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Search results 1 to 100 out of 320 for Npm1

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Brunetti L
Year: 2018
Journal: Cancer Cell
Title: Mutant NPM1 Maintains the Leukemic State through HOX Expression.
Volume: 34
Issue: 3
Pages: 499-512.e9
Publication
First Author: Mduff FK
Year: 2011
Journal: Lab Invest
Title: Determining the contribution of NPM1 heterozygosity to NPM-ALK-induced lymphomagenesis.
Volume: 91
Issue: 9
Pages: 1298-303
Publication
First Author: Ando K
Year: 2017
Journal: J Cell Biol
Title: NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus.
Volume: 216
Issue: 6
Pages: 1795-1810
Publication      
First Author: Loberg MA
Year: 2019
Journal: Leukemia
Title: Sequentially inducible mouse models reveal that Npm1 mutation causes malignant transformation of Dnmt3a-mutant clonal hematopoiesis.
Publication
First Author: Sportoletti P
Year: 2008
Journal: Blood
Title: Npm1 is a haploinsufficient suppressor of myeloid and lymphoid malignancies in the mouse.
Volume: 111
Issue: 7
Pages: 3859-62
Publication
First Author: Nachmani D
Year: 2019
Journal: Nat Genet
Title: Germline NPM1 mutations lead to altered rRNA 2'-O-methylation and cause dyskeratosis congenita.
Volume: 51
Issue: 10
Pages: 1518-1529
Publication
First Author: Chou SH
Year: 2012
Journal: PLoS One
Title: A knock-in Npm1 mutation in mice results in myeloproliferation and implies a perturbation in hematopoietic microenvironment.
Volume: 7
Issue: 11
Pages: e49769
Publication
First Author: Wang BB
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Inducible and reversible suppression of Npm1 gene expression using stably integrated small interfering RNA vector in mouse embryonic stem cells.
Volume: 347
Issue: 4
Pages: 1129-37
MGI Directed Relationship Property
Name: Non-mouse_Gene_Symbol
Value: NPM1
MGI Directed Relationship Property
Name: Non-mouse_Gene_Symbol
Value: NPM1
MGI Directed Relationship Property
Name: Non-mouse_Gene_Symbol
Value: NPM1
MGI Directed Relationship Property
Name: Non-mouse_Gene_Symbol
Value: NPM1
MGI Directed Relationship Property
Name: Non-mouse_Gene_Symbol
Value: NPM1
MGI Directed Relationship Property
Name: Non-mouse_Gene_Symbol
Value: NPM1
Protein
Organism: Mus musculus
Length: 257  
Fragment?: false
Publication
First Author: Rudorf A
Year: 2019
Journal: Blood
Title: NPM1c alters FLT3-D835Y localization and signaling in acute myeloid leukemia.
Volume: 134
Issue: 4
Pages: 383-388
Publication
First Author: Sportoletti P
Year: 2015
Journal: Leukemia
Title: Mouse models of NPM1-mutated acute myeloid leukemia: biological and clinical implications.
Volume: 29
Issue: 2
Pages: 269-78
Publication
First Author: Lin J
Year: 2017
Journal: Nucleic Acids Res
Title: Efficient DNA binding of NF-κB requires the chaperone-like function of NPM1.
Volume: 45
Issue: 7
Pages: 3707-3723
Publication
First Author: Mitrea DM
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Structural polymorphism in the N-terminal oligomerization domain of NPM1.
Volume: 111
Issue: 12
Pages: 4466-71
Publication
First Author: Okuwaki M
Year: 2012
Journal: Nucleic Acids Res
Title: Function of homo- and hetero-oligomers of human nucleoplasmin/nucleophosmin family proteins NPM1, NPM2 and NPM3 during sperm chromatin remodeling.
Volume: 40
Issue: 11
Pages: 4861-78
Publication
First Author: Dovey OM
Year: 2017
Journal: Blood
Title: Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia.
Volume: 130
Issue: 17
Pages: 1911-1922
Publication
First Author: Grisendi S
Year: 2005
Journal: Nature
Title: Role of nucleophosmin in embryonic development and tumorigenesis.
Volume: 437
Issue: 7055
Pages: 147-53
Publication
First Author: Khanna-Gupta A
Year: 2012
Journal: J Biol Chem
Title: Up-regulation of translation eukaryotic initiation factor 4E in nucleophosmin 1 haploinsufficient cells results in changes in CCAAT enhancer-binding protein α activity: implications in myelodysplastic syndrome and acute myeloid leukemia.
Volume: 287
Issue: 39
Pages: 32728-37
Publication
First Author: Guery L
Year: 2011
Journal: Blood
Title: Fine-tuning nucleophosmin in macrophage differentiation and activation.
Volume: 118
Issue: 17
Pages: 4694-704
Publication
First Author: Johansson H
Year: 2010
Journal: Aging (Albany NY)
Title: Core transcription factors, Oct4, Sox2 and Nanog, individually form complexes with nucleophosmin (Npm1) to control embryonic stem (ES) cell fate determination.
Volume: 2
Issue: 11
Pages: 815-22
Publication
First Author: Maggi LB Jr
Year: 2008
Journal: Mol Cell Biol
Title: Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome.
Volume: 28
Issue: 23
Pages: 7050-65
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Schmidt-Zachmann MS
Year: 1988
Journal: Chromosoma
Title: DNA cloning and amino acid sequence determination of a major constituent protein of mammalian nucleoli. Correspondence of the nucleoplasmin-related protein NO38 to mammalian protein B23.
Volume: 96
Issue: 6
Pages: 417-26
Publication
First Author: Ren Z
Year: 2020
Journal: Leukemia
Title: Opposing effects of NPM1wt and NPM1c mutants on AKT signaling in AML.
Volume: 34
Issue: 4
Pages: 1172-1176
Publication
First Author: Raval A
Year: 2012
Journal: Leukemia
Title: Effect of nucleophosmin1 haploinsufficiency on hematopoietic stem cells.
Volume: 26
Issue: 4
Pages: 853-5
Publication
First Author: Wanzel M
Year: 2008
Journal: Nat Cell Biol
Title: A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth.
Volume: 10
Issue: 9
Pages: 1051-61
Publication  
First Author: Otto J
Year: 1980
Journal: Mouse News Lett
Title: Submandibular gland esterproteases.
Volume: 63
Pages: 12
Publication
First Author: Wu MH
Year: 2002
Journal: J Biol Chem
Title: UV stimulation of nucleophosmin/B23 expression is an immediate-early gene response induced by damaged DNA.
Volume: 277
Issue: 50
Pages: 48234-40
Publication
First Author: Inouye CJ
Year: 1994
Journal: J Biol Chem
Title: Relief of YY1-induced transcriptional repression by protein-protein interaction with the nucleolar phosphoprotein B23.
Volume: 269
Issue: 9
Pages: 6506-10
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289400
Age: embryonic day 2.0
Specimen Label: 4-cell-A1-1
Detected: true
Specimen Num: 13
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289400
Age: embryonic day 2.0
Specimen Label: 4-cell-A1-2
Detected: true
Specimen Num: 14
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289400
Age: embryonic day 2.0
Specimen Label: 4-cell-A2-1
Detected: true
Specimen Num: 15
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289400
Age: embryonic day 2.0
Specimen Label: 4-cell-A2-2
Detected: true
Specimen Num: 16
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289400
Age: embryonic day 2.0
Specimen Label: 4-cell-A3-1
Detected: true
Specimen Num: 17
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289400
Age: embryonic day 2.0
Specimen Label: 4-cell-A3-2
Detected: true
Specimen Num: 18
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289400
Age: embryonic day 2.0
Specimen Label: 4-cell-A4-1
Detected: true
Specimen Num: 19
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289400
Age: embryonic day 2.0
Specimen Label: 4-cell-A4-2
Detected: true
Specimen Num: 20
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289400
Age: embryonic day 2.0
Specimen Label: 4-cell-B1-1
Detected: true
Specimen Num: 21
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289400
Age: embryonic day 2.0
Specimen Label: 4-cell-B1-2
Detected: true
Specimen Num: 22
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289400
Age: embryonic day 2.0
Specimen Label: 4-cell-B2-1
Detected: true
Specimen Num: 23
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289400
Age: embryonic day 2.0
Specimen Label: 4-cell-B2-2
Detected: true
Specimen Num: 24
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289400
Age: embryonic day 2.0
Specimen Label: 4-cell-B3-1
Detected: true
Specimen Num: 25
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289400
Age: embryonic day 2.0
Specimen Label: 4-cell-B3-2
Detected: true
Specimen Num: 26
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289400
Age: embryonic day 2.0
Specimen Label: 4-cell-B4-1
Detected: true
Specimen Num: 27
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289400
Age: embryonic day 2.0
Specimen Label: 4-cell-B4-2
Detected: true
Specimen Num: 28
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289400
Age: embryonic day 2.0
Specimen Label: 4-cell-C1-1
Detected: true
Specimen Num: 29
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289400
Age: embryonic day 2.0
Specimen Label: 4-cell-C1-2
Detected: true
Specimen Num: 30
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289400
Age: embryonic day 2.0
Specimen Label: 4-cell-C2-1
Detected: true
Specimen Num: 31
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289400
Age: embryonic day 2.0
Specimen Label: 4-cell-C2-2
Detected: true
Specimen Num: 32
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289400
Age: embryonic day 2.0
Specimen Label: 4-cell-C3-1
Detected: true
Specimen Num: 33
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289400
Age: embryonic day 2.0
Specimen Label: 4-cell-C3-2
Detected: true
Specimen Num: 34
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289400
Age: embryonic day 2.0
Specimen Label: 4-cell-C4-1
Detected: true
Specimen Num: 35
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289400
Age: embryonic day 2.0
Specimen Label: 4-cell-C4-2
Detected: true
Specimen Num: 36
GXD Expression      
Probe: MGI:6455502
Assay Type: RT-PCR
Annotation Date: 2020-09-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284523
Stage: TS23
Assay Id: MGI:6455507
Age: embryonic day 15.0
Specimen Label: E15
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6455502
Assay Type: RT-PCR
Annotation Date: 2020-09-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284525
Stage: TS25
Assay Id: MGI:6455507
Age: embryonic day 17.0
Specimen Label: E17
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6455502
Assay Type: RT-PCR
Annotation Date: 2020-09-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Stage: TS28
Assay Id: MGI:6455507
Age: postnatal day 7
Specimen Label: P7
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6455502
Assay Type: RT-PCR
Annotation Date: 2020-09-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Stage: TS28
Assay Id: MGI:6455507
Age: postnatal day 14
Specimen Label: P14
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6455503
Assay Type: Western blot
Annotation Date: 2020-09-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284523
Stage: TS23
Assay Id: MGI:6455508
Age: embryonic day 15.0
Specimen Label: E15
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6455503
Assay Type: Western blot
Annotation Date: 2020-09-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284525
Stage: TS25
Assay Id: MGI:6455508
Age: embryonic day 17.0
Specimen Label: E17
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6455503
Assay Type: Western blot
Annotation Date: 2020-09-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Stage: TS28
Assay Id: MGI:6455508
Age: postnatal day 7
Specimen Label: P7
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6455503
Assay Type: Western blot
Annotation Date: 2020-09-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Stage: TS28
Assay Id: MGI:6455508
Age: postnatal day 14
Specimen Label: P14
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289400
Age: embryonic day 1.5
Specimen Label: 2-cell-A1-1
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289400
Age: embryonic day 1.5
Specimen Label: 2-cell-A1-2
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289400
Age: embryonic day 1.5
Specimen Label: 2-cell-A2-1
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289400
Age: embryonic day 1.5
Specimen Label: 2-cell-A2-2
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289400
Age: embryonic day 1.5
Specimen Label: 2-cell-B1-1
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289400
Age: embryonic day 1.5
Specimen Label: 2-cell-B1-2
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289400
Age: embryonic day 1.5
Specimen Label: 2-cell-B2-1
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289400
Age: embryonic day 1.5
Specimen Label: 2-cell-B2-2
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289400
Age: embryonic day 1.5
Specimen Label: 2-cell-C1-1
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289400
Age: embryonic day 1.5
Specimen Label: 2-cell-C1-2
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289400
Age: embryonic day 1.5
Specimen Label: 2-cell-C2-1
Detected: true
Specimen Num: 11
GXD Expression      
Probe: MGI:5289050
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289400
Age: embryonic day 1.5
Specimen Label: 2-cell-C2-2
Detected: true
Specimen Num: 12
GXD Expression      
Probe: MGI:6455502
Assay Type: RT-PCR
Annotation Date: 2020-09-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6455507
Age: embryonic day 13.0
Specimen Label: E13
Detected: true
Specimen Num: 1