Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Neurotrophins are a family of secreted proteins that regulate development, maintenance and function of vertebrate nervous systems. They act via two different classes of receptor: p75NTR (a member of the TNF receptor superfamily), and neurotrophic tyrosine kinase receptors (NTRKs) - also known as tropomyosin-related kinases (Trks) []. NTRKs are multi-domain, transmembrane proteins - in addition to their cytoplasmic kinase domains, members of the family possess a number of extracellular leucine-rich repeat (LRR) and Ig-like C2-type regions. Ligand binding induces them to dimerise, resulting in activation of their cytoplasmic tyrosine kinase domains. The activated receptors couple to a variety of intracellular signalling cascades, including the Ras, phosphatidylinositol-3-kinase (PI-3 kinase), mitogen-activated protein (MAP) kinase, and phospholipase C (PLC)-gamma pathways []. NTRK1 (also termed TrkA) is a high-affinity receptor for nerve growth factor (NGF). The receptor is expressed in the dorsal root ganglia, trigeminal ganglia and sympathetic neurons of the peripheral nervous system, and in basal forebrain cholinergic neurons []. It is also expressed in peripheral sites, such as scalp skin []. Whereas p75NTR activation by NGF induces apoptosis, NTRK1 mediates the growth factor's cell survival-promoting effects []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Adly MA |
Year: |
2006 |
Journal: |
J Cutan Pathol |
Title: |
Expression of nerve growth factor and its high-affinity receptor, tyrosine kinase A proteins, in the human scalp skin. |
Volume: |
33 |
Issue: |
8 |
Pages: |
559-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoon SO |
Year: |
1998 |
Journal: |
J Neurosci |
Title: |
Competitive signaling between TrkA and p75 nerve growth factor receptors determines cell survival. |
Volume: |
18 |
Issue: |
9 |
Pages: |
3273-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lei L |
Year: |
2007 |
Journal: |
Cell Mol Life Sci |
Title: |
Transcriptional regulation of Trk family neurotrophin receptors. |
Volume: |
64 |
Issue: |
5 |
Pages: |
522-32 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753920 |
Pattern: |
Non-Uniform |
Stage: |
TS20 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 12.5 |
Image: |
Ntrk1 - E12.5 |
Note: |
There is strong staining in the ventricular zone of the ventral POA, PVH, VMH and ARH nuclei and the AVH and weak, scattered staining in the anterior and posterior IDs. Staining is either absent or ubiquitous in the ventricular zone of the dorsal POA. |
Specimen Label: |
Ntrk1 - E12.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3266522 |
Pattern: |
Non-Uniform |
Stage: |
TS22 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 14.5 |
Image: |
Ntrk1 - E14.5 |
Note: |
There is strong staining in the ventricular zone of the ganglionic eminences. Staining is either absent or ubiquitous in the mantle zone of the ganglionic eminences. |
Specimen Label: |
Ntrk1 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271120 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 12.5 |
Image: |
Ntrk1 - E12.5 |
Note: |
Staining is either absent or ubiquitous in the postmitotic neurons in the cortical plate of the cerebral cortex. |
Specimen Label: |
Ntrk1 - E12.5 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271122 |
Pattern: |
Scattered |
Stage: |
TS22 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 14.5 |
Image: |
Ntrk1 - E14.5 |
Note: |
There is weak, scattered staining in the postmitotic neurons in the cortical plate of the cerebral cortex. |
Specimen Label: |
Ntrk1 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271124 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 16.5 |
Image: |
Ntrk1 - E16.5 |
Note: |
There is moderate staining in the postmitotic neurons in the cortical plate of the cerebral cortex. |
Specimen Label: |
Ntrk1 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271220 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 12.5 |
Image: |
Ntrk1 - E12.5 |
Note: |
Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone of the cerebral cortex. |
Specimen Label: |
Ntrk1 - E12.5 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271222 |
Pattern: |
Scattered |
Stage: |
TS22 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 14.5 |
Image: |
Ntrk1 - E14.5 |
Note: |
There is weak, scattered staining in the postmitotic neurons in the intermediate zone of the cerebral cortex. |
Specimen Label: |
Ntrk1 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271224 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 16.5 |
Image: |
Ntrk1 - E16.5 |
Note: |
There is moderate staining in the postmitotic neurons in the intermediate zone of the cerebral cortex. |
Specimen Label: |
Ntrk1 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754320 |
Pattern: |
Non-Uniform |
Stage: |
TS20 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 12.5 |
Image: |
Ntrk1 - E12.5 |
Note: |
There is strong staining in the ventricular zone of the prethalamus. Staining is either absent or ubiquitous in the ventricular zone of the dorsal thalamus. |
Specimen Label: |
Ntrk1 - E12.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754322 |
Pattern: |
Non-Uniform |
Stage: |
TS22 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 14.5 |
Image: |
Ntrk1 - E14.5 |
Note: |
There is moderate staining in the ventricular zone of the prethalamus and moderate, scattered staining in the dorsal thalamus. |
Specimen Label: |
Ntrk1 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754324 |
Pattern: |
Non-Uniform |
Stage: |
TS24 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 16.5 |
Image: |
Ntrk1 - E16.5 |
Note: |
There is strong staining in the ventricular zone of the prethalamus. Staining is either absent or ubiquitous in the ventricular zone of the dorsal thalamus. |
Specimen Label: |
Ntrk1 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753720 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 12.5 |
Image: |
Ntrk1 - E12.5 |
Note: |
Staining is either absent or ubiquitous in the mantle zone of the dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH and anterior and posterior IDs. |
Specimen Label: |
Ntrk1 - E12.5 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753722 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 14.5 |
Image: |
Ntrk1 - E14.5 |
Note: |
Staining is either absent or ubiquitous in the mantle zone of the dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH and anterior and posterior IDs. |
Specimen Label: |
Ntrk1 - E14.5 |
|
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753724 |
Pattern: |
Non-Uniform |
Stage: |
TS24 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 16.5 |
Image: |
Ntrk1 - E16.5 |
Note: |
There is strong staining in the mantle zone of the dorsal POA, DMH, VMH and ARH nuclei and the PH. Staining is either absent or ubiquitous in the mantle zone of the ventral POA, PVH and SCH nuclei, the AVH and the DAH. |
Specimen Label: |
Ntrk1 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691319 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 11.5 |
Image: |
Ntrk1 - E11.5 |
Note: |
Staining is either absent or ubiquitous in the ventricular zone of the cerebral cortex and the ganglionic eminences. |
Specimen Label: |
Ntrk1 - E11.5 |
|
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271820 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 12.5 |
Image: |
Ntrk1 - E12.5 |
Note: |
Staining is either absent or ubiquitous in the mantle zone of the premam, mam and supramam zones and the TT. |
Specimen Label: |
Ntrk1 - E12.5 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271822 |
Pattern: |
Non-Uniform |
Stage: |
TS22 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 14.5 |
Image: |
Ntrk1 - E14.5 |
Note: |
There is weak, scattered staining in the mantle zone of the mam zone. Staining is either absent or ubiquitous in the mantle zone of the premam and supramam zones and the TT. |
Specimen Label: |
Ntrk1 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271824 |
Pattern: |
Non-Uniform |
Stage: |
TS24 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 16.5 |
Image: |
Ntrk1 - E16.5 |
Note: |
There is strong staining in the mantle zone of the premam zone and moderate staining in the mam and supramam zone. |
Specimen Label: |
Ntrk1 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1690819 |
Pattern: |
Non-Uniform |
Stage: |
TS19 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 11.5 |
Image: |
Ntrk1 - E11.5 |
Note: |
There is strong staining in the VZ of the ventral POA, VMH & ARH nuclei, AVH, anterior & posterior IDs, premam & mam zones & TT. Staining is either absent or ubiquitous in the VZ of dorsal thalamus, prethalamus, dorsal POA, PVH nucleus & supramam zone. |
Specimen Label: |
Ntrk1 - E11.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753922 |
Pattern: |
Non-Uniform |
Stage: |
TS22 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 14.5 |
Image: |
Ntrk1 - E14.5 |
Note: |
There is very strong staining in the VZ of the VMH & ARH nuclei, strong staining in the ventral POA, PVH nucleus & the AVH & weak, scattered staining in the anterior & posterior IDs. Staining is either absent or ubiquitous in the VZ of the dorsal POA. |
Specimen Label: |
Ntrk1 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753924 |
Pattern: |
Non-Uniform |
Stage: |
TS24 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 16.5 |
Image: |
Ntrk1 - E16.5 |
Note: |
There is very strong staining in the ventricular zone of the VMH and ARH nuclei and strong staining in the AVH and DAH. Staining is either absent or ubiquitous in the ventricular zone of the dorsal and ventral POAs, the PVH, SCH and DMH nuclei and the PH. |
Specimen Label: |
Ntrk1 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691119 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 11.5 |
Image: |
Ntrk1 - E11.5 |
Note: |
Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone and cortical plate of the cerebral cortex and in the mantle zone of the ganglionic eminences. |
Specimen Label: |
Ntrk1 - E11.5 |
|
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754720 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 12.5 |
Image: |
Ntrk1 - E12.5 |
Note: |
Staining is either absent or ubiquitous in the ventricular zone of the cerebral cortex. |
Specimen Label: |
Ntrk1 - E12.5 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754722 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 14.5 |
Image: |
Ntrk1 - E14.5 |
Note: |
Staining is either absent or ubiquitous in the ventricular zone of the cerebral cortex. |
Specimen Label: |
Ntrk1 - E14.5 |
|
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754724 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 16.5 |
Image: |
Ntrk1 - E16.5 |
Note: |
Staining is either absent or ubiquitous in the ventricular zone of the cerebral cortex. |
Specimen Label: |
Ntrk1 - E16.5 |
|
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271020 |
Pattern: |
Non-Uniform |
Stage: |
TS20 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 12.5 |
Image: |
Ntrk1 - E12.5 |
Note: |
There is strong staining in the ventricular zone of the premam and mam zones and weak, scattered staining in the TT and supramam zone. |
Specimen Label: |
Ntrk1 - E12.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271022 |
Pattern: |
Non-Uniform |
Stage: |
TS22 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 14.5 |
Image: |
Ntrk1 - E14.5 |
Note: |
There is very strong staining in the ventricular zone of the premam and mam zones and weak, scattered staining in the TT and supramam zone. |
Specimen Label: |
Ntrk1 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271024 |
Pattern: |
Non-Uniform |
Stage: |
TS24 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 16.5 |
Image: |
Ntrk1 - E16.5 |
Note: |
There is very strong staining in the ventricular zone of the premam and mam zones. Staining is either absent or ubiquitous in the ventricular zone of the supramam zone. |
Specimen Label: |
Ntrk1 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3266520 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 12.5 |
Image: |
Ntrk1 - E12.5 |
Note: |
Staining is either absent or ubiquitous in the ventricular and mantle zones of the ganglionic eminences. |
Specimen Label: |
Ntrk1 - E12.5 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3266524 |
Pattern: |
Non-Uniform |
Stage: |
TS24 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 16.5 |
Image: |
Ntrk1 - E16.5 |
Note: |
There is strong staining in the mantle zone of the ganglionic eminences. Staining is either absent or ubiquitous in the ventricular zone of the ganglionic eminences. |
Specimen Label: |
Ntrk1 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1690619 |
Pattern: |
Non-Uniform |
Stage: |
TS19 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 11.5 |
Image: |
Ntrk1 - E11.5 |
Note: |
There is moderate staining in the MZ of the prethalamus. Staining is either absent or ubiquitous in the MZ of the dorsal thalamus, dorsal & ventral POAs, the PVH, VMH & ARH nuclei, the AVH, anterior & posterior IDs, premam, mam & supramam zones & the TT. |
Specimen Label: |
Ntrk1 - E11.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754120 |
Pattern: |
Non-Uniform |
Stage: |
TS20 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 12.5 |
Image: |
Ntrk1 - E12.5 |
Note: |
There is moderate staining in the mantle zone of the prethalamus and weak staining in the dorsal thalamus. |
Specimen Label: |
Ntrk1 - E12.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754122 |
Pattern: |
Non-Uniform |
Stage: |
TS22 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 14.5 |
Image: |
Ntrk1 - E14.5 |
Note: |
There is weak, scattered staining in the mantle zone of the dorsal thalamus. Staining is either absent or ubiquitous in the mantle zone of the prethalamus. |
Specimen Label: |
Ntrk1 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442687 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754124 |
Pattern: |
Non-Uniform |
Stage: |
TS24 |
Assay Id: |
MGI:4450881 |
Age: |
embryonic day 16.5 |
Image: |
Ntrk1 - E16.5 |
Note: |
There is moderate staining in the mantle zone of the dorsal thalamus and weak staining in the prethalamus. |
Specimen Label: |
Ntrk1 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
799
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Bothwell M |
Year: |
1995 |
Journal: |
Annu Rev Neurosci |
Title: |
Functional interactions of neurotrophins and neurotrophin receptors. |
Volume: |
18 |
|
Pages: |
223-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang EJ |
Year: |
2001 |
Journal: |
Annu Rev Neurosci |
Title: |
Neurotrophins: roles in neuronal development and function. |
Volume: |
24 |
|
Pages: |
677-736 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kerr B |
Year: |
2009 |
Journal: |
Reproduction |
Title: |
NTRK1 and NTRK2 receptors facilitate follicle assembly and early follicular development in the mouse ovary. |
Volume: |
138 |
Issue: |
1 |
Pages: |
131-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakajima K |
Year: |
2020 |
Journal: |
Transl Psychiatry |
Title: |
Ntrk1 mutation co-segregating with bipolar disorder and inherited kidney disease in a multiplex family causes defects in neuronal growth and depression-like behavior in mice. |
Volume: |
10 |
Issue: |
1 |
Pages: |
407 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179390 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:6190978 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Ntrk1 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179390 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190978 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Ntrk1 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179390 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:6190978 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Ntrk1 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179390 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6190978 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Ntrk1 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179390 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6190978 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Ntrk1 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179390 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190978 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Ntrk1 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179390 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190978 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Ntrk1 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7643374 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-05-29 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3671019 |
|
Stage: |
TS19 |
Assay Id: |
MGI:7643434 |
Age: |
embryonic day 11.5 |
Image: |
S4B |
Note: |
Conditional ablation of Twist1 produces abnormal cellular aggregates. Expression of Ntrk1 was not detected in the aggregates. |
Specimen Label: |
S4B |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Smeyne RJ |
Year: |
1994 |
Journal: |
Nature |
Title: |
Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. |
Volume: |
368 |
Issue: |
6468 |
Pages: |
246-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matsuo S |
Year: |
2001 |
Journal: |
Neuroscience |
Title: |
trkA modulation of developing somatosensory neurons in oro-facial tissues: tooth pulp fibers are absent in trkA knockout mice. |
Volume: |
105 |
Issue: |
3 |
Pages: |
747-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
de Castro F |
Year: |
1998 |
Journal: |
Eur J Neurosci |
Title: |
Corneal innervation and sensitivity to noxious stimuli in trkA knockout mice. |
Volume: |
10 |
Issue: |
1 |
Pages: |
146-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fagan AM |
Year: |
1997 |
Journal: |
J Neurosci |
Title: |
A role for TrkA during maturation of striatal and basal forebrain cholinergic neurons in vivo. |
Volume: |
17 |
Issue: |
20 |
Pages: |
7644-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
GarcÃa-Suárez O |
Year: |
2000 |
Journal: |
J Neuroimmunol |
Title: |
TrkA is necessary for the normal development of the murine thymus. |
Volume: |
108 |
Issue: |
1-2 |
Pages: |
11-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Silos-Santiago I |
Year: |
1995 |
Journal: |
J Neurosci |
Title: |
Non-TrkA-expressing small DRG neurons are lost in TrkA deficient mice. |
Volume: |
15 |
Issue: |
9 |
Pages: |
5929-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Connor B |
Year: |
2023 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Transcytosis-mediated anterograde transport of TrkA receptors is necessary for sympathetic neuron development and function. |
Volume: |
120 |
Issue: |
6 |
Pages: |
e2205426120 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miyamoto Y |
Year: |
2013 |
Journal: |
Sci Signal |
Title: |
Akt and PP2A reciprocally regulate the guanine nucleotide exchange factor Dock6 to control axon growth of sensory neurons. |
Volume: |
6 |
Issue: |
265 |
Pages: |
ra15 |
|
•
•
•
•
•
|
Publication |
First Author: |
White FA |
Year: |
1996 |
Journal: |
J Neurosci |
Title: |
Synchronous onset of NGF and TrkA survival dependence in developing dorsal root ganglia. |
Volume: |
16 |
Issue: |
15 |
Pages: |
4662-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schober A |
Year: |
1997 |
Journal: |
J Neurosci |
Title: |
Reduced acetylcholinesterase (AChE) activity in adrenal medulla and loss of sympathetic preganglionic neurons in TrkA-deficient, but not TrkB-deficient, mice. |
Volume: |
17 |
Issue: |
3 |
Pages: |
891-903 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gorokhova S |
Year: |
2014 |
Journal: |
PLoS Genet |
Title: |
Uncoupling of molecular maturation from peripheral target innervation in nociceptors expressing a chimeric TrkA/TrkC receptor. |
Volume: |
10 |
Issue: |
2 |
Pages: |
e1004081 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fagan AM |
Year: |
1996 |
Journal: |
J Neurosci |
Title: |
TrkA, but not TrkC, receptors are essential for survival of sympathetic neurons in vivo. |
Volume: |
16 |
Issue: |
19 |
Pages: |
6208-18 |
|
•
•
•
•
•
|
Publication |
First Author: |
Middleton G |
Year: |
2001 |
Journal: |
Development |
Title: |
Populations of NGF-dependent neurones differ in their requirement for BAX to undergo apoptosis in the absence of NGF/TrkA signalling in vivo. |
Volume: |
128 |
Issue: |
23 |
Pages: |
4715-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Patel TD |
Year: |
2000 |
Journal: |
Neuron |
Title: |
Development of sensory neurons in the absence of NGF/TrkA signaling in vivo. |
Volume: |
25 |
Issue: |
2 |
Pages: |
345-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schimmang T |
Year: |
1997 |
Journal: |
Mech Dev |
Title: |
Survival of inner ear sensory neurons in trk mutant mice. |
Volume: |
64 |
Issue: |
1-2 |
Pages: |
77-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ichikawa H |
Year: |
2004 |
Journal: |
Acta Histochem |
Title: |
The development of myelinated nociceptors is dependent upon trks in the trigeminal ganglion. |
Volume: |
106 |
Issue: |
5 |
Pages: |
337-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ichikawa H |
Year: |
2000 |
Journal: |
Neuroreport |
Title: |
Developmental dependency of Meissner corpuscles on trkB but not trkA or trkC. |
Volume: |
11 |
Issue: |
2 |
Pages: |
259-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Minichiello L |
Year: |
1995 |
Journal: |
Development |
Title: |
Differential effects of combined trk receptor mutations on dorsal root ganglion and inner ear sensory neurons. |
Volume: |
121 |
Issue: |
12 |
Pages: |
4067-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Minichiello L |
Year: |
1996 |
Journal: |
Genes Dev |
Title: |
TrkB and TrkC neurotrophin receptors cooperate in promoting survival of hippocampal and cerebellar granule neurons. |
Volume: |
10 |
Issue: |
22 |
Pages: |
2849-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ichikawa H |
Year: |
2001 |
Journal: |
Brain Res Mol Brain Res |
Title: |
Developmental dependency of Merkel endings on trks in the palate. |
Volume: |
88 |
Issue: |
1-2 |
Pages: |
171-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nikoletopoulou V |
Year: |
2010 |
Journal: |
Nature |
Title: |
Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not. |
Volume: |
467 |
Issue: |
7311 |
Pages: |
59-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakajima K |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
Exome sequencing in the knockin mice generated using the CRISPR/Cas system. |
Volume: |
6 |
|
Pages: |
34703 |
|
•
•
•
•
•
|
Publication |
First Author: |
von Bohlen und Halbach O |
Year: |
2005 |
Journal: |
FASEB J |
Title: |
Haploinsufficiency for trkB and trkC receptors induces cell loss and accumulation of alpha-synuclein in the substantia nigra. |
Volume: |
19 |
Issue: |
12 |
Pages: |
1740-2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Piñon LG |
Year: |
1996 |
Journal: |
Development |
Title: |
Timing of neuronal death in trkA, trkB and trkC mutant embryos reveals developmental changes in sensory neuron dependence on Trk signalling. |
Volume: |
122 |
Issue: |
10 |
Pages: |
3255-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schubert L |
Year: |
2023 |
Journal: |
Biol Open |
Title: |
A functional sgRNA-CRISPR screening method for generating murine RET and NTRK1 rearranged oncogenes. |
Volume: |
12 |
Issue: |
8 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Gaillard S |
Year: |
2014 |
Journal: |
Neuron |
Title: |
GINIP, a Gαi-interacting protein, functions as a key modulator of peripheral GABAB receptor-mediated analgesia. |
Volume: |
84 |
Issue: |
1 |
Pages: |
123-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cronk KM |
Year: |
2002 |
Journal: |
Development |
Title: |
Diverse dependencies of developing Merkel innervation on the trkA and both full-length and truncated isoforms of trkC. |
Volume: |
129 |
Issue: |
15 |
Pages: |
3739-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vaegter CB |
Year: |
2011 |
Journal: |
Nat Neurosci |
Title: |
Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling. |
Volume: |
14 |
Issue: |
1 |
Pages: |
54-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Andres R |
Year: |
2008 |
Journal: |
Neurosci Lett |
Title: |
Regulation of sympathetic neuron differentiation by endogenous nerve growth factor and neurotrophin-3. |
Volume: |
431 |
Issue: |
3 |
Pages: |
241-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bourane S |
Year: |
2009 |
Journal: |
Neuron |
Title: |
Low-threshold mechanoreceptor subtypes selectively express MafA and are specified by Ret signaling. |
Volume: |
64 |
Issue: |
6 |
Pages: |
857-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Moqrich A |
Year: |
2004 |
Journal: |
Nat Neurosci |
Title: |
Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate. |
Volume: |
7 |
Issue: |
8 |
Pages: |
812-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fundin BT |
Year: |
1997 |
Journal: |
Dev Biol |
Title: |
Differential dependency of cutaneous mechanoreceptors on neurotrophins, trk receptors, and P75 LNGFR. |
Volume: |
190 |
Issue: |
1 |
Pages: |
94-116 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kuruvilla R |
Year: |
2004 |
Journal: |
Cell |
Title: |
A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling. |
Volume: |
118 |
Issue: |
2 |
Pages: |
243-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rice FL |
Year: |
1998 |
Journal: |
Dev Biol |
Title: |
Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophins, trk receptors, and p75LNGFR. |
Volume: |
198 |
Issue: |
1 |
Pages: |
57-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sedý J |
Year: |
2004 |
Journal: |
Dev Dyn |
Title: |
Pacinian corpuscle development involves multiple Trk signaling pathways. |
Volume: |
231 |
Issue: |
3 |
Pages: |
551-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tiberi A |
Year: |
2023 |
Journal: |
Front Cell Dev Biol |
Title: |
Reduced levels of NGF shift astrocytes toward a neurotoxic phenotype. |
Volume: |
11 |
|
Pages: |
1165125 |
|
•
•
•
•
•
|
Allele |
Name: |
neurotrophic tyrosine kinase, receptor, type 1; targeted mutation 1.2, Tadafumi Kato |
Allele Type: |
Targeted |
Attribute String: |
Not Specified |
|
•
•
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Allele |
Name: |
neurotrophic tyrosine kinase, receptor, type 1; targeted mutation 1.1, Tadafumi Kato |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change |
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
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