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Search results 1 to 100 out of 111 for Pan3

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Drosophila melanogaster
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Gene
Type: gene
Organism: Saccharomyces cerevisiae
Protein Domain
Type: Family
Description: Pan3 is a regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of the two eukaryotic poly(A) nuclease complexes (Ccr4-Caf1 and Pan2-Pan3) involved in mRNA decay [, ]. It contains a PABP-interacting motif 2 (PAM2) that binds to the C-terminal domain of polyA binding proteins (PABPs) []. It recruits the Pan2-Pan3 complex to mRNA through the Pan3-PABP interaction [].Regulation of mRNA decay rates in eukaryotic cells affects gene expression []. The Pan2-Pan3 complex shortens cytoplasmic mRNA 3' polyA tails to regulate mRNA stability []. In the complex Pan2 provides the catalytic activity, whereas Pan3 mediates Pan2 recruitment to mRNA targets [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein
Organism: Mus musculus
Length: 156  
Fragment?: true
Protein
Organism: Mus musculus
Length: 210  
Fragment?: true
Protein
Organism: Mus musculus
Length: 408  
Fragment?: false
Protein
Organism: Mus musculus
Length: 887  
Fragment?: false
Protein
Organism: Mus musculus
Length: 205  
Fragment?: true
Protein
Organism: Mus musculus
Length: 458  
Fragment?: true
Protein
Organism: Mus musculus
Length: 688  
Fragment?: true
Protein
Organism: Mus musculus
Length: 837  
Fragment?: false
Publication
First Author: Jonas S
Year: 2014
Journal: Nat Struct Mol Biol
Title: An asymmetric PAN3 dimer recruits a single PAN2 exonuclease to mediate mRNA deadenylation and decay.
Volume: 21
Issue: 7
Pages: 599-608
Publication
First Author: Wolf J
Year: 2014
Journal: EMBO J
Title: Structural basis for Pan3 binding to Pan2 and its function in mRNA recruitment and deadenylation.
Volume: 33
Issue: 14
Pages: 1514-26
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Siddiqui N
Year: 2007
Journal: J Biol Chem
Title: Poly(A) nuclease interacts with the C-terminal domain of polyadenylate-binding protein domain from poly(A)-binding protein.
Volume: 282
Issue: 34
Pages: 25067-75
Publication
First Author: Boeck R
Year: 1996
Journal: J Biol Chem
Title: The yeast Pan2 protein is required for poly(A)-binding protein-stimulated poly(A)-nuclease activity.
Volume: 271
Issue: 1
Pages: 432-8
Publication
First Author: Yamashita A
Year: 2005
Journal: Nat Struct Mol Biol
Title: Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover.
Volume: 12
Issue: 12
Pages: 1054-63
Publication
First Author: Wilusz CJ
Year: 2001
Journal: Nat Rev Mol Cell Biol
Title: The cap-to-tail guide to mRNA turnover.
Volume: 2
Issue: 4
Pages: 237-46
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Publication
First Author: Zheng D
Year: 2008
Journal: J Cell Biol
Title: Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells.
Volume: 182
Issue: 1
Pages: 89-101
Publication  
First Author: Cai Y
Year: 2015
Journal: BMC Pulm Med
Title: Transgenically-expressed secretoglobin 3A2 accelerates resolution of bleomycin-induced pulmonary fibrosis in mice.
Volume: 15
Pages: 72
Publication
First Author: Christie M
Year: 2013
Journal: Mol Cell
Title: Structure of the PAN3 pseudokinase reveals the basis for interactions with the PAN2 deadenylase and the GW182 proteins.
Volume: 51
Issue: 3
Pages: 360-73
Publication      
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Protein Domain
Type: Domain
Description: This is a pseudokinase (PK) domain found in PAB-dependent poly(A)-specific ribonuclease subunit PAN3. PAN3 proteins contain three prominent regions: an unstructured N-terminal region (N-term), a central PK domain, and a highly conserved C-terminal domain (C-term). The PAN3 PK domain has retained its ATP binding capacity, and this function is required for mRNA degradation in vivo. Analysis of Pan3 amino acids sequences show that, despite of retaining the general structural characteristics of protein kinases, the PK domain has substitutions in all the conserved motifs that are critical for kinase activity, such as in the catalytic VAIK and HRD motifs and in the Mg2+ binding DFG motif. However, the PAN3 PK domain has been shown to bind ATP. Furthermore, similar to other kinases, the ATP-binding site is located in the cleft between the N- and C-lobes of the kinase fold, however, the ATP-binding pocket is wider than that of typical kinases [].
UniProt Feature
Begin: 1
Description: PAN2-PAN3 deadenylation complex subunit Pan3
Type: chain
End: 837
Protein
Organism: Mus musculus
Length: 301  
Fragment?: false
Protein
Organism: Mus musculus
Length: 183  
Fragment?: true
Protein
Organism: Mus musculus
Length: 105  
Fragment?: true
Allele  
Name: PAN3 poly(A) specific ribonuclease subunit; wild type
Allele Type: Not Specified
Allele  
Name: PAN3 poly(A) specific ribonuclease subunit; gene trap OST348431, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: PAN3 poly(A) specific ribonuclease subunit; gene trap BGB533, BayGenomics
Allele Type: Gene trapped
Allele  
Name: PAN3 poly(A) specific ribonuclease subunit; gene trap XG307, BayGenomics
Allele Type: Gene trapped
Allele  
Name: PAN3 poly(A) specific ribonuclease subunit; gene trap YHB182, BayGenomics
Allele Type: Gene trapped
Allele  
Name: PAN3 poly(A) specific ribonuclease subunit; gene trap CSH548, BayGenomics
Allele Type: Gene trapped
Allele  
Name: PAN3 poly(A) specific ribonuclease subunit; gene trap CSI758, BayGenomics
Allele Type: Gene trapped
Allele  
Name: PAN3 poly(A) specific ribonuclease subunit; gene trap OST65480, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: PAN3 poly(A) specific ribonuclease subunit; gene trap OST359374, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: PAN3 poly(A) specific ribonuclease subunit; gene trap IST14631F4, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: PAN3 poly(A) specific ribonuclease subunit; gene trap IST15091A10, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele
Name: PAN3 poly(A) specific ribonuclease subunit; endonuclease-mediated mutation 1, Toronto Centre for Phenogenomics
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Strain
Attribute String: mutant stock, gene trap
Strain
Attribute String: mutant stock, gene trap
Allele  
Name: PAN3 poly(A) specific ribonuclease subunit; gene trap A045F04, German Gene Trap Consortium
Allele Type: Gene trapped
Strain
Attribute String: coisogenic, targeted mutation
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Genotype
Symbol: Pan3/Pan3
Background: C57BL/6N-Pan3/Tcp
Zygosity: hm
Has Mutant Allele: true
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus