title: |
NEDD4 ameliorates myocardial reperfusion injury by preventing macrophages pyroptosis. |
| Volume: |
21 |
| Issue: |
1 |
| Pages: |
29 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4354352 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2009-08-25 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3270422 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:4354836 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
Table S5 - Nedd4 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4354352 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2009-08-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3271122 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:4354836 |
| Age: |
embryonic day 14.5 |
|
| Note: |
Expression is present in the upper, but not the lower, cortical plate. |
| Specimen Label: |
Table S5 - Nedd4 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4354352 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2009-08-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1754722 |
| Pattern: |
Not Specified |
| Stage: |
TS22 |
| Assay Id: |
MGI:4354836 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
Table S5 - Nedd4 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wiszniak S |
| Year: |
2016 |
| Journal: |
Dev Biol |
| Title: |
Cell autonomous roles of Nedd4 in craniofacial bone formation. |
| Volume: |
410 |
| Issue: |
1 |
| Pages: |
98-107 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zeng Q |
| Year: |
2025 |
| Journal: |
J Biomed Sci |
| Title: |
K27-linked ROR?t ubiquitination by Nedd4 potentiates Th17-mediated autoimmunity. |
| Volume: |
32 |
| Issue: |
1 |
| Pages: |
26 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Van Campenhout CA |
| Year: |
2011 |
| Journal: |
Dev Cell |
| Title: |
Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3?ubiquitin ligases. |
| Volume: |
21 |
| Issue: |
3 |
| Pages: |
479-91 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Harvey KF |
| Year: |
2002 |
| Journal: |
J Biol Chem |
| Title: |
N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein. |
| Volume: |
277 |
| Issue: |
11 |
| Pages: |
9307-17 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Weston AD |
| Year: |
2000 |
| Journal: |
Mech Dev |
| Title: |
Analysis of Nedd4 expression during skeletal development in the mouse limb. |
| Volume: |
94 |
| Issue: |
1-2 |
| Pages: |
247-50 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li JJ |
| Year: |
2016 |
| Journal: |
Sci Rep |
| Title: |
Ubiquitin Ligase NEDD4 Regulates PPAR? Stability and Adipocyte Differentiation in 3T3-L1 Cells. |
| Volume: |
6 |
|
| Pages: |
38550 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Camera D |
| Year: |
2016 |
| Journal: |
Behav Brain Res |
| Title: |
Learning, memory and long-term potentiation are altered in Nedd4 heterozygous mice. |
| Volume: |
303 |
|
| Pages: |
176-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gautam V |
| Year: |
2013 |
| Journal: |
Neuropharmacology |
| Title: |
Nedd4 is a specific E3 ubiquitin ligase for the NMDA receptor subunit GluN2D. |
| Volume: |
74 |
|
| Pages: |
96-107 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jeon SA |
| Year: |
2018 |
| Journal: |
Bone |
| Title: |
E3-ubiquitin ligase NEDD4 enhances bone formation by removing TGF?1-induced pSMAD1 in immature osteoblast. |
| Volume: |
116 |
|
| Pages: |
248-258 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kumar S |
| Year: |
1997 |
| Journal: |
Genomics |
| Title: |
cDNA cloning, expression analysis, and mapping of the mouse Nedd4 gene. |
| Volume: |
40 |
| Issue: |
3 |
| Pages: |
435-43 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Noyes NC |
| Year: |
2016 |
| Journal: |
Biochemistry |
| Title: |
Regulation of Itch and Nedd4 E3 Ligase Activity and Degradation by LRAD3. |
| Volume: |
55 |
| Issue: |
8 |
| Pages: |
1204-13 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Flasza M |
| Year: |
2002 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Alternative splicing determines the domain structure of WWP1, a Nedd4 family protein. |
| Volume: |
290 |
| Issue: |
1 |
| Pages: |
431-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu Q |
| Year: |
2019 |
| Journal: |
Cell Death Differ |
| Title: |
E3 ubiquitin ligase Nedd4 is a key negative regulator for non-canonical inflammasome activation. |
| Volume: |
26 |
| Issue: |
11 |
| Pages: |
2386-2399 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhou Z |
| Year: |
2017 |
| Journal: |
Nat Commun |
| Title: |
NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes. |
| Volume: |
8 |
|
| Pages: |
15662 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kalinichenko SV |
| Year: |
2012 |
| Journal: |
PLoS One |
| Title: |
Identification of Nedd4 E3 ubiquitin ligase as a binding partner and regulator of MAK-V protein kinase. |
| Volume: |
7 |
| Issue: |
6 |
| Pages: |
e39505 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Windley SP |
| Year: |
2022 |
| Journal: |
Cell Death Dis |
| Title: |
Loss of NEDD4 causes complete XY gonadal sex reversal in mice. |
| Volume: |
13 |
| Issue: |
1 |
| Pages: |
75 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hirata H |
| Year: |
2021 |
| Journal: |
FASEB J |
| Title: |
PMEPA1 and NEDD4 control the proton production of osteoclasts by regulating vesicular trafficking. |
| Volume: |
35 |
| Issue: |
2 |
| Pages: |
e21281 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kamynina E |
| Year: |
2001 |
| Journal: |
FASEB J |
| Title: |
A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel. |
| Volume: |
15 |
| Issue: |
1 |
| Pages: |
204-214 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee JH |
| Year: |
2017 |
| Journal: |
J Bone Miner Res |
| Title: |
Nedd4 Deficiency in Vascular Smooth Muscle Promotes Vascular Calcification by Stabilizing pSmad1. |
| Volume: |
32 |
| Issue: |
5 |
| Pages: |
927-938 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yang B |
| Year: |
2008 |
| Journal: |
Nat Immunol |
| Title: |
Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells. |
| Volume: |
9 |
| Issue: |
12 |
| Pages: |
1356-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sun J |
| Year: |
2013 |
| Journal: |
Genes Dev |
| Title: |
E3-ubiquitin ligase Nedd4 determines the fate of AID-associated RNA polymerase II in B cells. |
| Volume: |
27 |
| Issue: |
16 |
| Pages: |
1821-33 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hong Z |
| Year: |
2023 |
| Journal: |
J Pharm Anal |
| Title: |
Celastrol targeting Nedd4 reduces Nrf2-mediated oxidative stress in astrocytes after ischemic stroke. |
| Volume: |
13 |
| Issue: |
2 |
| Pages: |
156-169 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Windley SP |
| Year: |
2025 |
| Journal: |
Endocrinology |
| Title: |
NEDD4 Promotes Sertoli Cell Proliferation and Adult Leydig Cell Differentiation in the Murine Testis. |
| Volume: |
166 |
| Issue: |
9 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lohraseb I |
| Year: |
2022 |
| Journal: |
Nat Commun |
| Title: |
Global ubiquitinome profiling identifies NEDD4 as a regulator of Profilin 1 and actin remodelling in neural crest cells. |
| Volume: |
13 |
| Issue: |
1 |
| Pages: |
2018 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Manning J |
| Year: |
2020 |
| Journal: |
J Proteomics |
| Title: |
Identification of novel interacting partners of the NEDD4 ubiquitin ligase in mouse testis. |
| Volume: |
223 |
|
| Pages: |
103830 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fimiani C |
| Year: |
2025 |
| Journal: |
Glia |
| Title: |
The E3 ubiquitin ligase Nedd4 fosters developmental myelination in the mouse central and peripheral nervous system. |
| Volume: |
73 |
| Issue: |
2 |
| Pages: |
422-444 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fotia AB |
| Year: |
2004 |
| Journal: |
J Biol Chem |
| Title: |
Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2. |
| Volume: |
279 |
| Issue: |
28 |
| Pages: |
28930-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Staub O |
| Year: |
1996 |
| Journal: |
EMBO J |
| Title: |
WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome. |
| Volume: |
15 |
| Issue: |
10 |
| Pages: |
2371-80 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Guo H |
| Year: |
2012 |
| Journal: |
Cell Rep |
| Title: |
E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activity. |
| Volume: |
1 |
| Issue: |
5 |
| Pages: |
472-82 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Harvey KF |
| Year: |
1999 |
| Journal: |
J Biol Chem |
| Title: |
All three WW domains of murine Nedd4 are involved in the regulation of epithelial sodium channels by intracellular Na+. |
| Volume: |
274 |
| Issue: |
18 |
| Pages: |
12525-30 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wiszniak S |
| Year: |
2026 |
| Journal: |
Nat Commun |
| Title: |
Neural crest cell-derived DKK1 and NEDD4 modulate Wnt signalling in the?second heart field to orchestrate outflow tract development. |
| Volume: |
17 |
| Issue: |
1 |
| Pages: |
1751 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gorla M |
| Year: |
2022 |
| Journal: |
J Neurosci |
| Title: |
A Nedd4 E3 Ubiquitin Ligase Pathway Inhibits Robo1 Repulsion and Promotes Commissural Axon Guidance across the Midline. |
| Volume: |
42 |
| Issue: |
40 |
| Pages: |
7547-7561 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wiszniak S |
| Year: |
2013 |
| Journal: |
Dev Biol |
| Title: |
The ubiquitin ligase Nedd4 regulates craniofacial development by promoting cranial neural crest cell survival and stem-cell like properties. |
| Volume: |
383 |
| Issue: |
2 |
| Pages: |
186-200 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bellet MM |
| Year: |
2014 |
| Journal: |
Cell Cycle |
| Title: |
NEDD4 controls the expression of GUCD1, a protein upregulated in proliferating liver cells. |
| Volume: |
13 |
| Issue: |
12 |
| Pages: |
1902-11 |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Publication |
| First Author: |
O'Leary CE |
| Year: |
2016 |
| Journal: |
Nat Commun |
| Title: |
Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells. |
| Volume: |
7 |
|
| Pages: |
11226 |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
263
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jolliffe CN |
| Year: |
2000 |
| Journal: |
Biochem J |
| Title: |
Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4. |
| Volume: |
351 Pt 3 |
| Issue: |
Pt 3 |
| Pages: |
557-65 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Harvey KF |
| Year: |
1999 |
| Journal: |
Trends Cell Biol |
| Title: |
Nedd4-like proteins: an emerging family of ubiquitin-protein ligases implicated in diverse cellular functions. |
| Volume: |
9 |
| Issue: |
5 |
| Pages: |
166-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lu PJ |
| Year: |
1999 |
| Journal: |
Science |
| Title: |
Function of WW domains as phosphoserine- or phosphothreonine-binding modules. |
| Volume: |
283 |
| Issue: |
5406 |
| Pages: |
1325-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fang NN |
| Year: |
2014 |
| Journal: |
Nat Cell Biol |
| Title: |
Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress. |
| Volume: |
16 |
| Issue: |
12 |
| Pages: |
1227-37 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tuckow AP |
| Year: |
2013 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Identification of ubiquitin-modified lysine residues and novel phosphorylation sites on eukaryotic initiation factor 2B epsilon. |
| Volume: |
436 |
| Issue: |
1 |
| Pages: |
41-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Murdaca J |
| Year: |
2004 |
| Journal: |
J Biol Chem |
| Title: |
Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation. |
| Volume: |
279 |
| Issue: |
25 |
| Pages: |
26754-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Timmins J |
| Year: |
2003 |
| Journal: |
J Mol Biol |
| Title: |
Ebola virus matrix protein VP40 interaction with human cellular factors Tsg101 and Nedd4. |
| Volume: |
326 |
| Issue: |
2 |
| Pages: |
493-502 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gormley K |
| Year: |
2003 |
| Journal: |
Biochem J |
| Title: |
Regulation of the epithelial sodium channel by accessory proteins. |
| Volume: |
371 |
| Issue: |
Pt 1 |
| Pages: |
1-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Persaud A |
| Year: |
2011 |
| Journal: |
EMBO J |
| Title: |
Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function. |
| Volume: |
30 |
| Issue: |
16 |
| Pages: |
3259-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zheng HL |
| Year: |
2021 |
| Journal: |
Cell Death Dis |
| Title: |
Beraprost ameliorates postmenopausal osteoporosis by regulating Nedd4-induced Runx2 ubiquitination. |
| Volume: |
12 |
| Issue: |
5 |
| Pages: |
497 |
|
•
•
•
•
•
|