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Search results 1 to 93 out of 93 for Nup214

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Drosophila melanogaster
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: Nuclear pore complex protein NUP214 (also known as Protein LONO1 and Protein EMBRYO DEFECTIVE 1011) is a component of the nuclear pore complex in Arabidopsis, required for mature mRNA export from the nucleus to the cytoplasm, essential for normal embryogenesis and seed viability []. It is important during early embryogenesis, being involved in the first asymmetrical cell division of the zygote and regulates the number and planes of cell divisions required for generating the normal embryo proper and suspensor, apical-basal axis, cotyledons and meristem [, ].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Braud C
Year: 2012
Journal: Plant Physiol
Title: LONO1 encoding a nucleoporin is required for embryogenesis and seed viability in Arabidopsis.
Volume: 160
Issue: 2
Pages: 823-36
Publication
First Author: Tzafrir I
Year: 2004
Journal: Plant Physiol
Title: Identification of genes required for embryo development in Arabidopsis.
Volume: 135
Issue: 3
Pages: 1206-20
Publication
First Author: Saito S
Year: 2016
Journal: Mol Cell Biol
Title: Leukemia-Associated Nup214 Fusion Proteins Disturb the XPO1-Mediated Nuclear-Cytoplasmic Transport Pathway and Thereby the NF-κB Signaling Pathway.
Volume: 36
Issue: 13
Pages: 1820-35
Gene
Type: gene
Organism: Homo sapiens
MGI Directed Relationship Property
Name: Non-mouse_Gene_Symbol
Value: NUP214
MGI Directed Relationship Property
Name: Non-mouse_Gene_Symbol
Value: Nup214
Publication
First Author: van Deursen J
Year: 1996
Journal: EMBO J
Title: G2 arrest and impaired nucleocytoplasmic transport in mouse embryos lacking the proto-oncogene CAN/Nup214.
Volume: 15
Issue: 20
Pages: 5574-83
Protein
Organism: Mus musculus
Length: 2085  
Fragment?: false
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:5642139
Assay Type: Western blot
Annotation Date: 2015-06-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:5642174
Age: postnatal adult
Specimen Label: None
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:3844006
Assay Type: RNA in situ
Annotation Date: 2009-05-13
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1609217
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:3844046
Age: embryonic day 10.5
Note: Expression was low in the dorsal spinal cord.
Specimen Label: Table 1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4359249
Assay Type: Immunohistochemistry
Annotation Date: 2009-09-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1646915
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4359466
Age: embryonic day 9.5
Specimen Label: S2 CAN/Nup214 wt
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4359249
Assay Type: Immunohistochemistry
Annotation Date: 2009-09-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1646915
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4359466
Age: embryonic day 9.5
Note: Expression was detected as in wild type.
Specimen Label: S2 CAN/Nup214 merm
Detected: true
Specimen Num: 2
Publication
First Author: Olsson M
Year: 2004
Journal: Exp Cell Res
Title: Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.
Volume: 292
Issue: 2
Pages: 359-70
Publication
First Author: Echeverría PC
Year: 2009
Journal: Mol Cell Biol
Title: Nuclear import of the glucocorticoid receptor-hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin beta.
Volume: 29
Issue: 17
Pages: 4788-97
Publication
First Author: Suntharalingam M
Year: 2003
Journal: Dev Cell
Title: Peering through the pore: nuclear pore complex structure, assembly, and function.
Volume: 4
Issue: 6
Pages: 775-89
Publication
First Author: Copeland NG
Year: 1993
Journal: Science
Title: A genetic linkage map of the mouse: current applications and future prospects.
Volume: 262
Issue: 5130
Pages: 57-66
Publication  
First Author: Masuda T
Year: 2009
Journal: Brain Res
Title: Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord.
Volume: 1249
Pages: 61-7
Publication
First Author: Pilz A
Year: 1996
Journal: Mouse Genome
Title: High resolution genetic linkage analysis of mouse Chromosome 2 in the region of homology with human Chromosome 9
Volume: 94
Issue: 4
Pages: 877-9
Publication
First Author: Lupu F
Year: 2008
Journal: Dev Cell
Title: Nuclear pore composition regulates neural stem/progenitor cell differentiation in the mouse embryo.
Volume: 14
Issue: 6
Pages: 831-42
Publication
First Author: Pilz A
Year: 1995
Journal: Genomics
Title: Comparative mapping of 50 human chromosome 9 loci in the laboratory mouse.
Volume: 25
Issue: 1
Pages: 139-49
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Protein
Organism: Mus musculus
Length: 1529  
Fragment?: false
UniProt Feature
Begin: 2
Description: Nuclear pore complex protein Nup214
Type: chain
End: 2085
Protein
Organism: Mus musculus
Length: 581  
Fragment?: true
Protein
Organism: Mus musculus
Length: 147  
Fragment?: true
Protein
Organism: Mus musculus
Length: 98  
Fragment?: true
Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Jan Cools
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
Allele
Name: transgene insertion 2969, Gerard C Grosveld
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Publication
First Author: Port SA
Year: 2015
Journal: Cell Rep
Title: Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-Binding Sites Involved in Nuclear Export.
Volume: 13
Issue: 4
Pages: 690-702
Protein Domain
Type: Domain
Description: CRM1 is the major nuclear export receptor. During translocation through the nuclear pore, transport complexes transiently interact with phenylalanine-glycine (FG) repeats of multiple nucleoporins. On the cytoplasmic side of the nuclear pore, CRM1 tightly interacts with the nucleoporin Nup214. Nup214 binds to N- and C-terminal regions of CRM1, thereby clamping CRM1 in a closed conformation and stabilizing the export complex. This entry represents an FG repeat region within the C terminus of Nup214 which is required for its interaction with CRM1 [].
Publication
First Author: Ozbek U
Year: 2007
Journal: Am J Pathol
Title: SET-CAN, the product of the t(9;9) in acute undifferentiated leukemia, causes expansion of early hematopoietic progenitors and hyperproliferation of stomach mucosa in transgenic mice.
Volume: 171
Issue: 2
Pages: 654-66
Genotype
Symbol: Tg(Ly6a-SET/NUP214)2969Gcg/?
Background: involves: FVB/NJ
Zygosity: ot
Has Mutant Allele: true
Publication
First Author: Sandén C
Year: 2015
Journal: Leukemia
Title: The DEK oncoprotein and its emerging roles in gene regulation.
Volume: 29
Issue: 8
Pages: 1632-6
Publication
First Author: Vanden Bempt M
Year: 2018
Journal: Cancer Cell
Title: Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia.
Volume: 34
Issue: 2
Pages: 271-285.e7
Publication  
First Author: Chen Z
Year: 2021
Journal: J Exp Med
Title: Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axis.
Volume: 218
Issue: 5
Publication  
First Author: Yin M
Year: 2019
Journal: JCI Insight
Title: A unique mutator phenotype reveals complementary oncogenic lesions leading to acute leukemia.
Volume: 4
Issue: 23
Publication
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 1
Pages: 35-48
Publication
First Author: Trost M
Year: 2009
Journal: Immunity
Title: The phagosomal proteome in interferon-gamma-activated macrophages.
Volume: 30
Issue: 1
Pages: 143-54
Publication
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
Publication
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
Publication
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112